| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Mellier, D Liu, G Bellot, A Lisa Holme, S Pervai. Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27. Cell death & disease. vol 4. 2014-06-12. PMID:24176848. |
the small chaperone protein hsp27 confers resistance to apoptosis, and therefore is an attractive anticancer drug target. |
2014-06-12 |
2023-08-12 |
Not clear |
| Meiying Li, Xuejun Yu, Hui Guo, Limei Sun, Aijun Wang, Qiji Liu, Xiuwen Wang, Jisheng L. Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 3. 2014-06-03. PMID:24218335. |
these data suggested that bufalin may trigger apoptosis by targeting hsp27, which could inhibit apoptosis by interfering with key apoptotic proteins. |
2014-06-03 |
2023-08-12 |
human |
| Fukumi Hiragami, Hirotoshi Motoda, Toshiaki Takezawa, Chiyuki Takabayashi, Shigeki Inoue, Yuji Wakatake, Yoshio Kan. Heat shock-induced three-dimensional-like proliferation of normal human fibroblasts mediated by pressed silk. International journal of molecular sciences. vol 10. issue 11. 2014-05-27. PMID:20087471. |
the results of an experiment using a p38 mapk inhibitor and hsp27 inhibitor suggest that activation of p38 mapk by heat shock is associated with 3d-like cell proliferation and that hsp27 contributes to the inhibition of apoptosis. |
2014-05-27 |
2023-08-12 |
human |
| Lisa M McGinley, Jill McMahon, Alessia Stocca, Aoife Duffy, Aidan Flynn, Daniel O'Toole, Timothy O'Brie. Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. Human gene therapy. vol 24. issue 10. 2014-05-08. PMID:23987185. |
furthermore, decreased apoptosis in the infarcted tissue and improved cardiac function was observed in the hsp27 group, enhancing the therapeutic effect of mscs. |
2014-05-08 |
2023-08-12 |
rat |
| Rooban B Nahomi, Allison Palmer, Katelyn M Green, Patrice E Fort, Ram H Nagara. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochimica et biophysica acta. vol 1842. issue 2. 2014-04-16. PMID:24252613. |
pro-inflammatory cytokines downregulate hsp27 and cause apoptosis of human retinal capillary endothelial cells. |
2014-04-16 |
2023-08-12 |
human |
| Rooban B Nahomi, Allison Palmer, Katelyn M Green, Patrice E Fort, Ram H Nagara. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochimica et biophysica acta. vol 1842. issue 2. 2014-04-16. PMID:24252613. |
downregulation of hsp27 by a sirna treatment promoted apoptosis in hrec. |
2014-04-16 |
2023-08-12 |
human |
| Rooban B Nahomi, Allison Palmer, Katelyn M Green, Patrice E Fort, Ram H Nagara. Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells. Biochimica et biophysica acta. vol 1842. issue 2. 2014-04-16. PMID:24252613. |
together, these data suggest that pro-inflammatory cytokines induce the formation of ros and no, which, through the formation of peroxynitrite, reduce the hsp27 content and bring about apoptosis of retinal capillary endothelial cells. |
2014-04-16 |
2023-08-12 |
human |
| In Seok Song, Soon-Suk Kang, Eun-Soon Kim, Hyun-Min Park, Chul Young Choi, Hungwon Tchah, Jae Yong Ki. Heat shock protein 27 phosphorylation is involved in epithelial cell apoptosis as well as epithelial migration during corneal epithelial wound healing. Experimental eye research. vol 118. 2014-02-18. PMID:24239511. |
the scratch-induced directional wounding assay, western blotting, using antibodies against non-phosphorylated and phosphorylated hsp27, non-phosphorylated and phosphorylated akt, and bcl-2-associated x protein (bax), immunofluorescence staining to determine the filament actin, flow cytometry to measure apoptosis, and proliferation assay were performed to determine the role of hsp27. |
2014-02-18 |
2023-08-12 |
human |
| In Seok Song, Soon-Suk Kang, Eun-Soon Kim, Hyun-Min Park, Chul Young Choi, Hungwon Tchah, Jae Yong Ki. Heat shock protein 27 phosphorylation is involved in epithelial cell apoptosis as well as epithelial migration during corneal epithelial wound healing. Experimental eye research. vol 118. 2014-02-18. PMID:24239511. |
in conclusion, the role of hsp27 in corneal epithelial wound healing can be epithelial cell apoptosis, as well as epithelial migration. |
2014-02-18 |
2023-08-12 |
human |
| Joanna Jakubowicz-Gil, Ewa Langner, Dorota Bądziul, Iwona Wertel, Wojciech Rzesk. Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment. Toxicology and applied pharmacology. vol 273. issue 3. 2014-02-10. PMID:24126416. |
our results indicate that blocking of hsp27 and hsp72 expression makes t98g cells and moggccm cells extremely vulnerable to apoptosis induction upon temozolomide and quercetin treatment and that programmed cell death is initiated by an internal signal. |
2014-02-10 |
2023-08-12 |
Not clear |
| Seung Wook Lee, Jeong Woo Lee, Jae Hoon Chung, Jung Ki J. Expression of heat shock protein 27 in prostate cancer cell lines according to the extent of malignancy and doxazosin treatment. The world journal of men's health. vol 31. issue 3. 2014-01-24. PMID:24459659. |
heat shock protein 27 (hsp27) is known as the material that plays a role in apoptosis control in tumor and cell protection including the immune response, drug tolerance, and so on. |
2014-01-24 |
2023-08-12 |
Not clear |
| Seung Wook Lee, Jeong Woo Lee, Jae Hoon Chung, Jung Ki J. Expression of heat shock protein 27 in prostate cancer cell lines according to the extent of malignancy and doxazosin treatment. The world journal of men's health. vol 31. issue 3. 2014-01-24. PMID:24459659. |
in this study, hsp27 expression according to the prostate cancer malignancy level was evaluated, and hsp27 expression was also analyzed after inducing apoptosis by doxazosin treatment of the prostate cancer cell lines. |
2014-01-24 |
2023-08-12 |
Not clear |
| Zhi Wang, Yanli Zho. Effects of sodium salicylate on the expression of HSP27 protein during oxidative stress in tissue-cultured human lens epithelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 6. 2014-01-23. PMID:17357510. |
the increased expression of hsp27 by sodium salicylate might play an important role in the protection of hydrogen peroxide-induced injury of human lens epithelial cells, suggesting that sodium salicylate could suppress, at least in part, the apoptosis of human lens epithelial cells. |
2014-01-23 |
2023-08-12 |
human |
| Norman Y Liaw, Louise See Hoe, Freya L Sheeran, Jason N Peart, John P Headrick, Michael M H Cheung, Salvatore Pep. Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium. American journal of physiology. Regulatory, integrative and comparative physiology. vol 305. issue 10. 2014-01-23. PMID:24068046. |
hearts from male c57bl/6 mice (neonates, 2, 4, 8, and 12 wk of age, n = 6/group) were assayed for survival signaling/effectors [akt, p38mapk, glycogen synthase kinase-3β (gsk-3β), heat shock protein 27 (hsp27), connexin-43, hypoxia-inducible factor-1α (hif-1α), and caveolin-3] and regulators of apoptosis (bax and bcl-2) and autophagy (lc3b, parkin, and beclin1). |
2014-01-23 |
2023-08-12 |
mouse |
| Nisha Verma, Mario Pink, Albert W Rettenmeier, Simone Schmitz-Spank. Benzo[a]pyrene-mediated toxicity in primary pig bladder epithelial cells: a proteomic approach. Journal of proteomics. vol 85. 2014-01-17. PMID:23624345. |
on the other hand, the expression of voltage-dependent anion channel 2 (vdac2), cathepsin d (ctsd), heat shock protein 27 (hsp27), and heat shock protein 70 (hsp70) hinted to apoptosis occurring through the intrinsic apoptotic mitochondrial pathway. |
2014-01-17 |
2023-08-12 |
Not clear |
| José Díaz-Chávez, Miguel A Fonseca-Sánchez, Elena Arechaga-Ocampo, Ali Flores-Pérez, Yadira Palacios-Rodríguez, Guadalupe Domínguez-Gómez, Laurence A Marchat, Lizeth Fuentes-Mera, Guillermo Mendoza-Hernández, Patricio Gariglio, César López-Camarill. Proteomic profiling reveals that resveratrol inhibits HSP27 expression and sensitizes breast cancer cells to doxorubicin therapy. PloS one. vol 8. issue 5. 2013-11-25. PMID:23724044. |
particularly, hsp27 overexpression has been associated to apoptosis inhibition and resistance of human cancer cells to therapy. |
2013-11-25 |
2023-08-12 |
human |
| Shan Liu, Xiaonan Dai, Lingbo Cai, Xiang Ma, Jinjuan Liu, Shiwen Jiang, Jiayin Liu, Yugui Cu. Effect of Hsp27 on early embryonic development in the mouse. Reproductive biomedicine online. vol 26. issue 5. 2013-11-12. PMID:23419798. |
previous studies by this study group have showed that heat shock protein 27 (hsp27), expressed in the oocyte of growing follicles, is down-regulated in polycystic ovary syndrome ovaries and that down-regulation of hsp27 improves the maturation of mouse oocytes and increases early apoptosis of oocytes. |
2013-11-12 |
2023-08-12 |
mouse |
| Shan Liu, Xiaonan Dai, Lingbo Cai, Xiang Ma, Jinjuan Liu, Shiwen Jiang, Jiayin Liu, Yugui Cu. Effect of Hsp27 on early embryonic development in the mouse. Reproductive biomedicine online. vol 26. issue 5. 2013-11-12. PMID:23419798. |
cell apoptosis in blastocysts, blastocyst formation rate and embryo quality were unaffected by hsp27 overexpression or gene silencing. |
2013-11-12 |
2023-08-12 |
mouse |
| Wenbo Ma, Yan Teng, Hui Hua, Jinlin Hou, Ting Luo, Yangfu Jian. Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23848600. |
little is known about the molecular mechanisms that dictate the sensitivity of cancer cells to act d. in this study, we investigated the effects of act d on heat shock proteins (hsps) and the expression and roles of hsp27 in act d-induced cancer cell apoptosis. |
2013-10-25 |
2023-08-12 |
Not clear |
| Wenbo Ma, Yan Teng, Hui Hua, Jinlin Hou, Ting Luo, Yangfu Jian. Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23848600. |
hsp27 knockdown leads to an increase in act d-induced caspase 3 and caspase 7 cleavage, and sensitizes rhabdosarcoma cells and breast cancer cells to act d-induced apoptosis. |
2013-10-25 |
2023-08-12 |
Not clear |