| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tapas Patra, Keith Meyer, Ratna B Ray, Tatsuo Kanda, Ranjit Ra. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells. Cell death & disease. vol 12. issue 11. 2021-11-17. PMID:34759291. |
mechanistic insights indicate that a combination of azd5363 and azd8055 activated foxo3a to induce bim-associated apoptosis in p53 mutated hcc cells, whereas cells retaining functional p53 enhanced bax. |
2021-11-17 |
2023-08-13 |
Not clear |
| Arzu Keskin-Aktan, Kazime Gonca Akbulut, Samira Abdi, Hakan Akbulu. SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin. Biologia futura. 2021-10-28. PMID:34708398. |
forkhead box-class o3a (foxo3a) transcription factor is one of the main targets of sirt2, and sirt2-mediated foxo3a deacetylation is closely related to aging, oxidative stress, and apoptosis. |
2021-10-28 |
2023-08-13 |
rat |
| Xiao-Chun Zhao, Xiao-Cheng Cao, Fei Liu, Mei-Fang Quan, Kai-Qun Ren, Jian-Guo Ca. Regulation of the FOXO3a/Bim signaling pathway by 5,7-dihydroxy-8-nitrochrysin in MDA-MB-453 breast cancer cells. Oncology letters. vol 5. issue 3. 2021-10-21. PMID:23425937. |
silencing of foxo3a resulted in a marked attenuation in the expression of bim, as well as protection against noc-mediated apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Ling Jiang, Xiao-Cheng Cao, Jian-Guo Cao, Fei Liu, Mei-Fang Quan, Xi-Feng Sheng, Kai-Qun Re. Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a. Oncology letters. vol 5. issue 5. 2021-10-21. PMID:23761826. |
casticin induces ovarian cancer cell apoptosis by repressing foxm1 through the activation of foxo3a. |
2021-10-21 |
2023-08-12 |
human |
| Li-Ping Liu, Xiao-Cheng Cao, Fei Liu, Mei-Fang Quan, Xi-Feng Sheng, Kai-Qun Re. Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. Oncology letters. vol 7. issue 5. 2021-10-21. PMID:24765206. |
notably, silencing foxo3a expression by sirna-mediated gene knockdown attenuated casticin-mediated apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |
| Li-Ping Liu, Xiao-Cheng Cao, Fei Liu, Mei-Fang Quan, Xi-Feng Sheng, Kai-Qun Re. Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. Oncology letters. vol 7. issue 5. 2021-10-21. PMID:24765206. |
collectively, these findings suggest that foxo3a is a critical mediator of the inhibitory effects of casticin on apoptosis in breast cancer cells. |
2021-10-21 |
2023-08-13 |
Not clear |
| Zhigang Li, Na Yi, Rou Chen, Yilei Meng, Yumei Wang, Huan Liu, Wenze Cao, Yi Hu, Yanqiong Gu, Chang Tong, Min Lu, Li Li, Luying Pen. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cellular signalling. vol 74. 2021-10-19. PMID:32707074. |
mir-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting foxo3a. |
2021-10-19 |
2023-08-13 |
mouse |
| Zhigang Li, Na Yi, Rou Chen, Yilei Meng, Yumei Wang, Huan Liu, Wenze Cao, Yi Hu, Yanqiong Gu, Chang Tong, Min Lu, Li Li, Luying Pen. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cellular signalling. vol 74. 2021-10-19. PMID:32707074. |
furthermore, overexpression or knockdown of mir-29b-3p showed its crucial roles on regulation of apoptosis and production of pro-inflammatory cytokines in nrcms through directly targeting foxo3a. |
2021-10-19 |
2023-08-13 |
mouse |
| Fang Wang, Xuemei Chen, Bo Sun, Yujia Ma, Wenbin Niu, Jun Zhai, Yingpu Su. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33393111. |
hypermethylation-mediated downregulation of lncrna pvt1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with foxo3a. |
2021-10-14 |
2023-08-13 |
mouse |
| Fang Wang, Xuemei Chen, Bo Sun, Yujia Ma, Wenbin Niu, Jun Zhai, Yingpu Su. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33393111. |
moreover, downregulating pvt1 promoted granulosa cell apoptosis by increasing the foxo3a protein levels. |
2021-10-14 |
2023-08-13 |
mouse |
| Fang Wang, Xuemei Chen, Bo Sun, Yujia Ma, Wenbin Niu, Jun Zhai, Yingpu Su. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. Journal of cellular physiology. vol 236. issue 7. 2021-10-14. PMID:33393111. |
hypermethylation-induced downregulation of pvt1 promotes granulosa cell apoptosis in poi by inhibiting foxo3a phosphorylation and increases the foxo3a transcription activity. |
2021-10-14 |
2023-08-13 |
mouse |
| Cheng Li, Xiao Miao, Shudong Wang, Yucheng Liu, Jian Sun, Quan Liu, Lu Cai, Yonggang Wan. Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-30. PMID:33244875. |
in this study, elabela treatment was found to have profound protective effects against diabetes-induced cardiac oxidative stress, inflammation, fibrosis and apoptosis; these protective effects may depend heavily upon sirt3-mediated foxo3a deacetylation. |
2021-09-30 |
2023-08-13 |
Not clear |
| Li Liu, Zhen Tian, Yalin Zhang, Peijun Liu, Zhiqian Xin, Yong Zhao, Yifan Li, Shan Miao, Junling Shi, Zhinan Chen, Jiyuan Liu, Hai Zhan. Ligand-based discovery of small molecules suppressing cancer cell proliferation via autophagic flux inhibition. Journal of molecular medicine (Berlin, Germany). vol 98. issue 11. 2021-09-27. PMID:32897390. |
further tests revealed that foxo3a and its downstream target genes regulating autophagy, apoptosis, and cell cycle progression were activated and overexpressed, suggesting such effects of lz02/01 on autophagy and apoptosis were associated with the activation and overexpression of foxo3a. |
2021-09-27 |
2023-08-13 |
mouse |
| Lingli Chen, Santie Li, Jianyu Zhu, Anfu You, Xingzhou Huang, Xinchu Yi, Mei Xu. Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway. Journal of cellular and molecular medicine. vol 25. issue 6. 2021-09-23. PMID:33523605. |
further studies revealed that mangiferin increased foxo3a deacetylation by up-regulating sirt1, thus preventing apoptosis, and adenovirus-mediated constitutive acetylation of foxo3a restricted the anti-apoptotic effects of mangiferin in vivo and in vitro. |
2021-09-23 |
2023-08-13 |
mouse |
| Hao Chen, Xin Tang, Ting-Li Han, Jia-Nan Zhu, Wei Zhou, Philip N Baker, Chang Chen, Hua Zhan. Potential role of FoxO3a in the regulation of trophoblast development and pregnancy complications. Journal of cellular and molecular medicine. vol 25. issue 9. 2021-09-22. PMID:33811439. |
western blot, immunohistochemistry, cell counting kit-8, wound-healing assay, matrigel invasion assay, cell apoptosis, cell cycle assay, rna sequencing, qrt-pcr and chip-qpcr were performed on the cells to study the potential role of foxo3a and the underlying mechanism. |
2021-09-22 |
2023-08-13 |
Not clear |
| Hao Chen, Xin Tang, Ting-Li Han, Jia-Nan Zhu, Wei Zhou, Philip N Baker, Chang Chen, Hua Zhan. Potential role of FoxO3a in the regulation of trophoblast development and pregnancy complications. Journal of cellular and molecular medicine. vol 25. issue 9. 2021-09-22. PMID:33811439. |
foxo3a depletion significantly reduced transcription of the promoter region of intercellular cell adhesion molecule-1 (icam1) gene in chip assays and led to reduced invasion and migration of trophoblast cells, arrested cell cycle in g1 phase and increased apoptosis under oxidative stress. |
2021-09-22 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
foxo3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the wnt/β‑catenin signaling pathway. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
the overexpression of foxo3a inhibited the proliferation, invasion and migration of nephroblastoma cells, while inducing apoptosis. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
cell apoptosis was predominantly increased by overexpressed foxo3a, which was reversed by shrna‑axin2‑1. |
2021-09-21 |
2023-08-13 |
Not clear |
| Cheng Qian, Qiang Li. FOXO3a inhibits nephroblastoma cell proliferation, migration and invasion, and induces apoptosis through downregulating the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 5. 2021-09-21. PMID:34515328. |
in conclusion, the findings of the present study suggested that foxo3a may inhibit nephroblastoma cell proliferation, migration and invasion, while inducing apoptosis, by downregulating the wnt/β‑catenin signaling pathway. |
2021-09-21 |
2023-08-13 |
Not clear |