| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T Baldari, Giuseppe Campian. A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-04-05. PMID:38579402. |
new selective class i hdac inhibitors (hdacis, 6a-g) were developed with increased potency over existing agents and preferentially interfering with the cll-relevant isoform hdac1, to unveil the role of class i hdacs in the upregulation of stat4 expression, which upregulates p66shc expression and hence normalizes cll cell apoptosis. |
2024-04-05 |
2024-04-10 |
Not clear |
| Guiping Ren, Xiaoqian Gu, Lu Zhang, Shimin Gong, Shuang Song, Shunkai Chen, Zhenjing Chen, Xiaoyan Wang, Zhanbiao Li, Yingshui Zhou, Longxi Li, Jiao Yang, Fan Lai, Yunkun Dan. Ribosomal frameshifting at normal codon repeats recodes functional chimeric proteins in human. Nucleic acids research. 2024-01-28. PMID:38281188. |
finally, we show a crfs-derived trans-frame protein (hdac1-fs) functions by antagonizing the activities of hdac1, thus affecting cell migration and apoptosis. |
2024-01-28 |
2024-01-31 |
human |
| Xiaofeng Zhou, Yingting He, Hongyan Quan, Xiangchun Pan, Yinqi Zhou, Zhe Zhang, Xiaolong Yuan, Jiaqi L. Cells. vol 12. issue 23. 2023-12-09. PMID:38067162. |
using the mouse model, we showed that trichostatin a (tsa), a histone deacetylase (hdac) inhibitor, downregulated the protein level of hdac1 in ovaries to promote the apoptosis of granulosa cells (gcs), and thus arrested follicular development and delayed sexual maturity. |
2023-12-09 |
2023-12-17 |
mouse |
| Li Liu, Ke Gu, Dong Hu. HDAC1 suppresses radiotherapy sensitivity in cervical cancer via regulating HIF-1α/VEGF signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015530. |
in vivo, we found that hdac1 silence hindered tumor growth and cell proliferation and promoted tumor cell apoptosis in nude mice after radiotherapy. |
2023-11-28 |
2023-11-29 |
mouse |
| Carter A Wright, Emily R Gordon, Sara J Coope. Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer. BMC cancer. vol 23. issue 1. 2023-11-26. PMID:37996815. |
integrative genomic analysis shows that hdac1 overexpression promotes activation of key resistance pathways including epithelial to mesenchymal transition, cell cycle, and apoptosis through global chromatin remodeling. |
2023-11-26 |
2023-11-28 |
Not clear |
| Yao Chen, Shuangqian Zhang, Zhijia Li, Bo Yin, Yi Liu, Lan Zhan. Discovery of a dual-target inhibitor of CDK7 and HDAC1 that induces apoptosis and inhibits migration in colorectal cancer. ChemMedChem. 2023-10-11. PMID:37821774. |
discovery of a dual-target inhibitor of cdk7 and hdac1 that induces apoptosis and inhibits migration in colorectal cancer. |
2023-10-11 |
2023-10-15 |
Not clear |
| Kaushik Kumar Bharadwaj, Iqrar Ahmad, Siddhartha Pati, Arabinda Ghosh, Bijuli Rabha, Tanmay Sarkar, Dorothy Bhattacharjya, Harun Patel, Debabrat Baishy. Screening of Phytocompounds for Identification of Prospective Histone Deacetylase 1 (HDAC1) Inhibitor: An In Silico Molecular Docking, Molecular Dynamics Simulation, and MM-GBSA Approach. Applied biochemistry and biotechnology. 2023-09-30. PMID:37776441. |
hdac1 inhibitors have thus emerged as possible therapeutic approaches against a variety of human malignancies, as they can inhibit the activity of certain hdacs, repair the overexpression of tumour suppressor genes, and induce cell differentiation, cell cycle arrest, and apoptosis. |
2023-09-30 |
2023-10-07 |
human |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on hdac1. |
2023-09-10 |
2023-10-07 |
Not clear |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
we then used cck-8, colony formation, mitochondrial membrane potential and apoptosis assays to confirm that colchicine could inhibit the proliferation and promote the apoptosis of ptc cells and verified by rt‒qpcr, western blot, and cellular immunofluorescence assays that colchicine could inhibit the expression of hdac1 in ptc cells. |
2023-09-10 |
2023-10-07 |
Not clear |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
we then applied an hdac1 inhibitor, pyroxamide, to verify that inhibition of hdac1 inhibits proliferation and promotes apoptosis in ptc cells. |
2023-09-10 |
2023-10-07 |
Not clear |
| Shuai Wang, Zhonghao Cui, Jian Zhu, Peng Zhou, Xianjiao Cao, Xiaolei Li, Yunhan Ma, Qingqing H. Colchicine inhibits the proliferation and promotes the apoptosis of papillary thyroid carcinoma cells likely due to the inhibitory effect on HDAC1. Biochemical and biophysical research communications. vol 679. 2023-09-10. PMID:37690423. |
therefore, we conclude that colchicine can inhibit the proliferation and promote the apoptosis of ptc cells likely due to its inhibitory effect on hdac1. |
2023-09-10 |
2023-10-07 |
Not clear |
| Chao Wen, Xiaoliang Lu, Yingyin Sun, Qi Li, Jing Liao, Lin L. Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling. Heliyon. vol 9. issue 5. 2023-05-19. PMID:37206002. |
here, we found that nar induced the apoptosis, decreased the expression of lncrna xist and hdac1, and increased the expression of microrna-34a in hl60 cells. |
2023-05-19 |
2023-08-14 |
Not clear |
| Changsheng Wang, Xiaobo Zhang, Xitian Zhu, Rongsheng Chen, Nancheng Lia. The RNA binding protein HuR promotes neuronal apoptosis in rats with spinal cord injury via the HDAC1/RAD21 axis. Neuroscience. 2023-05-10. PMID:37164303. |
the injection of hur shrna in tail vein of sci rats increased basso, beattie, and bresnahan score, relieved sci, reduced hur and hdac1 expression, elevated rad21 expression, and decreased neuronal-like apoptosis. |
2023-05-10 |
2023-08-14 |
rat |
| Changsheng Wang, Xiaobo Zhang, Xitian Zhu, Rongsheng Chen, Nancheng Lia. The RNA binding protein HuR promotes neuronal apoptosis in rats with spinal cord injury via the HDAC1/RAD21 axis. Neuroscience. 2023-05-10. PMID:37164303. |
in conclusion, down-regulation of hur alleviated sci and neuronal apoptosis in rats by suppressing hdac1 expression and promoting rad21 expression. |
2023-05-10 |
2023-08-14 |
rat |
| Luyang Wang, Anning Du, Yan Lu, Yunxi Zhao, Ming Qiu, Zhenyang Su, Huanyu Shu, Hui Shen, Wei Sun, Xiangqing Kon. Peptidase Inhibitor 16 Attenuates Left Ventricular Injury and Remodeling After Myocardial Infarction by Inhibiting the HDAC1-Wnt3a-β-Catenin Signaling Axis. Journal of the American Heart Association. 2023-05-09. PMID:37158154. |
pi16 also inhibited hdac1 (class i histone deacetylase) expression, and overexpression hdac1 abolished the inhibition of apoptosis and wnt signaling of pi16. |
2023-05-09 |
2023-08-14 |
mouse |
| Wenjun Jiao, Weifang Li, Tianyi Li, Tao Feng, Cong Wu, Di Zha. Induced pluripotent stem cell-derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury. Cell biology and toxicology. 2023-02-15. PMID:36790503. |
the in vitro studies suggested that ipsc-derived evs, sfpq or hdac1 overexpression, or hif-2α silencing diminished cell injury and apoptosis but elevated proliferation in retinal müller cells. |
2023-02-15 |
2023-08-14 |
rat |
| Fenqian Yuan, Jingkang Yong, Xueming Liu, Yifeng Wan. Selinexor assists vorinostat in inhibiting HDAC activity via promoting the accumulation of maspin in the nucleus of oral tongue squamous cell carcinoma cells. Cytotechnology. vol 75. issue 1. 2023-01-30. PMID:36713062. |
in vitro, both vorinostat and selinexor effectively inhibited cell viability, invasion, and migration, promoted cell apoptosis, down-regulated hdac1, matrix metalloproteinase 2 (mmp2), and b cell leukemia/lymphoma 2 (bcl-2), and up-regulated nuclear maspin and cleaved caspase 3. |
2023-01-30 |
2023-08-14 |
mouse |
| Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara, Christian Seise. A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. PLoS genetics. vol 18. issue 8. 2022-08-22. PMID:35994477. |
individual inactivation of hdac1 or hdac2 has only mild effects on cell viability, while hdac3 inactivation or loss results in dna damage and apoptosis. |
2022-08-22 |
2023-08-14 |
human |
| Hao Cui, Zan Hu, Kang Yang, Jingkun Huang, Yichao Wu, Quanwei Chen, Ran Wei, Penfeng Wang, Hui Wang, Hongmei Li, Yadong Chen, Tao Lu, Yuqin Yao, Yong Zh. Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer. European journal of medicinal chemistry. vol 238. 2022-06-01. PMID:35649291. |
compound iic showed good inhibitory activity against hdac1 and hct116 cells and showed higher sensitivity to activating the expression of the trail protein and promoting the apoptosis of hct-116 cells compared with onc201. |
2022-06-01 |
2023-08-13 |
Not clear |
| Shengkai Zhou, Peng Liu, Guobao Zhang, Zhaoyun Cheng, Sheng Wang, Jian Zha. HDAC1 depletion alleviates coronary heart disease via the microRNA-182-mediated TGF-β/Smad signaling pathway. Journal of cardiovascular pharmacology. 2022-03-15. PMID:35289769. |
using elisa, rt-qpcr, he staining, tunel assay and immunohistochemistry, we observed that hdac1 downregulation promoted cardiac function, restored lipid levels, reduced myocardial injury markers and inflammatory factors, and alleviated myocardial tissue damage and apoptosis in chd rats. |
2022-03-15 |
2023-08-13 |
rat |