| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung-Chan Kim, Jae-Yong Park, Eun Mi Hwan. Caspase-dependent apoptosis induces reactivation and gliogenesis of astrocytes in adult mice. Frontiers in cellular neuroscience. vol 16. 2022-12-19. PMID:36531137. |
we induced apoptosis of hippocampal ca1 astrocytes in ctg mice using gfap promoter-driven adeno-associated virus (aav) containing cre recombinase. |
2022-12-19 |
2023-08-14 |
mouse |
| Svetlana Sharifulina, Andrey Khaitin, Valeria Guzenko, Yuliya Kalyuzhnaya, Valentina Dzreyan, Alexandr Logvinov, Natalia Dobaeva, Yan Li, Lei Chen, Bin He, Svetlana Demyanenk. Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors. Biomedicines. vol 10. issue 10. 2022-10-27. PMID:36289917. |
γ-secretase inhibitor dapt down-regulated glial fibrillary acidic protein (gfap) in astrocytes, prevented mouse cerebral cortex cells from pts-induced apoptosis, and reduced the infarction volume. |
2022-10-27 |
2023-08-14 |
mouse |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Sae-Bom Yoon, Geonhee Lee, Sung Bum Park, Heeyeong Cho, Jeong-O Lee, Byumseok Ko. Properties of differentiated SH-SY5Y grown on carbon-based materials. RSC advances. vol 10. issue 33. 2022-05-06. PMID:35515479. |
the data suggest that sh-sy5y cells grown on cnt surfaces show an average 20.2% increase in cell viability; 5.7% decrease in the ratio of cells undergoing apoptosis; 78.3, 43.4 and 38.1% increases in sox2, gfap and neun expression, respectively; and a 29.7% increase in mean firing rate on a multi-electrode array. |
2022-05-06 |
2023-08-13 |
Not clear |
| Junni Yan, Fuping Zhang, Le Niu, Xiaonan Wang, Xinxin Lu, Chaoyue Ma, Chencheng Zhang, Jinggui Song, Zhaohui Zhan. High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway. Brain research bulletin. 2022-03-05. PMID:35247488. |
histological analysis focused on apoptosis, expression of gfap and fgf2, and fgf2 pathway-related proteins. |
2022-03-05 |
2023-08-13 |
rat |
| Honghua Niu, Wenchao Song, Dongyang Pei, Chen Ma, Fudong Liu, Yan Li, Shuaiwei Ha. Depleted histone deacetylase 3 or restored microRNA-19b-1-5p facilitates recovery of spinal cord injury via inactivating JAK2/STAT3 signaling pathway. Genomics. 2021-12-31. PMID:34971719. |
in a rat model, the role of hdac3 and mir-19b-1-5p in sci was identified through detecting motor function, serum inflammation, pathological damage, cell apoptosis and gfap expression. |
2021-12-31 |
2023-08-13 |
rat |
| Honghua Niu, Wenchao Song, Dongyang Pei, Chen Ma, Fudong Liu, Yan Li, Shuaiwei Ha. Depleted histone deacetylase 3 or restored microRNA-19b-1-5p facilitates recovery of spinal cord injury via inactivating JAK2/STAT3 signaling pathway. Genomics. 2021-12-31. PMID:34971719. |
restoration of mir-19b-1-5p or depletion of hdac3 attenuated motor function, inflammation, pathological damage and apoptosis, and reduced gfap expression in the spinal cord tissue of sci rats. |
2021-12-31 |
2023-08-13 |
rat |
| Jianmei Wang, Tao Yu, Liuqing Sheng, Hui Zhang, Fei Chen, Jie Zhu, Mingxing Din. Lotus Seedpod Proanthocyanidins Protect Against Light-Induced Retinal Damage via Antioxidative Stress, Anti-Apoptosis, and Neuroprotective Effects. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-12-24. PMID:34949755. |
moreover, lspcs treatment alleviated light-induced retinal apoptosis and limited the light-induced increase in gfap expression. |
2021-12-24 |
2023-08-13 |
rat |
| Suzan M Hazzaa, Asmaa Gaber Abdou, Essam O Ibraheim, Esraa A Salem, Mohamad H A Hassan, Hesham A D Abdel-Raze. Effect of L-carnitine and atorvastatin on a rat model of ischemia-reperfusion injury of spinal cord. Journal of immunoassay & immunochemistry. vol 42. issue 6. 2021-12-08. PMID:33900902. |
astrogliosis was detected by gfap, and increased apoptosis was demonstrated by increasing bax and decreasing bcl-2. |
2021-12-08 |
2023-08-13 |
rat |
| Grace T Akingbade, Omamuyovwi M Ijomone, Aminu Imam, Michael Aschner, Moyosore S Aja. D-Ribose-L-Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase-3 and GFAP Expressions Following Manganese-Induced Neurotoxicity. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34480735. |
mn caused a marked decrease in gsh levels, overexpression of gfap and caspase-3, reflecting astrocytosis and apoptosis, and altered ultrastructural integrities of the neuronal nuclei, mitochondria, and myelin sheath of the striatum and motor cortex respectively, while all interventions with ribcys minimized and prevented the neurotoxic events. |
2021-12-03 |
2023-08-13 |
rat |
| Hang Yin, Hao Qin, Tiantian Wang, Qiang Zhuang, Qixia Yan. The Protective Effects of Apremilast Against Oxygen-Glucose Deprivation/Reperfusion (OGD/R)-Induced Inflammation and Apoptosis in Astroglia Mediated by CREB/BDNF. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33826130. |
our findings show that treatment with apremilast could significantly reduce astrocyte apoptosis and cell death induced by ogd/r as evidenced by reduced release of glial fibrillary acidic protein (gfap) and improvement of the bax/bcl-2 ratio. |
2021-11-29 |
2023-08-13 |
Not clear |
| Georgios Katsipis, Elena E Tzekaki, Magda Tsolaki, Anastasia A Pantazak. Salivary GFAP as a potential biomarker for diagnosis of mild cognitive impairment and Alzheimer's disease and its correlation with neuroinflammation and apoptosis. Journal of neuroimmunology. vol 361. 2021-11-24. PMID:34655990. |
salivary gfap as a potential biomarker for diagnosis of mild cognitive impairment and alzheimer's disease and its correlation with neuroinflammation and apoptosis. |
2021-11-24 |
2023-08-13 |
Not clear |
| Georgios Katsipis, Elena E Tzekaki, Magda Tsolaki, Anastasia A Pantazak. Salivary GFAP as a potential biomarker for diagnosis of mild cognitive impairment and Alzheimer's disease and its correlation with neuroinflammation and apoptosis. Journal of neuroimmunology. vol 361. 2021-11-24. PMID:34655990. |
gfap and established biomarkers of neurodegeneration, inflammation, and apoptosis have been determined in the saliva of amnestic-single-domain mild cognitive impairment (mci) (Ν = 20), ad (Ν = 20) patients, and cognitively healthy controls (Ν = 20). |
2021-11-24 |
2023-08-13 |
Not clear |
| Valentina Alda Carozzi, Chiara Salio, Virginia Rodriguez-Menendez, Elisa Ciglieri, Francesco Ferrin. 2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy. European journal of histochemistry : EJH. vol 65. issue s1. 2021-11-10. PMID:34664808. |
conventional immunostaining, i.e., immunohistochemical detection of specific molecules in tissue slices can be employed to detect, localize and quantify particular markers of damage in neurons (i.e., nuclear expression atf3) or sgcs (i.e., increased expression of gfap), markers of apoptosis (i.e., caspases), markers of mitochondrial suffering and oxidative stress (i.e., 8-ohdg), markers of tissue inflammation (i.e., cd68 for macrophage infiltration), etc. |
2021-11-10 |
2023-08-13 |
Not clear |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
downregulation of mir-383 significantly inhibited the apoptosis and inflammatory response of hippocampal neurons, and increased the expression levels of gfap, bdnf and creb which were impacted in depression, as well as neurotransmitters, then attenuated neural injury in rats induced by cums. |
2021-11-08 |
2023-08-13 |
rat |
| Ying Zhou, Qiuyun Tian, Chenfei Zheng, Jinge Yang, Junming Fan, Yangping Shent. Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat. Brain research bulletin. vol 164. 2021-10-29. PMID:32871241. |
in addition, mi not only increased levels of il-1β, bax, and cleaved-caspase 3, but also increased iba-1 and gfap expression in the hippocampus, as compared to those in controls, suggesting a promotion of neuro-inflammation and apoptosis in hippocampus. |
2021-10-29 |
2023-08-13 |
rat |
| Rui Zhang, Haitao Pei, Lijuan Ru, Hongyun Li, Guangyi Li. Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury. Biomedical reports. vol 1. issue 6. 2021-10-21. PMID:24649049. |
the neuronal apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end-labelling (tunel) staining and the expression of nestin and gfap in the three groups was analyzed by immunohistochemistry. |
2021-10-21 |
2023-08-12 |
rat |
| Fahim Atif, Seema Yousuf, Claudia Espinosa-Garcia, Wayne A C Harris, Donald G Stei. Post-ischemic stroke systemic inflammation: Immunomodulation by progesterone and vitamin D hormone. Neuropharmacology. vol 181. 2021-09-23. PMID:32950558. |
we also measured infarction volume and markers of neuronal inflammation (gfap, il-6) and apoptosis (cleaved caspase-3) in brain post-stroke. |
2021-09-23 |
2023-08-13 |
rat |
| Qingtong Zhang, Jiangwen Yin, Feng Xu, Jingwen Zhai, Jieting Yin, Mingyue Ge, Wenyi Zhou, Nian Li, Xinlei Qin, Yan Li, Sheng Wan. Isoflurane post-conditioning contributes to anti-apoptotic effect after cerebral ischaemia in rats through the ERK5/MEF2D signaling pathway. Journal of cellular and molecular medicine. vol 25. issue 8. 2021-09-22. PMID:33621420. |
we measured the expression of mef2d, erk5, gfap and caspase-3 by immunofluorescent staining and western blotting, and tunel staining to assess the severity of apoptosis in hippocampal ca1 area. |
2021-09-22 |
2023-08-13 |
rat |
| Serpil Ünver Saraydin, Berna Özdenoglu Kutlu, Dursun Saraydı. Effects of diabetes on apoptosis and mitosis in rat hippocampus. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 6. 2021-09-17. PMID:32938250. |
we investigated caspase-3, caspase-7 and ki 67 levels immunohistochemically for mitotic activity, the tunel method for apoptosis and gfap for astrocyte cell density in the hippocampal ca1 region. |
2021-09-17 |
2023-08-13 |
rat |