| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S V Demyanenko, V A Dzreyan, M A Neginskaya, A B Uzdensk. Expression of Histone Deacetylases HDAC1 and HDAC2 and Their Role in Apoptosis in the Penumbra Induced by Photothrombotic Stroke. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31493239. |
expression of histone deacetylases hdac1 and hdac2 and their role in apoptosis in the penumbra induced by photothrombotic stroke. |
2020-10-07 |
2023-08-13 |
rat |
| Ting-Yi Sun, Hong-Jian Xie, Zhen Li, Ling-Fei Kong, Xiang-Nan Gou, Du-Juan Li, Yu-Jie Shi, Yan-Zhi Din. miR-34a regulates HDAC1 expression to affect the proliferation and apoptosis of hepatocellular carcinoma. American journal of translational research. vol 9. issue 1. 2020-10-01. PMID:28123637. |
mir-34a regulates hdac1 expression to affect the proliferation and apoptosis of hepatocellular carcinoma. |
2020-10-01 |
2023-08-13 |
Not clear |
| Zhiqiang Yu, Jun Zeng, Hui Liu, Tian Wang, Ziqi Yu, Jianyong Che. Role of HDAC1 in the progression of gastric cancer and the correlation with lncRNAs. Oncology letters. vol 17. issue 3. 2020-10-01. PMID:30867763. |
silencing of hdac1 decreased the proliferation and increased the apoptosis of sc-m1 cell lines, but had no effect on the migration of the sc-m1 cell lines. |
2020-10-01 |
2023-08-13 |
Not clear |
| Baojie Zhang, Bin Liu, Deng Chen, Rita Setroikromo, Hidde J Haisma, Wim J Qua. Histone Deacetylase Inhibitors Sensitize TRAIL-Induced Apoptosis in Colon Cancer Cells. Cancers. vol 11. issue 5. 2020-10-01. PMID:31083396. |
our data show that trail-mediated apoptosis is largely improved in widr cells by pre-incubation with entinostat-a hdac1, 2, and 3 inhibitor- and in dld-1 cells by rgfp966-a hdac3-specific inhibitor- or pci34051-a hdac8-specific inhibitor. |
2020-10-01 |
2023-08-13 |
Not clear |
| Masumeh Sanaei, Fraidoon Kavoos. Effect of 5-Aza-2'-Deoxycytidine in Comparison to Valproic Acid and Trichostatin A on Histone Deacetylase 1, DNA Methyltransferase 1, and CIP/KIP Family (p21, p27, and p57) Genes Expression, Cell Growth Inhibition, and Apoptosis Induction in Colon Cancer SW480 Cell Line. Advanced biomedical research. vol 8. 2020-10-01. PMID:31516890. |
the aim of the present study was to investigate the effect of 5-aza-2'-deoxycytidine (5-aza-cdr) in comparison to valproic acid (vpa) and trichostatin a (tsa) on hdac1, dnmt1, and cip/kip family (p21, p27, and p57) genes expression, cell growth inhibition, and apoptosis induction in colon cancer sw480 cell line. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yi Zhang, Jie Chen, Shan-Shan Wu, Meng-Jiao Lv, Yong-Sheng Yu, Zheng-Hao Tang, Xiao-Hua Chen, Guo-Qing Zan. HOXA10 knockdown inhibits proliferation, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells through HDAC1. Cancer management and research. vol 11. 2020-09-29. PMID:31440094. |
hoxa10 knockdown inhibits proliferation, induces cell cycle arrest and apoptosis in hepatocellular carcinoma cells through hdac1. |
2020-09-29 |
2023-08-13 |
human |
| Xiao-Li Li, Mei Hon. Aqueous extract of Dendrobium officinale confers neuroprotection against hypoxic-ischemic brain damage in neonatal rats. The Kaohsiung journal of medical sciences. vol 36. issue 1. 2020-06-08. PMID:31642199. |
the neonatal rat models of hibd presented impaired neurobehaviors and antioxidant capacity, increased neuronal apoptosis and expression of hif-1α and histone deacetylase 1 (hdac1), as well as diminished expression of neurotrophic factors and k |
2020-06-08 |
2023-08-13 |
rat |
| Jin-Feng Li, Ying-Shu Li, Yi-Yang Zhang, Shu-Feng Sun, Tie-Sheng Han, Yu-Hong Li, Fu-Min Fen. Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid-induced HL-7702 hepatocyte injury. Journal of cellular physiology. 2019-11-20. PMID:30786008. |
endoplasmic reticulum stress (ers) is one of the main pathways of apoptosis and is activated during inflammatory responses, but the roles of p300 and hdac1 in ers in antituberculosis drug-induced liver injury (adli) are not clear. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jin-Feng Li, Ying-Shu Li, Yi-Yang Zhang, Shu-Feng Sun, Tie-Sheng Han, Yu-Hong Li, Fu-Min Fen. Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid-induced HL-7702 hepatocyte injury. Journal of cellular physiology. 2019-11-20. PMID:30786008. |
this study confirms that isoniazid can change the states of p300 and hdac1 in hl-7702 hepatocyte metabolism and induce ers, causing hepatocyte injury and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zhen Zhou, Qin Fang, Peifan Li, Dan Ma, Nana Zhe, Mei Ren, Bingqing Chen, Zhengchang He, Jun Wang, Qin Zhong, Jishi Wan. Entinostat combined with Fludarabine synergistically enhances the induction of apoptosis in TP53 mutated CLL cells via the HDAC1/HO-1 pathway. Life sciences. vol 232. 2019-09-24. PMID:31226417. |
subsequently, we demonstrated entinostat (hdac1 inhibitor) combination with fludarabine significantly induced apoptosis in tp53 mutations cll cells. |
2019-09-24 |
2023-08-13 |
mouse |
| Zhen Zhou, Qin Fang, Peifan Li, Dan Ma, Nana Zhe, Mei Ren, Bingqing Chen, Zhengchang He, Jun Wang, Qin Zhong, Jishi Wan. Entinostat combined with Fludarabine synergistically enhances the induction of apoptosis in TP53 mutated CLL cells via the HDAC1/HO-1 pathway. Life sciences. vol 232. 2019-09-24. PMID:31226417. |
more importantly, we also confirmed that upregulation of hdac1 could resistant entinostat-induced apoptosis in tp53 mutations cll cells by activating the hdac1/p38/ho-1 pathway. |
2019-09-24 |
2023-08-13 |
mouse |
| Huayi Li, Xingwen Wang, Cheng Zhang, Yiwei Cheng, Miao Yu, Kunming Zhao, Wenjie Ge, Anyong Cai, Yao Zhang, Fengtong Han, Ying H. HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma. Cancer letters. vol 432. 2019-09-03. PMID:29890207. |
of particular importance, hdac1 inhibitor vorinostat restored aspp2 transcription and produced a synergistic effect with 5-fu in elevating aspp2, promoting apoptosis and inhibiting emt in both in vitro and in vivo rcc models. |
2019-09-03 |
2023-08-13 |
Not clear |
| Shu-Huey Chen, Jyh-Ming Chow, Yao-Yu Hsieh, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Beished M Shabangu, Chia-Hwa Le. HDAC1,2 Knock-Out and HDACi Induced Cell Apoptosis in Imatinib-Resistant K562 Cells. International journal of molecular sciences. vol 20. issue 9. 2019-08-30. PMID:31071955. |
using crispr/cas9 genomic editing, we found that hdac1 and hdac2 knockout cells significantly induced cell apoptosis, indicating that the regulation of hdac1 and hdac2 is extremely important in maintaining k562 cell survival. |
2019-08-30 |
2023-08-13 |
Not clear |
| Chao Wen, Yuan-Kang Xie, Yi-Jian Che. [Efflect of miR-34a-Tangeted Regulation of HDACI on Apoptosis of AML Cells]. Zhongguo shi yan xue ye xue za zhi. vol 27. issue 3. 2019-07-11. PMID:31204933. |
to investigate the regulation of mir-34a on hdac1 expression and its effect on the apoptosis of acute myeloid leukemia (aml) cells. |
2019-07-11 |
2023-08-13 |
Not clear |
| Preeti Patel, Vijay K Patel, Avineesh Singh, Talha Jawaid, Mehnaz Kamal, Harish Raja. Identification of Hydroxamic Acid Based Selective HDAC1 Inhibitors: Computer Aided Drug Design Studies. Current computer-aided drug design. vol 15. issue 2. 2019-07-05. PMID:29732991. |
thus, hdac1 inhibitors have emerged as the potential therapeutic leads against multiple human cancers, as they can block the activity of particular hdacs, renovate the expression of several tumour suppressor genes and bring about cell differentiation, cell cycle arrest and apoptosis. |
2019-07-05 |
2023-08-13 |
human |
| Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang, Chia-Hwa Le. HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. International journal of molecular sciences. vol 20. issue 2. 2019-05-01. PMID:30669676. |
hdac1 and hdac2 double knockout triggers cell apoptosis in advanced thyroid cancer. |
2019-05-01 |
2023-08-13 |
Not clear |
| Libin Zhang, Liang Bu, Jiang Hu, Zheyuan Xu, Libo Ruan, Yan Fang, Ping Wan. HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. Biological chemistry. vol 399. issue 6. 2019-03-25. PMID:29537214. |
hdac1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. |
2019-03-25 |
2023-08-13 |
Not clear |
| Libin Zhang, Liang Bu, Jiang Hu, Zheyuan Xu, Libo Ruan, Yan Fang, Ping Wan. HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. Biological chemistry. vol 399. issue 6. 2019-03-25. PMID:29537214. |
the tunel assay was used to evaluate the role of hdac1 in nsclc apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Libin Zhang, Liang Bu, Jiang Hu, Zheyuan Xu, Libo Ruan, Yan Fang, Ping Wan. HDAC1 knockdown inhibits invasion and induces apoptosis in non-small cell lung cancer cells. Biological chemistry. vol 399. issue 6. 2019-03-25. PMID:29537214. |
furthermore, downregulation of hdac1 inhibited cell proliferation, prevented cell migration, decreased cell invasion, reduced tumor angiogenesis and induced cell apoptosis. |
2019-03-25 |
2023-08-13 |
Not clear |
| Yi Li, Zhengyi Zhang, Xiangnan Zhou, Rui Li, Yan Cheng, Bo Shang, Yu Han, Bin Liu, Xiaodong Xi. Histone Deacetylase 1 Inhibition Protects Against Hypoxia-Induced Swelling in H9c2 Cardiomyocytes Through Regulating Cell Stiffness. Circulation journal : official journal of the Japanese Circulation Society. vol 82. issue 1. 2019-03-08. PMID:28747611. |
hdac1 inhibition improved cell viability, decreased lactate dehydrogenase leakage, cell apoptosis, malondialdehyde concentration, cell volume, and particles on the cell surface, and increased superoxide dismutase activity. |
2019-03-08 |
2023-08-13 |
Not clear |