| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rongmao Nong, Chunyan Qin, Qiqing Lin, Yi Lu, Jun L. Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35285407. |
septic mice were injected with hdac1 low expression-, mir-124-5p high expression- or hmgb1 low expression-related structures to observe cardiac function, inflammatory response, oxidative stress response, myocardial pathological changes and apoptosis in myocardial tissues of septic mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Rongmao Nong, Chunyan Qin, Qiqing Lin, Yi Lu, Jun L. Down-regulated HDAC1 and up-regulated microRNA-124-5p recover myocardial damage of septic mice. Bioengineered. vol 13. issue 3. 2022-03-14. PMID:35285407. |
restored mir-124-5p/depleted hdac1 or hmgb1 recovered the cardiac function, improved cardiac function, inflammatory response, oxidative stress response, myocardial pathological changes and inhibit ed cardiomyocyte apoptosis in septic mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Zhitao Ren, Nishikant A Raut, Temitope O Lawal, Shital R Patel, Simon M Lee, Gail B Mahad. Peonidin-3-O-glucoside and cyanidin increase osteoblast differentiation and reduce RANKL-induced bone resorption in transgenic medaka. Phytotherapy research : PTR. vol 35. issue 11. 2021-11-25. PMID:34704297. |
in addition, treatment of serum starvation of hfob osteoblasts with anthocyanins and resveratrol at 1.0 μg/ml reduced apoptosis, the bax/bcl-2 ratio, p53, and hdac1 expression, but increased sirt1/3 and pgc1α mrna expression, suggesting mitochondrial and epigenetic regulation. |
2021-11-25 |
2023-08-13 |
human |
| Jui-Sheng Chen, Hao-Kuang Wang, Chien-Yu Hsu, Yu-Ting Su, Jia-Shing Chen, Cheng-Loong Liang, Patrick Ching-Ho Hsieh, Cheng-Chun Wu, Aij-Lie Kwa. HDAC1 deregulation promotes neuronal loss and deficit of motor function in stroke pathogenesis. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34381129. |
we found that hdac1 inhibition promoted the infarct volume, neuronal loss, dna damage, neuronal apoptosis after stroke, and levels of reactive oxygen species and inflammation cytokines. |
2021-11-12 |
2023-08-13 |
rat |
| Sonali Bahl, Hongbo Ling, Nuwan P N Acharige, Irene Santos-Barriopedro, Mary Kay H Pflum, Edward Set. EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33976119. |
by deacetylating histones and non-histone proteins, hdac1 has a profound effect on the regulation of gene transcription and many processes related to cell growth and cell death, including cell cycle progression, dna repair, and apoptosis. |
2021-10-14 |
2023-08-13 |
human |
| Longzhou Zhang, Zengjin Liu, Yang Dong, Lingchang Kon. Epigenetic targeting of SLC30A3 by HDAC1 is related to the malignant phenotype of glioblastoma. IUBMB life. vol 73. issue 5. 2021-09-21. PMID:33715270. |
moreover, overexpression of hdac1 resulted in a significant increase in dna replication activity, a significant decline in apoptosis and cell cycle arrest in gbm cells. |
2021-09-21 |
2023-08-13 |
Not clear |
| Xuming Zhu, Matthew Leboeuf, Fang Liu, Marina Grachtchouk, John T Seykora, Edward E Morrisey, Andrzej A Dlugosz, Sarah E Milla. HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53. The Journal of investigative dermatology. 2021-09-20. PMID:34284046. |
we find that homozygous epidermal codeletion of hdac1 and hdac2 in adult mouse epidermis causes reduced basal cell proliferation, apoptosis, inappropriate differentiation, and eventual loss of hdac1/2-null keratinocytes. |
2021-09-20 |
2023-08-13 |
mouse |
| Min Woo Shin, Se Lim Kim, Hee Chan Yang, Sung Kyun Yim, Seung Young Seo, Soo Teik Lee, Hee-Kwon Kim, Sang-Wook Ki. The HDAC1 Inhibitor CBUD-1001 Enhances TRAIL-induced Apoptosis in Colorectal Cancer Cells. Anticancer research. vol 41. issue 9. 2021-09-13. PMID:34475055. |
the hdac1 inhibitor cbud-1001 enhances trail-induced apoptosis in colorectal cancer cells. |
2021-09-13 |
2023-08-13 |
Not clear |
| Qiongwei Wu, Wenying Zhang, Yu Liu, Yuhua Huang, Huiheng Wu, Chengbin M. Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer. Oncology letters. vol 22. issue 4. 2021-08-26. PMID:34429761. |
the effects of hdac1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by cck-8, flow cytometry, wound-healing, transwell chamber and |
2021-08-26 |
2023-08-13 |
Not clear |
| Jiangtao Guo, Xuqing Cao, Wei Zhao, Hong Zhu, Xiaoli Ma, Chunfang Hao, Lili Wu, Mingzhu Zhang, Yashan Yang, Jingtian Zhao, Kunting Chen, Zhe Yi. MicroRNA-449 targets histone deacetylase 1 to regulate the proliferation, invasion, and apoptosis of synovial fibroblasts in rheumatoid arthritis. Annals of palliative medicine. vol 10. issue 7. 2021-08-09. PMID:34353082. |
the study aimed to explore the effects of microrna (mir)-449 and histone deacetylase 1 (hdac1) on the proliferation, invasion, and apoptosis of synovial fibroblasts in rheumatoid arthritis. |
2021-08-09 |
2023-08-13 |
Not clear |
| Se Lim Kim, Minh Thanh La, Min Woo Shin, Sang-Wook Kim, Hee-Kwon Ki. A novel HDAC1 inhibitor, CBUD‑1001, exerts anticancer effects by modulating the apoptosis and EMT of colorectal cancer cells. International journal of oncology. vol 57. issue 4. 2021-07-14. PMID:32945468. |
a novel hdac1 inhibitor, cbud‑1001, exerts anticancer effects by modulating the apoptosis and emt of colorectal cancer cells. |
2021-07-14 |
2023-08-13 |
Not clear |
| Meng Gao, Chao Wan. [The role of histone deacetylases 1/2 in regulating murine oogenesis]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 3. 2021-07-08. PMID:34230954. |
hdac1 and 2 jointly regulate the global transcription and the incidence of apoptosis of growing oocytes and affect its subsequent growth and development, which reflects their compensatory function. |
2021-07-08 |
2023-08-13 |
Not clear |
| Yin-Gi Jang, Eul-Bee Ko, Kyung-Chul Cho. Gallic acid, a phenolic acid, hinders the progression of prostate cancer by inhibition of histone deacetylase 1 and 2 expression. The Journal of nutritional biochemistry. vol 84. 2021-05-31. PMID:32615369. |
western blot analysis revealed down-regulated expression of hdac1 and 2, leading to up-regulation of acetyl-p53 expression at the protein level, subsequent to down-regulating the expression of cell-cycle-related genes, i.e., proliferating cell nuclear antigen (pcna), cyclin d1 and e1, up-regulating the expression of cell cycle arrest gene p21 and regulating the expression of apoptosis intrinsic pathway-related genes, such as bax, bcl-2, cleaved caspase-3 and poly (adp-ribose) polymerase 1 in both pca cell lines. |
2021-05-31 |
2023-08-13 |
mouse |
| Shanji Nan, Ying Wang, Chengbi Xu, Haitao Wan. Interfering microRNA-410 attenuates atherosclerosis via the HDAC1/KLF5/IKBα/NF-κB axis. Molecular therapy. Nucleic acids. vol 24. 2021-05-14. PMID:33981482. |
furthermore, silencing mir-410 or overexpressing hdac1 increased cell viability and suppressed apoptosis and an inflammatory reaction in huvecs in atherosclerosis. |
2021-05-14 |
2023-08-13 |
mouse |
| Youhua Wei, Zhijun Wang, Li Wei, Shen Li, Xuemei Qiu, Chengwen Li. MicroRNA-874-3p promotes testosterone-induced granulosa cell apoptosis by suppressing HDAC1-mediated p53 deacetylation. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-20. PMID:33732332. |
mir-874-3p inhibitor failed to attenuate hdac1 overexpression-induced gc apoptosis. |
2021-03-20 |
2023-08-13 |
Not clear |
| Nastaran Injinari, Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Hossein Teimor. Apoptotic effects of valproic acid on miR-34a, miR-520h and HDAC1 gene in breast cancer. Life sciences. vol 269. 2021-02-16. PMID:33453248. |
we evaluated the impact of vpa on the expression of mir-34a, mir-520h, and their target gene histone deacetylase 1 (hdac1), as well as their relationship with apoptosis in breast cancer. |
2021-02-16 |
2023-08-13 |
Not clear |
| Nastaran Injinari, Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Hossein Teimor. Apoptotic effects of valproic acid on miR-34a, miR-520h and HDAC1 gene in breast cancer. Life sciences. vol 269. 2021-02-16. PMID:33453248. |
the anticancer impact of vpa on apoptosis and the expression levels of mir-34a, mir-520h, and hdac1 gene were measured in mcf-7 and mda-mb-231 cell lines. |
2021-02-16 |
2023-08-13 |
Not clear |
| Masumeh Sanaei, Fraidoon Kavoos. Investigation of the Effect of Zebularine in Comparison to and in Combination with Trichostatin A on p21Cip1/Waf1/ Sdi1, p27Kip1, p57Kip2, DNA Methyltransferases and Histone Deacetylases in Colon Cancer LS 180 Cell Line. Asian Pacific journal of cancer prevention : APJCP. vol 21. issue 6. 2021-02-11. PMID:32592383. |
the current study was designed to evaluate the effect of zebularine in comparison to and in combination with trichostatin a (tsa) on p21cip1/waf1/sdi1, p27kip1, p57kip2, dna methyltransferases (dnmt1, 3a and 3b) and histone deacetylases (hdac1, 2, and 3) genes expression, cell growth inhibition and apoptosis induction in colon cancer ls 180 cell line. |
2021-02-11 |
2023-08-13 |
Not clear |
| Hao Wang, Kazuo Sugimoto, Hao Lu, Wan-Yong Yang, Ji-Yue Liu, Hong-Yu Yang, Yue-Bo Song, Dong Yan, Tian-Yu Zou, Si She. HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2. Molecular therapy. Nucleic acids. vol 23. 2021-01-30. PMID:33510945. |
we intended to characterize functional relevance of microrna (mir)-224-3p in endothelial cell (ec) apoptosis and reactive oxygen species (ros) accumulation in atherosclerosis, considering also the integral involvement of histone deacetylase 1 (hdac1)-mediated hypoxia-inducible factor-1α (hif1α) deacetylation. |
2021-01-30 |
2023-08-13 |
Not clear |
| Li-Zhen Zhang, Jin-E Yang, Yu-Wei Luo, Feng-Ting Liu, Yun-Fei Yuan, Shi-Mei Zhuan. A p53/lnc-Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 7. issue 21. 2020-11-13. PMID:33173727. |
furthermore, lnc-ip53 impedes p53 acetylation by interacting with histone deacetylase 1 (hdac1) and e1a binding protein p300 (p300) to prevent hdac1 degradation and attenuate p300 activity, resulting in abrogation of p53 activity and subsequent cell proliferation and apoptosis resistance. |
2020-11-13 |
2023-08-13 |
mouse |