| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhilin Qi, Lei Shen, Huiting Zhou, Yi Jiang, Lei Lan, Lan Luo, Zhimin Yi. Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24686082. |
however, available reports on the role of hsp27 phosphorylation in apoptosis remain elusive. |
2015-01-10 |
2023-08-12 |
human |
| Zhilin Qi, Lei Shen, Huiting Zhou, Yi Jiang, Lei Lan, Lan Luo, Zhimin Yi. Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24686082. |
in this study, we investigated the role of hsp27 phosphorylation in tnf-α induced apoptosis in human cervical carcinoma (hela) cells. |
2015-01-10 |
2023-08-12 |
human |
| Zhilin Qi, Lei Shen, Huiting Zhou, Yi Jiang, Lei Lan, Lan Luo, Zhimin Yi. Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24686082. |
we found that tnf-α induced apoptosis was enhanced if we suppressed the tnf-α induced hsp27 phosphorylation by specific inhibitor cmpd1 or mapkapk2 (mk2) knockdown or by overexpression of non-phosphorylatable mutant hsp27-3a. |
2015-01-10 |
2023-08-12 |
human |
| Zhilin Qi, Lei Shen, Huiting Zhou, Yi Jiang, Lei Lan, Lan Luo, Zhimin Yi. Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24686082. |
taken together, our data indicated that hsp27 phosphorylation was involved in modulating the tnf-α induced apoptosis via interacting with tak1 and regulating tak1 post-translational modifications in hela cells. |
2015-01-10 |
2023-08-12 |
human |
| Zhilin Qi, Lei Shen, Huiting Zhou, Yi Jiang, Lei Lan, Lan Luo, Zhimin Yi. Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24686082. |
this study demonstrates that hsp27 phosphorylation serves as a novel regulator in tnf-α-induced apoptosis, and provides a new insight into the cytoprotective role of hsp27 phosphorylation. |
2015-01-10 |
2023-08-12 |
human |
| B Bahr, H L Galan, J A Arroy. Decreased expression of phosphorylated placental heat shock protein 27 in human and ovine intrauterine growth restriction (IUGR). Placenta. vol 35. issue 6. 2015-01-09. PMID:24680694. |
hsp27 has been shown to be involved in the control of apoptosis. |
2015-01-09 |
2023-08-12 |
human |
| D Sadeh-Mestechkin, G Epstein Shochet, M Pomeranz, A Fishman, L Drucker, T Biron-Shental, M Lishner, S Tartakover Matalo. The effect of heat shock protein 27 on extravillous trophoblast differentiation and on eukaryotic translation initiation factor 4E expression. Molecular human reproduction. vol 20. issue 5. 2014-12-28. PMID:24431103. |
hsp27 regulates cell apoptosis, migration, protein stability and the availability of eukaryotic translation initiation factors, such as eukaryotic translation initiation factor 4e (eif4e). |
2014-12-28 |
2023-08-12 |
human |
| C Antognelli, I Palumbo, C Aristei, V N Tales. Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB. British journal of cancer. vol 111. issue 2. 2014-11-11. PMID:24918814. |
glyoxalase i inhibition induces apoptosis in irradiated mcf-7 cells via a novel mechanism involving hsp27, p53 and nf-κb. |
2014-11-11 |
2023-08-13 |
Not clear |
| Louiza Belkacemi, Matthew O Heb. HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma multiforme. Anticancer research. vol 34. issue 9. 2014-11-11. PMID:25202074. |
hsp27 knockdown produces synergistic induction of apoptosis by hsp90 and kinase inhibitors in glioblastoma multiforme. |
2014-11-11 |
2023-08-13 |
Not clear |
| Maria Katsogiannou, Claudia Andrieu, Palma Rocch. Heat shock protein 27 phosphorylation state is associated with cancer progression. Frontiers in genetics. vol 5. 2014-10-23. PMID:25339975. |
hsp27 (hspb1), a member of the small hsp family, represents one of the key players of many signaling pathways contributing to tumorigenicity, treatment resistance, and apoptosis inhibition. |
2014-10-23 |
2023-08-13 |
Not clear |
| Shimei Qi, Yinqiang Xin, Zhilin Qi, Yimiao Xu, Ying Diao, Lei Lan, Lan Luo, Zhimin Yi. HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308965. |
heat shock protein 27 (hsp27) regulates critical cellular functions such as development, differentiation, cell growth and apoptosis. |
2014-10-01 |
2023-08-12 |
Not clear |
| Shimei Qi, Yinqiang Xin, Zhilin Qi, Yimiao Xu, Ying Diao, Lei Lan, Lan Luo, Zhimin Yi. HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308965. |
however, most previous studies focused on the role of hsp27 protein itself in apoptosis, the particular role of its phosphorylation state in signaling transduction remains largely unclear. |
2014-10-01 |
2023-08-12 |
Not clear |
| Shimei Qi, Yinqiang Xin, Zhilin Qi, Yimiao Xu, Ying Diao, Lei Lan, Lan Luo, Zhimin Yi. HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2. Cellular signalling. vol 26. issue 3. 2014-10-01. PMID:24308965. |
in hela cells, suppression of hsp27 phosphorylation by specific inhibitor kribb3 or mapkapk2 (mk2) knockdown and by overexpression of non-phosphorylatable hsp27(3a) mutant demonstrated that hindered hsp27 phosphorylation enhanced the trail-induced apoptosis. |
2014-10-01 |
2023-08-12 |
Not clear |
| Frank R Sharp, Xinhua Zhan, Da-Zhi Li. Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential. Translational stroke research. vol 4. issue 6. 2014-09-15. PMID:24323422. |
in the brain, protein kinase d phosphorylates hsp27 following ischemia which then binds apoptosis signal-regulating kinase 1 to prevent mkk4/7, c-jun nh(2)-terminal kinase, and jun-induced apoptosis, and decrease infarct volumes following focal cerebral ischemia. |
2014-09-15 |
2023-08-12 |
Not clear |
| B Zhang, H S Zhou, Q Cheng, L Lei, B H. Overexpression of HSP27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway. Genetics and molecular research : GMR. vol 12. issue 4. 2014-09-02. PMID:24391005. |
overexpression of hsp27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway. |
2014-09-02 |
2023-08-12 |
human |
| B Zhang, H S Zhou, Q Cheng, L Lei, B H. Overexpression of HSP27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway. Genetics and molecular research : GMR. vol 12. issue 4. 2014-09-02. PMID:24391005. |
we investigated in vitro the effect of low-frequency and low-energy ultrasound (lfleu) on apoptosis of an overexpressed hsp27 human aortic smooth muscle cell (hasmc) line. |
2014-09-02 |
2023-08-12 |
human |
| B Zhang, H S Zhou, Q Cheng, L Lei, B H. Overexpression of HSP27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway. Genetics and molecular research : GMR. vol 12. issue 4. 2014-09-02. PMID:24391005. |
apoptosis was determined 24 h after treatment by flow cytometry; gene display was evaluated with affimax chips, and hsp27 mrna and protein expression levels were measured by rt-pcr and western blotting. |
2014-09-02 |
2023-08-12 |
human |
| B Zhang, H S Zhou, Q Cheng, L Lei, B H. Overexpression of HSP27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway. Genetics and molecular research : GMR. vol 12. issue 4. 2014-09-02. PMID:24391005. |
the apoptosis rate (at 30 s) was significantly lower in hasmc transfected with hsp27 (7.14 ± 1.73%), compared with cells transfected with a mock plasmid (17.31 ± 2.72%) or a control group (14.23 ± 2.77%), indicating a protective function for apoptosis induced by lfleu. |
2014-09-02 |
2023-08-12 |
human |
| B Zhang, H S Zhou, Q Cheng, L Lei, B H. Overexpression of HSP27 in cultured human aortic smooth muscular cells reduces apoptosis induced by low-frequency and low-energy ultrasound by inhibition of an intrinsic pathway. Genetics and molecular research : GMR. vol 12. issue 4. 2014-09-02. PMID:24391005. |
we suggest that overexpressed hsp27 is capable of protecting the lfleu from apoptosis and that the pathway for this protection is via downregulated caspase-9 and caspase-3 expression. |
2014-09-02 |
2023-08-12 |
human |
| Lingbo Cai, Xiang Ma, Shan Liu, Jinjuan Liu, Wei Wang, Yugui Cui, Wei Ding, Yundong Mao, Huiping Chen, Jie Huang, Zuomin Zhou, Jiayin Li. Effects of upregulation of Hsp27 expression on oocyte development and maturation derived from polycystic ovary syndrome. PloS one. vol 8. issue 12. 2014-08-25. PMID:24391762. |
heat shock protein 27 (hsp27) is a heat shock protein family member which can inhibit apoptosis. |
2014-08-25 |
2023-08-12 |
human |