| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenxi Lu, Yanbin Song, Xiaopeng Wu, Wangrui Lei, Junmin Chen, Xin Zhang, Qiong Liu, Chao Deng, Zhenxing Liang, Ying Chen, Jun Ren, Yang Yan. Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury. Journal of advanced research. 2024-04-23. PMID:38653371. |
growth arrest-specific gene 6 (gas6) is vitamin k-dependent secretory protein, to promote cell proliferation and inhibit inflammation and apoptosis through binding with tyro3, axl, and mertk (tam) receptors. |
2024-04-23 |
2024-04-26 |
Not clear |
| Han Yin, Yue Hua, Songwei Feng, Yi Xu, Yue Ding, Sicong Liu, Dongsheng Chen, Furong Du, Gaolin Liang, Wenjun Zhan, Yang She. In Situ Nanofiber Formation Blocks AXL and GAS6 Binding to Suppress Ovarian Cancer Development. Advanced materials (Deerfield Beach, Fla.). 2024-03-28. PMID:38546279. |
in vivo and in vitro experiments demonstrate that in situ formed nap-ir nanofibers efficiently induce apoptosis of ovarian cancer cells by blocking axl activation and disrupting subsequent downstream signaling events. |
2024-03-28 |
2024-03-30 |
Not clear |
| Kenji Morimoto, Tadaaki Yamada, Soichi Hirai, Yuki Katayama, Sarina Fukui, Ryo Sawada, Yusuke Tachibana, Yohei Matsui, Ryota Nakamura, Masaki Ishida, Hayato Kawachi, Kei Kunimasa, Takaaki Sasaki, Makoto Nishida, Naoki Furuya, Satoshi Watanabe, Shinsuke Shiotsu, Naoya Nishioka, Mano Horinaka, Toshiyuki Sakai, Hisanori Uehara, Seiji Yano, Bo-Kyung Son, Shinsaku Tokuda, Koichi Takayam. AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells. Cancer letters. 2024-02-11. PMID:38342232. |
axl inhibition reduced the viability of axl-overexpressing kras g12c-mutated lung cancer cells by enhancing kras g12c inhibition-induced apoptosis. |
2024-02-11 |
2024-02-14 |
rat |
| Mirko Terragno, Anastassiya Vetrova, Oleg Semenov, A Emre Sayan, Marina Kriajevska, Eugene Tulchinsk. Mesenchymal-epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38172210. |
the clinically-relevant axl inhibitor tp-0903 induced met and synergised with art to generate ros, dna damage and apoptosis in tnbc cells. |
2024-01-03 |
2024-01-06 |
Not clear |
| Soichi Hirai, Tadaaki Yamada, Yuki Katayama, Masaki Ishida, Hayato Kawachi, Yohei Matsui, Ryota Nakamura, Kenji Morimoto, Mano Horinaka, Toshiyuki Sakai, Yoshitaka Sekido, Shinsaku Tokuda, Koichi Takayam. Effects of Combined Therapeutic Targeting of AXL and ATR on Pleural Mesothelioma Cells. Molecular cancer therapeutics. 2023-10-06. PMID:37802502. |
the axl and atr inhibitor combination increased cell apoptosis via the bim protein and suppressed cell migration when compared to each monotherapy. |
2023-10-06 |
2023-10-15 |
Not clear |
| Pascal Gelebart, May Eriksen Gjerstad, Susanne Benjaminsen, Jianhua Han, Ida Karlsen, Mireia Mayoral Safont, Calum Leitch, Zinayida Fandalyuk, Mihaela Popa, Lars Helgeland, Bela Papp, Fanny Baran-Marszak, Emmet McCormac. Inhibition of a new AXL isoform (AXL3) induces apoptosis of mantle cell lymphoma cells. Blood. 2023-06-20. PMID:37339584. |
inhibition of a new axl isoform (axl3) induces apoptosis of mantle cell lymphoma cells. |
2023-06-20 |
2023-08-14 |
mouse |
| Yang Qiu, Ying Li, Meng Chai, Huiming Hua, Rui Wang, Samuel Waxman, Yongkui Jin. The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors. Cell death discovery. vol 9. issue 1. 2023-02-04. PMID:36739272. |
the gsk3β/mcl-1 axis is regulated by both flt3-itd and axl and determines the apoptosis induction abilities of flt3-itd inhibitors. |
2023-02-04 |
2023-08-14 |
Not clear |
| Yang Qiu, Ying Li, Meng Chai, Huiming Hua, Rui Wang, Samuel Waxman, Yongkui Jin. The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors. Cell death discovery. vol 9. issue 1. 2023-02-04. PMID:36739272. |
gilteritinib and crenolanib inhibit both flt3-itd and axl and induce apoptosis in molm-13/sor cells, in which they activate gsk3β and downregulate mcl-1. |
2023-02-04 |
2023-08-14 |
Not clear |
| Jun Hong, Selma Maacha, Nataliya Pidkovka, Andreia Bates, Safia N Salaria, Mary K Washington, Abbes Belkhir. AXL Promotes Metformin-Induced Apoptosis Through Mediation of Autophagy by Activating ROS-AMPK-ULK1 Signaling in Human Esophageal Adenocarcinoma. Frontiers in oncology. vol 12. 2022-08-08. PMID:35936716. |
axl promotes metformin-induced apoptosis through mediation of autophagy by activating ros-ampk-ulk1 signaling in human esophageal adenocarcinoma. |
2022-08-08 |
2023-08-14 |
human |
| Jun Hong, Selma Maacha, Nataliya Pidkovka, Andreia Bates, Safia N Salaria, Mary K Washington, Abbes Belkhir. AXL Promotes Metformin-Induced Apoptosis Through Mediation of Autophagy by Activating ROS-AMPK-ULK1 Signaling in Human Esophageal Adenocarcinoma. Frontiers in oncology. vol 12. 2022-08-08. PMID:35936716. |
we demonstrate that axl expression is required for metformin-induced apoptosis in eac cells |
2022-08-08 |
2023-08-14 |
human |
| Wangrui Lei, Songdi Wu, Aizhen Zhao, Zhen Wu, Baoping Ding, Wenwen Yang, Chenxi Lu, Xue Wu, Xiyang Li, Shaofei Zhang, Ye Tian, Yang Yan. Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling. Phytotherapy research : PTR. 2022-05-18. PMID:35583809. |
growth arrest-specific gene 6 (gas6) and its receptor, axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. |
2022-05-18 |
2023-08-13 |
Not clear |
| Zhen Wang, Deng Liu, Qi Yan, Fang Liu, Mengting Zhan, Shunli Qi, Qi Fang, Lei Yao, Weizhi Wang, Ruixin Zhang, Jian Du, Lijian Che. Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression. Transplantation. 2022-05-12. PMID:35546091. |
axl is a member of the tyro3, axl, mertk family and is involved in immune and apoptosis processes in multiple organs. |
2022-05-12 |
2023-08-13 |
Not clear |
| Xuejun Gao, Dandan Xue, Jingjing Cheng, Xin Zhang, Xia Ca. Inhibition of Axl Promotes the Therapeutic Effect of Targeted Inhibition of the PI3K/Akt Pathway in NRAS Mutant Melanoma Cells. Journal of oncology. vol 2022. 2022-03-21. PMID:35310910. |
finally, a melanoma mouse model was established, and it detected the proliferation and apoptosis of mouse tumor cells induced by axl inhibitor and akt inhibitor. |
2022-03-21 |
2023-08-13 |
mouse |
| Xuejun Gao, Dandan Xue, Jingjing Cheng, Xin Zhang, Xia Ca. Inhibition of Axl Promotes the Therapeutic Effect of Targeted Inhibition of the PI3K/Akt Pathway in NRAS Mutant Melanoma Cells. Journal of oncology. vol 2022. 2022-03-21. PMID:35310910. |
the addition of axl inhibitor can synergistically promote the effect of akt inhibitor, slow down the proliferation of tumor cells, and induce cell apoptosis. |
2022-03-21 |
2023-08-13 |
mouse |
| Xiaochen Niu, Ye Cheng, Meng Zhang, Luyang Du, Xue Wu, Chenxi Lu, Xiyang Li, Shuai Liu, Aizhen Zhao, Shaofei Zhang, Zhen Wu, Baoping Ding, Wenzhen Shi, Changyu Wang, Yang Yang, Ye Tia. Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells. Frontiers in cell and developmental biology. vol 9. 2022-02-10. PMID:35141232. |
the biological functions of gas6 are mediated by the interaction with tam (tyro3, axl and mertk) receptors, including cell survival and proliferation, immune regulation and apoptosis. |
2022-02-10 |
2023-08-13 |
human |
| Meng-He Zhao, Wen Liu, Yan Zhang, Juan-Juan Liu, Hui Song, Bing Lu. Epstein-Barr virus miR-BART4-3p regulates cell proliferation, apoptosis, and migration by targeting AXL in gastric carcinoma. Virus genes. 2022-01-27. PMID:35083633. |
epstein-barr virus mir-bart4-3p regulates cell proliferation, apoptosis, and migration by targeting axl in gastric carcinoma. |
2022-01-27 |
2023-08-13 |
Not clear |
| Meng-He Zhao, Wen Liu, Yan Zhang, Juan-Juan Liu, Hui Song, Bing Lu. Epstein-Barr virus miR-BART4-3p regulates cell proliferation, apoptosis, and migration by targeting AXL in gastric carcinoma. Virus genes. 2022-01-27. PMID:35083633. |
to investigate the role of mir-bart4-3p in ebv-associated gastric cancer (ebvagc) and its regulation of cell proliferation, apoptosis, and migration by targeting axl in gc. |
2022-01-27 |
2023-08-13 |
Not clear |
| Meng-He Zhao, Wen Liu, Yan Zhang, Juan-Juan Liu, Hui Song, Bing Lu. Epstein-Barr virus miR-BART4-3p regulates cell proliferation, apoptosis, and migration by targeting AXL in gastric carcinoma. Virus genes. 2022-01-27. PMID:35083633. |
moreover, both inhibition of mir-bart4-3p and axl inhibited cell proliferation and migration and promoted cell apoptosis. |
2022-01-27 |
2023-08-13 |
Not clear |
| Meng-He Zhao, Wen Liu, Yan Zhang, Juan-Juan Liu, Hui Song, Bing Lu. Epstein-Barr virus miR-BART4-3p regulates cell proliferation, apoptosis, and migration by targeting AXL in gastric carcinoma. Virus genes. 2022-01-27. PMID:35083633. |
mir-bart4-3p may inhibit the proliferation and migration and promote apoptosis of gc cells by directly targeting axl. |
2022-01-27 |
2023-08-13 |
Not clear |
| Akash Sabarwal, Johannes Wedel, Kaifeng Liu, David Zurakowski, Samik Chakraborty, Evelyn Flynn, David M Briscoe, Murugabaskar Balan, Soumitro Pa. A combination therapy using mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells, and restricts renal tumor growth following an organ transplantation. Carcinogenesis. 2021-12-29. PMID:34965300. |
this combination induced toxic autophagy and apoptosis to promote cancer cell death; and was associated with a reduced expression of the tumor-promoting receptor tyrosine kinase axl. |
2021-12-29 |
2023-08-13 |
Not clear |