| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Foluso A Atiba, Amos A Fatokun, Innocent O Imosemi, Adefolarin O Malom. Kola nut from Cola nitida vent. Schott administered to pregnant rats induces histological alterations in pups' cerebellum. PloS one. vol 16. issue 3. 2021-09-13. PMID:33684143. |
paraffin sections of the cerebellum were stained with haematoxylin and eosin for cerebellar cytoarchitecture, cresyl violet stain for purkinje cell count, glial fibrillary acidic protein (gfap) immunohistochemistry (ihc) for estimation of gliosis, and b-cell lymphoma 2 (bcl-2) ihc for apoptosis induction. |
2021-09-13 |
2023-08-13 |
human |
| Xiao Xiao, Weiwei Li, Dingchao Rong, Zhenchao Xu, Zhen Zhang, Hongru Ye, Liqiong Xie, Yunqi Wu, Yilu Zhang, Xiyang Wan. Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis. Cell death discovery. vol 7. issue 1. 2021-08-31. PMID:34381025. |
levels of neun, gfap, and nf200 in spinal cord tissues were detected and cell apoptosis was measured. |
2021-08-31 |
2023-08-13 |
human |
| Carlos Henrique Rocha Catalão, Nilton Nascimento Santos-Junior, Luís Henrique Angenendt da Costa, Anderson Oliveira Souza, Evelin Capellari Cárnio, Adriano Sebollela, Luciane Carla Alberici, Maria José Alves Roch. Simvastatin Prevents Long-Term Cognitive Deficits in Sepsis Survivor Rats by Reducing Neuroinflammation and Neurodegeneration. Neurotoxicity research. vol 38. issue 4. 2021-08-20. PMID:32524380. |
immunofluorescence revealed a reduction of glial activation, neurodegeneration, apoptosis, and amyloid aggregates confirmed by quantification of gfap, iba-1, phospho ser |
2021-08-20 |
2023-08-13 |
rat |
| Shotaro Otsuka, Harutoshi Sakakima, Akira Tani, Kazuki Nakanishi, Seiya Takada, Kosuke Norimatsu, Hiroshi Maejima, Ikuro Maruyam. Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats. Brain structure & function. vol 226. issue 7. 2021-08-11. PMID:34114048. |
infarct volume, neurological deficits, sensorimotor function, expression levels of brain-derived neurotrophic factor (bdnf), hypoxia-induced factor-1α (hif-1α), glial fibrillary acidic protein (gfap), and p2x7 receptors, and apoptosis activity were examined using immunohistochemical and western blot analyses. |
2021-08-11 |
2023-08-13 |
rat |
| Kunchi Zhao, Ran Li, Qing Ruan, Chunyang Meng, Fei Yin, Qingsan Zh. microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury. Journal of cellular and molecular medicine. 2021-07-13. PMID:33951295. |
bbb scores were elevated, the expression of nestin, neun, gfap, nf-200 and bcl-2 protein was enhanced but that of bax protein was reduced, and cell apoptosis was inhibited in sci rats after up-regulating mir-125b or silencing atf2. |
2021-07-13 |
2023-08-13 |
rat |
| Chia-Li Chung, Chieh-Hsin Wu, Yu-Hua Huang, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwa. Blocking Hepatoma-Derived Growth Factor Attenuates Vasospasm and Neuron Cell Apoptosis in Rats Subjected to Subarachnoid Hemorrhage. Translational stroke research. 2021-07-06. PMID:34227049. |
immunofluorescence staining for iba-1, gfap, tunel, and neun was detected proliferation of microglia and astrocyte and apoptosis of neuron cells. |
2021-07-06 |
2023-08-13 |
rat |
| Rafael Bandeira Fabres, Nathalia Lima Montes, Yahi de Menezes Camboim, Samir Khal de Souza, Fabrício Nicola, Isadora D'Ávila Tassinari, Maria Flavia Marques Ribeiro, Carlos Alexandre Netto, Luciano Stürmer de Frag. Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia. Cellular and molecular neurobiology. vol 40. issue 8. 2021-06-21. PMID:32170571. |
this is the first study suggesting prog-dependent akt activation is able to regulate negatively cleaved caspase-3 and gfap expression protecting neonatal hypoxic-ischemic brain tissue from apoptosis and reactive gliosis. |
2021-06-21 |
2023-08-13 |
rat |
| Sining Feng, Shuai Wang, Shi Sun, Hao Su, Lixin Zhan. Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats. Molecular medicine reports. vol 23. issue 4. 2021-05-17. PMID:33649786. |
notably, combination therapy further alleviated sci‑induced spinal cord lesions and neuronal apoptosis, increased gap‑43, ngf and bdnf expression levels, downregulated gfap expression levels and inhibited activation of the raf/mek/erk signaling pathway in sci model rats compared with the corresponding monotherapy groups. |
2021-05-17 |
2023-08-13 |
rat |
| Yun Han, Xiao Bing Zhu, Ya Ye, Kai Yu Deng, Xi Yang Zhang, Yan Ping Son. Ribonuclease attenuates retinal ischemia reperfusion injury through inhibition of inflammatory response and apoptosis in mice. International immunopharmacology. vol 85. 2021-04-30. PMID:32447222. |
it was found that rnase administration (1) reduced the significant loss of retinal morphology caused by i/r injury; (2) down-regulated the expression of nf-κbp65, il-6 and gfap relative to the i/r mice; (3) decreased the apoptosis of retinal cells and the levels of caspase-3; (4) attenuated exrnas levels in retinal tissues on day 7 after retinal i/r. |
2021-04-30 |
2023-08-13 |
mouse |
| Yuehui Fan, Weiping Wang, Weifeng Li, Xianjun L. miR‑15a inhibits cell apoptosis and inflammation in a temporal lobe epilepsy model by downregulating GFAP. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945401. |
mir‑15a inhibits cell apoptosis and inflammation in a temporal lobe epilepsy model by downregulating gfap. |
2021-04-30 |
2023-08-13 |
rat |
| Yuehui Fan, Weiping Wang, Weifeng Li, Xianjun L. miR‑15a inhibits cell apoptosis and inflammation in a temporal lobe epilepsy model by downregulating GFAP. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945401. |
rescue experiments indicated that increasing the expression levels of gfap effectively attenuated the inhibitory effects of the high expression levels of mir‑15a on apoptosis and inflammation. |
2021-04-30 |
2023-08-13 |
rat |
| Yuehui Fan, Weiping Wang, Weifeng Li, Xianjun L. miR‑15a inhibits cell apoptosis and inflammation in a temporal lobe epilepsy model by downregulating GFAP. Molecular medicine reports. vol 22. issue 4. 2021-04-30. PMID:32945401. |
in conclusion, the results of the present study suggested that the upregulation of mir‑15a may inhibit cell apoptosis and inflammation in tle by targeting gfap, thus providing a potential therapeutic target for the treatment of tle. |
2021-04-30 |
2023-08-13 |
rat |
| Juan Yu, Chao Liu, Hai-Yu Ji, An-Jun Li. The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa. International journal of biological macromolecules. vol 159. 2021-03-19. PMID:32422265. |
annexin v-fitc/pi staining and cell cycle distribution results showed that gfap could induce the apoptosis of h22 and hepg2 cells via arresting them in g1 and s phases respectively. |
2021-03-19 |
2023-08-13 |
Not clear |
| Juan Yu, Chao Liu, Hai-Yu Ji, An-Jun Li. The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa. International journal of biological macromolecules. vol 159. 2021-03-19. PMID:32422265. |
rh123, jc-1 staining and western blotting results suggested that gfap could significantly increase the permeability of mitochondrial membrane of hcc cells, and upregulated the expressions of bax, cytochrome c, cleaved-caspase-3 and cleaved-caspase-9, which indicated that gfap could trigger apoptosis of hcc cells through mitochondria apoptotic pathway in a caspases-dependent pattern. |
2021-03-19 |
2023-08-13 |
Not clear |
| E V N Beshay, S A El-Refai, G S Sadek, A A Elbadry, F H Shalan, A F Afif. Mesenchymal stem cells combined with albendazole as a novel therapeutic approach for experimental neurotoxocariasis. Parasitology. vol 147. issue 7. 2021-02-16. PMID:32178741. |
interestingly, mscs combined with albendazole demonstrated a healing effect on brain inflammation, gliosis, apoptosis and significantly reduced brain damage biomarkers (s100b and gfap) and t. canis dna. |
2021-02-16 |
2023-08-13 |
mouse |
| Lipeng Du, Zhigang Mei, Yaguang Huang, Wei Tao, Kai Wang, Weifeng Huang, Huajun Zhou, Zhitao Fen. Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-02-16. PMID:32361162. |
data indicated that the gj extracts could increase the cell viability and decrease apoptosis and the expression of glial fibrillary acidic protein (gfap) in ogd/r-induced astrocytes. |
2021-02-16 |
2023-08-13 |
rat |
| Shubhi Saini, Charanjeet Kaur, Indra Pal, Punit Kumar, Tony George Jacob, Alok Thakar, Kallol Kumar Roy, Tara Sankar Ro. Morphological development of the human cochlear nucleus. Hearing research. vol 382. 2021-01-04. PMID:31522073. |
twenty-three fetuses and seven postnatal brainstems were processed for cresyl violet (cv) staining and immunoexpression of neun (neurons), gfap (astrocytes), ki-67 (proliferation) and tunel (apoptosis) and 3-d reconstruction. |
2021-01-04 |
2023-08-13 |
human |
| Jamshid Tabeshpour, Soghra Mehri, Khalil Abnous, Hossein Hosseinzade. Role of Oxidative Stress, MAPKinase and Apoptosis Pathways in the Protective Effects of Thymoquinone Against Acrylamide-Induced Central Nervous System Toxicity in Rat. Neurochemical research. vol 45. issue 2. 2020-11-23. PMID:31728856. |
tq reversed the alterations in the protein contents of map kinase and apoptosis signaling pathways as well as mbp and gfap contents, induced by acr. |
2020-11-23 |
2023-08-13 |
rat |
| Kenta H T Cho, Guido Wassink, Robert Galinsky, Bing Xu, Sam Mathai, Simerdeep K Dhillon, Lotte G van den Heuij, Joanne O Davidson, Luke Weaver-Mikaere, Laura Bennet, Alistair J Gunn, Mhoyra Frase. Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep. Scientific reports. vol 9. issue 1. 2020-10-22. PMID:31267031. |
there were reduced numbers of cells showing cleaved caspase-3 positive apoptosis and astrogliosis (glial fibrillary acidic protein, gfap) in both white matter regions. |
2020-10-22 |
2023-08-13 |
Not clear |
| Qi Guo, Jing Zhang, Zhaoshi Zheng, Xinxin Li, Fuli Wang, Songyan Li. Lentivirus-mediated microRNA-26a-modified neural stem cells improve brain injury in rats with cerebral palsy. Journal of cellular physiology. vol 235. issue 2. 2020-10-16. PMID:31264214. |
the neurobehavioral functions, morphology, and ultrastructure of cerebral cortex and hippocampus, apoptosis of brain cells, expression of apoptosis-related protein caspase-3 and bax, together with the expression of the glial fibrillary acidic protein (gfap) in cerebral cortex and hippocampus were determined. |
2020-10-16 |
2023-08-13 |
rat |