| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gholam-Reza Mahmoudiasl, Hojjat Allah Abbaszadeh, Mostafa Rezaei-Tavirani, Mohammad-Amin Abdollahifar, Yousef Sadeghi, Maryam Sadat Khoramgah, Somayeh Niknazar, Shahram Darab. Postmortem Study of Molecular and Histological Changes in the CA1 Hippocampal Region of Chronic Methamphetamine User. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 4. 2020-09-28. PMID:32184870. |
chronic meth use can induce gfap and iba-1 upregulation and neuronal apoptosis in the ca1 region of the postmortem hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
astrocyte activation was examined by immunohistochemical staining and western blotting for glial fibrillary acid protein (gfap), while expression levels of the pro-inflammatory cytokine-tumor necrosis factor alpha (tnf-α) and interleukin 1 beta (il-1β), the apoptosis effector cysteinyl aspartate specific proteinase-3 (caspase-3), and the neuroprotectant brain-derived neurotrophic factor (bdnf) and the trkb receptor were estimated by western blotting. |
2020-08-31 |
2023-08-13 |
rat |
| Hua Fang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Fang-Xiang Zhang, Jian-Ping Zhan. NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage. Cell cycle (Georgetown, Tex.). vol 18. issue 9. 2020-05-27. PMID:30990350. |
expression of rcan1, nf-κb signaling pathway-related genes and glial fibrillary acidic protein (gfap), s-100β and acetylcholine (ach) level, and acetylcholinesterase (ache) activity were determined with neuron apoptosis detected to further explore the function of nf-κb signaling pathway. |
2020-05-27 |
2023-08-13 |
rat |
| Hua Fang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Fang-Xiang Zhang, Jian-Ping Zhan. NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage. Cell cycle (Georgetown, Tex.). vol 18. issue 9. 2020-05-27. PMID:30990350. |
by activation of nf-κb or overexpression of rcan1, the number of neuronal apoptosis, s-100β protein level, and ache level increased significantly, ach activity decreased significantly, and gfap positive cells increased. |
2020-05-27 |
2023-08-13 |
rat |
| Fernanda Huf, Solange Bandiera, Carolina B Müller, Luiza Gea, Fabiano B Carvalho, Francine L Rahmeier, Keli C Reiter, Lucas S Tortorelli, Rosane Gomez, Marilda da Cruz Fernande. Comparative study on the effects of cigarette smoke exposure, ethanol consumption and association: Behavioral parameters, apoptosis, glial fibrillary acid protein and S100β immunoreactivity in different regions of the rat hippocampus. Alcohol (Fayetteville, N.Y.). vol 77. 2020-05-06. PMID:30870710. |
the present study investigated the chronic effects of exposure to cigarette smoke and/or ethanol on behavioral parameters, apoptosis, and alteration in immunoreactivity of glial fibrillary acid protein (gfap) and s100β in the ca1, ca3, and dentate gyrus (dg) of the rat hippocampus. |
2020-05-06 |
2023-08-13 |
rat |
| Mohd Faraz Zafeer, Fakiha Firdaus, Ehraz Anis, M Mobarak Hossai. Prolong treatment with Trans-ferulic acid mitigates bioenergetics loss and restores mitochondrial dynamics in streptozotocin-induced sporadic dementia of Alzheimer's type. Neurotoxicology. vol 73. 2020-04-27. PMID:31029786. |
furthermore, fa treatment has shown mitigation in intracerebral-ventricular streptozocin (icv-stz) induced bioenergetics loss and dynamic changes by regulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1alpha) protein levels in nucleus and hence, mitigating exacerbation of drp-1 dependent mitochondrial fission and apoptosis by alleviating loss of mitochondrial membrane potential (ΔΨm), downregulating cytochrome-c release into the cytosol by limiting mitochondrial permeability transition pore (mptp) opening concomitant increase in caspase3 activation, bax expression and dna fragmentation along with downregulating glial fibrillary acidic protein (gfap) expression. |
2020-04-27 |
2023-08-13 |
Not clear |
| Parvaneh Mehrbod, Sudharsana R Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, Mohammad Hashemi, Kathleen K M Glover, Affan A Sher, Kevin M Coombs, Saeid Ghavam. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections. Virulence. vol 10. issue 1. 2020-03-05. PMID:30966844. |
abbreviation: aids: acquired immunodeficiency syndrome; atf6: activating transcription factor 6; atg6: autophagy-specific gene 6; bag3: bcl associated athanogene 3; bak: bcl-2-anatagonist/killer1; bax; bcl-2: associated x protein; bcl-2: b cell lymphoma 2x; bip: chaperon immunoglobulin heavy chain binding protein; card: caspase recruitment domain; cart: combination antiretroviral therapy; ccr5: c-c chemokine receptor type 5; cd4: cluster of differentiation 4; chop: c/ebp homologous protein; cxcr4: c-x-c chemokine receptor type 4; cyto c: cytochrome c; dcs: dendritic cells; edem1: er-degradation enhancing-a-mannosidase-like protein 1; env: envelope; er: endoplasmic reticulum; fasr: fas receptor;g2: gap 2; g2/m: gap2/mitosis; gfap: glial fibrillary acidic protein; gp120: glycoprotein120; gp41: glycoprotein41; hand: hiv associated neurodegenerative disease; hek: human embryonic kidney; hela: human cervical epithelial carcinoma; hiv: human immunodeficiency virus; ips-1: ifn-β promoter stimulator 1; ire-1: inositol requiring enzyme 1; irgm: immunity related gtpase family m protein; lamp2a: lysosome associated membrane protein 2a; lc3: microtubule associated light chain 3; mda5: melanoma differentiation associated gene 5; mef: mouse embryonic fibroblast; mmp: mitochondrial membrane permeabilization; nef: negative regulatory factor; oasis: old astrocyte specifically induced substrate; pamp: pathogen-associated molecular pattern; perk: pancreatic endoplasmic reticulum kinase; prr: pattern recognition receptor; puma: p53 upregulated modulator of apoptosis; rig-i: retinoic acid-inducible gene-i; tat: transactivator protein of hiv; tlr: toll-like receptor; ulk1: unc51 like autophagy activating kinase 1; upr: unfolded protein response; vpr: viral protein regulatory; xbp1: x-box binding protein 1. |
2020-03-05 |
2023-08-13 |
mouse |
| Linda Frintrop, Stefanie Trinh, Johanna Liesbrock, Christina Leunissen, Julia Kempermann, Serhat Etdöger, Martien J Kas, René Tolba, Nicole Heussen, Joseph Neulen, Kerstin Konrad, Vera Päfgen, Fabian Kiessling, Beate Herpertz-Dahlmann, Cordian Beyer, Jochen Seit. The reduction of astrocytes and brain volume loss in anorexia nervosa-the impact of starvation and refeeding in a rodent model. Translational psychiatry. vol 9. issue 1. 2020-02-06. PMID:31164627. |
furthermore, mean astrocytic gfap mrna expression was similarly reduced in the aba animals, as was the mean cell proliferation rate, whereas the mean apoptosis rate did not increase. |
2020-02-06 |
2023-08-13 |
rat |
| Wei-Shu Xue, Nan Wang, Ning-Yao Wang, Yue-Fen Ying, Guo-Hui X. miR-145 protects the function of neuronal stem cells through targeting MAPK pathway in the treatment of cerebral ischemic stroke rat. Brain research bulletin. vol 144. 2020-01-16. PMID:30179678. |
compared with the blank group, over-expression of mir-145 in nscs promoted the up-regulation of cyclin d1, nestin, neuron-specific enolase (nse), and glial fibrillary acidic protein (gfap) proteins, enhanced the activity of nscs, and promoted cell proliferation and differentiation, while inhibited the cell apoptosis and the cleaved-caspase 3 expression. |
2020-01-16 |
2023-08-13 |
rat |
| Wei-Shu Xue, Nan Wang, Ning-Yao Wang, Yue-Fen Ying, Guo-Hui X. miR-145 protects the function of neuronal stem cells through targeting MAPK pathway in the treatment of cerebral ischemic stroke rat. Brain research bulletin. vol 144. 2020-01-16. PMID:30179678. |
after treatment of nscs in the sb203580 group, the nestin, nse, and gfap were decreased; cell viability, proliferation and differentiation were inhibited, while cleaved-caspase 3 protein and cell apoptosis rate increased. |
2020-01-16 |
2023-08-13 |
rat |
| Janet D Pierce, Raeesa Gupte, Amanda Thimmesch, Qiuhua Shen, John B Hiebert, William M Brooks, Richard L Clancy, Francisco J Diaz, Janna L Harri. Ubiquinol treatment for TBI in male rats: Effects on mitochondrial integrity, injury severity, and neurometabolism. Journal of neuroscience research. vol 96. issue 6. 2019-11-25. PMID:29380912. |
we found when ubiquinol was administered before or after tbi, rats had an acute reduction in brain mitochondrial damage, apoptosis, and two serum biomarkers of tbi severity, glial fibrillary acidic protein (gfap) and ubiquitin c-terminal hydrolase-l1 (uch-l1). |
2019-11-25 |
2023-08-13 |
rat |
| Olena Y Glushakova, Andriy O Glushakov, Cesar V Borlongan, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats. Journal of neurotrauma. vol 35. issue 1. 2019-07-08. PMID:28637381. |
immunofluorescence experiments further showed cellular co-localization of cleaved-caspase-3 with gfap and cd68 and its adjacent localization with eba, suggesting involvement of apoptosis and neuroinflammation in mechanisms of delayed bbb and microvascular damage that could contribute to white matter changes. |
2019-07-08 |
2023-08-13 |
rat |
| Shu-Ting Liu, Shu-Min Zhong, Xue-Yan Li, Feng Gao, Fang Li, Meng-Lu Zhang, Ke Zhu, Xing-Huai Sun, Xin Wang, Yanying Miao, Xiong-Li Yang, Zhongfeng Wan. EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model. Acta neuropathologica communications. vol 6. issue 1. 2019-06-12. PMID:30355282. |
the ephrinb1-fc treatment did not induce müller cell gliosis, as evidenced by unchanged gfap expression, but significantly up-regulated mrna and protein levels of tumor necrosis factor-α (tnf-α) in müller cells, thereby promoting rgc apoptosis. |
2019-06-12 |
2023-08-13 |
rat |
| Melissa H Galinato, Yoshio Takashima, McKenzie J Fannon, Leon W Quach, Roberto J Morales Silva, Karthik K Mysore, Michael J Terranova, Rahul R Dutta, Ryan W Ostrom, Sucharita S Somkuwar, Chitra D Mandya. Neurogenesis during Abstinence Is Necessary for Context-Driven Methamphetamine-Related Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 8. 2019-05-20. PMID:29363584. |
male gfap-tk rats were trained to self-administer methamphetamine or sucrose and were administered the antiviral drug valganciclovir (valcyte) to produce apoptosis of actively dividing gfap type 1 stem-like cells to inhibit neurogenesis during abstinence. |
2019-05-20 |
2023-08-13 |
rat |
| Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang W. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-κB activation in reactive astrocytes. Journal of cellular biochemistry. vol 119. issue 8. 2019-05-16. PMID:29665049. |
ttc staining was applied in order to detect the cerebral infarction volume, a tunel assay to detect the apoptosis rate of neurons, an elisa to measure mda, sod, inos, ldh, tnf-α, il-1β, il-6, and il-10 levels, and both rt-qpcr and western blotting methods in order to detect pgrn, gfap, grp78, chop, and nf-κb p65 expressions. |
2019-05-16 |
2023-08-13 |
rat |
| Qing Shu, Hua Fan, Shi-Jun Li, Dan Zhou, Wei Ma, Xiao-Yan Zhao, Jun-Qiang Yan, Gang W. Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-κB activation in reactive astrocytes. Journal of cellular biochemistry. vol 119. issue 8. 2019-05-16. PMID:29665049. |
both the in vivo and in vitro results, in comparison with the i/r and the nc groups, the pgrn-high dose and pgrn-low dose groups both presented a decrease in cerebral infarction volume, apoptosis rate of neurons, mda, ldh, inos, tnf-α, il-1β, il-6 levels, and gfap, grp78, chop, nf-κb p65 expressions, and an increase in sod, il-10, and pgrn levels as well as cell proliferation depending on dosage. |
2019-05-16 |
2023-08-13 |
rat |
| Rajesh Kushwaha, Juhi Mishra, Sachin Tripathi, Waseem Raza, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. Arsenic Attenuates Heparin-Binding EGF-Like Growth Factor/EGFR Signaling That Promotes Matrix Metalloprotease 9-Dependent Astrocyte Damage in the Developing Rat Brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 2. 2019-02-25. PMID:29228391. |
this reduced hb-egf/egfr was essentially responsible for arsenic-induced astrocyte damage, obvious from a recombinant-hb-egf-mediated recovery in gfap levels and astrocyte morphology and reduction in astrocyte apoptosis, and the reverse by gefitinib. |
2019-02-25 |
2023-08-13 |
rat |
| Rajesh Kushwaha, Juhi Mishra, Sachin Tripathi, Waseem Raza, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. Arsenic Attenuates Heparin-Binding EGF-Like Growth Factor/EGFR Signaling That Promotes Matrix Metalloprotease 9-Dependent Astrocyte Damage in the Developing Rat Brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 2. 2019-02-25. PMID:29228391. |
exploring the pathways downstream of reduced hb-egfr/egfr revealed that an upregulated matrix metalloproteinase 9 (mmp9) within the astrocytes ultimately led to apoptosis and gfap loss. |
2019-02-25 |
2023-08-13 |
rat |
| Tie-Jun Liu, Bin Wang, Qun-Xi Li, Xiao-Liu Dong, Xiao-Liang Han, Shu-Bo Zhan. Effects of microRNA-206 and its target gene IGF-1 on sevoflurane-induced activation of hippocampal astrocytes in aged rats through the PI3K/AKT/CREB signaling pathway. Journal of cellular physiology. vol 233. issue 5. 2019-02-21. PMID:29052839. |
compared with the normal/blank group, the sevo, and mir-206 nc+sevo groups showed decreased mir-206 and gfap expressions, cell viability and mtp but increased expressions of igf-1, pi3k, akt, creb, ppi3k, pakt, pcreb, cyt-c and caspase-3, as well as cell apoptosis. |
2019-02-21 |
2023-08-13 |
rat |
| Marília M Wallauer, Fernanda Huf, Lucas S Tortorelli, Francine L Rahmeier, Fabiano B Carvalho, Rosalva T Meurer, Marilda da Cruz Fernande. Morphological changes in the cerebellum as a result of ethanol treatment and cigarette smoke exposure: A study on astrogliosis, apoptosis and Purkinje cells. Neuroscience letters. vol 672. 2019-02-18. PMID:29477594. |
the combination of both etoh and tob exposure induced an increase in gfap immunoreactivity, whilst tob alone increased apoptosis in the white matter of the cerebellum. |
2019-02-18 |
2023-08-13 |
human |