| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Evren Önay Uçar, Aslıhan Şengele. Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cells. Cell stress & chaperones. vol 24. issue 4. 2020-06-10. PMID:31073903. |
the highest effect was observed in the 15 μm resveratrol and 25 nm sirna combination group (suppressed hsp27 expression by 93.4% and induced apoptosis by 101.2%). |
2020-06-10 |
2023-08-13 |
human |
| Zhi-Feng Liu, Jing-Jing Ji, Dong Zheng, Lei Su, Tianqing Pen. Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation. Journal of cellular physiology. vol 234. issue 7. 2020-05-11. PMID:30417356. |
in cultured primary mouse neonatal cardiomyocytes (mncs), heat stress (43°c for 2 hr) induced a heat-shock response, as indicated by upregulated heat-shock protein 27 (hsp27) expression and cellular apoptosis, as indicated by increased caspase-3 activity, dna fragmentation and decreased cell viability. |
2020-05-11 |
2023-08-13 |
mouse |
| Yiyi Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Chuan Liu, Aijun Che. The effects of HSP27 against UVB-induced photoaging in rat skin. Biochemical and biophysical research communications. vol 512. issue 3. 2020-04-06. PMID:30902393. |
evidence suggests that hsp27 can protect cells from apoptosis induced by various stimuli in vivo and in vitro. |
2020-04-06 |
2023-08-13 |
rat |
| Yiyi Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Chuan Liu, Aijun Che. The effects of HSP27 against UVB-induced photoaging in rat skin. Biochemical and biophysical research communications. vol 512. issue 3. 2020-04-06. PMID:30902393. |
however, in hsp27 deletion group, the expression of antiapoptotic factor bcl-2 was decreased, while the apoptosis factor bax was increased after uvb irradiation. |
2020-04-06 |
2023-08-13 |
rat |
| Yiyi Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Chuan Liu, Aijun Che. The effects of HSP27 against UVB-induced photoaging in rat skin. Biochemical and biophysical research communications. vol 512. issue 3. 2020-04-06. PMID:30902393. |
these findings suggested that hsp27 was involved in oxidative stress, aging and apoptosis of skin after uv exposure. |
2020-04-06 |
2023-08-13 |
rat |
| Chuan Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Yi-Yi Liu, Ai-Jun Che. Interference of Hsp27 Results in Apoptosis Induced by Photodamage via Regulation of Subcellular Localization of p21 in Immortalized Human Keratinocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31592001. |
interference of hsp27 results in apoptosis induced by photodamage via regulation of subcellular localization of p21 in immortalized human keratinocytes. |
2020-03-09 |
2023-08-13 |
human |
| Chuan Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Yi-Yi Liu, Ai-Jun Che. Interference of Hsp27 Results in Apoptosis Induced by Photodamage via Regulation of Subcellular Localization of p21 in Immortalized Human Keratinocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31592001. |
heat shock protein 27 (hsp27) is well known for suppressing apoptosis. |
2020-03-09 |
2023-08-13 |
human |
| Chuan Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Yi-Yi Liu, Ai-Jun Che. Interference of Hsp27 Results in Apoptosis Induced by Photodamage via Regulation of Subcellular Localization of p21 in Immortalized Human Keratinocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31592001. |
material and methods the hsp27 gene was interfered to assess the expression of its downstream effectors, cell apoptosis, and cell proliferation ability. |
2020-03-09 |
2023-08-13 |
human |
| Chuan Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Yi-Yi Liu, Ai-Jun Che. Interference of Hsp27 Results in Apoptosis Induced by Photodamage via Regulation of Subcellular Localization of p21 in Immortalized Human Keratinocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31592001. |
results hsp27 knockdown decreased cell viability and increased the incidence of uvb-induced apoptosis. |
2020-03-09 |
2023-08-13 |
human |
| Chuan Liu, Xin Huang, Ping Wang, Yun Pan, Di Cao, Yi-Yi Liu, Ai-Jun Che. Interference of Hsp27 Results in Apoptosis Induced by Photodamage via Regulation of Subcellular Localization of p21 in Immortalized Human Keratinocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-03-09. PMID:31592001. |
compared with control group, activation of phosphorylated-akt (p-akt)-dependent pathway resulted in the nuclear accumulation of p21 and suppression of cell proliferation, while promoting apoptosis in hsp27 knockdown group. |
2020-03-09 |
2023-08-13 |
human |
| Hongqin Zhuang, Weiwei Jiang, Wei Cheng, Kui Qian, Wei Dong, Lin Cao, Qilai Huang, Shufeng Li, Fei Dou, Jen-Fu Chiu, Xue-Xun Fang, Min Lu, Zi-Chun Hu. Corrigendum to "Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis" [Lung Cancer 68 (1) (2010) 27-38]. Lung cancer (Amsterdam, Netherlands). vol 141. 2020-02-25. PMID:31955911. |
corrigendum to "down-regulation of hsp27 sensitizes trail-resistant tumor cell to trail-induced apoptosis" [lung cancer 68 (1) (2010) 27-38]. |
2020-02-25 |
2023-08-13 |
Not clear |
| Jing Li, Xiaomei Zhang, Jiaying Shen, Jun Guo, Xiaolin Wang, Jiaqiang Li. Bortezomib promotes apoptosis of multiple myeloma cells by regulating HSP27. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322176. |
bortezomib promotes apoptosis of multiple myeloma cells by regulating hsp27. |
2020-01-13 |
2023-08-13 |
human |
| Jing Li, Xiaomei Zhang, Jiaying Shen, Jun Guo, Xiaolin Wang, Jiaqiang Li. Bortezomib promotes apoptosis of multiple myeloma cells by regulating HSP27. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322176. |
compared with the control group, bortezomib or ogx‑427 (hsp27 inhibitor) treatment inhibited u266 cell proliferation, promoted u266 cell apoptosis (p<0.05) and significantly decreased hsp27 expression (p<0.05). |
2020-01-13 |
2023-08-13 |
human |
| Jing Li, Xiaomei Zhang, Jiaying Shen, Jun Guo, Xiaolin Wang, Jiaqiang Li. Bortezomib promotes apoptosis of multiple myeloma cells by regulating HSP27. Molecular medicine reports. vol 20. issue 3. 2020-01-13. PMID:31322176. |
in conclusion, bortezomib promotes the apoptosis of mm cells, potentially by downregulating the expression of hsp27, providing a potential novel target for the clinical treatment of multiple myeloma. |
2020-01-13 |
2023-08-13 |
human |
| Encieh Choghaei, Gholamreza Khamisipour, Mojtaba Falahati, Behrooz Naeimi, Majid Mossahebi-Mohammadi, Rahim Tahmasebi, Mojtaba Hasanpour, Shakib Shamsian, Zahra Sadat Hashem. Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells. Oncology research. vol 23. issue 1. 2019-11-20. PMID:29021023. |
our results revealed that inhibitors of microrna-29a promote apoptosis through upregulation of hsp60 level and downregulation of hsp27, hsp40, hsp70, and hsp90 levels and could be contemplated as a compelling alternative for taxol employment with similar effects and/or to sensitize cancer cells to chemotherapy with fewer side effects. |
2019-11-20 |
2023-08-13 |
Not clear |
| Myung-Shin Lee, Jisu Lee, Suhyuk Lee, Seung-Min Yoo, Joo Heon Kim, Won Tae Kim, Wun-Jae Kim, Jinsung Par. Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer. Oncotarget. vol 9. issue 8. 2019-11-20. PMID:29487706. |
interestingly, although our shrnas had obvious knockdown effects on hsp27 in bc cells, we did not find consistent effects on apoptosis of bc cells or chemotherapeutic sensitivity of bc cells to cisplatin. |
2019-11-20 |
2023-08-13 |
Not clear |
| Wilson Max Almeida Monteiro De Moraes, Pamella Ramona Moraes de Souza, Nathalie Alves da Paixão, Luís Gustavo Oliveira de Sousa, Daniel Araki Ribeiro, Andrea G Marshall, Jonato Prestes, Maria Claudia Irigoyen, Patricia Chakur Brum, Alessandra Medeiro. Aerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in rats. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-10. PMID:29265674. |
5/6nxs presented a trend towards to atrophy, with a reduction in motor performance, down-regulation of protein synthesis and up-regulation of apoptosis signalling; increases in ups activity, misfolded proteins, grp78, derlin, hsp27 and hsp70 protein levels, atf4 and grp78 genes; and increase in oxidative damage compared to cs group. |
2019-10-10 |
2023-08-13 |
rat |
| Toshiaki Tanaka, Mitsuyoshi Iino, Kaoru Got. Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27. Cellular signalling. vol 49. 2019-09-13. PMID:29729335. |
sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 mapk, mk2, and hsp27. |
2019-09-13 |
2023-08-13 |
Not clear |
| Toshiaki Tanaka, Mitsuyoshi Iino, Kaoru Got. Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27. Cellular signalling. vol 49. 2019-09-13. PMID:29729335. |
even though several studies have demonstrated that sec6 is involved in various cellular physiological functions, the relationship between sec6 and hsp27 or p38 mapk during cell migration and apoptosis remains unclear. |
2019-09-13 |
2023-08-13 |
Not clear |
| Chengmin Li, Yiru Wang, Lian Li, Zhaoyu Han, Shengyong Mao, Genlin Wan. Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production. Cell stress & chaperones. vol 24. issue 2. 2019-08-30. PMID:30805833. |
during heat stress, betaine decreased the mrna expression level of hsp70 and hsp27 in mac-t. bax/bcl-2 ratio and caspase-3, the markers of apoptosis, were also elevated in mac-t under heat stress. |
2019-08-30 |
2023-08-13 |
cat |