| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yinan Yao, Luyun Cui, Jiani Ye, Guangdie Yang, Guohua Lu, Xiaomei Fang, Zhu Zeng, Jianying Zho. Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma. International journal of biological sciences. vol 16. issue 15. 2021-04-07. PMID:33061803. |
furthermore, we noted that the accumulation of intracellular reactive oxygen species (ros) was triggered by dioscin in lung scc cells, leading to the phosphorylation of hsp27 through p38-mapk and consequent cell apoptosis. |
2021-04-07 |
2023-08-13 |
mouse |
| Xiang-Xue Kong, Shuai Jiang, Tong Liu, Gao-Feng Liu, Mei Don. Paclitaxel increases sensitivity of SKOV3 cells to hyperthermia by inhibiting heat shock protein 27. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-25. PMID:33113434. |
to further examine the role of hsp27 in the apoptosis, bcl-2, bax and caspase-3 protein expression were additionally determined after reducing hsp27 levels using an sirna strategy, and apoptosis was detected using the annexin v/pi assay. |
2021-02-25 |
2023-08-13 |
Not clear |
| Xiang-Xue Kong, Shuai Jiang, Tong Liu, Gao-Feng Liu, Mei Don. Paclitaxel increases sensitivity of SKOV3 cells to hyperthermia by inhibiting heat shock protein 27. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-25. PMID:33113434. |
furthermore, paclitaxel could upregulate the bax / bcl-2 ratio by inhibiting hsp27 expression, and in turn, promoting apoptosis due to hyperthermia. |
2021-02-25 |
2023-08-13 |
Not clear |
| Xiang-Xue Kong, Shuai Jiang, Tong Liu, Gao-Feng Liu, Mei Don. Paclitaxel increases sensitivity of SKOV3 cells to hyperthermia by inhibiting heat shock protein 27. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 132. 2021-02-25. PMID:33113434. |
paclitaxel could also promote apoptosis by inhibiting hsp27 in skov3 cells. |
2021-02-25 |
2023-08-13 |
Not clear |
| Daniela Brünnert, Clara Langer, Luise Zimmermann, Ralf C Bargou, Martin Burchardt, Manik Chatterjee, Matthias B Stop. The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-23. PMID:31222811. |
the heat shock protein 70 inhibitor ver155008 suppresses the expression of hsp27, hop and hsp90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth. |
2021-02-23 |
2023-08-13 |
Not clear |
| Gen-Long Bai, Ping Wang, Xin Huang, Zi-Yue Wang, Di Cao, Chuan Liu, Yi-Yi Liu, Ruo-Lin Li, Ai-Jun Che. Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of p53 and Phosphorylated HSP27. Frontiers in cell and developmental biology. vol 9. 2021-02-23. PMID:33614662. |
here, we investigate the role of rapamycin and hsp27, which we have previously identified as an inhibitor of uv-induced apoptosis and senescence in hacat cells, in a uva-induced photoaging model of primary human dermal fibroblasts (hdfs). |
2021-02-23 |
2023-08-13 |
human |
| Junichi Okada, Noriaki Sunaga, Eijiro Yamada, Tsugumichi Saito, Atsushi Ozawa, Yasuyo Nakajima, Kazuya Okada, Jeffrey E Pessin, Shuichi Okada, Masanobu Yamad. FAM83G Is a Novel Inducer of Apoptosis. Molecules (Basel, Switzerland). vol 25. issue 12. 2021-02-18. PMID:32570757. |
by contrast, the introduction of a synthetic peptide encompassing fam83g s356 into hct116 and hepg2 cells decreased hsp27 s15 and s82 phosphorylation and induced spontaneous apoptosis. |
2021-02-18 |
2023-08-13 |
Not clear |
| Junichi Okada, Noriaki Sunaga, Eijiro Yamada, Tsugumichi Saito, Atsushi Ozawa, Yasuyo Nakajima, Kazuya Okada, Jeffrey E Pessin, Shuichi Okada, Masanobu Yamad. FAM83G Is a Novel Inducer of Apoptosis. Molecules (Basel, Switzerland). vol 25. issue 12. 2021-02-18. PMID:32570757. |
taken together, these data demonstrate that fam83g s356 phosphorylation modulates hsp27 phosphorylation and apoptosis regulation and that hsp27 is a counterpart of fam83g. |
2021-02-18 |
2023-08-13 |
Not clear |
| Zhi-Bin Zhou, Gao-Xiang Huang, Jia-Jia Lu, Jun Ma, Qi-Jun Yuan, Yan Cao, Lei Zh. Up-regulation of heat shock protein 27 inhibits apoptosis in lumbosacral nerve root avulsion-induced neurons. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31391542. |
it was found that hsp27 expression was elevated in the anterior horn area of the injured spinal cord and the up-regulation of hsp27 protected neurons against apoptosis after lumbosacral nerve root avulsion. |
2020-10-27 |
2023-08-13 |
Not clear |
| Zhi-Bin Zhou, Gao-Xiang Huang, Jia-Jia Lu, Jun Ma, Qi-Jun Yuan, Yan Cao, Lei Zh. Up-regulation of heat shock protein 27 inhibits apoptosis in lumbosacral nerve root avulsion-induced neurons. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31391542. |
these findings indicated that hsp27 may play a key role in resistance to lumbosacral nerve root avulsion-induced neuron apoptosis and may prove to be a potential strategy for improving prognosis after lumbosacral nerve root avulsion. |
2020-10-27 |
2023-08-13 |
Not clear |
| Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Andrea Perrelli, Claudia Fornelli, Francesca Retta, Paola Cassoni, Vincenzo Nicola Talesa, Saverio Francesco Rett. Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function. Data in brief. vol 16. 2020-10-01. PMID:29511711. |
overall, they support, complement and extend original findings demonstrating that krit1 loss-of-function induces a redox-sensitive and jnk-dependent sustained upregulation of the master nrf2 antioxidant defense pathway and its downstream target glyoxalase 1 (glo1), and a drop in intracellular levels of ap-modified hsp70 and hsp27 proteins, leading to a chronic adaptive redox homeostasis that sensitizes cells to oxidative dna damage and apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Cinzia Antognelli, Eliana Trapani, Simona Delle Monache, Andrea Perrelli, Claudia Fornelli, Francesca Retta, Paola Cassoni, Vincenzo Nicola Talesa, Saverio Francesco Rett. Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function. Data in brief. vol 16. 2020-10-01. PMID:29511711. |
finally, the role of glo1 in the downregulation of ap-modified hsp70 and hsp27 proteins, and the increase in apoptosis susceptibility associated with krit1 loss-of-function was addressed by si-rna-mediated glo1 gene silencing in krit1-knockout mef cells. |
2020-10-01 |
2023-08-13 |
human |
| Seul-Ki Choi, Heejin Kam, Kye-Young Kim, Suk In Park, Yun-Sil Le. Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment? Cancers. vol 11. issue 8. 2020-10-01. PMID:31426426. |
hsp27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. |
2020-10-01 |
2023-08-13 |
Not clear |
| Seul-Ki Choi, Heejin Kam, Kye-Young Kim, Suk In Park, Yun-Sil Le. Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment? Cancers. vol 11. issue 8. 2020-10-01. PMID:31426426. |
hsp27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wu Ye, Zhijun Li, Tingyu Tang, Jianzong Du, Xiaoxi Zhou, Haiyan Wu, Xuefang Li, Guangyue Qi. ERp29 downregulation enhances lung adenocarcinoma cell chemosensitivity to gemcitabine by upregulating HSP27 phosphorylation. Experimental and therapeutic medicine. vol 17. issue 1. 2020-09-30. PMID:30651868. |
the effects of gemcitabine in combination with erp29 sirna on cell apoptosis, cell cycle and heat shock protein 27 (hsp27) expression were assessed. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chengfeng Shen, Weili Liu, Shuang Zhang, Lingling Pu, Bingnan Deng, Qiang Zeng, Zhaoli Chen, Xinxing Wan. Downregulation of miR-541 induced by heat stress contributes to malignant transformation of human bronchial epithelial cells via HSP27. Environmental research. vol 184. 2020-09-28. PMID:32145546. |
heat shock protein 27 (hsp27) promoted heat stress-induced anchorage-independent proliferation and autophagy, but suppressed mitochondrial apoptosis, indicating that hsp27 might act as an oncogene in the malignant transformation of lung epithelial cells. |
2020-09-28 |
2023-08-13 |
human |
| Zhengyong Liu, Yi Liu, Yupeng Long, Baohua Liu, Xiangfeng Wan. Role of HSP27 in the multidrug sensitivity and resistance of colon cancer cells. Oncology letters. vol 19. issue 3. 2020-09-28. PMID:32194698. |
heat shock 27 kd protein 1 (hsp27) is associated with cell apoptosis and resistance to chemotherapy. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xiang-Chen Kong, Dan Zhang, Cheng Qian, Geng-Tao Liu, Xiu-Qi Ba. Corrigendum to "FLZ, a novel HSP27 and HSP70 inducer, protects SH-SY5Y cells from apoptosis caused by MPP(+)" [Brain Res. 1383 (2011) 99-107]. Brain research. vol 1747. 2020-09-17. PMID:32763497. |
corrigendum to "flz, a novel hsp27 and hsp70 inducer, protects sh-sy5y cells from apoptosis caused by mpp(+)" [brain res. |
2020-09-17 |
2023-08-13 |
Not clear |
| Evren Önay Uçar, Aslıhan Şengele. Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cells. Cell stress & chaperones. vol 24. issue 4. 2020-06-10. PMID:31073903. |
the aim of the present study was to asses the effect of resveratrol on hsp27 expression and apoptosis in non-transfected and transfected u-87 mg human glioblastoma cells. |
2020-06-10 |
2023-08-13 |
human |
| Evren Önay Uçar, Aslıhan Şengele. Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cells. Cell stress & chaperones. vol 24. issue 4. 2020-06-10. PMID:31073903. |
we also determined that silencing of hsp27 with sirna makes the cells more vulnerable to apoptosis upon resveratrol treatment. |
2020-06-10 |
2023-08-13 |
human |