| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hava Karsenty Avraham, Shuxian Jiang, Yigong Fu, Edward Rockenstein, Alexandros Makriyannis, Alexander Zvonok, Eliezer Masliah, Shalom Avraha. The cannabinoid CB₂ receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis. British journal of pharmacology. vol 171. issue 2. 2014-08-26. PMID:24148086. |
hiv-1 glycoprotein gp120 induces apoptosis in rodent and human neurons in vitro and in vivo. hiv-1/gp120 is involved in the pathogenesis of hiv-associated dementia (had) and inhibits proliferation of adult neural progenitor cells (npcs) in glial fibrillary acidic protein (gfap)/gp120 transgenic (tg) mice. |
2014-08-26 |
2023-08-12 |
mouse |
| C Sticozzi, G Belmonte, A Meini, P Carbotti, G Grasso, M Palm. IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca²⁺-calmodulin/ERK mitogen-activated protein kinase signaling pathway. Neuroscience. vol 252. 2014-06-11. PMID:23928073. |
il-1β induces gfap expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via nfκb/ca²⁺-calmodulin/erk mitogen-activated protein kinase signaling pathway. |
2014-06-11 |
2023-08-12 |
human |
| C Sticozzi, G Belmonte, A Meini, P Carbotti, G Grasso, M Palm. IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca²⁺-calmodulin/ERK mitogen-activated protein kinase signaling pathway. Neuroscience. vol 252. 2014-06-11. PMID:23928073. |
we investigated in human astrocytoma cells and the rat brain striatum, the role of the nuclear factor-kb (nf-kb) intracellular ca(2+) concentration ([ca(2+)]i) calmodulin (cam) and extracellular regulated mitogen-activated protein kinases (erk1/2) in il-1β-induced expression of glial fibrillary acidic protein (gfap) and neuronal apoptosis associated to a brain trauma. |
2014-06-11 |
2023-08-12 |
human |
| C Sticozzi, G Belmonte, A Meini, P Carbotti, G Grasso, M Palm. IL-1β induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFκB/Ca²⁺-calmodulin/ERK mitogen-activated protein kinase signaling pathway. Neuroscience. vol 252. 2014-06-11. PMID:23928073. |
data in vivo supported these findings and showed that gfap expression induced by il-1β (50 ng/ml) correlated with attenuated glial scar formation and reduced neuronal apoptosis. |
2014-06-11 |
2023-08-12 |
human |
| Anusha Hemamali Tennakoon, Takeshi Izawa, Kavindra Kumara Wijesundera, Hossain M Golbar, Miyuu Tanaka, Chisa Ichikawa, Mitsuru Kuwamura, Jyoji Yamat. Characterization of glial fibrillary acidic protein (GFAP)-expressing hepatic stellate cells and myofibroblasts in thioacetamide (TAA)-induced rat liver injury. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 7-8. 2014-06-07. PMID:23806769. |
gfap positive mfs showed the proliferating activity, but they did not undergo apoptosis. |
2014-06-07 |
2023-08-12 |
rat |
| Agata Grazia D'Amico, Soraya Scuderi, Salvatore Saccone, Alessandro Castorina, Filippo Drago, Velia D'Agat. Antiproliferative effects of PACAP and VIP in serum-starved glioma cells. Journal of molecular neuroscience : MN. vol 51. issue 2. 2014-05-30. PMID:23900722. |
cell viability, expression of proteins related to cell proliferation (cyclin d1), apoptosis (bcl2, p53, and cleaved caspase-3), and cell malignancy (gfap and nestin) were assessed by mtt assay, immunoblot, and immunolocalization, respectively. |
2014-05-30 |
2023-08-12 |
Not clear |
| Christoph Tappeiner, Jasmin Balmer, Matias Iglicki, Kaspar Schuerch, Anna Jazwinska, Volker Enzmann, Markus Tschop. Characteristics of rod regeneration in a novel zebrafish retinal degeneration model using N-methyl-N-nitrosourea (MNU). PloS one. vol 8. issue 8. 2014-03-06. PMID:23951079. |
histology with staining for apoptosis (tunel), proliferation (pcna), activated müller glial cells (gfap), rods (rhodopsin) and cones (zpr-1) were performed. |
2014-03-06 |
2023-08-12 |
zebrafish |
| Patricia Rivera, Margarita Pérez-Martín, Francisco J Pavón, Antonia Serrano, Ana Crespillo, Manuel Cifuentes, María-Dolores López-Ávalos, Jesús M Grondona, Margarita Vida, Pedro Fernández-Llebrez, Fernando Rodríguez de Fonseca, Juan Suáre. Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus. PloS one. vol 8. issue 5. 2014-02-18. PMID:23741384. |
then, plasma levels of metabolites and metabolic hormones, cell proliferation in the subgranular zone of the dentate gyrus (sgz), and immunohistochemical markers of hippocampal cell apoptosis (caspase-3), gliosis (gfap and iba-1), food reward factor fosb and estrogen receptor alpha (erα) were analyzed. |
2014-02-18 |
2023-08-12 |
rat |
| M Arons, M Pilmane, É Vasilevskis, A Shchegolev, I Évan. [Morphological changes in the lumbar dorsal root ganglion of the domestic porcine after pulsed radiofrequency stimulation]. Anesteziologiia i reanimatologiia. issue 4. 2014-02-18. PMID:24341038. |
using standard immunohistochemical reactions, the materials were tinted to define biomarkers nf, gfap, hsp-70 expression and apoptosis by tunel kit. |
2014-02-18 |
2023-08-12 |
Not clear |
| Mohammad Amin Sherafat, Abdolaziz Ronaghi, Leila Ahmad-Molaei, Mohammad Nejadhoseynian, Rasoul Ghasemi, Arman Hosseini, Nima Naderi, Fereshteh Motamed. Kindling-induced learning deficiency and possible cellular and molecular involved mechanisms. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 6. 2014-01-17. PMID:22744648. |
the tunel assay was used for evaluation of neuronal apoptosis and the glial fibriliary acetic protein (gfap) was used for assessment of inflammatory reaction. |
2014-01-17 |
2023-08-12 |
rat |
| Eduardo Blanco-Calvo, Patricia Rivera, Sergio Arrabal, Antonio Vargas, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Pablo Galeano, Leticia Rubio, Juan Suárez, Fernando Rodriguez de Fonsec. Pharmacological blockade of either cannabinoid CB1 or CB2 receptors prevents both cocaine-induced conditioned locomotion and cocaine-induced reduction of cell proliferation in the hippocampus of adult male rat. Frontiers in integrative neuroscience. vol 7. 2014-01-10. PMID:24409127. |
additionally, we measured cell apoptosis (as monitored by the expression of cleaved caspase-3) and glial activation [by analyzing the expression of glial fibrillary acidic protein (gfap) and iba-1] in the striatum and hippocampus during acute and repeated (4 days) cocaine administration (20 mg/kg). |
2014-01-10 |
2023-08-12 |
rat |
| Asit Rai, Shailendra Kumar Maurya, Rolee Sharma, Shakir Al. Down-regulated GFAPα: a major player in heavy metal induced astrocyte damage. Toxicology mechanisms and methods. vol 23. issue 2. 2013-07-02. PMID:22901236. |
taken together, these observations are the first to show that mm disturbs the composition of the gfap isoforms, and a suppressed gfapα promotes apoptosis in the matured rat astrocytes. |
2013-07-02 |
2023-08-12 |
rat |
| Nan Zhang, Tingguo Kang, Yang Xia, Qingping Wen, Xiaodan Zhang, Hongyan Li, Yv Hu, Haiguang Hao, Dan Zhao, Dong Sun, Yaping Yan, Guang-Xian Zhang, Jingxian Yan. Effects of salvianolic acid B on survival, self-renewal and neuronal differentiation of bone marrow derived neural stem cells. European journal of pharmacology. vol 697. issue 1-3. 2013-05-02. PMID:23085027. |
here, we demonstrate that salvianolic acid b (sal b), a potent aqueous of a well known chinese medicine herb, salvia miltiorrhiza, possesses the ability to promote bm-nscs proliferation in a dose dependent manner as verified by growth curve and bromodeoxyuridine (brdu) incorporation assays; while in differentiation medium, sal b promoted nestin(+) bm-nscs differentiated into greater numbers of nf-m(+) neurons and ng2(+) oligodendrocyte precursors, but fewer gfap(+) astrocytes as verified by triple immunostaining and quantitative analysis; upon exposure to h(2)o(2), sal b facilitated the cells survival, reduced ldh leakage, and inhibited apoptosis, displaying a dose-dependent neuroprotective effect on bm-nscs. |
2013-05-02 |
2023-08-12 |
Not clear |
| Xu Wang, Fahad Haroon, Saoussen Karray, Martina Deckert, Dirk Schlüte. Astrocytic Fas ligand expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis. European journal of immunology. vol 43. issue 1. 2013-04-08. PMID:23011975. |
to address the role of astrocytic fasl in the regulation of t-cell apoptosis in experimental autoimmune encephalomyelitis, we immunized c57bl/6 glial fibrillary acid protein (gfap)-cre fasl(fl/fl) mice selectively lacking fasl in astrocytes with mog(35-55) peptide. |
2013-04-08 |
2023-08-12 |
mouse |
| Tine Zgavc, An-Gaëlle Ceulemans, Said Hachimi-Idrissi, Ron Kooijman, Sophie Sarre, Yvette Michott. The neuroprotective effect of post ischemic brief mild hypothermic treatment correlates with apoptosis, but not with gliosis in endothelin-1 treated rats. BMC neuroscience. vol 13. 2013-03-08. PMID:22920191. |
apoptosis was determined using caspase-3 immunohistochemistry, phagocytic cells were visualized by cd-68 expression and astrogliosis was studied by glial fibrillary acidic protein (gfap) staining. |
2013-03-08 |
2023-08-12 |
rat |
| Supriya Swarnkar, Sarika Singh, Poonam Goswami, Ramesh Mathur, Ishan K Patro, Chandishwar Nat. Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage. Neurochemical research. vol 37. issue 10. 2013-02-19. PMID:22846965. |
rotenone elevated expression of gfap and caspase-3 that indicates glial cell activation and apoptosis, respectively. |
2013-02-19 |
2023-08-12 |
rat |
| Alejandro Garanto, Javier Vicente-Tejedor, Marina Riera, Pedro de la Villa, Roser Gonzàlez-Duarte, Román Blanco, Gemma Marfan. Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer. Biochimica et biophysica acta. vol 1822. issue 8. 2013-01-18. PMID:22549043. |
however, some clear and consistent signals of gliosis and retinal stress were detected by the statistically significant increase of i) the glial fibrillary antigen protein (gfap) expression, and ii) apoptosis, as detected by tunel. |
2013-01-18 |
2023-08-12 |
mouse |
| Hayden J Selvadurai, John O Maso. Activation of Wnt/β-catenin signalling affects differentiation of cells arising from the cerebellar ventricular zone. PloS one. vol 7. issue 8. 2013-01-10. PMID:22880037. |
activation of the pathway at the cerebellar ventricular zone led to a reduction in the number of cells expressing the glial lineage markers sox9 and gfap and the interneuron marker pax2, but had no consistent effect on either proliferation or apoptosis. |
2013-01-10 |
2023-08-12 |
Not clear |
| Juan Perucho, Maria J Casarejos, Ana Gomez, Rosa M Solano, Justo Garcia de Yébenes, Maria A Men. Trehalose protects from aggravation of amyloid pathology induced by isoflurane anesthesia in APP(swe) mutant mice. Current Alzheimer research. vol 9. issue 3. 2012-12-21. PMID:22272607. |
in this study, we have shown that repetitive exposure to isoflurane in pre-symptomatic mature app(swe) mice increases apoptosis in hippocampus and cerebral cortex, enhances astrogliosis and the expression of gfap and that these effects are prevented by co-treatment with trehalose, a disaccharide with known effects as enhancer of autophagy. |
2012-12-21 |
2023-08-12 |
mouse |
| Xiao-Li He, Yue-Hua Wang, Ming-Gang Bi, Guan-Hua D. Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats. European journal of pharmacology. vol 680. issue 1-3. 2012-09-13. PMID:22314218. |
at 52days after ligation, the escape latency in morris water maze was significantly increased in rats subjected to 2vo, the neuronal damage was also increased accompanied by a large proliferation in glial fibrillary acidic protein (gfap) immunoreactivity with marked white matter lesions, and neuronal cell apoptosis, all of which were significantly alleviated by long treatment of chrysin (30mg/kg). |
2012-09-13 |
2023-08-12 |
rat |