| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jörg C Heinrich, Sainitin Donakonda, V Joachim Haupt, Petra Lennig, Yixin Zhang, Michael Schroede. New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells. Oncotarget. vol 7. issue 42. 2018-02-23. PMID:27626687. |
hsp27 is overexpressed in many cancer types and influences cellular processes such as apoptosis, dna repair, recombination, and formation of metastases. |
2018-02-23 |
2023-08-13 |
human |
| Roberta Ceci, Maria Reyes Beltran Valls, Guglielmo Duranti, Ivan Dimauro, Federico Quaranta, Monica Pittaluga, Stefania Sabatini, Paolo Caserotti, Paolo Parisi, Attilio Parisi, Daniela Capoross. Oxidative stress responses to a graded maximal exercise test in older adults following explosive-type resistance training. Redox biology. vol 2. 2018-01-11. PMID:25460722. |
blood glutathione (gsh, gssg, gsh/gssg), plasma malonaldehyde (mda), protein carbonyls and creatine kinase (ck) levels, as well as pbmcs cellular damage (comet assay, apoptosis) and stress-protein response (hsp70 and hsp27 expression) were evaluated. |
2018-01-11 |
2023-08-13 |
human |
| Chia-Lin Liu, Su-Feng Chen, Min-Zu Wu, Shu-Wen Jao, Yaoh-Shiang Lin, Chin-Yuh Yang, Tsai-Yu Lee, Lian-Wu Wen, Guo-Lun Lan, Shin Nie. The molecular and clinical verification of therapeutic resistance via the p38 MAPK-Hsp27 axis in lung cancer. Oncotarget. vol 7. issue 12. 2017-12-15. PMID:26872057. |
knockdown of hsp27 or p38 decreased cisplatin resistance and increased apoptosis in drsps. |
2017-12-15 |
2023-08-13 |
Not clear |
| Xiao-Mei Mo, Li Li, Ping Zhu, Yu-Jie Dai, Ting-Ting Zhao, Ling-Yao Liao, George G Chen, Zhi-Min Li. Up-regulation of Hsp27 by ERα/Sp1 facilitates proliferation and confers resistance to apoptosis in human papillary thyroid cancer cells. Molecular and cellular endocrinology. vol 431. 2017-10-31. PMID:27179757. |
up-regulation of hsp27 by erα/sp1 facilitates proliferation and confers resistance to apoptosis in human papillary thyroid cancer cells. |
2017-10-31 |
2023-08-13 |
human |
| Xiao-Mei Mo, Li Li, Ping Zhu, Yu-Jie Dai, Ting-Ting Zhao, Ling-Yao Liao, George G Chen, Zhi-Min Li. Up-regulation of Hsp27 by ERα/Sp1 facilitates proliferation and confers resistance to apoptosis in human papillary thyroid cancer cells. Molecular and cellular endocrinology. vol 431. 2017-10-31. PMID:27179757. |
moreover, we showed that the up-regulation of hsp27 by erα/sp1 facilitates proliferation and confers resistance to apoptosis through interaction with procaspase-3. |
2017-10-31 |
2023-08-13 |
human |
| Ben Davidson, Kristin Valborg Reinertsen, Don Trinh, Wenche Reed, Per Johannes Bøhle. BAG-1/SODD, HSP70, and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma. Human pathology. vol 54. 2017-08-14. PMID:27038683. |
breast carcinomas (n=410) were analyzed for protein expression of phosphorylated mitogen-activated protein kinases (p-erk, p-jnk, p-p38) and phosphoinositide 3-kinase signaling pathway proteins (p-akt, p-mtor, p-p70s6k); the bag family proteins bag-1 and bag-4/sodd; the antiapoptotic protein bcl-2; the inhibitor of apoptosis family member survivin; and the heat shock protein family members hsp27, hsp70, and hsp90. |
2017-08-14 |
2023-08-13 |
Not clear |
| Chih-Cheng Chien, Chi-Jung Huang, Lu-Tai Tien, Yu-Che Cheng, Chia-Ying Ke, Yih-Jing Le. Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model. Investigative ophthalmology & visual science. vol 58. issue 7. 2017-07-19. PMID:28632846. |
suppression of hsp27 restores retinal function and protects photoreceptors from apoptosis in a light-induced retinal degeneration animal model. |
2017-07-19 |
2023-08-13 |
Not clear |
| Aeri Yoo, Hyun-Min Park, Soon-Suk Kang, Eun-Soon Kim, Hungwon Tchah, Jae Yong Ki. RNA Interference-based Investigation of the Function of Heat Shock Protein 27 during Corneal Epithelial Wound Healing. Journal of visualized experiments : JoVE. issue 115. 2017-07-07. PMID:27768052. |
we conclude that hsp27 has roles in corneal epithelial wound healing that may involve epithelial cell apoptosis and migration. |
2017-07-07 |
2023-08-13 |
human |
| Mariangela Garofalo, Barbara Iovine, Lukasz Kuryk, Cristian Capasso, Mari Hirvinen, Andrea Vitale, Marjo Yliperttula, Maria Assunta Bevilacqua, Vincenzo Cerull. Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity. Molecular cancer therapeutics. vol 15. issue 4. 2017-06-15. PMID:26861248. |
we found that complex induces apoptosis in both cell lines, by using two different mechanisms, enhancing viral replication and affecting the expression of hsp27. |
2017-06-15 |
2023-08-13 |
Not clear |
| Xuyu He, Junqing Yang, Liwen Li, Hong Tan, Ying Wu, Peng Ran, Shuo Sun, Jiyan Chen, Yingling Zho. Atorvastatin protects against contrast-induced nephropathy via anti-apoptosis by the upregulation of Hsp27 in vivo and in vitro. Molecular medicine reports. vol 15. issue 4. 2017-05-12. PMID:28260077. |
the results of the present study suggested that atorvastatin protected against contrast‑induced renal tubular cell apoptosis through the upregulation of hsp27 in vivo and in vitro. |
2017-05-12 |
2023-08-13 |
human |
| Megumi Kitami, Masaru Kaku, Juan Marcelo Rosales Rocabado, Takako Ida, Nami Akiba, Katsumi Uoshim. Prolonged Survival of Transplanted Osteoblastic Cells Does Not Directly Accelerate the Healing of Calvarial Bone Defects. Journal of cellular physiology. vol 231. issue 9. 2017-05-03. PMID:26754153. |
transient overexpression of hsp27 rescued mc3t3-e1 osteoblastic cells from h2 o2 -induced apoptosis without affecting osteoblastic differentiation in culture. |
2017-05-03 |
2023-08-13 |
Not clear |
| Zhifeng Liu, Tianyu Zhong, Dong Zheng, Inga Cepinskas, Tianqing Peng, Lei S. Heat stress pretreatment decreases lipopolysaccharide-induced apoptosis via the p38 signaling pathway in human umbilical vein endothelial cells. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27222013. |
heat stress pretreatment inhibited lps‑induced cellular apoptosis, increased the phosphorylation of p38, and increased the expression levels of hsp27, hsp90 and bcl‑2. |
2017-04-06 |
2023-08-13 |
human |
| Zhifeng Liu, Tianyu Zhong, Dong Zheng, Inga Cepinskas, Tianqing Peng, Lei S. Heat stress pretreatment decreases lipopolysaccharide-induced apoptosis via the p38 signaling pathway in human umbilical vein endothelial cells. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27222013. |
these findings demonstrated that heat stress pretreatment decreased lps‑induced bcl‑2‑associated apoptosis in huvecs by attenuating p38 activation, thereby increasing the expression levels of hsp27 and hsp90. |
2017-04-06 |
2023-08-13 |
human |
| O L Nosareva, N V Ryazantseva, E A Stepovaya, E V Shakhristova, E A Stepanova, V S Gulay. [The role of heat shock proteins 27 and 70 in redox-dependent regulation of apoptosis in Jurkat tumor cells]. Biomeditsinskaia khimiia. vol 62. issue 6. 2017-03-21. PMID:28026811. |
the objective of the study was to investigate the role of hsp27 in maintaining the balance of the glutathione system and hsp70 concentrations as well as in implementing jurkat tumor cell apoptosis. |
2017-03-21 |
2023-08-13 |
Not clear |
| O L Nosareva, N V Ryazantseva, E A Stepovaya, E V Shakhristova, E A Stepanova, V S Gulay. [The role of heat shock proteins 27 and 70 in redox-dependent regulation of apoptosis in Jurkat tumor cells]. Biomeditsinskaia khimiia. vol 62. issue 6. 2017-03-21. PMID:28026811. |
addition of the hsp27 inhibitor kribb3 (5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)-isoxazol) to jurkat cells resulted in glutathione redox imbalance (increased gssg and increased glutathione reductase activity), a decrease in hsp70 concentrations, and also increased cell apoptosis as compared with to the intact cell culture. |
2017-03-21 |
2023-08-13 |
Not clear |
| T Ahmed, B D Banerje. HSP27 modulates survival signaling in endosulfan-exposed human peripheral blood mononuclear cells treated with curcumin. Human & experimental toxicology. vol 35. issue 7. 2017-02-17. PMID:26242398. |
to assess the role of hsp27 on endosulfan-induced apoptosis, the expression of hsp27 was examined. |
2017-02-17 |
2023-08-13 |
human |
| Xin Tian, Lei Zhao, Xianjing Song, Youyou Yan, Ning Liu, Tianyi Li, Bingdi Yan, Bin Li. HSP27 Inhibits Homocysteine-Induced Endothelial Apoptosis by Modulation of ROS Production and Mitochondrial Caspase-Dependent Apoptotic Pathway. BioMed research international. vol 2016. 2017-02-13. PMID:27190988. |
hsp27 inhibits homocysteine-induced endothelial apoptosis by modulation of ros production and mitochondrial caspase-dependent apoptotic pathway. |
2017-02-13 |
2023-08-13 |
human |
| Xin Tian, Lei Zhao, Xianjing Song, Youyou Yan, Ning Liu, Tianyi Li, Bingdi Yan, Bin Li. HSP27 Inhibits Homocysteine-Induced Endothelial Apoptosis by Modulation of ROS Production and Mitochondrial Caspase-Dependent Apoptotic Pathway. BioMed research international. vol 2016. 2017-02-13. PMID:27190988. |
this study aims to investigate the protective effect of hsp27 against hcy-induced endothelial cell apoptosis in human umbilical vein endothelial cells (huvecs) and to determine the underlying mechanisms. |
2017-02-13 |
2023-08-13 |
human |
| Xin Tian, Lei Zhao, Xianjing Song, Youyou Yan, Ning Liu, Tianyi Li, Bingdi Yan, Bin Li. HSP27 Inhibits Homocysteine-Induced Endothelial Apoptosis by Modulation of ROS Production and Mitochondrial Caspase-Dependent Apoptotic Pathway. BioMed research international. vol 2016. 2017-02-13. PMID:27190988. |
in addition, hsp27 could protect the cell against hcy-induced apoptosis and inhibit the effect of hcy on huvecs. |
2017-02-13 |
2023-08-13 |
human |
| Xin Tian, Lei Zhao, Xianjing Song, Youyou Yan, Ning Liu, Tianyi Li, Bingdi Yan, Bin Li. HSP27 Inhibits Homocysteine-Induced Endothelial Apoptosis by Modulation of ROS Production and Mitochondrial Caspase-Dependent Apoptotic Pathway. BioMed research international. vol 2016. 2017-02-13. PMID:27190988. |
therefore, we concluded that hsp27 played a protective role against hcy-induced endothelial apoptosis through modulation of ros production and the mitochondrial caspase-dependent apoptotic pathway. |
2017-02-13 |
2023-08-13 |
human |