| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Sun, Ying Guo, Beibei Bie, Mengchen Zhu, Hongwei Tian, Jing Tian, Jun Li, Yi Yang, Fanpu Ji, Guangyao Kong, Zongfang L. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-23. PMID:31231887. |
in vitro loss-of-function experiments revealed that silencing of hoxd-as1 could dramatically suppress the proliferation, migration, and invasion, and induce s or/and g2/m phase cell cycle arrest as well as apoptosis of bel-7402 and mhcc97h cells accompanying the changes in expression levels of cyclin b1, cyclin d1, bcl-2, bax, and mmp2. |
2021-02-23 |
2023-08-13 |
Not clear |
| Guangjie Zhan, Jun Hu, Benjian Xiao, Xianli Wang, Zixian Yang, Guohua Yang, Lili L. Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinoma cells. Medical oncology (Northwood, London, England). vol 37. issue 5. 2020-11-12. PMID:32270306. |
trillin could down-regulate bcl-2 and survivin, up-regulate cleaved prap, leading to dramatically apoptosis; trillin could also down-regulate mmp1, mmp2, muci and vegf, which displayed an inhibition effect on hepatocellular tumor cells invasion and development. |
2020-11-12 |
2023-08-13 |
Not clear |
| Xin Jiang, Yanwei Du, Xinxin Meng, Hongmei Zhang, Di Zhao, Lijing Zhao, Junyu Chen, Shengxiang Xiao, Hongyu Jian. Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin. Dose-response : a publication of International Hormesis Society. vol 16. issue 4. 2020-10-01. PMID:30622447. |
the histology of tumor tissue was observed by hematoxylin and eosin staining, the apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling, and the expression of ki67, bcl-2, bax, cleaved caspase3, matrix metalloproteinase 2 (mmp2), mmp9, and cd34 was detected by western blot. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiaochen Yuan, Qingbin Wu, Peng Wang, Yingli Jing, Haijiang Yao, Yinshan Tang, Zhigang Li, Honggang Zhang, Ruijuan Xi. Exosomes Derived From Pericytes Improve Microcirculation and Protect Blood-Spinal Cord Barrier After Spinal Cord Injury in Mice. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31040762. |
in addition, the exosomes could improve the endothelial ability to regulate blood flow, protect the blood-spinal cord barrier, reduce edema, decrease the expression of hif-1α, bax, aquaporin-4, and mmp2, increase the expression of claudin-5, bcl-2 and inhibit apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |
| Jie Li, Fang Liu, Shulong Jiang, Jie Liu, Xiuhong Chen, Shangnuan Zhang, Haibo Zha. Berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the MMP2 and Bcl-2/Bax signaling pathways. Oncology letters. vol 15. issue 5. 2020-09-30. PMID:29725453. |
berberine hydrochloride inhibits cell proliferation and promotes apoptosis of non-small cell lung cancer via the suppression of the mmp2 and bcl-2/bax signaling pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Ying Wen, Xiaoyan Cai, Shaolian Chen, Wei Fu, Dong Chai, Huainian Zhang, Yongli Zhan. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Frontiers in oncology. vol 10. 2020-09-28. PMID:32117722. |
7-methoxy-1-tetralone induces apoptosis, suppresses cell proliferation and migration in hepatocellular carcinoma via regulating c-met, p-akt, nf-κb, mmp2, and mmp9 expression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ning Zhu, Yijia Xiang, Xuyong Zhao, Changhong Cai, Hao Chen, Wenbing Jiang, Yi Wang, Chunlai Zen. Thymoquinone suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation, migration and neointimal formation. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31638340. |
molecules including the mitochondria-dependent apoptosis factors, matrix metalloproteinase 2 (mmp2), matrix metalloproteinase 9 (mmp9), pten/akt and mitogen-activated protein kinases (mapks) were determined by western blot. |
2020-09-22 |
2023-08-13 |
rat |
| Shuo Fang, Hai Tao, Kezhou Xia, Weichun Gu. Proscillaridin A induces apoptosis and inhibits the metastasis of osteosarcoma in vitro and in vivo. Biochemical and biophysical research communications. vol 521. issue 4. 2020-08-03. PMID:31708095. |
conclusively, proscillaridin a suppressed proliferation, induced apoptosis, and inhibited 143b cell metastasis in vitro and in vivo, and these effects could be mediated by downregulating the expressions of bcl-xl and mmp2. |
2020-08-03 |
2023-08-13 |
mouse |
| Yanyu Jiang, Yupei Liang, Lihui Li, Lisha Zhou, Wei Cheng, Xi Yang, Xuguang Yang, Hui Qi, Jinha Yu, Lak Shin Jeong, Robert M Hoffman, Peiyong Zheng, Lijun Ji. Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis. Cell biology and toxicology. vol 35. issue 3. 2020-07-16. PMID:31140025. |
mechanistically, mln4924 efficiently inhibits the expression of mmp2, mmp9, and vimentin and disrupts the actin cytoskeleton at an early stage to impair invasive potential and subsequently causes a dna damage response, cell cycle arrest, and apoptosis upon long exposure to mln4924. |
2020-07-16 |
2023-08-13 |
Not clear |
| Rubiao Qiu, Xueyu Li, Kaibing Qin, Xiong Chen, Ruyue Wang, Yan Dai, Li Deng, Yu Y. Antimetastatic effects of calycosin on osteosarcoma and the underlying mechanism. BioFactors (Oxford, England). vol 45. issue 6. 2020-04-17. PMID:31322783. |
in cell-line study, cc-treated human os cells exhibited induced cell apoptosis, reduced cell proliferation, and cellular mmp2 and pcna concentration, inhibited cell migration, lowered expressions of iκbα ect2 mrnas, and proteins. |
2020-04-17 |
2023-08-13 |
mouse |
| Laura Beatriz M Maifrino, Nathalia E A de Lima, Mara R Marques, Clever G Cardoso, Lidiane B de Souza, Tabata de Carvalho Tomé, Hananiah Tardivo Quintana, Flavia de Oliveira, Beatriz da Costa Aguiar Alves Reis, Fernando Luiz Affonso Fonsec. Evaluation of Collagen Fibers, MMP2, MMP9, 8-OHdG and Apoptosis in the Aorta of Ovariectomized LDL Knockout Mice Submitted to Aerobic Exercise. Arquivos brasileiros de cardiologia. vol 112. issue 2. 2020-01-22. PMID:30570072. |
evaluation of collagen fibers, mmp2, mmp9, 8-ohdg and apoptosis in the aorta of ovariectomized ldl knockout mice submitted to aerobic exercise. |
2020-01-22 |
2023-08-13 |
mouse |
| Zahra Malekpour-Dehkordi, Shahram Teimourian, Mitra Nourbakhsh, Yousof Naghiaee, Roya Sharifi, Javad Mohiti-Ardakan. Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. Life sciences. vol 233. 2019-09-30. PMID:31348945. |
here we investigated the effect of antidiabetic drug, metformin, on the factors that play role in fibrosis such as; integrin/erk pathway, collagen vi, mmp2, mmp9, apoptosis markers including dapk1, dapk3, dap, siva, necrosis markers including ripk1, ripk3, and mlkl in insulin resistant and hypertrophied adipocytes. |
2019-09-30 |
2023-08-13 |
Not clear |
| Hao Yu, Qun Zhong, Yali Xia, Enchun Li, Shufang Wang, Rong Re. MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. Die Pharmazie. vol 74. issue 4. 2019-06-14. PMID:30940310. |
microrna-2861 targets stat3 and mmp2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. |
2019-06-14 |
2023-08-13 |
Not clear |
| Hao Yu, Qun Zhong, Yali Xia, Enchun Li, Shufang Wang, Rong Re. MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis. Die Pharmazie. vol 74. issue 4. 2019-06-14. PMID:30940310. |
additionally, stat3 and mmp2 were confirmed as the targets of mir-2861, and the effects of knockdown of stat3 or mmp2on regulating cell proliferation and apoptosis were opposite with inhibition of mir-2861. |
2019-06-14 |
2023-08-13 |
Not clear |
| Zhenwen Lin, Sheng Li, Peng Guo, Liyang Wang, Lisheng Zheng, Zixing Yan, Xi Chen, Zhuqin Cheng, Haiyi Yan, Cui Zheng, Congkuai Zha. Columbamine suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK1/2 MAPK signaling pathways. Life sciences. vol 218. 2019-03-01. PMID:30582951. |
meanwhile decreases of migration indicated with increasing expression of e-cadherin and decreasing expression of n-cadherin, and of invasion labelled with decreasing expressions of mmp2 and mmp9, are accompanying the col suppression along with the col promoted apoptosis of the tumor cells. |
2019-03-01 |
2023-08-13 |
human |
| Hai Huang, Qiong Wang, Tao Du, Chunhao Lin, Yiming Lai, Dingjun Zhu, Wanhua Wu, Xiaoming Ma, Soumin Bai, Zean Li, Leyuan Liu, Qi L. Matrine inhibits the progression of prostate cancer by promoting expression of GADD45B. The Prostate. vol 78. issue 5. 2019-02-07. PMID:29356020. |
it has been demonstrated to exhibit antiproliferative properties, promote apoptosis, and inhibit cell invasion in a number of cancer cell lines by modulating the nf-κb pathway to downregulate the expression of mmp2 and mm9. |
2019-02-07 |
2023-08-13 |
Not clear |
| Kota Nishihama, Taro Yasuma, Yutaka Yano, Corina N D' Alessandro-Gabazza, Masaaki Toda, Josephine A Hinneh, Prince Baffour Tonto, Atsuro Takeshita, Toshiaki Totoki, Rumi Mifuji-Moroka, Tetsu Kobayashi, Motoh Iwasa, Yoshiyuki Takei, John Morser, Isaac Cann, Esteban C Gabazz. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus. Metabolism: clinical and experimental. vol 82. 2018-12-31. PMID:29366755. |
this study tested the hypothesis that mmp2 inhibits cell apoptosis, including islet β-cells. |
2018-12-31 |
2023-08-13 |
human |
| Shuo Chen, Li-Li Wang, Kai-Xuan Sun, Yao Liu, Xue Guan, Zhi-Hong Zong, Yang Zha. LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 9 Pt B. 2018-12-11. PMID:29920344. |
overexpression of lncrna tdrg1 promoted endometrial carcinoma cell viability, invasion and migratory ability, inhibited apoptosis, and upregulated vegf-a, pi3k, bcl-2, mmp2 and survivin; knockdown of lncrna tdrg1 had the opposite effects. |
2018-12-11 |
2023-08-13 |
human |
| Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Ji. PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845265. |
the expression levels of the cell apoptosis and tumor metastasis associated proteins b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein, e‑cadherin, twist, matrix metalloproteinase (mmp)‑9 and mmp2 were measured via western blotting. |
2018-10-19 |
2023-08-13 |
human |
| Li Liu, Ning Luo, Jing Guo, Yan Xie, Li Chen, Zhongping Chen. Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: Imply the possible treatment of adenomyosis. Journal of pharmacological sciences. vol 137. issue 1. 2018-09-05. PMID:29752208. |
bbr markedly exhibited a growth inhibitory effect on eescs by triggering apoptosis and cell cycle arrest, and alleviating the expression of inflammatory invasive phenotypes (il-6, il-8, tgf-β, egf, vegf, and mmp2). |
2018-09-05 |
2023-08-13 |
Not clear |