| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Astrid Hagelkruys, Sabine Lagger, Julia Krahmer, Alexandra Leopoldi, Matthias Artaker, Oliver Pusch, Jürgen Zezula, Simon Weissmann, Yunli Xie, Christian Schöfer, Michaela Schlederer, Gerald Brosch, Patrick Matthias, Jim Selfridge, Hans Lassmann, Jürgen A Knoblich, Christian Seise. A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. Development (Cambridge, England). vol 141. issue 3. 2014-03-20. PMID:24449838. |
by contrast, combined deletion of hdac1 and hdac2 resulted in impaired chromatin structure, dna damage, apoptosis and embryonic lethality. |
2014-03-20 |
2023-08-12 |
mouse |
| Jiwoon Lee, Bum-Kyu Lee, Jeffrey M Gros. Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Human molecular genetics. vol 22. issue 17. 2014-02-19. PMID:23669349. |
together, these data support a model in which p53-dependent apoptosis needs to be tightly regulated for normal optic cup formation and that bcl6a, bcor, rnf2 and hdac1 activities mediate this regulation. |
2014-02-19 |
2023-08-12 |
xenopus_laevis |
| Yang Han, Yong Zhang, Lian-he Yang, Xiao-yi Mi, Shun-dong Dai, Qing-chang Li, Hong-tao Xu, Juan-han Yu, Guang Li, Jing Zhao, Chong Han, Xi-ming Yuan, En-hua Wan. X-radiation inhibits histone deacetylase 1 and 2, upregulates Axin expression and induces apoptosis in non-small cell lung cancer. Radiation oncology (London, England). vol 7. 2013-06-10. PMID:23110995. |
the aims of this study were to investigate the relationships between hdac1, hdac2, clinicopathologic characteristics, patient prognosis and apoptosis, to clarify the mechanism of upregulation of the axis inhibitor axin (an important regulator of the wnt pathway) by x-radiation and to elucidate the effect of sirna on radiation therapy of non-small cell lung cancer (nsclc). |
2013-06-10 |
2023-08-12 |
Not clear |
| Sook-Ja Lee, Haerim Jang, Chaehwa Par. Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. International journal of molecular medicine. vol 29. issue 2. 2012-04-13. PMID:22076034. |
maspin inhibited histone deacetylase 1 (hdac1) and thus increased the acetylation of ku70 and the dissociation of bax from ku70, which led to the induction of apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Pengpeng Ma, Hua Pan, Rusty L Montgomery, Eric N Olson, Richard M Schult. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 8. 2012-04-12. PMID:22223663. |
compensatory functions of histone deacetylase 1 (hdac1) and hdac2 regulate transcription and apoptosis during mouse oocyte development. |
2012-04-12 |
2023-08-12 |
mouse |
| José García, Gianluigi Franci, Raquel Pereira, Rosaria Benedetti, Angela Nebbioso, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Lucia Altucci, Angel R de Ler. Epigenetic profiling of the antitumor natural product psammaplin A and its analogues. Bioorganic & medicinal chemistry. vol 19. issue 12. 2011-11-22. PMID:21215647. |
whereas the derivatives of psammaplin a with modifications in the length of the connecting chain, the oxime bond and the disulfide unit showed lower potency, the analogues with changes on the bromotyrosine ring exhibited activities comparable to those of the parent compound in the inhibition of hdac1 and in the induction of apoptosis. |
2011-11-22 |
2023-08-12 |
human |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
expression of a dominant-negative mutant of hdac1 or downregulation of hdac1 by rnai both suppressed tgf-β1-induced apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
in addition, overexpression of hdac1 enhanced tgf-β1-induced apoptosis, and the rescue of hdac1 expression in hdac1 rnai cells restored the apoptotic response of cells to tgf-β1. |
2011-09-15 |
2023-08-12 |
mouse |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
these data indicate that hdac1 functions as a proapoptotic factor in tgf-β1-induced apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| W-W Lei, K-H Zhang, X-C Pan, D-M Wang, Y Hu, Y-N Yang, J-G Son. Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2. Cell death & disease. vol 1. 2011-09-15. PMID:21364650. |
taken together, our data demonstrate that hdac1 and 2 reciprocally affect cell viability by differential regulation of erk1/2; these observations provide insight into the roles and potential mechanisms of hdac1 and 2 in apoptosis. |
2011-09-15 |
2023-08-12 |
mouse |
| Jennifer Jurkin, Gordin Zupkovitz, Sabine Lagger, Reinhard Grausenburger, Astrid Hagelkruys, Lukas Kenner, Christian Seise. Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis. Cell cycle (Georgetown, Tex.). vol 10. issue 3. 2011-07-04. PMID:21270520. |
combined ablation of hdac1 and hdac2 in different cell types led to a severe proliferation defects or enhanced apoptosis supporting the idea that both enzymes are relevant targets for tumor therapy. |
2011-07-04 |
2023-08-12 |
Not clear |
| M A Khan, S Mittal, S Kumar, J Sengupta, D Ghos. Quantitative analysis of six gene products as candidate markers of early placental villi development in the human. Indian journal of physiology and pharmacology. vol 54. issue 4. 2011-06-30. PMID:21675027. |
taking together our previous array based data and the present study we conclude that a categorical balance exists between the expression of erbb2 and hdac1 genes affecting cell proliferation and differentiation in one hand, and cxcr4 and tnfrsf1a affecting chemotaxis, inflammatory response and apoptosis on the other hand. |
2011-06-30 |
2023-08-12 |
human |
| Sabine Lagger, Dominique Meunier, Mario Mikula, Reinhard Brunmeir, Michaela Schlederer, Matthias Artaker, Oliver Pusch, Gerda Egger, Astrid Hagelkruys, Wolfgang Mikulits, Georg Weitzer, Ernst W Muellner, Martin Susani, Lukas Kenner, Christian Seise. Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. The EMBO journal. vol 29. issue 23. 2011-01-12. PMID:20967026. |
surprisingly, loss of hdac1 was not only linked to increased apoptosis, but also to significantly enhanced proliferation. |
2011-01-12 |
2023-08-12 |
mouse |
| Roel H Wilting, Eva Yanover, Marinus R Heideman, Heinz Jacobs, James Horner, Jaco van der Torre, Ronald A DePinho, Jan-Hermen Dannenber. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. The EMBO journal. vol 29. issue 15. 2010-08-26. PMID:20571512. |
dual inactivation of hdac1 and hdac2 results in apoptosis of megakaryocytes and thrombocytopenia. |
2010-08-26 |
2023-08-12 |
Not clear |
| Jiro Kikuchi, Taeko Wada, Rumi Shimizu, Tohru Izumi, Miyuki Akutsu, Kanae Mitsunaga, Kaoru Noborio-Hatano, Masaharu Nobuyoshi, Keiya Ozawa, Yasuhiko Kano, Yusuke Furukaw. Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma. Blood. vol 116. issue 3. 2010-08-20. PMID:20351311. |
short-interfering rna-mediated knockdown of hdac1 enhanced bortezomib-induced apoptosis and histone hyperacetylation, whereas hdac1 overexpression inhibited them. |
2010-08-20 |
2023-08-12 |
Not clear |
| Douglas C Marchion, Elona Bicaku, Joel G Turner, Morgen L Schmitt, Dawn R Morelli, Pamela N Munste. HDAC2 regulates chromatin plasticity and enhances DNA vulnerability. Molecular cancer therapeutics. vol 8. issue 4. 2009-06-08. PMID:19372552. |
furthermore, depletion of hdac2 but not hdac1 or hdac6 was sufficient to sensitize breast cancer cells to topoisomerase inhibitor-induced apoptosis. |
2009-06-08 |
2023-08-12 |
Not clear |
| Chunyan Tian, Guichun Xing, Ping Xie, Kefeng Lu, Jing Nie, Jian Wang, Li Li, Mei Gao, Lingqiang Zhang, Fuchu H. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nature cell biology. vol 11. issue 5. 2009-06-02. PMID:19377469. |
here we report that apak (atm and p53-associated kznf protein), a krüppel-associated box (krab)-type zinc-finger protein, binds directly to p53 in unstressed cells, specifically downregulates pro-apoptotic genes, and suppresses p53-mediated apoptosis by recruiting krab-box-associated protein (kap)-1 and histone deacetylase 1 (hdac1) to attenuate the acetylation of p53. |
2009-06-02 |
2023-08-12 |
Not clear |
| Muthusamy Thangaraju, Kristina N Carswell, Puttur D Prasad, Vadivel Ganapath. Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. The Biochemical journal. vol 417. issue 1. 2009-01-16. PMID:18789002. |
hdac1 and hdac3 are up-regulated in colon cancer cells and in primary colon cancer, and sirna (small interfering rna)-mediated silencing of hdac1 and hdac3 in colon cancer cells induces apoptosis. |
2009-01-16 |
2023-08-12 |
human |
| Seung Jin Noh, Woo Jin Jeong, Jee Hyun Rho, Dong Min Shin, Hee Bae Ahn, Woo Chan Park, Sae Heun Rho, Young Hwa Soung, Tae Hyun Kim, Bong Soo Park, Young Hyun Yo. Sensitization of RPE cells by alphaB-crystallin siRNA to SAHA-induced stage 1 apoptosis through abolishing the association of alphaB-crystallin with HDAC1 in SC35 speckles. Investigative ophthalmology & visual science. vol 49. issue 11. 2008-11-18. PMID:18552382. |
sensitization of rpe cells by alphab-crystallin sirna to saha-induced stage 1 apoptosis through abolishing the association of alphab-crystallin with hdac1 in sc35 speckles. |
2008-11-18 |
2023-08-12 |
Not clear |
| Changqi C Zhu, Douglas J Bornemann, David Zhitomirsky, Ellen L Miller, Michael B O'Connor, Jeffrey A Simo. Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis. PLoS genetics. vol 4. issue 2. 2008-06-13. PMID:18454196. |
in contrast, although hdac1 mutants also display small imaginal discs, this appears to result from reduced proliferation rather than from elevated apoptosis. |
2008-06-13 |
2023-08-12 |
drosophila_melanogaster |