| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sneha Jakhotia, Mudili Sivaprasad, Tattari Shalini, Paduru Yadagiri Reddy, Kalluru Viswanath, Khubchand Jakhotia, Rakesh Sahay, Manisha Sahay, Geereddy Bhanuprakash Redd. Circulating levels of Hsp27 in microvascular complications of diabetes: Prospects as a biomarker of diabetic nephropathy. Journal of diabetes and its complications. vol 32. issue 2. 2019-06-20. PMID:29175119. |
heat shock protein 27 (hsp27) is a small heat shock protein known to protect the cells from apoptosis under stress. |
2019-06-20 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
rosmarinic acid and sirna combined therapy represses hsp27 (hspb1) expression and induces apoptosis in human glioma cells. |
2019-05-21 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
high expression of hsp27 in glioma cells has been closely associated with tumor cell proliferation and apoptosis inhibition. |
2019-05-21 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
the aim of the present study was to asses the effects of rosmarinic acid (ra) on hsp27 expression and apoptosis in non-transfected and transfected human u-87 mg cells. |
2019-05-21 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
western blotting technique was used to assess the hsp27 expression, and caspase-3 colorimetric activity assay was performed to determine apoptosis induction. |
2019-05-21 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
according to the results, it was found that ra and quercetin effectively silenced hsp27 and both agents induced apoptosis by activating the caspase-3 pathway. |
2019-05-21 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
eighty and 215 μm ra decreased the level of hsp27 by 28.8 and 46.7% and induced apoptosis by 30 and 54%, respectively. |
2019-05-21 |
2023-08-13 |
human |
| Aslıhan Şengelen, Evren Önay-Uça. Rosmarinic acid and siRNA combined therapy represses Hsp27 (HSPB1) expression and induces apoptosis in human glioma cells. Cell stress & chaperones. vol 23. issue 5. 2019-05-21. PMID:29627902. |
it was also observed that apoptosis was induced at a higher level as a result of hsp27 sirna and subsequent quercetin or ra treatment. |
2019-05-21 |
2023-08-13 |
human |
| Yong Yang, Yan Bao, Guo-Kai Yang, Jia Wan, Ling-Juan Du, Zhen-Huan M. MiR-214 sensitizes human colon cancer cells to 5-FU by targeting Hsp27. Cellular & molecular biology letters. vol 24. 2019-05-17. PMID:30915129. |
hsp27 also sensitized ht-29 and lovo to 5-fu by enhancing cell apoptosis. |
2019-05-17 |
2023-08-13 |
human |
| Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Andrea Perrelli, Martina Daga, Stefania Pizzimenti, Giuseppina Barrera, Paola Cassoni, Adriano Angelucci, Lorenza Trabalzini, Vincenzo Nicola Talesa, Luca Goitre, Saverio Francesco Rett. KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease. Free radical biology & medicine. vol 115. 2019-05-03. PMID:29170092. |
experimental outcomes showed that krit1 loss-of-function induces a redox-sensitive sustained upregulation of nrf2 and glo1, and a drop in intracellular levels of mg-modified hsp70 and hsp27 proteins, leading to a chronic adaptive redox homeostasis that counteracts intrinsic oxidative stress but increases susceptibility to oxidative dna damage and apoptosis, sensitizing cells to further oxidative challenges. |
2019-05-03 |
2023-08-13 |
Not clear |
| S-Q Li, P Wang, D-M Wang, H-J Lu, R-F Li, L-X Duan, S Zhu, S-L Wang, Y-Y Zhang, Y-L Wan. Molecular mechanism for the influence of gender dimorphism on alcoholic liver injury in mice. Human & experimental toxicology. vol 38. issue 1. 2019-03-28. PMID:29792338. |
our study suggested that ethanol treatment induced more expression of hsp27 and hsp70, faster hepatocyte proliferation, higher level of glycogen, and interleukin-6 signaling pathway activation, but less hepatocyte apoptosis and cyp2e1 expression in male mice than female mice, which could be helpful to understand the molecular mechanism for the influence of sex difference on alcoholic liver injury. |
2019-03-28 |
2023-08-13 |
mouse |
| Haifeng Chen, Nan Lu, Changsheng Xu, Meifan Zhen. The role of heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by Visfatin. Microvascular research. vol 121. 2019-03-14. PMID:30145138. |
to study the mechanism of heat shock protein 27 (hsp27) phosphorylation in the visfatin-induced proliferation and its protective effect against high-glucose induced apoptosis in huvecs. |
2019-03-14 |
2023-08-13 |
human |
| Matías Exequiel Rodríguez, Daniela Elisa Arévalo, Laura Milla Sanabria, Fernando Darío Cuello Carrión, Mariel Andrea Fanelli, Viviana Alicia Rivarol. Heat shock protein 27 modulates autophagy and promotes cell survival after photodynamic therapy. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. vol 18. issue 2. 2019-03-14. PMID:30681107. |
we demonstrated that pdt promoted hsp27 expression, which in turn triggered autophagic cell survival as well as inhibited apoptosis in colon cancer cells. |
2019-03-14 |
2023-08-13 |
Not clear |
| Jungnam Lee, JoAnn S Roberts, Kalina R Atanasova, Nityananda Chowdhury, Özlem Yilma. A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27. Cellular microbiology. vol 20. issue 5. 2019-01-24. PMID:29359393. |
therefore, we hypothesised p. gingivalis-ndk can phosphorylate hsp27 for inhibition of apoptosis in gecs. |
2019-01-24 |
2023-08-13 |
human |
| Jungnam Lee, JoAnn S Roberts, Kalina R Atanasova, Nityananda Chowdhury, Özlem Yilma. A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27. Cellular microbiology. vol 20. issue 5. 2019-01-24. PMID:29359393. |
thus, we show for the first time the phosphorylation of hsp27 by a bacterial effector-p. gingivalis-ndk-and a novel function of ndks that is directly involved in inhibition of host cell apoptosis and the subsequent bacterial survival. |
2019-01-24 |
2023-08-13 |
human |
| Fen Zhou, Xin Huang, Yun Pan, Di Cao, Chuan Liu, Yiyi Liu, Aijun Che. Resveratrol protects HaCaT cells from ultraviolet B-induced photoaging via upregulation of HSP27 and modulation of mitochondrial caspase-dependent apoptotic pathway. Biochemical and biophysical research communications. vol 499. issue 3. 2018-10-09. PMID:29604279. |
resveratrol inhibited uvb-induced apoptosis by upregulating the expression of hsp27, reducing the production of proapoptotic proteins such as p65, bax, and cleaved caspase-3, and promoting the expression of anti-apoptotic protein bcl-2. |
2018-10-09 |
2023-08-13 |
Not clear |
| Hung-Hua Liang, Chien-Yu Huang, Ching-Wen Chou, Precious Takondwa Makondi, Ming-Te Huang, Po-Li Wei, Yu-Jia Chan. Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation. Life sciences. vol 209. 2018-10-03. PMID:30056019. |
therefore, as silencing of hsp27 increases curcumin resistance by reducing apoptosis and reactive oxidative stress production, hsp27 is a potential selective target for curcumin treatment in crc. |
2018-10-03 |
2023-08-13 |
Not clear |
| Zhicheng Huang, Changliang Yang, Shuangyan Sun, Yingji Nan, Zhiguo Lang, Xiu Wang, Jihong Zhao, Ying Li. Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 Cell. Pharmacology. vol 100. issue 5-6. 2018-07-13. PMID:28848138. |
additionally, the knockdown of hsp27 blocked tgf-β-induced cisplatin resistance via decreasing cell viability and increasing cell apoptosis in a549 cell. |
2018-07-13 |
2023-08-13 |
human |
| Yao Le, Peng Jia, Yilin Jin, Wei Liu, Kuntong Jia, Meisheng Y. The antiviral role of heat shock protein 27 against red spotted grouper nervous necrosis virus infection in sea perch. Fish & shellfish immunology. vol 70. 2018-06-25. PMID:28860076. |
heat shock protein 27 (hsp27), functioning as a stress induced protective protein, has been reported to participate in various biological processes, including apoptosis, thermal protection, and virus infection. |
2018-06-25 |
2023-08-13 |
zebrafish |
| Yu-Che Cheng, Chi-Jung Huang, Yih-Jing Lee, Lu-Tai Tien, Wei-Chi Ku, Raymond Chien, Fa-Kung Lee, Chih-Cheng Chie. Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells. Scientific reports. vol 6. 2018-05-22. PMID:27444754. |
additionally, cellular phenomena including the absence of apoptosis and rare proliferation in hsp27-silenced pdmcs, combined with molecular events such as cleaved caspase-3 and the loss of stemness with cleaved nanog, indicated that hsp27 is located upstream of neuronal differentiation and constrains that process. |
2018-05-22 |
2023-08-13 |
mouse |