| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daopeng Luo, Baofei Sun, Wenjuan Wang, Aihua Zhan. The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons. Biological trace element research. 2024-12-18. PMID:39693001. |
specifically, markers of astrocyte activation, such as glial fibrillary acidic protein (gfap) and inducible nitric oxide synthase (inos), as well as the inflammatory cytokine interleukin (il)-1β, were significantly upregulated, and apoptosis was markedly increased, indicating neurotoxic damage. |
2024-12-18 |
2024-12-21 |
rat |
| Sylvie Carmona, Jehanne Aghzadi, Thierry Vincent, Pierre Labauge, Clarisse Carra-Dallière, Sylvain Lehmann, Sophie Desplat-Jégo, Xavier Ayrigna. TWEAK and TNFɑ Pro-inflammatory Soluble Cytokines and their Specific Autoantibodies Secretion in Multiple Sclerosis Patients. Inflammation. 2024-12-06. PMID:39641859. |
we sought to explore the modulation of the pro-inflammatory cytokines tumor necrosis factor-alpha (tnfɑ) and tnf-like weak inducer of apoptosis (tweak), along with their respective autoantibodies, tnab and twab, and to decipher potential associations between these and clinical characteristics which could assist personalized therapy in ms. we also assessed the complementarity to leading candidate biomarkers in ms patient monitoring, namely, glial fibrillary acidic protein (gfap) and neurofilament light chain (nfl). |
2024-12-06 |
2024-12-08 |
Not clear |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Jie Chen, Chenxu Liu, Li Li, WeiTing Tao, Xiaonan Zhang, Shidi Zhao, Chun Wang, Li Huan. Exogenous leptin alleviates glutamate-excitotoxic damage caused by cerebral ischemia-reperfusion in mice by affecting the expression of glutamate transporters. Brain research. 2024-08-28. PMID:39197570. |
on this basis, we observed the changes of cortical apoptosis injury, intracellular calcium fluorescence intensity and astrocyte glial fibrillary acidic protein (gfap) expression and morphological changes. |
2024-08-28 |
2024-09-01 |
mouse |
| Shaobin Yang, Xiaoqian Zhao, Yimeng Zhang, Qi Tang, Yanhong Li, Yaqin Du, Peng Y. Tirzepatide shows neuroprotective effects via regulating brain glucose metabolism in APP/PS1 mice. Peptides. 2024-07-13. PMID:39002758. |
app/ps1 mice for 8 weeks with at 10 nmol/kg once-weekly, it significantly decreased the levels of glp-1r, and gfap protein expression and amyloid plaques in the cortex, it also lowered neuronal apoptosis induced by amyloid-β (aβ), but did not affect the anxiety and cognitive function in app/ps1 mice. |
2024-07-13 |
2024-07-16 |
mouse |
| Hassan Reda Hassan Elsayed, Eyad Mohamed Tolba Ali, Mohammed Rami Rabei, Eman Mohamad El Nashar, Mansour Abdullah Alghamdi, Norah Saeed Al-Zahrani, Shaker Hassan Alshehri, Rashid A Aldahhan, Amira Ibrahim Mors. Angiotensin II Type 1 receptor blockade attenuates the neuropathological changes in the spinal cords of diabetic rats with modulation of nuclear factor erythroid 2-related factor 2/ heme oxygenase 1 system. Tissue & cell. vol 88. 2024-05-25. PMID:38795506. |
after two months, the pathological alteration in the spinal cord was investigated, and an immunohistochemical study was performed for neuronal, astrocytic, and microglial markers; nuclear protein (neun), glial fibrillary acidic protein (gfap), and ionized calcium-binding adaptor molecule 1 (iba1), respectively, and for an apoptosis marker; caspase-3, and the inflammatory marker; nuclear factor kappa b (nf-kb) signaling, heme oxygenase-1 (ho-1) and nuclear factor erythroid 2-related factor 2 (nrf2); physiological antioxidant system. |
2024-05-25 |
2024-05-31 |
rat |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr treatment mitigated sevoflurane-induced cognitive decline, reduced microglial and astrocyte activation (decreased iba-1 and gfap expression), and countered neuronal apoptosis (reduced bax, cleaved-caspase3, and cleaved-parp expression). |
2024-04-16 |
2024-04-18 |
rat |
| Yuke Ji, Jing Li, Sha Liu, Junya Zhu, Jin Yao, Ke-Ran Li, Biao Ya. Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration. Genomics. 2024-01-01. PMID:38163571. |
cdcaf6 silencing could reduce oxidative stress-induced rgc apoptosis in vitro and alleviate retinal neurodegeneration in vivo as shown by increased neuronal nuclei antigen (neun, neuronal bodies) and beta-iii-tubulin (tubb3, neuronal filaments) staining and reduced glial fibrillary acidic protein (gfap, activated glial cells) and vimentin (activated glial cells) staining. |
2024-01-01 |
2024-01-05 |
Not clear |
| Changsheng Wang, Yi Zhu, Rongsheng Chen, Xitian Zhu, Xiaobo Zhan. microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury. Chemico-biological interactions. 2023-12-31. PMID:38161044. |
mir-143 up-regulation inhibited tgf-β stimulated-proliferation, promoted cell apoptosis, and reduced gfap, vimentin, cspg, and ctgf expression in astrocytes, which was counterweighed by sirt2 overexpression. |
2023-12-31 |
2024-01-05 |
rat |
| Changsheng Wang, Yi Zhu, Rongsheng Chen, Xitian Zhu, Xiaobo Zhan. microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury. Chemico-biological interactions. 2023-12-31. PMID:38161044. |
sirt2 silencing reduced the proliferation and gfap, vimentin, cspg, and ctgf expression while augmenting the apoptosis in tgf-β stimulated astrocytes, which was abrogated by plaur silencing. |
2023-12-31 |
2024-01-05 |
rat |
| Xiaonan Wang, Fuping Zhang, Le Niu, Junni Yan, Huanhuan Liu, Di Wang, Juan Hui, Haiyue Dai, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation improves depressive-like behaviors in CUMS-induced rats by modulating astrocyte GLT-1 to reduce glutamate toxicity. Journal of affective disorders. 2023-12-30. PMID:38159655. |
histological analysis focused on gfap and glt-1 expression, synaptic plasticity, apoptosis and pi3k/akt/creb pathway-related proteins. |
2023-12-30 |
2024-01-05 |
rat |
| Ren Yang, Chen Zen. Protective effects of MiR-146b in cerebral infarction via targeting SIRT1/FOXO1 signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 12. 2023-12-08. PMID:38063102. |
subsequently, the levels of superoxide dismutase (sod) and reactive oxygen species (ros) in the brain tissues in each group were measured via enzyme-linked immunosorbent assay (elisa), the apoptosis of nerve cells in the brain tissues was detected by terminal deoxynucleotidyl transferase dutp nick end labeling (tunel), and glial fibrillary acidic protein (gfap), s100β gene and sirt1/foxo1 pathway-related genes and proteins in the brain tissues were determined through qrt-pcr and western blotting. |
2023-12-08 |
2023-12-17 |
rat |
| I V Arutyunyan, A G Soboleva, E A Kovtunov, A M Kosyreva, V V Kudelkina, A I Alekseeva, A V Elchaninov, E D Jumaniyazova, D V Goldshtein, G B Bolshakova, T Kh Fatkhudino. Gene Expression Profile of 3D Spheroids in Comparison with 2D Cell Cultures and Tissue Strains of Diffuse High-Grade Gliomas. Bulletin of experimental biology and medicine. 2023-09-28. PMID:37770789. |
using real time pcr, we evaluated the expression of gfap, cd44, pten, s100b, vegfa, hif1a, sox2, melk, gdnf, and mgmt genes playing an important role in the progression of gliomas and regulating tumor cell proliferation, adhesion, invasion, plasticity, apoptosis, dna repair, and recruitment of tumor-associated cells. |
2023-09-28 |
2023-10-07 |
Not clear |
| Fan Xie, Li Li, Min Peng, Huan Zhan. Overexpression of miR-199a-5p improves brain injury in newborn rats with intrauterine infection via inhibition of astrocyte activation. Brain research. 2023-08-30. PMID:37648092. |
results from cell models showed that mir-199a-5p overexpression inhibited astrocyte activation, shown by enhanced cell viability, weakened cell apoptosis, and decreased gfap, il-6, and tnf-α. |
2023-08-30 |
2023-09-07 |
rat |
| Rita Chaaya, Joel R Steele, Brian G Oliver, Hui Chen, Rita Machaalan. Effects of e-vapour and high-fat diet on the immunohistochemical staining of nicotinic acetylcholine receptors, apoptosis, microglia and astrocytes in the adult male mouse hippocampus. Journal of chemical neuroanatomy. 2023-06-21. PMID:37343645. |
this study, using a mouse model, investigated the effects of exposure to e-vapour (± nicotine) and hfd (43% fat) consumption, on the expression of nicotinic acetylcholine receptor (nachr) subunits α3, α4, α7 and β2, apoptosis markers caspase-3 and tunel, microglial marker iba-1, and astrocyte marker gfap, in hippocampal subregions of dentate gyrus (dg) and cornu ammonis (ca) 1-3. |
2023-06-21 |
2023-08-14 |
mouse |
| Xiao-Ling Fang, Qin Zhang, Wen-Wen Xue, Jin-Hua Tao, Hai-Dong Zou, Qiu-Rong Lin, Yu-Lan Wan. Suppression of cAMP/PKA/CREB signaling ameliorates retinal injury in diabetic retinopathy. The Kaohsiung journal of medical sciences. 2023-06-20. PMID:37338034. |
as glucose concentration increases, gliosis of müller cells became apparent, as evidenced by a decline in cell activity, an increase in apoptosis, downregulation of kir4.1 level, and overexpression of gfap, aqp4, and vegf. |
2023-06-20 |
2023-08-14 |
rat |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Natalia Ziółkowska, Bogdan Lewczuk, Natalia Szyryńska, Aleksandra Rawicka, Alla Vyniarsk. Low-Intensity Blue Light Exposure Reduces Melanopsin Expression in Intrinsically Photosensitive Retinal Ganglion Cells and Damages Mitochondria in Retinal Ganglion Cells in Wistar Rats. Cells. vol 12. issue 7. 2023-04-13. PMID:37048087. |
retinal cryosections were immunolabeled for glial fibrillary acid protein (gfap) and with terminal deoxynucleotidyl transferase dutp nick-end labelling for apoptosis detection. |
2023-04-13 |
2023-08-14 |
rat |
| Xiangwu Chen, Shuqi You, Qing Xia, Xiaofen M. s7,8-Dihydroxiflavone protects retinal ganglion cells and promotes axonal regeneration through TrkB signaling pathway followed by AKT and ERK activation. Neuroscience research. 2023-02-28. PMID:36854354. |
our results revealed that 7,8-dhf significantly promoted the average density and length of regenerated neurites and suppressed the apoptosis of gcl cells in three-dimensional culture system and significantly increased the number of rbpms-positive cells and inhibited the gfap expression and apoptosis of gcl cells in onc rats. |
2023-02-28 |
2023-08-14 |
rat |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |