| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richa Rai, Sudhir Kumar Chauhan, Vikas Vikram Singh, Madhukar Rai, Geeta Ra. Heat shock protein 27 and its regulatory molecules express differentially in SLE patients with distinct autoantibody profiles. Immunology letters. vol 164. issue 1. 2015-11-20. PMID:25655337. |
the decreased expressions of hsp27, brn3a along with elevated levels of hsa-mir-939 are selectively associated with anti-ena(+) patients and hsp27 was observed to be inversely associated with apoptosis. |
2015-11-20 |
2023-08-13 |
Not clear |
| Gina Shaw-Hallgren, Katarzyna Chmielarska Masoumi, Reihaneh Zarrizi, Ulf Hellman, Per Karlsson, Khalil Helou, Ramin Massoum. Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells. PloS one. vol 9. issue 5. 2015-10-19. PMID:24816797. |
the nuclear localization of nlk was mediated through direct interaction with heat shock protein 27 (hsp27) which further protected cancer cells from apoptosis. |
2015-10-19 |
2023-08-13 |
human |
| Gina Shaw-Hallgren, Katarzyna Chmielarska Masoumi, Reihaneh Zarrizi, Ulf Hellman, Per Karlsson, Khalil Helou, Ramin Massoum. Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells. PloS one. vol 9. issue 5. 2015-10-19. PMID:24816797. |
the present study provides evidence of a novel mechanism by which hsp27 recognizes nlk in the breast cancer cells and prevents nlk-mediated cell apoptosis. |
2015-10-19 |
2023-08-13 |
human |
| Suhas V Vasaikar, Sourish Ghosh, Priyam Narain, Anirban Basu, James Gome. HSP70 mediates survival in apoptotic cells-Boolean network prediction and experimental validation. Frontiers in cellular neuroscience. vol 9. 2015-09-18. PMID:26379495. |
it was observed that hsp70 contributed more toward rescuing cells from apoptosis in comparison to hsp27, hsp40, and hsp90. |
2015-09-18 |
2023-08-13 |
Not clear |
| Rujun Li, Junyang Li, Dongping Sang, Qing La. Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro. Journal of neuro-oncology. vol 121. issue 1. 2015-09-14. PMID:25200832. |
cell growth was detected using cck-8 assay; caspase-3 activity assay kits and flow cytometry were used in apoptosis analysis; western blot analysis was used to detect p-hsp27 and p-akt levels; rna interference using the sirna oligos of hsp27 was performed to knockdown gene expression of hsp27. |
2015-09-14 |
2023-08-13 |
Not clear |
| Yang Guo, Andreas Ziesch, Sandra Hocke, Eric Kampmann, Stephanie Ochs, Enrico N De Toni, Burkhard Göke, Eike Gallmeie. Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis. Journal of cellular and molecular medicine. vol 19. issue 2. 2015-08-31. PMID:25331547. |
overexpression of heat shock protein 27 (hsp27) increases gemcitabine sensitivity in pancreatic cancer cells through s-phase arrest and apoptosis. |
2015-08-31 |
2023-08-13 |
Not clear |
| Yang Guo, Andreas Ziesch, Sandra Hocke, Eric Kampmann, Stephanie Ochs, Enrico N De Toni, Burkhard Göke, Eike Gallmeie. Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis. Journal of cellular and molecular medicine. vol 19. issue 2. 2015-08-31. PMID:25331547. |
utilizing a pancreatic cancer cell model with stable hsp27 overexpression, cell cycle arrest and apoptosis induction were analysed by flow cytometry, nuclear staining, immunoblotting and mitochondrial staining. |
2015-08-31 |
2023-08-13 |
Not clear |
| Yang Guo, Andreas Ziesch, Sandra Hocke, Eric Kampmann, Stephanie Ochs, Enrico N De Toni, Burkhard Göke, Eike Gallmeie. Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis. Journal of cellular and molecular medicine. vol 19. issue 2. 2015-08-31. PMID:25331547. |
finally, hsp27-overexpressing pancreatic cancer cells displayed an increased sensitivity also towards death receptor-targeting agents, suggesting another pro-apoptotic role of hsp27 along the extrinsic apoptosis pathway. |
2015-08-31 |
2023-08-13 |
Not clear |
| Hai-Feng Chen, Shu-Juan Liu, Gang Che. Heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by high glucose through the phosphoinositide 3‑kinase/Akt and extracellular signal‑regulated kinase 1/2 pathways. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25373458. |
in the present study, the effect of the heat shock protein 27 (hsp27) signaling pathway on the proliferation and apoptosis of human umbilical vein endothelial cells (huvecs) induced by high glucose (hg) was investigated. |
2015-07-30 |
2023-08-13 |
human |
| Hai-Feng Chen, Shu-Juan Liu, Gang Che. Heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by high glucose through the phosphoinositide 3‑kinase/Akt and extracellular signal‑regulated kinase 1/2 pathways. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25373458. |
huvec proliferation induced by hg was observed to be reduced by the hsp27 inhibitor quercetin in a concentration‑dependent manner, with a concomitant increase in apoptosis. |
2015-07-30 |
2023-08-13 |
human |
| Hai-Feng Chen, Shu-Juan Liu, Gang Che. Heat shock protein 27 phosphorylation in the proliferation and apoptosis of human umbilical vein endothelial cells induced by high glucose through the phosphoinositide 3‑kinase/Akt and extracellular signal‑regulated kinase 1/2 pathways. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25373458. |
in conclusion, hsp27 phosphorylation is important in mediating the proliferation and apoptosis of huvecs induced by high glucose, and pi3k/akt and erk1/2 are important signaling pathways that contribute to hsp27 phosphorylation. |
2015-07-30 |
2023-08-13 |
human |
| Qiongmei Guo, Xuefang Du, Yanli Zhao, Dong Zhang, Lihui Yue, Zhenxian Wan. Ischemic postconditioning prevents renal ischemia reperfusion injury through the induction of heat shock proteins in rats. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25322861. |
in conclusion, this study showed that ipo can attenuate lipid peroxidation, apoptosis and inflammation as well as renal iri by upregulating the expression of hsp70, hsp27 and ho‑1. |
2015-06-19 |
2023-08-13 |
rat |
| Simona Dedoni, Maria C Olianas, Pierluigi Onal. Interferon-β counter-regulates its own pro-apoptotic action by activating p38 MAPK signalling in human SH-SY5Y neuroblastoma cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 10. 2015-05-26. PMID:25086905. |
these results indicate that ifn-β-induced apoptosis of human sh-sy5y neuroblastoma cells is associated with a long-lasting up-regulation of p38 mapk activity, stimulation of mk2 and phosphorylation of the pro-survival protein hsp27. |
2015-05-26 |
2023-08-13 |
human |
| Rooban B Nahomi, Michael A DiMauro, Benlian Wang, Ram H Nagara. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. The Biochemical journal. vol 465. issue 1. 2015-04-14. PMID:25332102. |
we found that scrambling the last four amino acids in the two peptides (kaiv in hsp20 and ktlv in hsp27) made them unable to enter cells and ineffective against stress-induced apoptosis. |
2015-04-14 |
2023-08-13 |
human |
| Rooban B Nahomi, Michael A DiMauro, Benlian Wang, Ram H Nagara. Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities. The Biochemical journal. vol 465. issue 1. 2015-04-14. PMID:25332102. |
our study has identified peptides from hsp20 and hsp27 that may have therapeutic benefit in diseases where protein aggregation and apoptosis are contributing factors. |
2015-04-14 |
2023-08-13 |
human |
| Dong-Ping Sang, Ru-Jun Li, Qing La. Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27. Acta pharmacologica Sinica. vol 35. issue 6. 2015-04-06. PMID:24902789. |
quercetin is an effective hsp27 inhibitor and has been reported to facilitate tumor cell apoptosis. |
2015-04-06 |
2023-08-13 |
human |
| Wei-Ming Fu, Wei-Mao Wang, Hua Wang, Xiao Zhu, Yan Liang, Hsiang-Fu Kung, Jin-Fang Zhan. 1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma. Cell biology international. vol 38. issue 2. 2015-02-20. PMID:24123829. |
we previously showed that the small molecule 1,3,5-trihydroxy-13,13-dimethyl-2h-pyran [7,6-b] xanthone (tdp) induces apoptosis in hepatocellular carcinoma (hcc) by suppressing hsp27 expression, although the mechanism is not fully understood. |
2015-02-20 |
2023-08-12 |
Not clear |
| Honggang Huang, Martin R Larsen, Giuseppe Palmisano, Jie Dai, René Lametsc. Quantitative phosphoproteomic analysis of porcine muscle within 24 h postmortem. Journal of proteomics. vol 106. 2015-02-20. PMID:24769528. |
the high phosphorylation level of heat shock proteins (hsps) in early pm may be an adaptive response to slaughter stress and protect muscle cell from apoptosis, as observed in the serine 84 of hsp27. |
2015-02-20 |
2023-08-13 |
Not clear |
| Xiaoxia Wang, Meijuan Chen, Jing Zhou, Xu Zhan. HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review). International journal of oncology. vol 45. issue 1. 2015-01-15. PMID:24789222. |
in this review, we summarize the role of hsp90, hsp70 and hsp27 in apoptosis and the emerging strategies that have been developed for cancer therapy based on the inhibition of the three hsps. |
2015-01-15 |
2023-08-13 |
Not clear |
| Zhilin Qi, Lei Shen, Huiting Zhou, Yi Jiang, Lei Lan, Lan Luo, Zhimin Yi. Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling. Cellular signalling. vol 26. issue 7. 2015-01-10. PMID:24686082. |
heat shock protein 27 (hsp27), an important cellular chaperone, is believed to protect cells from apoptosis. |
2015-01-10 |
2023-08-12 |
human |