| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marios Lampros, Nikolaos Vlachos, Spyridon Voulgaris, George A Alexio. The Role of Hsp27 in Chemotherapy Resistance. Biomedicines. vol 10. issue 4. 2022-04-23. PMID:35453647. |
although numerous signaling pathways and molecular mechanisms were implicated in that chemotherapy resistance, hsp27 most commonly contributed to the upregulation of akt/mtor signaling cascade and inactivation of p53, thus inhibiting the chemotherapy-mediated induction of apoptosis. |
2022-04-23 |
2023-08-13 |
Not clear |
| Zi-Yue Wang, Ang Li, Xin Huang, Gen-Long Bai, Yu-Xin Jiang, Ruo-Lin Li, Chuan Liu, Zhu-Yuan Wen, Ping Wang, Ai-Jun Che. HSP27 Protects Skin From Ultraviolet B -Induced Photodamage by Regulating Autophagy and Reactive Oxygen Species Production. Frontiers in cell and developmental biology. vol 10. 2022-04-21. PMID:35445017. |
heat shock protein 27 (hsp27) is a vital protein involved in cell growth, autophagy, apoptosis, drug resistance, tumor genesis and metastasis. |
2022-04-21 |
2023-08-13 |
human |
| Elin Bergsten, Mattias Rydberg, Lars B Dahlin, Malin Zimmerma. Carpal Tunnel Syndrome and Ulnar Nerve Entrapment at the Elbow Are Not Associated With Plasma Levels of Caspase-3, Caspase-8 or HSP27. Frontiers in neuroscience. vol 16. 2022-03-21. PMID:35310100. |
the relationships between cts and une and two biomarkers of apoptosis, i.e., caspase-3 and caspase-8, and the neuroprotective factor heat shock protein 27 (hsp27) in plasma were examined in a population-based cohort. |
2022-03-21 |
2023-08-13 |
Not clear |
| Pin-Hong Li, Yi-Jie Cai, Xiang-Long Zhu, Jia-Deng-Hui Yang, Shi-Qi Yang, Wei Huang, Shi-Na Wei, Sheng Zhou, Jing-Guang Wei, Qi-Wei Qin, Hong-Yan Su. Epinephelus coioides Hsp27 negatively regulates innate immune response and apoptosis induced by Singapore grouper iridovirus (SGIV) infection. Fish & shellfish immunology. 2021-12-21. PMID:34933091. |
epinephelus coioides hsp27 negatively regulates innate immune response and apoptosis induced by singapore grouper iridovirus (sgiv) infection. |
2021-12-21 |
2023-08-13 |
Not clear |
| Pin-Hong Li, Yi-Jie Cai, Xiang-Long Zhu, Jia-Deng-Hui Yang, Shi-Qi Yang, Wei Huang, Shi-Na Wei, Sheng Zhou, Jing-Guang Wei, Qi-Wei Qin, Hong-Yan Su. Epinephelus coioides Hsp27 negatively regulates innate immune response and apoptosis induced by Singapore grouper iridovirus (SGIV) infection. Fish & shellfish immunology. 2021-12-21. PMID:34933091. |
over-expression of e. coioides hsp27 significantly upregulated the expressions of the key sgiv genes (vp19, litaf, mcp, and icp18), downgraded the expressions of the e. coioides immune factors (irf3, irf7, isg15, and traf6) and proinflammatory factors (tnf-α, il-8), downgraded the activation of nuclear factor kappa-b (nf-κb) and activator protein-1 (ap-1), and substantially inhibited the cell apoptosis induced by sgiv infection. |
2021-12-21 |
2023-08-13 |
Not clear |
| Ragu Kanagasabai, Krishnamurthy Karthikeyan, Jay L Zweier, Govindasamy Ilangova. Serine mutations in overexpressed Hsp27 abrogate the protection against doxorubicin-induced p53-dependent cardiac apoptosis in mice. American journal of physiology. Heart and circulatory physiology. vol 321. issue 5. 2021-11-08. PMID:34477462. |
serine mutations in overexpressed hsp27 abrogate the protection against doxorubicin-induced p53-dependent cardiac apoptosis in mice. |
2021-11-08 |
2023-08-13 |
mouse |
| James Patrick Heiserman, Sameera Nallanthighal, Cody C Gifford, Kayla Graham, Rohan Samarakoon, Chao Gao, Jessica J Sage, Wenzheng Zhang, Paul J Higgins, Dong-Joo Cheo. Heat Shock Protein 27, a Novel Downstream Target of Collagen Type XI alpha 1, Synergizes with Fatty Acid Oxidation to Confer Cisplatin Resistance in Ovarian Cancer Cells. Cancers. vol 13. issue 19. 2021-10-16. PMID:34638339. |
hsp27 knockdown or inhibition also decreases nfκb activity as well as the expression of inhibitors of apoptosis proteins (iaps), which are known downstream effector molecules of col11a1 that promote cisplatin resistance. |
2021-10-16 |
2023-08-13 |
Not clear |
| Pia Grotegut, Philipp Johannes Hoerdemann, Sabrina Reinehr, Nupur Gupta, H Burkhard Dick, Stephanie C Joachi. Heat Shock Protein 27 Injection Leads to Caspase Activation in the Visual Pathway and Retinal T-Cell Response. International journal of molecular sciences. vol 22. issue 2. 2021-09-13. PMID:33419223. |
histological and rt-qpcr analyses revealed an increase in endogenous hsp27 in the retina and an activation of components of the intrinsic and extrinsic apoptosis pathway. |
2021-09-13 |
2023-08-13 |
Not clear |
| Laura Hernández-Padilla, Homero Reyes de la Cruz, Jesús Campos-Garcí. Antiproliferative effect of bacterial cyclodipeptides in the HeLa line of human cervical cancer reveals multiple protein kinase targeting, including mTORC1/C2 complex inhibition in a TSC1/2-dependent manner. Apoptosis : an international journal on programmed cell death. vol 25. issue 9-10. 2021-07-30. PMID:32617785. |
in addition, the cdps blocked protein kinases from multiple signaling pathways involved in survival, proliferation, invasiveness, apoptosis, autophagy, and energy metabolism, such as pi3k/akt/mtor, ras/raf/mek/erk1/2, pi3k/jnk/pka, p27kip1/cdk1/survivin, mapk, hif-1, wnt/β-catenin, hsp27, emt, cscs, and receptors, such as egf/erbb2/hgf/met. |
2021-07-30 |
2023-08-13 |
human |
| Ruiting Shan, Ning Liu, Youyou Yan, Bin Li. Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27. Pharmacological research. vol 166. 2021-07-29. PMID:33053445. |
apoptosis, autophagy and atherosclerosis: relationships and the role of hsp27. |
2021-07-29 |
2023-08-13 |
Not clear |
| Ruiting Shan, Ning Liu, Youyou Yan, Bin Li. Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27. Pharmacological research. vol 166. 2021-07-29. PMID:33053445. |
a large number of studies have demonstrated that hsp27 plays an important role in regulating apoptosis. |
2021-07-29 |
2023-08-13 |
Not clear |
| Ruiting Shan, Ning Liu, Youyou Yan, Bin Li. Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27. Pharmacological research. vol 166. 2021-07-29. PMID:33053445. |
we further explore the involvement of hsp27 in apoptosis, autophagy, and atherosclerosis. |
2021-07-29 |
2023-08-13 |
Not clear |
| Ruiting Shan, Ning Liu, Youyou Yan, Bin Li. Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27. Pharmacological research. vol 166. 2021-07-29. PMID:33053445. |
we speculate that hsp27 may exert its anti-atherosclerotic role via the regulation of apoptosis and autophagy; this may provide the basis for the development of new approaches for the prevention and treatment of atherosclerosis. |
2021-07-29 |
2023-08-13 |
Not clear |
| Sangah Lee, Jiyae Jung, Yu-Jin Lee, Seon-Kyu Kim, Jung-Ae Kim, Bo-Kyung Kim, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Ha. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers. vol 13. issue 12. 2021-07-05. PMID:34203709. |
hsf1 inhibition by using hsf1 shrnas or kribb11 decreased the expression of hsf1 downstream proteins, such as hsp70 and hsp27, and also decreased the expression of hsp90/hsp70/bag3 client proteins, such as bcl2, mcl1, egfr, met, and axl, causing apoptosis of egfr-tki-resistant cancer cells. |
2021-07-05 |
2023-08-13 |
Not clear |
| Adrian Zając, Joanna Sumorek-Wiadro, Ewa Langner, Iwona Wertel, Aleksandra Maciejczyk, Bożena Pawlikowska-Pawlęga, Jarosław Pawelec, Magdalena Wasiak, Monika Hułas-Stasiak, Dorota Bądziul, Wojciech Rzeski, Michał Reichert, Joanna Jakubowicz-Gi. Involvement of PI3K Pathway in Glioma Cell Resistance to Temozolomide Treatment. International journal of molecular sciences. vol 22. issue 10. 2021-06-10. PMID:34068110. |
transfection with hsp27 sirna significantly increased apoptosis related to er stress. |
2021-06-10 |
2023-08-13 |
Not clear |
| Nahyeon Kim, Irfan Ullah, Kunho Chung, Dahye Lee, Min-Ji Cha, Hongseok Ban, Chang Seon Choi, Sunghwa Kim, Ki-Chul Hwang, Priti Kumar, Sang-Kyung Le. Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction. Molecular pharmaceutics. vol 17. issue 6. 2021-06-07. PMID:32364395. |
hsp27 is considered to be a therapeutic option for the treatment of ischemic heart disease due to its protective effects on hypoxia-induced apoptosis. |
2021-06-07 |
2023-08-13 |
rat |
| Nahyeon Kim, Irfan Ullah, Kunho Chung, Dahye Lee, Min-Ji Cha, Hongseok Ban, Chang Seon Choi, Sunghwa Kim, Ki-Chul Hwang, Priti Kumar, Sang-Kyung Le. Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction. Molecular pharmaceutics. vol 17. issue 6. 2021-06-07. PMID:32364395. |
this approach enabled selective delivery of hsp27 to cardiomyocytes, rescued cells from apoptosis, reduced the area of fibrosis, and improved cardiac function in the rat mi model, thus suggesting its applicability as a cardiomyocyte-targeted protein delivery system to inhibit apoptosis induced by ischemic injury. |
2021-06-07 |
2023-08-13 |
rat |
| Shunichi Matsumoto, Junichi Okada, Eijiro Yamada, Tsugumichi Saito, Kazuya Okada, Takuya Watanabe, Yasuyo Nakajima, Atsushi Ozawa, Shuichi Okada, Masanobu Yamad. Overexpressed exocyst complex component 3-like 1 spontaneously induces apoptosis. Biomedical research (Tokyo, Japan). vol 42. issue 3. 2021-06-07. PMID:34092752. |
since sec6 suppresses apoptosis via hsp27, we investigated the involvement of exoc3l1 expression in apoptosis. |
2021-06-07 |
2023-08-13 |
Not clear |
| Shunichi Matsumoto, Junichi Okada, Eijiro Yamada, Tsugumichi Saito, Kazuya Okada, Takuya Watanabe, Yasuyo Nakajima, Atsushi Ozawa, Shuichi Okada, Masanobu Yamad. Overexpressed exocyst complex component 3-like 1 spontaneously induces apoptosis. Biomedical research (Tokyo, Japan). vol 42. issue 3. 2021-06-07. PMID:34092752. |
thus, although sec6 reduces apoptosis by increasing hsp27 phosphorylation, overexpressed exoc3l1 alone can spontaneously induce apoptosis without apoptotic stimulators or inducers. |
2021-06-07 |
2023-08-13 |
Not clear |
| Julia Ketteler, Alina Wittka, Daniela Leonetti, Victoria Veas Roy, Hala Estephan, Patrick Maier, Henning Reis, Carsten Herskind, Verena Jendrossek, Francois Paris, Diana Klei. Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor-stroma interactions. Cell death & disease. vol 11. issue 4. 2021-04-08. PMID:32273493. |
enhanced apoptosis sensitivity of cav1-deficient ec was associated with increased asmase activity, ceramide generation, formation of large lipid platforms, and finally an altered p38 mitogen-activated protein kinase (mapk)/heat-shock protein 27 (hsp27)/akt (protein kinase b, pkb) signaling. |
2021-04-08 |
2023-08-13 |
human |