| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Moumita Datta, Ori Staszewski, Elena Raschi, Maximilian Frosch, Nora Hagemeyer, Tuan Leng Tay, Thomas Blank, Mario Kreutzfeldt, Doron Merkler, Stephanie Ziegler-Waldkirch, Patrick Matthias, Melanie Meyer-Luehmann, Marco Prin. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. vol 48. issue 3. 2018-11-27. PMID:29548672. |
mechanistically, the promoters of pro-apoptotic and cell cycle genes were hyperacetylated in absence of hdac1 and hdac2, leading to increased apoptosis and reduced survival. |
2018-11-27 |
2023-08-13 |
mouse |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Yangwei Li, Kang Zhang, Wei Ma. Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328474. |
inhibition of mir‑34a prevents endothelial cell apoptosis by directly targeting hdac1 in the setting of atherosclerosis. |
2018-08-14 |
2023-08-13 |
human |
| Yangwei Li, Kang Zhang, Wei Ma. Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328474. |
this indicated that mir‑34a inhibitor promoted cell viability and prevented cell apoptosis of haecs through regulating hdac1. |
2018-08-14 |
2023-08-13 |
human |
| Yangwei Li, Kang Zhang, Wei Ma. Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328474. |
in conclusion, it was demonstrated that mir‑34a promoted atherosclerotic formation by modulating the proliferation and apoptosis of haecs, and regulating the expression of apoptosis‑related proteins by targeting hdac1. |
2018-08-14 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of hdac1 and oxidative stress. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
histone deacetylase1 (hdac1) is an epigenetic regulator in cellular apoptosis. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
we found that hg treatment decreased cell vitality, upregulated hdac1 protein level, promoted reactive oxygen species production, induced cell cycle arrest and cell apoptosis in hmec-1 cells, which were all rectified by vac. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
both scavenging reactive oxygen species and inhibition of hdac1 alleviated the apoptosis of hmec-1 cells in response to hg. |
2018-07-27 |
2023-08-13 |
human |
| Xuexue Zhu, Yueyue Lei, Fanggen Tan, Leilei Gong, Haifeng Gong, Wei Yang, Ting Chen, Zhixuan Zhang, Weiwei Cai, Bao Hou, Xu Wang, Haijian Sun, Yuetao Zhou, Liying Qi. Vaccarin protects human microvascular endothelial cells from apoptosis via attenuation of HDAC1 and oxidative stress. European journal of pharmacology. vol 818. 2018-07-27. PMID:29128366. |
taken together, these data suggested that vac protected against hg-induced endothelial cell apoptosis via inhibition of reactive oxygen species accumulation and hdac1 expression. |
2018-07-27 |
2023-08-13 |
human |
| Vincent Pillonel, Nina Reichert, Chun Cao, Marinus R Heideman, Teppei Yamaguchi, Gabriele Matthias, Alexandar Tzankov, Patrick Matthia. Histone deacetylase 1 plays a predominant pro-oncogenic role in Eμ-myc driven B cell lymphoma. Scientific reports. vol 6. 2018-07-10. PMID:27886239. |
our data show that hdac1 and hdac2 impact on eμ-myc b cell proliferation and apoptosis and suggest that a critical level of hdac activity may be required for eμ-myc tumorigenesis and proper b cell development. |
2018-07-10 |
2023-08-13 |
mouse |
| Hengyu Zhou, Ying Cai, Dina Liu, Menghui Li, Yu Sha, Wenlu Zhang, Kai Wang, Jianping Gong, Ni Tang, Ailong Huang, Jie Xi. Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21 Cell proliferation. vol 51. issue 3. 2018-06-26. PMID:29484736. |
pharmacological or transcriptional inhibition of both hdac1 and 2 leads to cell cycle blockage and apoptosis via p21 histone deacetylases (hdacs) are commonly dysregulated in cancer and represent promising therapeutic targets. |
2018-06-26 |
2023-08-13 |
Not clear |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
knockdown of hdac1 expression suppresses invasion and induces apoptosis in glioma cells. |
2018-04-23 |
2023-08-13 |
mouse |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
downregulation of hdac1 inhibited cell proliferation, prevented invasion of glioma cell lines, and induced cell apoptosis. |
2018-04-23 |
2023-08-13 |
mouse |
| Xiao-Qiang Wang, Hong-Min Bai, Shi-Ting Li, Hui Sun, Ling-Zhao Min, Bang-Bao Tao, Jun Zhong, Bin L. Knockdown of HDAC1 expression suppresses invasion and induces apoptosis in glioma cells. Oncotarget. vol 8. issue 29. 2018-04-23. PMID:28624794. |
the expression of apoptosis and metastasis related molecules were detected by rt-pcr and western blot, respectively, in u251 and t98g cells with hdac1 knockdown. |
2018-04-23 |
2023-08-13 |
mouse |
| Jianyun Zhao, Chengzhi Xie, Holly Edwards, Guan Wang, Jeffrey W Taub, Yubin G. Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells. Oncotarget. vol 8. issue 4. 2018-02-22. PMID:28030834. |
we found that inhibition of both hdac1 and hdac2 was necessary to decrease the expression of brca1, chk1, and rad51, enhance cytarabine- or daunorubicin-induced dna damage and apoptosis, and abrogate cytarabine- or daunorubicin-induced cell cycle checkpoint activation in aml cells. |
2018-02-22 |
2023-08-13 |
Not clear |
| Feng Yin, Kuan Hu, Yangzi Chen, Mengying Yu, Dongyuan Wang, Qianqian Wang, Ken-Tye Yong, Fei Lu, Yongye Liang, Zigang L. SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer. Theranostics. vol 7. issue 5. 2018-01-05. PMID:28435453. |
the systematic mechanistic elucidation of the dual gene silencing effects indicated the inactivation of both the hdac1 and the k-ras gene, thereby causing apoptosis, proliferation inhibition and cell cycle arrest in treated mia paca-2 cells. |
2018-01-05 |
2023-08-13 |
Not clear |
| Tianyi Zhang, Zhentao Sheng, Wei D. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mechanisms of development. vol 141. 2017-12-26. PMID:27378074. |
inactivation of hdac1 and its homolog hdac2 or addition of hdac inhibitors in mammalian systems induces apoptosis, cell cycle arrest, and developmental defects. |
2017-12-26 |
2023-08-13 |
drosophila_melanogaster |
| Tianyi Zhang, Zhentao Sheng, Wei D. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mechanisms of development. vol 141. 2017-12-26. PMID:27378074. |
in this study, we show that inactivation of rpd3, the only hdac1 and hdac2 ortholog in drosophila, induced apoptosis and clone elimination in the developing eye and wing imaginal discs. |
2017-12-26 |
2023-08-13 |
drosophila_melanogaster |
| Yajiao Zhou, Fang Gan, Lili Hou, Xuan Zhou, Yassin Abdulrahim Adam Ibrahim, Kehe Huan. Modulations of DNMT1 and HDAC1 are involved in the OTA-induced cytotoxicity and apoptosis in vitro. Chemico-biological interactions. vol 278. 2017-12-12. PMID:29080797. |
modulations of dnmt1 and hdac1 are involved in the ota-induced cytotoxicity and apoptosis in vitro. |
2017-12-12 |
2023-08-13 |
Not clear |