| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias B Stope, Luise Wiegank, Martin Weiss, Karoline Diesing, Dominique Koensgen, Martin Burchardt, Marek Zygmunt, Alexander Muste. Drug-induced Modulation of Heat Shock Protein HSPB1 in an Ovarian Cancer Cell Model. Anticancer research. vol 36. issue 7. 2017-01-06. PMID:27354589. |
heat-shock protein hspb1 (alternative name hsp27) plays a pivotal role in cell survival pathways, apoptosis, metastasis and has been frequently linked to treatment resistance in ovarian cancer (oc) and other malignancies. |
2017-01-06 |
2023-08-13 |
Not clear |
| Jisun Kim, Haesoon Lim, Sangwoo Kim, Hyejung Cho, Yong Kim, Xiaojie Li, Hongran Choi, Okjoon Ki. Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells. Oncology reports. vol 35. issue 4. 2016-12-19. PMID:26820233. |
therefore, in the present study, we investigated the effects of hsp27 and hsp70 on pdt-induced cell death of oral cancer cells through autophagy and apoptosis. |
2016-12-19 |
2023-08-13 |
Not clear |
| Jisun Kim, Haesoon Lim, Sangwoo Kim, Hyejung Cho, Yong Kim, Xiaojie Li, Hongran Choi, Okjoon Ki. Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells. Oncology reports. vol 35. issue 4. 2016-12-19. PMID:26820233. |
downregulation of hsp27 and hsp70 induced cell death and pdt resistance through autophagy and apoptosis. |
2016-12-19 |
2023-08-13 |
Not clear |
| Chi Zhang, Shunlin Qu, Xing Wei, Yansheng Feng, Honglin Zhu, Jia Deng, Kangkai Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xia. HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell stress & chaperones. vol 21. issue 2. 2016-12-13. PMID:26515559. |
although hsp25 might have biological functions similar to its human homolog hsp27, the mechanism of hsp25 is still unclear in doxorubicin-induced cardiomyocyte apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Encieh Choghaei, Gholamreza Khamisipour, Mojtaba Falahati, Behrooz Naeimi, Majid Mossahebi-Mohammadi, Rahim Tahmasebi, Mojtaba Hasanpour, Shakib Shamsian, Zahra Sadat Hashem. Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells. Oncology research. vol 23. issue 1-2. 2016-10-24. PMID:26802653. |
our results revealed that inhibitors of microrna-29a promote apoptosis through upregulation of hsp60 level and downregulation of hsp27, hsp40, hsp70, and hsp90 levels and could be contemplated as a compelling alternative for taxol employment with similar effects and/or to sensitize cancer cells to chemotherapy with fewer side effects. |
2016-10-24 |
2023-08-13 |
Not clear |
| Xi Chen, Xiu-Shuai Dong, Hai-Yan Gao, Yong-Fang Jiang, Ying-Lan Jin, Yu-Ying Chang, Li-Yan Chen, Jing-Hua Wan. Suppression of HSP27 increases the anti‑tumor effects of quercetin in human leukemia U937 cells. Molecular medicine reports. vol 13. issue 1. 2016-09-26. PMID:26648539. |
heat shock protein 27 (hsp27) has been reported to promote the development of leukemia by protecting tumor cells from apoptosis through various mechanisms. |
2016-09-26 |
2023-08-13 |
human |
| Yanan Liu, Gengbiao Zhou, Zhenglian Wang, Xiaohua Guo, Qiulin Xu, Qiaobing Huang, Lei S. NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Scientific reports. vol 5. 2016-07-25. PMID:26337463. |
when nf-κb signaling was inhibited by bay11-7082, or a small interference rna (sirna) targeting p65, a significant increase in cell apoptosis and caspase-3 activity was observed, as well as reduced expression and translocation of hsp27 into the nucleus, an accumulation of reactive oxygen species, and prolonged phosphorylation of mitogen-activated protein kinases (mapks). |
2016-07-25 |
2023-08-13 |
human |
| Yanan Liu, Gengbiao Zhou, Zhenglian Wang, Xiaohua Guo, Qiulin Xu, Qiaobing Huang, Lei S. NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Scientific reports. vol 5. 2016-07-25. PMID:26337463. |
when hsp27 was overexpressed, pretreatment of huvecs with the antioxidant, apocynin, or n-acetyl cysteine, suppressed apoptosis. |
2016-07-25 |
2023-08-13 |
human |
| Yanan Liu, Gengbiao Zhou, Zhenglian Wang, Xiaohua Guo, Qiulin Xu, Qiaobing Huang, Lei S. NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Scientific reports. vol 5. 2016-07-25. PMID:26337463. |
similarly, inhibition of jnk and p38 with sp600125 and sb203580, respectively, also suppressed apoptosis, whereas sirna-mediated hsp27 knockdown and treatment with the erk 1/2 inhibitor pd98059 did otherwise. |
2016-07-25 |
2023-08-13 |
human |
| Yanan Liu, Gengbiao Zhou, Zhenglian Wang, Xiaohua Guo, Qiulin Xu, Qiaobing Huang, Lei S. NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Scientific reports. vol 5. 2016-07-25. PMID:26337463. |
in conclusion, these findings suggest a novel role for an nf-κb signaling pathway involving hsp27, ros, and mapks that confers a protective effect against heat stress-induced cell apoptosis. |
2016-07-25 |
2023-08-13 |
human |
| Megan A Peppenelli, Kyle C Arend, Olesea Cojohari, Nathaniel J Moorman, Gary C Cha. Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes. Journal of virology. vol 90. issue 6. 2016-07-22. PMID:26739047. |
mechanistically, hcmv upregulated two specific cellular antiapoptotic proteins, myeloid leukemia sequence 1 (mcl-1) and heat shock protein 27 (hsp27), to block the two proteolytic cleavages necessary for the formation of fully active caspase 3 and the subsequent initiation of apoptosis. |
2016-07-22 |
2023-08-13 |
human |
| George Mihai Nitulescu, Constantin Draghici, Octavian Tudorel Olaru, Lilia Matei, Aldea Ioana, Laura Denisa Dragu, Coralia Bleot. Synthesis and apoptotic activity of new pyrazole derivatives in cancer cell lines. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-06-29. PMID:26193760. |
they also reduced the levels of apoptosis inhibitory proteins and the expression of the heat-shock proteins hsp27 and hsp70. |
2016-06-29 |
2023-08-13 |
human |
| Yun Bai, Li-Ping Ye, Yuan-Sheng Ga. [Recent progress in the development of atherosclerosis: role of heat shock protein]. Sheng li ke xue jin zhan [Progress in physiology]. vol 45. issue 1. 2016-05-25. PMID:24873136. |
while hsp27 may protect the blood vessels from oxidative stress, reduce inflammatory response, inhibit proliferation, migration and apoptosis of vascular smooth muscle cells, and stabilize the atherosclerotic plaque. |
2016-05-25 |
2023-08-13 |
Not clear |
| Feng Huang, Ming Huang, Hong Zhang, Chunjiang Zhang, Dequan Zhang, Guanghong Zho. Changes in apoptotic factors and caspase activation pathways during the postmortem aging of beef muscle. Food chemistry. vol 190. 2016-02-26. PMID:26212948. |
these results demonstrated that the mitochondrial pathway was one of the apoptosis pathways in pm beef muscle and that bax and hsp27 were two key regulation factors in apoptosis in pm beef muscle. |
2016-02-26 |
2023-08-13 |
Not clear |
| Barbara Lelj-Garolla, Masafumi Kumano, Eliana Beraldi, Lucia Nappi, Palma Rocchi, Diana N Ionescu, Ladan Fazli, Amina Zoubeidi, Martin E Gleav. Hsp27 Inhibition with OGX-427 Sensitizes Non-Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy. Molecular cancer therapeutics. vol 14. issue 5. 2016-02-01. PMID:25740245. |
hsp27 is induced by erlotinib and protects nsclc cells from treatment-induced apoptosis, whereas ogx-427 sensitizes nsclc cells to erlotinib. |
2016-02-01 |
2023-08-13 |
mouse |
| Janice G L Tan, Yih Yean Lee, Tianhua Wang, Miranda G S Yap, Tin Wee Tan, Say Kong N. Heat shock protein 27 overexpression in CHO cells modulates apoptosis pathways and delays activation of caspases to improve recombinant monoclonal antibody titre in fed-batch bioreactors. Biotechnology journal. vol 10. issue 5. 2016-01-27. PMID:25740626. |
these results suggest that hsp27 modulates apoptosis signaling pathways and delays caspase activities to improve performance of cho fed-batch bioreactor cultures. |
2016-01-27 |
2023-08-13 |
human |
| Ning Wei, Edward Chu, Shao-yu Wu, Peter Wipf, John C Schmit. The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells. Oncotarget. vol 6. issue 7. 2016-01-12. PMID:25544765. |
this drug combination resulted in induction of apoptosis as determined by flow cytometry, increased parp cleavage, and decreased activation of the anti-apoptotic protein hsp27. |
2016-01-12 |
2023-08-13 |
human |
| Vishnu Vignesh Kanagaraj, Lakshmikanthan Panneerselvam, Vimal Govindarajan, Jaishabanu Ameeramja, Ekambaram Peruma. Caffeic acid, a phyto polyphenol mitigates fluoride induced hepatotoxicity in rats: A possible mechanism. BioFactors (Oxford, England). vol 41. issue 2. 2016-01-12. PMID:25845575. |
further, fluoride induced upregulation of nox4, p38α mapk, hsp60, and downregulation of hsp27 are the indicators for the detection of oxidative damage, apoptosis, and mitochondrial stress was also modulated by ca. |
2016-01-12 |
2023-08-13 |
rat |
| Justin Evans, YooSeung Ko, Wilmer Mata, Muhammad Saquib, Joel Eldridge, Aaron Cohen-Gadol, H Anne Leaver, Shukun Wang, Maria Teresa Rizz. Arachidonic acid induces brain endothelial cell apoptosis via p38-MAPK and intracellular calcium signaling. Microvascular research. vol 98. 2016-01-04. PMID:24802256. |
pharmacological and rna interference-mediated p38α or p38β suppression abrogated aa signaling to caspase-3 and hsp27, suggesting involvement of both p38 isoforms in aa-induced hbec apoptosis. |
2016-01-04 |
2023-08-13 |
human |
| Richa Rai, Sudhir Kumar Chauhan, Vikas Vikram Singh, Madhukar Rai, Geeta Ra. Heat shock protein 27 and its regulatory molecules express differentially in SLE patients with distinct autoantibody profiles. Immunology letters. vol 164. issue 1. 2015-11-20. PMID:25655337. |
a negative correlation was observed between the expression of hsp27 and apoptosis markers caspase 3 and parp. |
2015-11-20 |
2023-08-13 |
Not clear |