| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoya Wang, Sanhua Wei, Yong Zhao, Changhong Shi, Peijuan Liu, Caiqin Zhang, Yingfeng Lei, Bo Zhang, Bing Bai, Yong Huang, Hai Zhan. Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer letters. vol 385. 2017-08-08. PMID:27810405. |
the anti-proliferation effect of itraconazole-induced apoptosis and autophagy via hedgehog pathway inhibition was confirmed with gli1 inhibitor gant61 and shh sirna, gant61 and shh sirna synergistically enhanced cytotoxicity induced by itraconazole. |
2017-08-08 |
2023-08-13 |
mouse |
| Jing-Bo Shao, Zhi-Mei Gao, Wen-Yan Huang, Zhi-Bao L. The mechanism of epithelial-mesenchymal transition induced by TGF-β1 in neuroblastoma cells. International journal of oncology. vol 50. issue 5. 2017-07-26. PMID:28393230. |
gant61, which is a targeted inhibitor of gli1 and gli2, decreased cell viability and promoted cell apoptosis. |
2017-07-26 |
2023-08-13 |
human |
| Pei Yu, Jinqing Yang, Yan Zhan. Identification and characterization of two novel PTCH1 splice variants. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28390897. |
finally, all these isoforms have been revealed to inhibit gli1 activation by either the classical hh signaling pathway or a new pathway not reliant on both smo and apoptosis. |
2017-06-12 |
2023-08-13 |
mouse |
| Monica Benvenuto, Laura Masuelli, Enrico De Smaele, Massimo Fantini, Rosanna Mattera, Danilo Cucchi, Elena Bonanno, Enrica Di Stefano, Giovanni Vanni Frajese, Augusto Orlandi, Isabella Screpanti, Alberto Gulino, Andrea Modesti, Roberto Be. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget. vol 7. issue 8. 2017-01-06. PMID:26843616. |
gdc-0449 and gant-61 exhibited the following effects: a) inhibited breast cancer cell survival; b) induced apoptosis; c) inhibited hh pathway activity by decreasing the mrna expression levels of gli1 and ptch and inhibiting the nuclear translocation of gli1; d) increased/decreased egfr and erbb2 protein expression, reduced p21-ras and erk1/erk2 mapk activities and inhibited akt activation; and e) decreased the nuclear translocation of nf-κb. |
2017-01-06 |
2023-08-13 |
mouse |
| Anmada Nayak, Shakti Ranjan Satapathy, Dipon Das, Sumit Siddharth, Neha Tripathi, Prasad V Bharatam, ChanakyaNath Kund. Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1. Scientific reports. vol 6. 2017-01-04. PMID:26846872. |
the expressions of hh-gli components, gli1 promoter activity and apoptosis were unaltered in nqc treated gli1-knockdown cells. |
2017-01-04 |
2023-08-13 |
mouse |
| Anmada Nayak, Shakti Ranjan Satapathy, Dipon Das, Sumit Siddharth, Neha Tripathi, Prasad V Bharatam, ChanakyaNath Kund. Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1. Scientific reports. vol 6. 2017-01-04. PMID:26846872. |
thus, nqc induced apoptosis in cancers through inhibition of hh-gli cascade by gli1. |
2017-01-04 |
2023-08-13 |
mouse |
| Wenjia Guo, Hailong Tian, Xiaogang Dong, Jinping Bai, Xinling Yan. Knockdown of Gli1 by small-interfering RNA enhances the effects of BCNU on the proliferation and apoptosis of glioma U251 cells. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-12-14. PMID:26339341. |
knockdown of gli1 by small-interfering rna enhances the effects of bcnu on the proliferation and apoptosis of glioma u251 cells. |
2016-12-14 |
2023-08-13 |
Not clear |
| Andrea Comba, Luciana L Almada, Ezequiel J Tolosa, Eriko Iguchi, David L Marks, Marianela Vara Messler, Renata Silva, Maite G Fernandez-Barrena, Elisa Enriquez-Hesles, Anne L Vrabel, Bruno Botta, Lucia Di Marcotulio, Volker Ellenrieder, Aldo R Eynard, Maria E Pasqualini, Martin E Fernandez-Zapic. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. The Journal of biological chemistry. vol 291. issue 4. 2016-08-22. PMID:26601952. |
we provide evidence that aa-induced apoptosis and down-regulation of antiapoptotic genes can be inhibited by overexpressing gli1 in aa-sensitive cells. |
2016-08-22 |
2023-08-13 |
Not clear |
| Andrea Comba, Luciana L Almada, Ezequiel J Tolosa, Eriko Iguchi, David L Marks, Marianela Vara Messler, Renata Silva, Maite G Fernandez-Barrena, Elisa Enriquez-Hesles, Anne L Vrabel, Bruno Botta, Lucia Di Marcotulio, Volker Ellenrieder, Aldo R Eynard, Maria E Pasqualini, Martin E Fernandez-Zapic. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. The Journal of biological chemistry. vol 291. issue 4. 2016-08-22. PMID:26601952. |
treatment with antioxidants impaired the aa-induced apoptosis and down-regulation of gli1 and nfatc1 activation, indicating that nfatc1 activation and gli1 repression require the generation of reactive oxygen species. |
2016-08-22 |
2023-08-13 |
Not clear |
| Zhenkun Ma, Wei Liu, Jin Zeng, Jiancheng Zhou, Peng Guo, Hongjun Xie, Zhao Yang, Long Zheng, Shan Xu, Xinyang Wang, Luke S Chang, Dalin He, Lei L. Silibinin induces apoptosis through inhibition of the mTOR-GLI1-BCL2 pathway in renal cell carcinoma. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26323996. |
in the present study, we confirmed that silibinin induced growth inhibition of rcc through caspase-dependent apoptosis and downregulation of gli1 and bcl2, which could be partially reversed by gli1 overexpression. |
2016-07-18 |
2023-08-13 |
mouse |
| Jixue Zou, Zhigang Zhou, Liping Wan, Yin Tong, Youwen Qin, Chun Wang, Kun Zho. Targeting the Sonic Hedgehog-Gli1 Pathway as a Potential New Therapeutic Strategy for Myelodysplastic Syndromes. PloS one. vol 10. issue 8. 2016-05-24. PMID:26317501. |
gli1 silencing also induced apoptosis and g0/g1 phase arrest. |
2016-05-24 |
2023-08-13 |
Not clear |
| Purusottam Mohapatra, Shakti Ranjan Satapathy, Sumit Siddharth, Dipon Das, Anmada Nayak, Chanakya Nath Kund. Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling. The international journal of biochemistry & cell biology. vol 66. 2016-05-20. PMID:26212257. |
un-alteration of the expressions of the above proteins and gli1 promoter activity in p21(waf/cip1) knockout cells suggests this combination caused apoptosis through p21(waf/cip1). |
2016-05-20 |
2023-08-13 |
mouse |
| Jiancheng Zhou, Guodong Zhu, Jun Huang, Lei Li, Yuefeng Du, Yang Gao, Dapeng Wu, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Kaijie W. Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target. Cancer letters. vol 370. issue 2. 2016-05-03. PMID:26577809. |
up-regulation of gli1 and gli2 promoted rcc proliferation and clonogenic ability, whereas, a combination of glis inhibitor gant61 and akt inhibitor perifosine synergistically suppressed rcc growth and induced apoptosis in vitro and in vivo. |
2016-05-03 |
2023-08-13 |
human |
| Chuan Bian Lim, Cecilia M Prêle, Svetlana Baltic, Peter G Arthur, Jenette Creaney, D Neil Watkins, Philip J Thompson, Steven E Mutsaer. Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis. Oncotarget. vol 6. issue 3. 2015-12-01. PMID:25544756. |
exposure of mme cells to gant61 led to g1 phase arrest and apoptosis, which involved ros but not its purported targets, gli1 or gli2. |
2015-12-01 |
2023-08-13 |
human |
| Feng Wu, William N Rom, Minori Koshiji, Yiqun Mo, Yukio Hosomi, Kam-Meng Tchou-Won. Role of GLI1 and NDRG1 in Increased Resistance to Apoptosis Induction. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 34. issue 3. 2015-11-26. PMID:26349604. |
role of gli1 and ndrg1 in increased resistance to apoptosis induction. |
2015-11-26 |
2023-08-13 |
mouse |
| Feng Wu, William N Rom, Minori Koshiji, Yiqun Mo, Yukio Hosomi, Kam-Meng Tchou-Won. Role of GLI1 and NDRG1 in Increased Resistance to Apoptosis Induction. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 34. issue 3. 2015-11-26. PMID:26349604. |
ectopic expression of gli1 in pw cells induced anchorage-independent growth and increased resistance to staurosporine-induced apoptosis, and overexpression of gli1 in h441 cells caused resistance to apoptosis induced by staurosporine and etoposide. |
2015-11-26 |
2023-08-13 |
mouse |
| Feng Wu, William N Rom, Minori Koshiji, Yiqun Mo, Yukio Hosomi, Kam-Meng Tchou-Won. Role of GLI1 and NDRG1 in Increased Resistance to Apoptosis Induction. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 34. issue 3. 2015-11-26. PMID:26349604. |
downregulation of gli1 expression in a549 cells by sirna transfection increased sensitivity to etoposide-induced apoptosis, and downregulation of ndrg1 expression in h441 cells by sirna transfection increased sensitivity to etoposide-induced apoptosis. |
2015-11-26 |
2023-08-13 |
mouse |
| Xinyi Cai, Kun Yu, Lijuan Zhang, Yunfeng Li, Qiang Li, Zhibin Yang, Tao Shen, Lincan Duan, Wei Xiong, Weiya Wan. Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. OncoTargets and therapy. vol 8. 2015-05-06. PMID:25945059. |
knocking down endogenous gli1 reduced colon carcinoma cell viability through inducing cell apoptosis. |
2015-05-06 |
2023-08-13 |
Not clear |
| Fei Duan, Ming Lin, Chuanyin Li, Xia Ding, Guanxiang Qian, He Zhang, Shengfang Ge, Xianqun Fan, Jin L. Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells. Cancer biology & therapy. vol 15. issue 5. 2015-04-15. PMID:24553082. |
cyclopamine treatment effectively increased apoptosis and inhibited cell proliferation, migration, and epithelial-to-mesenchymal transition (emt) by downregulating the hh final arbiter glioblastoma 1 (gli1), which regulates the transcription of target genes in the nucleus. |
2015-04-15 |
2023-08-12 |
human |
| Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. |
utilizing smosirna transfected esophageal squamous carcinoma ec9706 cells, adopting rt-pcr and western blot technology to detect smo, gli1 mrna and protein expression in each group of cells, employing mtt and fcm to detect the influence of smosirna on cell proliferation and apoptosis. |
2015-01-22 |
2023-08-13 |
human |