| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinhua Li, Shuting Yang, Lin Han, Keya Mao, Shuying Yan. Ciliary IFT80 is essential for intervertebral disc development and maintenance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 5. 2021-01-22. PMID:32227389. |
mechanistic analyses showed that loss of ift80 caused a significant increase in cell apoptosis in the ivd, and a marked decrease in expression of chondrogenic markers - type ii collagen, sox9, aggrecan, and hedgehog (hh) signaling components, including gli1 and patch1 in the ivd of ift80 |
2021-01-22 |
2023-08-13 |
mouse |
| Syeda Kiran Riaz, Yuepeng Ke, Fen Wang, Mahmood Akhtar Kayani, Muhammad Faraz Arshad Mali. Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells. Scientific reports. vol 9. issue 1. 2020-10-19. PMID:31036836. |
interestingly, gant61 (gli1 inhibitor) exposure significantly reduced cell viability and induced apoptosis at 10 µm. |
2020-10-19 |
2023-08-13 |
Not clear |
| Zhongxiao Lin, Hansong Sheng, Chaoguo You, Ming Cai, Yiping Zhang, Li Sheng Yu, Xiaoming Yu, Jian Lin, Nu Zhan. Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1. Experimental and therapeutic medicine. vol 13. issue 1. 2020-10-01. PMID:28123507. |
therefore, the present study investigated whether the shh signaling pathway promotes the apoptosis of mb cells via downregulation of gli1. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chao-Tao Tang, Qian Liang, Li Yang, Xiao-Lu Lin, Shan Wu, Yong Chen, Xin-Tian Zhang, Yun-Jie Gao, Zhi-Zheng G. RAB31 Targeted by MiR-30c-2-3p Regulates the GLI1 Signaling Pathway, Affecting Gastric Cancer Cell Proliferation and Apoptosis. Frontiers in oncology. vol 8. 2020-10-01. PMID:30534536. |
rab31 targeted by mir-30c-2-3p regulates the gli1 signaling pathway, affecting gastric cancer cell proliferation and apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maojian Chen, Wei Jiang, Chanchan Xiao, Weiping Yang, Qinghong Qin, Anyun Mao, Qixing Tan, Bin Lian, Changyuan We. Sodium Butyrate Combined with Docetaxel for the Treatment of Lung Adenocarcinoma A549 Cells by Targeting Gli1. OncoTargets and therapy. vol 13. 2020-10-01. PMID:32982280. |
this study is aimed to investigate the combined treating efficacy of sodium butyrate and docetaxel on proliferation and apoptosis of the lung adenocarcinoma a549 cell line based on gli1 regulation in vitro and in vivo. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yanan Chang, Hong Chen, Jie Duan, Wang Wu, Fangshu Le, Fen Mo. The inhibitory effect and safety of GANT61 on HeLa cells in nude mice. Experimental and molecular pathology. vol 113. 2020-07-20. PMID:31809711. |
these findings suggest that gant61 could be used as a hedgehog inhibitor to inhibit emt and proliferation and to promote apoptosis via gli1 downregulation. |
2020-07-20 |
2023-08-13 |
mouse |
| Jianwei Zhu, Yang Sun, Ying Lu, Xiubo Jiang, Bo Ma, Lisha Yu, Jie Zhang, Xiaochen Dong, Qi Zhan. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899333. |
we demonstrated that glaucocalyxin a induced apoptosis via inhibiting five-zinc finger glis 1 (gli1) activation by overexpression and knockdown of gli1 in vitro. |
2019-11-05 |
2023-08-13 |
human |
| Jianwei Zhu, Yang Sun, Ying Lu, Xiubo Jiang, Bo Ma, Lisha Yu, Jie Zhang, Xiaochen Dong, Qi Zhan. Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899333. |
in conclusion, our results suggested that glaucocalyxin a induced apoptosis in osteosarcoma by inhibiting nuclear translocation of gli1 via regulating pi3k/akt signaling pathway. |
2019-11-05 |
2023-08-13 |
human |
| Chao-Tao Tang, Xiao-Lu Lin, Shan Wu, Qian Liang, Li Yang, Yun-Jie Gao, Zhi-Zheng G. NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway. Cellular signalling. vol 46. 2019-08-20. PMID:29496628. |
nox4-driven ros formation regulates proliferation and apoptosis of gastric cancer cells through the gli1 pathway. |
2019-08-20 |
2023-08-13 |
Not clear |
| Chao-Tao Tang, Xiao-Lu Lin, Shan Wu, Qian Liang, Li Yang, Yun-Jie Gao, Zhi-Zheng G. NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway. Cellular signalling. vol 46. 2019-08-20. PMID:29496628. |
in summary, the findings indicate that nox4 plays an important role in gastric cancer cell growth and apoptosis through the generation of ros and subsequent activation of gli1 signaling. |
2019-08-20 |
2023-08-13 |
Not clear |
| Stephanie Hehlgans, Patrick Booms, Ömer Güllülü, Robert Sader, Claus Rödel, Panagiotis Balermpas, Franz Rödel, Shahram Ghanaat. Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib. International journal of molecular sciences. vol 19. issue 9. 2018-12-11. PMID:30142876. |
we found that vismodegib decreases expression of the hedgehog target genes glioma-associated oncogene homologue (gli1) and the inhibitor of apoptosis protein (iap) survivin in a cell line- and irradiation-dependent manner, most pronounced in squamous cell carcinoma (scc) cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Hui Liang, Qi-Li Zheng, Peng Fang, Jian Zhang, Tuo Zhang, Wei Liu, Min Guo, Christopher L Robinson, Shui-Bing Chen, Xiao-Ping Chen, Fang-Ping Chen, Hui Zen. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Scientific reports. vol 7. 2018-10-15. PMID:28098170. |
by contrast, neither the expression of gli1 nor apoptosis in response to ara-c treatment of aml cells was significantly affected by pi3k inhibition. |
2018-10-15 |
2023-08-13 |
Not clear |
| Hui Liang, Qi-Li Zheng, Peng Fang, Jian Zhang, Tuo Zhang, Wei Liu, Min Guo, Christopher L Robinson, Shui-Bing Chen, Xiao-Ping Chen, Fang-Ping Chen, Hui Zen. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Scientific reports. vol 7. 2018-10-15. PMID:28098170. |
furthermore, co-inhibition of gli1 and pi3k induced apoptosis of hematopoietic stem/progenitor cells (hspcs), which raised serious concerns about the side effects of this treatment. |
2018-10-15 |
2023-08-13 |
Not clear |
| Dazhong Cao, Ting Yu, Xilong O. MiR-873-5P controls gastric cancer progression by targeting hedgehog-GLI signaling. Die Pharmazie. vol 71. issue 10. 2018-02-27. PMID:29441930. |
the role of gli1 and mir-873-5p on gastric cancer cell viability, apoptosis and cell cycle was determined using mtt assay and flow cytometry, respectively. |
2018-02-27 |
2023-08-13 |
human |
| Dazhong Cao, Ting Yu, Xilong O. MiR-873-5P controls gastric cancer progression by targeting hedgehog-GLI signaling. Die Pharmazie. vol 71. issue 10. 2018-02-27. PMID:29441930. |
meanwhile, knockdown of gli1 obviously induced sgc-7901 cell apoptosis and cell cycle arrest. |
2018-02-27 |
2023-08-13 |
human |
| K J Falkenberg, A Newbold, C M Gould, J Luu, J A Trapani, G M Matthews, K J Simpson, R W Johnston. A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity. Cell death and differentiation. vol 23. issue 7. 2018-01-10. PMID:26868908. |
the mechanism by which gli1 loss of function sensitized tumor cells to vorinostat-induced apoptosis is at least in part through interactions with vorinostat to alter gene expression in a manner that favored apoptosis. |
2018-01-10 |
2023-08-13 |
Not clear |
| Helen O Oladapo, Michael Tarpley, Scott J Sauer, Kezia A Addo, Shalonda M Ingram, Dillon Strepay, Ben K Ehe, Lhoucine Chdid, Michael Trinkler, Jose R Roques, David B Darr, Jodie M Fleming, Gayathri R Devi, Kevin P William. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer letters. vol 411. 2017-12-05. PMID:28965853. |
in addition, gant61 and jk184 significantly down-regulated gli1 targets that regulate cell cycle (cyclin d and e) and apoptosis (bcl2). |
2017-12-05 |
2023-08-13 |
Not clear |
| A Po, M Silvano, E Miele, C Capalbo, A Eramo, V Salvati, M Todaro, Z M Besharat, G Catanzaro, D Cucchi, S Coni, L Di Marcotullio, G Canettieri, A Vacca, G Stassi, E De Smaele, M Tartaglia, I Screpanti, R De Maria, E Ferrett. Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma. Oncogene. vol 36. issue 32. 2017-09-26. PMID:28368412. |
suppression of gli1, by silencing or drug-mediated, inhibits lac cells proliferation, attenuates their stemness and increases their susceptibility to apoptosis in vitro and in vivo. |
2017-09-26 |
2023-08-13 |
human |
| Anmada Nayak, Sumit Siddharth, Sarita Das, Deepika Nayak, Chinmayee Sethy, Chanakya Nath Kund. Nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between GLI1 and β catenin through activation of GSK3β. Toxicology and applied pharmacology. vol 330. 2017-08-14. PMID:28720477. |
nanoquinacrine caused apoptosis in oral cancer stem cells by disrupting the interaction between gli1 and β catenin through activation of gsk3β. |
2017-08-14 |
2023-08-13 |
Not clear |
| Xiaoya Wang, Sanhua Wei, Yong Zhao, Changhong Shi, Peijuan Liu, Caiqin Zhang, Yingfeng Lei, Bo Zhang, Bing Bai, Yong Huang, Hai Zhan. Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer letters. vol 385. 2017-08-08. PMID:27810405. |
itraconazole treatment inhibited hedgehog pathway key molecular expression, such as shh and gli1, resulting in promotion of apoptosis and autophagy. |
2017-08-08 |
2023-08-13 |
mouse |