| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marília M Wallauer, Fernanda Huf, Lucas S Tortorelli, Francine L Rahmeier, Fabiano B Carvalho, Rosalva T Meurer, Marilda da Cruz Fernande. Morphological changes in the cerebellum as a result of ethanol treatment and cigarette smoke exposure: A study on astrogliosis, apoptosis and Purkinje cells. Neuroscience letters. vol 672. 2019-02-18. PMID:29477594. |
the combination of both etoh and tob exposure induced an increase in gfap immunoreactivity, whilst tob alone increased apoptosis in the white matter of the cerebellum. |
2019-02-18 |
2023-08-13 |
human |
| Ye Ji Jeong, Yeonghoon Son, Na-Kyung Han, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee, Hae-June Le. Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice. International journal of molecular sciences. vol 19. issue 7. 2018-10-29. PMID:30029554. |
in addition, levels of markers for dna damage (8-hydroxy-2'-deoxyguanosine, p53, p21, γh2ax, and bax), apoptosis (cleaved caspase-3 and cleaved poly(adp-ribose) polymerase 1 (parp-1)), astrocyte (gfap), and microglia (iba-1) were significantly elevated in the brains of aged mice. |
2018-10-29 |
2023-08-13 |
mouse |
| Jie Xia, Cheng-Yan Li, Hui Wang, Qi-Mei Zhang, Zhong-Mou Ha. Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-10-05. PMID:29793313. |
in vitro, we confirmed that scoparone inhibited lps-caused astrocytes activation as proved by the reduced glial fibrillary acidic protein (gfap) levels, inflammation and apoptosis, which were at least partly dependent on akt suppression. |
2018-10-05 |
2023-08-13 |
mouse |
| Nan Tang, Jian Chang, Hu-Chen Lu, Zong Zhuang, Hui-Lin Cheng, Ji-Xin Shi, Jing Ra. Rhein induces apoptosis and autophagy in human and rat glioma cells and mediates cell differentiation by ERK inhibition. Microbial pathogenesis. vol 113. 2018-07-23. PMID:29056497. |
pd98059, a specific inhibitor for erk activation imitates rhein effects on morphology and expressions of gfap but did not help to induce any apoptosis or autophagy. |
2018-07-23 |
2023-08-13 |
human |
| Arvind Palanisamy, Ramaswamy Kannappan, Zhiqiang Xu, Audrey Martino, Matthew B Friese, Justin D Boyd, Gregory Crosby, Deborah J Culle. Oxytocin alters cell fate selection of rat neural progenitor cells in vitro. PloS one. vol 13. issue 1. 2018-02-20. PMID:29346405. |
next, we examined the effects of sot on npc death, apoptosis, proliferation, and differentiation using antibodies to neun (neurons), olig2 (oligodendrocytes), and gfap (astrocytes). |
2018-02-20 |
2023-08-13 |
rat |
| K Dec, A Łukomska, D Maciejewska, K Jakubczyk, I Baranowska-Bosiacka, D Chlubek, A Wąsik, I Gutowsk. The Influence of Fluorine on the Disturbances of Homeostasis in the Central Nervous System. Biological trace element research. vol 177. issue 2. 2017-06-29. PMID:27787813. |
all of those changes lead to abnormal cell differentiation and the activation of apoptosis through the changes in the expression of neural cell adhesion molecules (ncam), glial fibrillary acidic protein (gfap), brain-derived neurotrophic factor (bdnf) and map kinases. |
2017-06-29 |
2023-08-13 |
human |
| Anne Günther, Vince Luczak, Ted Abel, Arnd Bauman. Caspase-3 and GFAP as early markers for apoptosis and astrogliosis in shRNA-induced hippocampal cytotoxicity. The Journal of experimental biology. vol 220. issue Pt 8. 2017-06-16. PMID:28167801. |
caspase-3 and gfap as early markers for apoptosis and astrogliosis in shrna-induced hippocampal cytotoxicity. |
2017-06-16 |
2023-08-13 |
mouse |
| Yu Jie, Yang Xuefeng, Yang Mengxue, Yang Xuesong, Yang Jing, Tang Yin, Xu Ji. Mechanism of nonylphenol-induced neurotoxicity in F1 rats during sexual maturity. Wiener klinische Wochenschrift. vol 128. issue 11-12. 2017-05-05. PMID:26905877. |
the purpose of this study was to examine whether gestational and lactational exposure to environmental endocrine disrupting chemical, nonylphenol (np), in pregnant dams would lead to the alterations in hormone levels in the body, apoptosis and glial fibrillary acidic protein (gfap) in hippocampus during weaning and sexual maturity periods in pups of rats. |
2017-05-05 |
2023-08-13 |
rat |
| W Brad Hubbard, Shaylen Greenberg, Carly Norris, Joseph Eck, Erin Lavik, Pamela VandeVor. Distinguishing the Unique Neuropathological Profile of Blast Polytrauma. Oxidative medicine and cellular longevity. vol 2017. 2017-05-02. PMID:28424745. |
levels of reactive astrocytes (gfap), apoptosis (cleaved caspase-3 expression), and vascular damage (smi-71) were significantly elevated in bpt compared to blast-induced mtbi. |
2017-05-02 |
2023-08-13 |
Not clear |
| Gamze Tanriverdi, Fatma Kaya-Dagistanli, Sule Ayla, Sibel Demirci, Mediha Eser, Z Seda Unal, Mujgan Cengiz, Huseyin Okta. Resveratrol can prevent CCl₄-induced liver injury by inhibiting Notch signaling pathway. Histology and histopathology. vol 31. issue 7. 2017-04-12. PMID:26742567. |
after treatment, immunostaining was performed to detect notch1, notch3, notch4, transforming growth factor (tgf)-beta, alpha-smooth muscle actin (sma), glial fibrillary acidic protein (gfap), and proliferating cell nuclear antigen (pcna), and tunel assays were performed to evaluate apoptosis. |
2017-04-12 |
2023-08-13 |
rat |
| Mykhailo M Guzyk, Artem A Tykhomyrov, Victor S Nedzvetsky, Irina V Prischepa, Tatiana V Grinenko, Lesya V Yanitska, Tamara M Kuchmerovsk. Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors Reduce Reactive Gliosis and Improve Angiostatin Levels in Retina of Diabetic Rats. Neurochemical research. vol 41. issue 10. 2017-04-04. PMID:27255598. |
moreover, extensive fragmentation of both parp-1 and gfap (hallmarks of apoptosis and macroglia reactivation, respectively) in diabetic retina was also observed. |
2017-04-04 |
2023-08-13 |
rat |
| Tourandokht Baluchnejadmojarad, Monireh Mansouri, Jamileh Ghalami, Zahra Mokhtari, Mehrdad Roghan. Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-13. PMID:28157651. |
sesamin at a dose of 20mg/kg attenuated motor imbalance in narrow beam test, lowered striatal level of malondialdehyde (mda) and reactive oxygen species (ros), improved superoxide dismutase (sod) activity, lowered striatal caspase 3 activity and α-synuclein expression, attenuated glial fibrillary acidic protein (gfap) immunoreactivity, depressed nigral neuronal apoptosis, and prevented damage of dopaminergic neurons using tyrosine hydroxylase (th) immunohistochemistry. |
2017-03-13 |
2023-08-13 |
rat |
| Xing Su, Xiaojiang Liu, Lanchun Ni, Wei Shi, Hui Zhu, Jinlong Shi, Jian Chen, Zhikai Gu, Yilu Gao, Qing Lan, Qingfeng Huan. GFAP expression is regulated by Pax3 in brain glioma stem cells. Oncology reports. vol 36. issue 3. 2017-03-08. PMID:27432276. |
furthermore, we studied the cell proliferation, invasion, apoptosis, differentiation and expression of pax3 and gfap in pax3 sirna-knockdown and pax3-overexpressing bgsc models by cck-8, transwell migration, flow cytometry and western blot assays. |
2017-03-08 |
2023-08-13 |
human |
| Takeshi Tanaka, Hajime Abe, Masayuki Kimura, Nobuhiko Onda, Sayaka Mizukami, Toshinori Yoshida, Makoto Shibutan. Developmental exposure to T-2 toxin reversibly affects postnatal hippocampal neurogenesis and reduces neural stem cells and progenitor cells in mice. Archives of toxicology. vol 90. issue 8. 2017-03-02. PMID:26314264. |
in the hippocampal dentate gyrus of male pnd 21 offspring, gfap(+) and blbp(+) type-1 stem cells and pax6(+) and tbr2(+) type-2 progenitor cells decreased in the subgranular zone (sgz) at 9 and ≥3 ppm, respectively, in parallel with increased apoptosis at ≥3 ppm. |
2017-03-02 |
2023-08-13 |
mouse |
| Rozina Noristani, Sandra Kuehn, Gesa Stute, Sabrina Reinehr, Mathias Stellbogen, H Burkhard Dick, Stephanie C Joachi. Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26746422. |
at 14 and 28 days, immune-histological and western blot analyses were performed to investigate the optic nerve structure (smi-32), retinal ganglion cells (brn-3a), apoptosis (cleaved caspase 3, fasl), and glial profile (iba1, ed1, gfap, vimentin). |
2016-12-26 |
2023-08-13 |
rat |
| Yulong Ma, Hang Guo, Lixia Zhang, Liang Tao, Anqi Yin, Zhaoyu Liu, Yan Li, Hailong Dong, Lize Xiong, Wugang Ho. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Scientific reports. vol 6. 2016-12-19. PMID:26891996. |
and 10 nm e2, dpn or e2+mpp (erα antagonist), but not ppt or e2+phtpp (erβ antagonist), significantly reduced neuronal apoptosis following the subjection of astrocyte and neuronal cocultures to ogd-r. we also found that either 50 μg/kg e2 or 8 mg/kg dpn replacement (3 weeks) significantly increased gfap expression and reduced gci-induced neuronal apoptosis in hippocampal ca1 region of ovariectomized mice. |
2016-12-19 |
2023-08-13 |
mouse |
| Venkata Siva Sai Sujith Sajja, W Brad Hubbard, Christina S Hall, Farhad Ghoddoussi, Matthew P Galloway, Pamela J VandeVor. Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury. Scientific reports. vol 5. 2016-09-26. PMID:26537106. |
gliosis (gfap) increased in all regions except the nac but only pfc was positive for apoptosis (caspase-3). |
2016-09-26 |
2023-08-13 |
Not clear |
| Kumar Abhiram Jha, Tapas Chandra Nag, Vivek Kumar, Pankaj Kumar, Binit Kumar, Shashi Wadhwa, Tara Sankar Ro. Differential Expression of AQP1 and AQP4 in Avascular Chick Retina Exposed to Moderate Light of Variable Photoperiods. Neurochemical research. vol 40. issue 11. 2016-08-24. PMID:26285902. |
additionally, morphological changes, apoptosis (by tunel) and levels of glutamate and gfap (a marker of injury) in the retina were examined to correlate these with aqp expressions. |
2016-08-24 |
2023-08-13 |
chicken |
| Taranjeet Kaur, Shaffi Manchanda, Vedangana Saini, Sukhwinder S Lakhman, Gurcharan Kau. Efficacy of Anti-Epileptic Drugs in the Treatment of Tumor and Its Associated Epilepsy: An in vitro Perspective. Annals of neurosciences. vol 23. issue 1. 2016-08-18. PMID:27536020. |
morphometry, cell cycle analysis, apoptosis, expression of different protein markers, viz., gfap, hsp70 and nuclear factor-κb (nfκb) were studied in aed-treated cultures. |
2016-08-18 |
2023-08-13 |
rat |
| Zhong-Yue Yuan, Yu-Lan Hu, Jian-Qing Ga. Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats. PloS one. vol 10. issue 8. 2016-05-17. PMID:26248340. |
besides, apoptosis and necrosis of neurons, slight inflammatory response in the frontal cortex, and decrease of gfap expression in the cerebellum were also detected in mouse injected with tmcs-nps. |
2016-05-17 |
2023-08-13 |
mouse |