| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideto Sano, Jared P Leboeuf, Sergey V Novitskiy, Seungwoon Seo, Snjezana Zaja-Milatovic, Mikhail M Dikov, Tsutomu Kum. The Foxc2 transcription factor regulates tumor angiogenesis. Biochemical and biophysical research communications. vol 392. issue 2. 2010-03-19. PMID:20060810. |
consistently, expression levels of several angiogenic factors, including vascular endothelial growth factor (vegf), matrix metallopeptidase 2 (mmp2), and platelet-derived growth factor-b (pdgfb), were significantly decreased in b16 tumors grown in foxc2+/- mice, and tumor blood vessels formed in foxc2+/- mice showed reduced coverage of mural cells and endothelial cell apoptosis. |
2010-03-19 |
2023-08-12 |
mouse |
| Zamaneh Kassiri, Gavin Y Oudit, Vijay Kandalam, Ahmed Awad, Xiuhua Wang, Xiuhua Ziou, Nobuyo Maeda, Andrew M Herzenberg, James W Schole. Loss of TIMP3 enhances interstitial nephritis and fibrosis. Journal of the American Society of Nephrology : JASN. vol 20. issue 6. 2009-06-30. PMID:19406980. |
in addition, timp3-/- mice had greater interstitial fibrosis; increased synthesis and deposition of type i collagen; increased activation of fibroblasts; enhanced apoptosis; and greater activation of mmp2, but not mmp9, after uuo. |
2009-06-30 |
2023-08-12 |
mouse |
| Nesrine El-Bizri, Christophe Guignabert, Lingli Wang, Alexander Cheng, Kryn Stankunas, Ching-Pin Chang, Yuji Mishina, Marlene Rabinovitc. SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development (Cambridge, England). vol 135. issue 17. 2008-10-29. PMID:18667463. |
in human brain microvascular pericytes, knock-down of bmpr1a reduced mmp2 activity and knock-down of either bmpr1a or mmp2 caused resistance to apoptosis. |
2008-10-29 |
2023-08-12 |
mouse |
| Ekaterina Vorotnikova, Mark Tries, Susan Braunhu. Retinoids and TIMP1 prevent radiation-induced apoptosis of capillary endothelial cells. Radiation research. vol 161. issue 2. 2004-04-06. PMID:14731072. |
in the present studies, we demonstrated that radiation (10 gy) induced an immediate increase in the amounts and activation of mmp1 and mmp2 in the cell fraction and medium of bovine capillary endothelial cells followed by an incidence of apoptosis. |
2004-04-06 |
2023-08-12 |
cattle |
| B Levkau, R D Kenagy, A Karsan, B Weitkamp, A W Clowes, R Ross, E W Raine. Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478473. |
we observe a physical association of mmp2 with beta1 and alphav integrins, which increased three- to fourfold during apoptosis and is dependent upon integrin beta1 levels and activation state. |
2003-07-30 |
2023-08-12 |
human |