| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suryaa Manoharan, Hemamalini Vedagiri, Ekambaram Peruma. Potent FOXO3a Activators from Biologically Active Compound Library for Cancer Therapeutics: An in silico Approach. Applied biochemistry and biotechnology. 2023-04-05. PMID:37017892. |
the forkhead transcription factor foxo3a is a member of the foxo subfamily, which controls a number of cellular processes including apoptosis, proliferation, cell cycle progression, dna damage, and carcinogenesis. |
2023-04-05 |
2023-08-14 |
Not clear |
| Hui Yang, Yuting Chen, Minjuan Zeng, Haipeng Wu, Xiangli Zou, Tiantian Fang, Lu Zhai, Hairong Liang, Hao Luo, Gaiqin Tian, Qizhan Liu, Huanwen Tan. Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 255. 2023-03-19. PMID:36934544. |
long non-coding rna linc01480 is activated by foxo3a and promotes hydroquinone-induced tk6 cell apoptosis by inhibiting the pi3k/akt pathway. |
2023-03-19 |
2023-08-14 |
Not clear |
| Hui Yang, Yuting Chen, Minjuan Zeng, Haipeng Wu, Xiangli Zou, Tiantian Fang, Lu Zhai, Hairong Liang, Hao Luo, Gaiqin Tian, Qizhan Liu, Huanwen Tan. Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway. Ecotoxicology and environmental safety. vol 255. 2023-03-19. PMID:36934544. |
from these findings, we can conclude that linc01480 is activated by foxo3a, and promotes hq-induced apoptosis by inhibiting the pi3k/akt pathway, suggesting that linc01480 might become a possible target for therapeutic intervention of hq-induced toxicity. |
2023-03-19 |
2023-08-14 |
Not clear |
| Wenliang Gong, Xinyu Li, Yuliang Feng, Ming Ji, Dianjun Zhang, Binjie Chen, Siman Wang, Xiafang Wu, Lulu Cui, Baoman Li, Maosheng Xi. Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice. Journal of psychiatric research. vol 161. 2023-03-18. PMID:36933445. |
we initially discovered that pathological stress associated with ptsd increased the activation of glycogen synthesis kinase-beta (gsk-3β) in neurons and induced the translocation of the transcription factor forkhead box-class o3a (foxo3a) from the cytoplasm to the nucleus, which decreased the expression of uncoupling protein 2 (ucp2) and increased mitochondrial production of reactive oxygen species (ros) to trigger neuronal apoptosis in the prefrontal cortex (pfc). |
2023-03-18 |
2023-08-14 |
mouse |
| Aniello Maiese, Federica Spina, Giacomo Visi, Fabio Del Duca, Alessandra De Matteis, Raffaele La Russa, Marco Di Paolo, Paola Frati, Vittorio Finesch. The Expression of FOXO3a as a Forensic Diagnostic Tool in Cases of Traumatic Brain Injury: An Immunohistochemical Study. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768906. |
this study shows the important role of foxo3a in neuronal autophagy and apoptosis regulation and suggests foxo3a as a possible potential pharmacological target. |
2023-02-11 |
2023-08-14 |
human |
| Zhangdi Xu, Bihui Pan, Yi Miao, Yue Li, Shuchao Qin, Jinhua Liang, Yilin Kong, Xinyu Zhang, Jing Tang, Yi Xia, Huayuan Zhu, Li Wang, Jianyong Li, Jiazhu Wu, Wei X. Prognostic value and therapeutic targeting of XPO1 in chronic lymphocytic leukemia. Clinical and experimental medicine. 2023-02-04. PMID:36738306. |
we showed the effects of selinexor on proliferation inhibition, cell cycle arrest, and apoptosis in cll cell lines with jvm3, mec1, and ibrutinib-resistant (mr) cells via nuclear retention of cargo proteins of iκbα, p65, p50, and foxo3a. |
2023-02-04 |
2023-08-14 |
Not clear |
| Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Che. Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export. Cell death discovery. vol 9. issue 1. 2023-01-31. PMID:36720853. |
regorafenib induces bim-mediated intrinsic apoptosis by blocking akt-mediated foxo3a nuclear export. |
2023-01-31 |
2023-08-14 |
Not clear |
| Beini Sun, Hongce Chen, Xiaoping Wang, Tongsheng Che. Regorafenib induces Bim-mediated intrinsic apoptosis by blocking AKT-mediated FOXO3a nuclear export. Cell death discovery. vol 9. issue 1. 2023-01-31. PMID:36720853. |
most importantly, akt agonist (sc79) not only inhibited rego-induced foxo3a nuclear localization and apoptosis but also restored the proliferation and migration ability of cancer cells, further demonstrating that rego prevented foxo3a nuclear export by deactivating pi3k/akt. |
2023-01-31 |
2023-08-14 |
Not clear |
| Pallabi Bhattacharyya, Atanu Biswas, Subhas C Biswa. Brain-enriched miR-128: Reduced in exosomes from Parkinson's patient plasma, improves synaptic integrity, and prevents 6-OHDA mediated neuronal apoptosis. Frontiers in cellular neuroscience. vol 16. 2023-01-30. PMID:36713778. |
this neuroprotective effect was found to be induced by mir-128-mediated inhibition of foxo3a activation, a transcription factor involved in apoptosis. |
2023-01-30 |
2023-08-14 |
Not clear |
| Juan Yu, Xingyou Liu, Keyao Wang, Huimin Wang, Yufeng Han, Jie Kang, Ruiqiang Deng, Huaijun Zhou, Zhibian Dua. Underlying mechanism of Qiling Jiaogulan Powder in the treatment of broiler ascites syndrome. Poultry science. vol 102. issue 1. 2022-11-05. PMID:36334473. |
qljp may regulate lung oxidative stress, the cell cycle and apoptosis by activating the foxo3a signaling pathway to interfere with the occurrence and development of as in broilers. |
2022-11-05 |
2023-08-14 |
Not clear |
| Huan Zhou, Pengyu Pan, Qiuyu Zhao, Wenjun Liu, Ye Sun, Jianbo Wang, Chunying Liu, Chun Wan. Overcoming Basal Autophagy, Kangai Injection Enhances Cisplatin Cytotoxicity by Regulating FOXO3a-Dependent Autophagic Cell Death and Apoptosis in Human Lung Adenocarcinoma A549/DDP Cells. BioMed research international. vol 2022. 2022-09-12. PMID:36093402. |
we also found that the apoptosis and autophagic cell death induced by cotreatment of kai and cisplatin in a549/ddp cells were foxo3a-dependent as indicated by decreased p-foxo3a expression and increased foxo3a nuclear localization, respectively. |
2022-09-12 |
2023-08-14 |
human |
| Suming Pan, Xiangguo Zhang, Yugan Guo, Yin L. DPCPX induces Bim-dependent apoptosis in nasopharyngeal carcinoma cells. Cell biology international. 2022-08-22. PMID:35989488. |
dpcpx induced bim-dependent apoptosis in npc cells irrespective of p53 status via the foxo3a pathway following pi3k/akt inhibition. |
2022-08-22 |
2023-08-14 |
Not clear |
| Ricássio S Barberino, Thae Lanne B G Lins, Alane P O Monte, Regina Lucia S Silva, Kíscyla O Andrade, Daniela S P Campinho, Raimundo C Palheta Junior, Johan E J Smitz, Maria Helena T Mato. Epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated Akt, FOXO3a and rpS6. Reproductive toxicology (Elmsford, N.Y.). 2022-08-18. PMID:35981663. |
epigallocatechin-3-gallate attenuates cyclophosphamide-induced damage in mouse ovarian tissue via suppressing inflammation, apoptosis, and expression of phosphorylated akt, foxo3a and rps6. |
2022-08-18 |
2023-08-14 |
mouse |
| Yaxin Zhang, Jihang Dai, Lianqi Yan, Qun Lin, Haixiang Miao, Xingkai Wang, Jingcheng Wang, Yu Su. DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a. Oxidative medicine and cellular longevity. vol 2022. 2022-08-01. PMID:35910845. |
nbp upregulated the expression of foxo3a by inhibiting the pi3k/akt pathway, which subsequently inhibited the apoptosis of human oa chondrocytes. |
2022-08-01 |
2023-08-14 |
human |
| Lei Meng, Bin Feng, Liming Luan, Zhihao Fang, Guangyu Zha. MeCP2 inhibits ischemic neuronal injury by enhancing methylation of the FOXO3a promoter to repress the SPRY2-ZEB1 axis. Experimental & molecular medicine. 2022-08-01. PMID:35915222. |
using functional analysis, we demonstrated that mecp2 accelerated foxo3a methylation and subsequently inhibited its expression, thus repressing the apoptosis of neuronal cells. |
2022-08-01 |
2023-08-14 |
mouse |
| Eleanor K Greenwood, Dafina M Angelova, Hadassah M I Büchner, David R Brow. The AICD fragment of APP initiates a FoxO3a mediated response via FANCD2. Molecular and cellular neurosciences. 2022-07-28. PMID:35901928. |
foxo3a is a transcription factor associated with neuronal longevity and apoptosis. |
2022-07-28 |
2023-08-14 |
Not clear |
| Yong-Qing Zhang, Rui-Lin Chen, Li-Qun Shang, Shu-Mei Yan. Nicotine-induced miR-21-3p promotes chemoresistance in lung cancer by negatively regulating FOXO3a. Oncology letters. vol 24. issue 2. 2022-06-29. PMID:35765274. |
the regulatory effect of mir-21-3p and foxo3a on lung cancer cell proliferation and apoptosis induced by docetaxel or cisplatin treatment was evaluated by performing cell counting kit-8 and annexin v/pi staining assays, respectively. |
2022-06-29 |
2023-08-14 |
Not clear |
| Chao Yu, Tingting Li, Jialu Li, Binbin Cui, Na Liu, George Bayliss, Shougang Zhuan. Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin-induced acute kidney injury. Journal of cellular and molecular medicine. 2022-06-23. PMID:35734954. |
mechanistically, eed226 treatment inhibited cisplatin-induced phosphorylation of p53 and foxo3a, two transcriptional factors contributing to apoptosis, and preserved expression of sirtuin 3 and pgc1α, two proteins associated with mitochondrial protection in vivo and in vitro. |
2022-06-23 |
2023-08-14 |
Not clear |
| Huaxiang Shi, Pengfei Li, Hu Zhou, Zhiyong Nie, Jingxin Zhang, Xin Sui, Jiabin Guo, Yongan Wang, Liyun Wan. Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice. Brain research. 2022-06-20. PMID:35724762. |
similarly, western blot assays revealed upregulation of foxo1a, foxo3a, caspase-3 and bax, and downregulation of bcl-2, indicating a temporal influence of ahh on mitochondrial function and neuronal apoptosis. |
2022-06-20 |
2023-08-14 |
mouse |
| Ying Liu, Yu Wang, Xiaoge Li, Yi Jia, Jianxun Wang, Xiang A. FOXO3a in cancer drug resistance. Cancer letters. 2022-05-11. PMID:35545128. |
recent studies have shown that foxo3a dysregulation contributes to drug resistance development through various mechanisms, including modulating oncogenic signaling pathways, evading apoptosis, promoting excessive drug efflux, inducing autophagy, facilitating epithelial to mesenchymal transition, enhancing dna damage repair, and altering the characteristics of cancer stem cells. |
2022-05-11 |
2023-08-13 |
Not clear |