| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Zhang, Xuejie Han, Jing Chang, Jian Liu, Yingming Liu, Hongxia Wang, Fenghe Du, Xiangjun Zeng, Caixia Gu. Soluble RAGE attenuates myocardial I/R injuries via FoxO3-Bnip3 pathway. Cellular and molecular life sciences : CMLS. vol 79. issue 5. 2022-05-02. PMID:35501612. |
srage inhibited mitochondrial depolarization and cardiac apoptosis during i/r, which correlated with reduced expression of bnip3, sirt2, phosphorylation of akt and foxo3a which translocated into nucleus in cultured cardiomyocytes. |
2022-05-02 |
2023-08-13 |
mouse |
| Chao Wang, Xiaohong Tu, Yufen Jiang, Panpan Jiao, Xiaohong Deng, Yuancai Xie, Long Zhan. Prognostic value of high FOXO3a expression in patients with solid tumors: A meta-analysis and systematic review. The International journal of biological markers. 2022-04-29. PMID:35484793. |
foxo3a (previously termed fkhrl1), plays an evolutionarily conserved role in the control of biological process, including dna damage, apoptosis, and cell cycle regulation. |
2022-04-29 |
2023-08-13 |
Not clear |
| Conghua Lu, Rui Yu, Chong Zhang, Caiyu Lin, Yuanyao Dou, Di Wu, Yonghong Pan, Tao Peng, Huan Tang, Rui Han, Yong H. Protective autophagy decreases lorlatinib cytotoxicity through Foxo3a-dependent inhibition of apoptosis in NSCLC. Cell death discovery. vol 8. issue 1. 2022-04-23. PMID:35459209. |
meanwhile, we found that the combination of lorlatinib and cq, an inhibitor of autophagy, inhibited autophagy and promoted apoptosis both in vitro and in vivo, which sensitized cells to lorlatinib through the dephosphorylation of foxo3a and promoted nuclear translocation, then activation of foxo3a/bim axis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Mona A Kortam, Asmaa S Alawady, Nermin Abdel Hamid Sadik, Nevine Fath. Fenofibrate mitigates testosterone induced benign prostatic hyperplasia via regulation of Akt/FOXO3a pathway and modulation of apoptosis and proliferation in rats. Archives of biochemistry and biophysics. 2022-04-17. PMID:35430215. |
fenofibrate significantly suppressed ps473 akt expression causing foxo3a nuclear inclusion, which triggered induction of apoptosis. |
2022-04-17 |
2023-08-13 |
rat |
| Nirmala Tilija Pun, Naeun Lee, Sang-Hoon Song, Chul-Ho Jeon. Pitavastatin Induces Cancer Cell Apoptosis by Blocking Autophagy Flux. Frontiers in pharmacology. vol 13. 2022-04-07. PMID:35387352. |
further, the foxo3a protein accumulated due to the blockade of autophagy flux which in turn was associated with the induction of er stress by transcriptional upregulation of perk-chop pathway, subsequently causing apoptosis due to pitavastatin treatment. |
2022-04-07 |
2023-08-13 |
human |
| Nirmala Tilija Pun, Naeun Lee, Sang-Hoon Song, Chul-Ho Jeon. Pitavastatin Induces Cancer Cell Apoptosis by Blocking Autophagy Flux. Frontiers in pharmacology. vol 13. 2022-04-07. PMID:35387352. |
taken together, pitavastatin-mediated blockade of autophagy flux caused an accumulation of foxo3a protein, thereby leading to the induction of perk, ultimately causing chop-mediated apoptosis in cancer cells. |
2022-04-07 |
2023-08-13 |
human |
| Saba Ubaid, Shivani Pandey, Mohd Sohail Akhtar, Mohammad Rumman, Babita Singh, Abbas Ali Mahd. SIRT1 Mediates Neuroprotective and Neurorescue Effects of Camel α-Lactalbumin and Oleic Acid Complex on Rotenone-Induced Parkinson's Disease. ACS chemical neuroscience. 2022-04-06. PMID:35385250. |
sirt1 upregulates the expression of foxo3a and hsf-1, thus inhibiting apoptosis and maintaining the homeostasis of cellular proteins. |
2022-04-06 |
2023-08-13 |
Not clear |
| Rui Chen, Min Yan. Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis. International heart journal. vol 63. issue 2. 2022-03-31. PMID:35354753. |
melatonin treatment also led to an increased level of apoptosis repressor with caspase recruitment domain (arc), which was inhibited by foxo3a sirna. |
2022-03-31 |
2023-08-13 |
Not clear |
| Xiaozhi Li, Longyu Jin, M Yuchao, Zhibin Jiang, Hao Tang, Xiyuan Ton. Xanthohumol inhibits non-small cell lung cancer by activating PUMA-mediated apoptosis. Toxicology. 2022-03-08. PMID:35259468. |
silent puma or foxo3a impaired xanthohumol-induced apoptosis in nsclc cells. |
2022-03-08 |
2023-08-13 |
mouse |
| Benkai Bao, Dong Gao, Ning Li, Manman Wu, Chengfen Xin. Near-Infrared Light Regulation of Tumor PI3K/Akt Signaling Pathway for Enhancing Cancer Cell Apoptosis through Conjugated Polymer Nanoparticles. ACS applied bio materials. vol 3. issue 4. 2022-01-13. PMID:35025292. |
therefore, the phosphorylation of gsk-3β downstream of the signaling pathway is reduced, and the phosphorylation of foxo3a is enhanced, which can promote apoptosis of cancer cells. |
2022-01-13 |
2023-08-13 |
Not clear |
| Zhe-Bin Dong, Heng-Miao Wu, Yi-Cheng He, Zhong-Ting Huang, Yi-Hui Weng, Hong Li, Chao Liang, Wei-Ming Yu, Wei Che. MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1. Cell death & disease. vol 13. issue 1. 2022-01-11. PMID:35013144. |
we also found that mir-124-3p.1 maintains the dephosphorylation and acetylation of foxo3a, leading to the nuclear location of foxo3a and enhanced sorafenib-induced apoptosis. |
2022-01-11 |
2023-08-13 |
mouse |
| Yan Wang, Chun Jie Wu, Yu Du, Yu Qing Liu, Jing Ran Cai, Xue Qing Wu, Shu Qun H. SIRT2 tyrosine nitration by peroxynitrite in response to renal ischaemia/reperfusion injury. Free radical research. 2022-01-04. PMID:34979841. |
notably, peroxynitrite-evoked nitration of sirt2 destroyed its enzymatic activity and the capability to deacetylate foxo3a, and enhanced expression of bim and caspase3, facilitating renal cell apoptosis in renal ischaemia/reperfusion and sin-1(peroxynitrite donor) treatment in vitro, and these effects were reversed by fetmpyp, a peroxynitrite decomposition scavenger. |
2022-01-04 |
2023-08-13 |
rat |
| Tao Wang, Fei Zhang, Wuxun Peng, Lei Wang, Jian Zhang, Wentao Dong, Xiaobin Tian, Chuan Ye, Yanlin Li, Yuekun Gon. Overexpression of NMNAT3 improves mitochondrial function and enhances anti-oxidative stress of bone marrow mesenchymal stem cells via the NAD+-Sirt3 pathway. Bioscience reports. 2022-01-04. PMID:34981121. |
we further revealed the mechanism of nmnat3-mediated resistance to stress-induced apoptosis in bmscs. we increased the level of nicotinamide adenine dinucleotide (nad+) by overexpressing nmnat3 in bmscs and found that it could significantly increase the activity of silent mating type information regulation 2 homolog 3 (sirt3) and significantly decrease the acetylation levels of sirt3-dependent deacetylation-related proteins isocitrate dehydrogenase 2 (idh2) and forkhead-box protein o3a (foxo3a). these findings show that nmnat3 may increase the activity of sirt3 by increasing nad+ levels. our results confirm that the nmnat3-nad+-sirt3 axis is a potential mechanism for improving mitochondrial function and enhancing anti-oxidative stress of bmscs. in this study, we take advantage of the role of nmnat3 in inhibiting stress-induced apoptosis of bmscs and provide new methods and ideas for breaking through the bottleneck of transplantation efficacy of bmscs in the clinic. |
2022-01-04 |
2023-08-13 |
Not clear |
| Feng Yun Yang, Lu Zhang, Yan Zheng, He Don. Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. vol 13. issue 1. 2022-01-03. PMID:34974801. |
dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box o3a (foxo3a)/p53-upregulated modulator of apoptosis (puma) signaling signaling. |
2022-01-03 |
2023-08-13 |
mouse |
| Feng Yun Yang, Lu Zhang, Yan Zheng, He Don. Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling. Bioengineered. vol 13. issue 1. 2022-01-03. PMID:34974801. |
in addition, h/r and i/r injury increased p53 expression and forkhead box o3a (foxo3a)/p53-upregulated modulator of apoptosis (puma) signaling in h9c2 cardiomyocyte cells and cardiomyocytes. |
2022-01-03 |
2023-08-13 |
mouse |
| Yunqi Zhu, Xiangmin Tong, Ying Wang, Xiaoya L. WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia. Cell death & disease. vol 13. issue 1. 2021-12-21. PMID:34930905. |
wtip upregulates foxo3a and induces apoptosis through puma in acute myeloid leukemia. |
2021-12-21 |
2023-08-13 |
Not clear |
| Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielsk. FOXO3a and Its Regulators in Prostate Cancer. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830408. |
forkhead box o3 (foxo3a) is a member of a subfamily of forkhead transcription factors involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle regulation, and dna damage. |
2021-11-30 |
2023-08-13 |
Not clear |
| Mohammad Rehan, Deepali Kurundkar, Ashish R Kurundkar, Naomi J Logsdon, Samuel R Smith, Diptiman Chanda, Karen Bernard, Yan Y Sanders, Jessy S Deshane, Kevin G Dsouza, Sunad Rangarajan, Jaroslaw W Zmijewski, Victor J Thannicka. Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice. Nature aging. vol 1. issue 2. 2021-11-29. PMID:34386777. |
over-expression of the sirt3 cdna via airway delivery restored capacity for fibrosis resolution in aged mice, in association with activation of the forkhead box transcription factor, foxo3a, in fibroblasts, upregulation of pro-apoptotic members of the bcl-2 family, and recovery of apoptosis susceptibility. |
2021-11-29 |
2023-08-13 |
mouse |
| Bruna Bortoloni Gouveia, Ricássio de Sousa Barberino, Regina Lucia Dos Santos Silva, Thae Lanne Barbosa Gama Lins, Valéria da Silva Guimarães, Alane Pains Oliveira do Monte, Raimundo Campos Palheta, Maria Helena Tavares de Mato. Involvement of PTEN and FOXO3a Proteins in the Protective Activity of Protocatechuic Acid Against Cisplatin-Induced Ovarian Toxicity in Mice. Reproductive sciences (Thousand Oaks, Calif.). vol 28. issue 3. 2021-11-23. PMID:33174187. |
in conclusion, pca at 20 mg/kg reduced apoptosis, maintained cell proliferation and mitochondrial function, reduced ros production, and increased gsh expression likely through the involvement of pten and foxo3a proteins. |
2021-11-23 |
2023-08-13 |
mouse |
| Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Gu. Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts. Aging. vol 13. issue 20. 2021-11-17. PMID:34711685. |
this study aimed to assess whether the up-regulation of sirt1 induced by 17beta-estradiol (17β-e2) could promote autophagy and inhibit apoptosis in osteoblasts via the ampk-mtor and foxo3a pathways, respectively. |
2021-11-17 |
2023-08-13 |
Not clear |