| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke Wang, Li Pan, Xiaoming Che, Daming Cui, Chao L. Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. Journal of neuro-oncology. vol 98. issue 3. 2010-09-17. PMID:20024601. |
depletion of gli1 expression by small interfering rna (sirna) interference led to remarkably decreased cell proliferation and enhanced apoptosis in u87 glioma cell line. |
2010-09-17 |
2023-08-12 |
human |
| Ke Wang, Li Pan, Xiaoming Che, Daming Cui, Chao L. Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. Journal of neuro-oncology. vol 98. issue 3. 2010-09-17. PMID:20024601. |
in conclusion, our findings support an important role of gli1 in cell-cycle and apoptosis regulation in human brain gliomas; hence, it can serve as a potential target of new therapeutic strategies for these diseases. |
2010-09-17 |
2023-08-12 |
human |
| Jin-Hyeok Hwang, Sang Hyub Lee, Kwang Hyuck Lee, Keung Youp Lee, Haeryoung Kim, Ji Kon Ryu, Yong Bum Yoon, Yong-Tae Ki. Cathepsin B is a target of Hedgehog signaling in pancreatic cancer. Cancer letters. vol 273. issue 2. 2009-01-19. PMID:19004543. |
cyclopamine (hh signal inhibitor) suppressed expression of shh, as well as hh-induced transcription factor gli1, and induced apoptosis in shh-positive pancreatic cancer cell line (panc-1). |
2009-01-19 |
2023-08-12 |
human |
| Katherine E Galvin, Hong Ye, Derek J Erstad, Rod Feddersen, Cynthia Wetmor. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18276799. |
gli1 induces g2/m arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. |
2008-08-15 |
2023-08-12 |
Not clear |
| Katherine E Galvin, Hong Ye, Derek J Erstad, Rod Feddersen, Cynthia Wetmor. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18276799. |
to determine whether gli1 was sufficient to enhance nsc proliferation, we overexpressed this mitogen and were surprised to find that gli1 resulted in decreased proliferation, accumulation of nscs in the g2/m phase of cell cycle, and apoptosis. |
2008-08-15 |
2023-08-12 |
Not clear |
| Katherine E Galvin, Hong Ye, Derek J Erstad, Rod Feddersen, Cynthia Wetmor. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem cells (Dayton, Ohio). vol 26. issue 4. 2008-08-15. PMID:18276799. |
in contrast to normal stem cells, tumor-derived stem cells had markedly higher basal gli1 expression and did not undergo apoptosis with further elevation of gli1. |
2008-08-15 |
2023-08-12 |
Not clear |
| Eli E Bar, Duncan Stearn. New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination. Expert opinion on investigational drugs. vol 17. issue 2. 2008-02-14. PMID:18230052. |
this review explores the relationship between cholesterol and cancer in light of a recent study that demonstrated that the hedgehog (hh) antagonist cyclopamine blocked expression of the hh pathway targets ptch1 and gli1, lowered bcl2 levels and increased apoptosis in medulloblastoma cells. |
2008-02-14 |
2023-08-12 |
human |
| Eli E Bar, Aneeka Chaudhry, Mohamed H Farah, Charles G Eberhar. Hedgehog signaling promotes medulloblastoma survival via Bc/II. The American journal of pathology. vol 170. issue 1. 2007-02-21. PMID:17200206. |
we found that mrna levels of the hedgehog pathway effector gli1 were significantly associated with bclii expression in medulloblastoma and that gli1 and bclii are both present in regions of decreased apoptosis in nodular medulloblastoma. |
2007-02-21 |
2023-08-12 |
Not clear |
| Eli E Bar, Aneeka Chaudhry, Mohamed H Farah, Charles G Eberhar. Hedgehog signaling promotes medulloblastoma survival via Bc/II. The American journal of pathology. vol 170. issue 1. 2007-02-21. PMID:17200206. |
the hedgehog antagonist cyclopamine blocked expression of the hh pathway targets ptch1 and gli1, lowered bclii levels, and increased apoptosis in daoy and uw228 medulloblastoma cells. |
2007-02-21 |
2023-08-12 |
Not clear |
| Xiaoli Ma, Tao Sheng, Yuanxin Zhang, Xiaoli Zhang, Jing He, Shuhong Huang, Kai Chen, Josh Sultz, Patrick A Adegboyega, Hongwei Zhang, Jingwu Xi. Hedgehog signaling is activated in subsets of esophageal cancers. International journal of cancer. vol 118. issue 1. 2005-12-13. PMID:16003737. |
our data also indicate that downregulation of gli1 expression may be an important mechanism by which kaad-cyclopamine inhibits growth and induces apoptosis in esophageal cancer cells. |
2005-12-13 |
2023-08-12 |
Not clear |
| Xiaoli Ma, Kai Chen, Shuhong Huang, Xiaoli Zhang, Patrick A Adegboyega, B Mark Evers, Hongwei Zhang, Jingwu Xi. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905200. |
treatment of gastric cancer cells with kaad-cyclopamine, a hedgehog signaling inhibitor, decreases expression of gli1 and ptch1, resulting in cell growth inhibition and apoptosis. |
2005-11-08 |
2023-08-12 |
human |
| Xiaoli Ma, Kai Chen, Shuhong Huang, Xiaoli Zhang, Patrick A Adegboyega, B Mark Evers, Hongwei Zhang, Jingwu Xi. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905200. |
overexpression of gli1 under the control of the cytomegalovirus (cmv) promoter renders these cells resistant to cyclopamine-induced apoptosis. |
2005-11-08 |
2023-08-12 |
human |
| Joon Won Yoon, Yasuhiro Kita, Daniel J Frank, Rebecca R Majewski, Beth A Konicek, Marcelo A Nobrega, Howard Jacob, David Walterhouse, Philip Iannaccon. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. The Journal of biological chemistry. vol 277. issue 7. 2002-03-21. PMID:11719506. |
genes whose expression was altered by gli1 included cell cycle genes, cell adhesion genes, signal transduction genes, and genes regulating apoptosis. |
2002-03-21 |
2023-08-12 |
human |