| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa D Mills, Lizhi Zhang, Ronald Marler, Phyllis Svingen, Maite G Fernandez-Barrena, Maneesh Dave, William Bamlet, Robert R McWilliams, Gloria M Petersen, William Faubion, Martin E Fernandez-Zapic. Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24737325. |
finally, decreased levels of apoptosis were detected in tumor tissue in the absence of gli1 by tunel staining. |
2014-10-07 |
2023-08-13 |
mouse |
| Y Sun, W Guo, T Ren, W Liang, W Zhou, Q Lu, G Jiao, T Ya. Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells. Cell death & disease. vol 5. 2014-09-02. PMID:24384722. |
gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on erk1/2 activity in human chondrosarcoma cells. |
2014-09-02 |
2023-08-12 |
human |
| Y Sun, W Guo, T Ren, W Liang, W Zhou, Q Lu, G Jiao, T Ya. Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells. Cell death & disease. vol 5. 2014-09-02. PMID:24384722. |
the transcription factor glioma-associated oncogene 1 (gli1) has been recognized as a very important nuclear executor at the distal end of the hedgehog (hh) signal pathway, which has crucial roles in regulating many developmental processes, such as pattern formation, differentiation, proliferation, and apoptosis. |
2014-09-02 |
2023-08-12 |
human |
| Y Sun, W Guo, T Ren, W Liang, W Zhou, Q Lu, G Jiao, T Ya. Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells. Cell death & disease. vol 5. 2014-09-02. PMID:24384722. |
here we show that the ihh signal pathway was activated in chondrosarcoma, and knocking down the expression of gli1 attenuated the disturbed ihh signal pathway, which not only suppressed cell proliferation and promoted g2/m cell cycle arrest but also enhanced cell apoptosis by downregulating bcl-2 and bcl-xl expression. |
2014-09-02 |
2023-08-12 |
human |
| D Mazzà, P Infante, V Colicchia, A Greco, R Alfonsi, M Siler, L Antonucci, A Po, E De Smaele, E Ferretti, C Capalbo, D Bellavia, G Canettieri, G Giannini, I Screpanti, A Gulino, L Di Marcotulli. PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress. Cell death and differentiation. vol 20. issue 12. 2014-06-05. PMID:24013724. |
restoring gli1 levels rescues the growth arrest and apoptosis effect triggered by genotoxic drugs. |
2014-06-05 |
2023-08-12 |
mouse |
| Joon Won Yoon, Marisa Gallant, Marilyn L G Lamm, Stephen Iannaccone, Karl-Frederic Vieux, Maria Proytcheva, Elizabeth Hyjek, Philip Iannaccone, David Walterhous. Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma. Molecular cancer research : MCR. vol 11. issue 6. 2014-04-17. PMID:23525267. |
exposure to sonic or indian hedgehog or cyclopamine (smo inhibitor) does not modulate gli1 expression, cell proliferation, or apoptosis in most burkitt lymphoma cell lines. |
2014-04-17 |
2023-08-12 |
human |
| Joon Won Yoon, Marisa Gallant, Marilyn L G Lamm, Stephen Iannaccone, Karl-Frederic Vieux, Maria Proytcheva, Elizabeth Hyjek, Philip Iannaccone, David Walterhous. Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma. Molecular cancer research : MCR. vol 11. issue 6. 2014-04-17. PMID:23525267. |
inhibition of gli1 by gant61 increases apoptosis and reduces viability of some burkitt lymphoma cells. |
2014-04-17 |
2023-08-12 |
human |
| Shiori Kanda, Takeshi Mitsuyasu, Yu Nakao, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Seiji Nakamur. Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma. International journal of oncology. vol 43. issue 3. 2014-04-07. PMID:23835807. |
furthermore, in the presence of shh neutralizing antibody, nuclear translocation of gli1 and gli2 was abolished, apoptosis was induced, bcl-2 expression decreased and bax expression increased. |
2014-04-07 |
2023-08-12 |
Not clear |
| Zhonglu Peng, Zhengyu Ji, Fang Mei, Meiling Lu, Yu Ou, Xiaodong Chen. Lithium inhibits tumorigenic potential of PDA cells through targeting hedgehog-GLI signaling pathway. PloS one. vol 8. issue 4. 2013-11-26. PMID:23626687. |
herein, we report that lithium inhibits cell proliferation, blocks g1/s cell-cycle progression, induces cell apoptosis and suppresses tumorigenic potential of pda cells through down-regulation of the expression and activity of gli1. |
2013-11-26 |
2023-08-12 |
Not clear |
| Jiefang Guo, Jun Gao, Zhaoshen Li, Yanfang Gong, Xiaohua Man, Jing Jin, Hongyu W. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. Cancer letters. vol 339. issue 2. 2013-11-08. PMID:23791879. |
adenovirus vector-mediated gli1 sirna induces growth inhibition and apoptosis in human pancreatic cancer with smo-dependent or smo-independent hh pathway activation in vitro and in vivo. |
2013-11-08 |
2023-08-12 |
mouse |
| Jiefang Guo, Jun Gao, Zhaoshen Li, Yanfang Gong, Xiaohua Man, Jing Jin, Hongyu W. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. Cancer letters. vol 339. issue 2. 2013-11-08. PMID:23791879. |
our study indicates that gli1-targeting sirna could induce growth inhibition and apoptosis in pc through knockdown of gli1 and its target genes; and this method may represent a more effective therapeutic strategy for pc with smo-dependent or smo-independent hh pathway activation. |
2013-11-08 |
2023-08-12 |
mouse |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23563640. |
the growth inhibition rate of the cells was measured by mtt assay, apoptosis was detected by flow cytometry, the expression levels of shh, gli1, e-cadherin and vimentin were detected by western blot analysis, and cell invasion and migration ability were examined by transwell cell invasion assay and wound healing assay. |
2013-10-29 |
2023-08-12 |
Not clear |
| Xiao-Dong Sun, Xing-E Liu, Dong-Sheng Huan. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the Hedgehog signaling pathway. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23563640. |
the tgf-β1-stimulated panc-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited tgf-β1-stimulated panc-1 cell proliferation and induced apoptosis, compared with other groups (p<0.01), and the expression levels of shh, gli1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (p<0.01, respectively). |
2013-10-29 |
2023-08-12 |
Not clear |
| Junsheng Fu, Mariana Rodova, Sanjit K Roy, Jay Sharma, Karan P Singh, Rakesh K Srivastava, Sharmila Shanka. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer letters. vol 330. issue 1. 2013-05-09. PMID:23200667. |
suppression of both gli1 plus gli2 by shrna mimicked the changes in cell viability, spheroid formation, apoptosis and gene expression observed in gant-61-treated pancreatic cscs. |
2013-05-09 |
2023-08-12 |
mouse |
| Xiaojia Guo, John C Schmitz, Barton C Kenney, Edward M Uchio, Sanjay Kulkarni, Charles H Ch. Intermedin is overexpressed in hepatocellular carcinoma and regulates cell proliferation and survival. Cancer science. vol 103. issue 8. 2013-05-07. PMID:22625651. |
blockage of imd signaling using either an antagonist peptide or a neutralizing antibody inhibited growth in a dose-dependent manner with concomitant induction of apoptosis, causing cleavage of caspase-8 and downregulation of gli1 and bcl2. |
2013-05-07 |
2023-08-12 |
human |
| Malin Wickström, Cecilia Dyberg, Takashi Shimokawa, Jelena Milosevic, Ninib Baryawno, Ole M Fuskevåg, Rolf Larsson, Per Kogner, Peter G Zaphiropoulos, John I Johnse. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. International journal of cancer. vol 132. issue 7. 2013-04-04. PMID:22949014. |
gant61 downregulated gli1, c-myc, mycn and cyclin d1 expression and induced apoptosis of neuroblastoma cells. |
2013-04-04 |
2023-08-12 |
mouse |
| Wenxia Su, Fankai Meng, Lifang Huang, Miao Zheng, Wenli Liu, Hanying Su. Sonic hedgehog maintains survival and growth of chronic myeloid leukemia progenitor cells through β-catenin signaling. Experimental hematology. vol 40. issue 5. 2012-06-12. PMID:22240607. |
c-myc, gli1, bcl-2, and p21 were also found to be downstream targets of shh signaling, mediating apoptosis or g(2)/m cell cycle arrest of progenitor cells. |
2012-06-12 |
2023-08-12 |
human |
| Z I Thomas, W Gibson, J Z Sexton, K M Aird, S M Ingram, A Aldrich, H K Lyerly, G R Devi, K P William. Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration. British journal of cancer. vol 104. issue 10. 2011-08-01. PMID:21505458. |
targeting gli1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration. |
2011-08-01 |
2023-08-12 |
human |
| Yeon-Jin Kwon, Douglas R Hurst, Adam D Steg, Kun Yuan, Kedar S Vaidya, Danny R Welch, Andra R Fros. Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines. Clinical & experimental metastasis. vol 28. issue 5. 2011-06-23. PMID:21442356. |
sustained suppression of gli1 expression decreased growth of mda-mb-231 in vitro by increasing apoptosis and decreasing proliferation. |
2011-06-23 |
2023-08-12 |
human |
| Ke Wang, Li Pan, Xiaoming Che, Daming Cui, Chao L. Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. Journal of neuro-oncology. vol 98. issue 3. 2010-09-17. PMID:20024601. |
gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. |
2010-09-17 |
2023-08-12 |
human |