| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Chen, Wenting Luo, Peijun Ji, Zhujuan Li, Yi Yan, Qin Zho. Effects of BMI1 Gene on Regulating Apoptosis, Invasion, and Migration of HEC-1B Cells Induced by Ionizing Radiation. Journal of healthcare engineering. vol 2022. 2022-03-14. PMID:35281533. |
cell proliferation was detected by cell counting kit-8 (cck-8); cell migration and invasion were detected by transwell test; cell apoptosis was detected by flow cytometry; and the expression of mmp2, mmp7, mmp9, rock1, rhoa, p53, p21, and bax protein was detected by the western blot. |
2022-03-14 |
2023-08-13 |
human |
| Wen Xiong, Jiazheng Zhao, Xiaowei Ma, Zhangying Fen. Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis. ACS omega. vol 7. issue 5. 2022-02-14. PMID:35155962. |
the experiment validated quercetin might suppress chondrocyte apoptosis mediated by il-1β and reduce sele, mmp2, and col1 expression. |
2022-02-14 |
2023-08-13 |
rat |
| Huining Gu, Siyuan Chen, Mingzheng Zhang, Yu Wen, Bin L. Differences in the expression profiles of lncRNAs and mRNAs in partially injured anterior cruciate ligament and medial collateral ligament of rabbits. PeerJ. vol 10. 2022-01-24. PMID:35070509. |
several important lncrnas and genes were identified, namely, col7a1, lif, fgfr2, epha2, csf1, mmp2, mmp9, sox5, lox, mstrg.1737.1, mstrg.26038.25, mstrg.20209.5, mstrg.22764.1, and mstrg.18113.1, which are closely related to inflammatory response, tissue damage repair, cell proliferation, differentiation, migration, and apoptosis. |
2022-01-24 |
2023-08-13 |
Not clear |
| Xiaoxia Yang, Pengfei Shang, Jianbo Ji, Christina Malichewe, Zhiyin Yao, Jing Liao, Dandan Du, Chao Sun, Lei Wang, Ya-Jie Tang, Xiuli Gu. Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer. Molecular pharmaceutics. 2021-12-15. PMID:34910493. |
in addition, the ccmdh nps could inhibit proliferation and promote apoptosis by regulating the protein expression of b-cell lymphoma-2 (bcl-2) and poly(adp-ribose) polymerase (parp) and inhibit invasion, metastasis, and adhesion by regulating e-cadherin, n-cadherin, mmp2, cd44, and snail molecules. |
2021-12-15 |
2023-08-13 |
mouse |
| Alper Yalçın, Ali Güre. Effects of N-acetylcysteine on kidney tissue, matrix metalloproteinase-2, irisin and oxidative stress in a diabetes mellitus model. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 96. issue 8. 2021-11-29. PMID:33596748. |
we investigated the possible effects of the antioxidant, n-acetylcysteine (nac), on kidney morphology, apoptosis, matrix metalloproteinase-2 (mmp2) activity, irisin levels and oxidative stress in an experimental dm model. |
2021-11-29 |
2023-08-13 |
rat |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. 2021-11-17. PMID:33014432. |
we further show that mmp2 is a key substrate of serpina3n, and mmp2 specific inhibitor (arp100) can protect against neuronal apoptosis and cognitive dysfunction in mice after hsi. |
2021-11-17 |
2023-08-13 |
mouse |
| Sadaf Dorandish, Asana Williams, Sarah Atali, Sophia Sendo, Deanna Price, Colton Thompson, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells. Scientific reports. vol 11. issue 1. 2021-10-28. PMID:33958632. |
cell viability or apoptosis upon treatment with either mmp2 or mmp9 sirna along with aβ immunodepletion, showed that mmp2 is the predominant regulator of the cytotoxic effects induced by aβ in lung cancer cells. |
2021-10-28 |
2023-08-13 |
Not clear |
| Xiaozhi Liu, Lei Chen, Zhongmin Jiang, Junfei Wang, Zhiguo Su, Gang Li, Shizhu Yu, Zhenlin Li. Malignant behaviorial characteristics of CD133(+/-) glioblastoma cells from a Northern Chinese population. Experimental and therapeutic medicine. vol 5. issue 1. 2021-10-21. PMID:23251243. |
a comparison of tumor subtypes demonstrated that cd133(+) glioblastoma cells had a lower incidence of cell apoptosis in the tumor tissue and higher protein expression levels of oct4, sox2, pcna, egfr, ang2, mmp2 and mmp9 compared with cd133(-) cells. |
2021-10-21 |
2023-08-12 |
mouse |
| Zhi-Meng Wang, Cong Liu, Ying-Ying Wang, Yu-Sen Deng, Xuan-Cheng He, Hong-Zhen Du, Chang-Mei Liu, Zhao-Qian Ten. SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury. Cell death discovery. vol 6. issue 1. 2021-10-13. PMID:34535636. |
we further show that mmp2 is a key substrate of serpina3n, and mmp2 specific inhibitor (arp100) can protect against neuronal apoptosis and cognitive dysfunction in mice after hsi. |
2021-10-13 |
2023-08-13 |
mouse |
| Linyan Wang, Juan Zhan. Long intergenic ncRNA 00473 improves the invasion of trophoblastic cells via miR-16-5p. Pregnancy hypertension. vol 23. 2021-09-24. PMID:33422740. |
linc00473 overexpression increased cell viability, migration, invasion, and mmp2, mmp9 and bcl-2 levels, yet decreased the apoptosis rates and bax and c caspase-3 levels in cells; however, linc00473 silencing had the opposite effect. |
2021-09-24 |
2023-08-13 |
human |
| Cong Li, Suling Hu, Yan Yu. Ultrasound Microbubble-Mediated VHL Regulates the Biological Behavior of Ovarian Cancer Cells. Ultrasound in medicine & biology. vol 47. issue 3. 2021-08-26. PMID:33261909. |
overexpression of liposome-mediated vhl inhibited the proliferation and migration; caused cell-cycle arrest; promoted apoptosis: downregulated the expressions of mmp2, mmp9, e-cadherin, akt and bcl-2; and upregulated the expressions of vhl and bcl2-associated x protein (bax) in ovcar-3 cells. |
2021-08-26 |
2023-08-13 |
Not clear |
| Junmiao Wu, Tongfu Yang, Xiaojun Wang, Wenjuan Li, Min Pang, Hongbin Sun, Hong Liang, Feng Yan. Development of a multi-target anticancer Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complex. Dalton transactions (Cambridge, England : 2003). vol 50. issue 31. 2021-08-11. PMID:34313274. |
multiple mechanisms underlie the antitumor effect of c5, and they include acting against dna, inducing apoptosis, and inhibiting the activities of anti-apoptotic bcl-xl protein, metalloproteinase mmp2 and topoisomerase ii. |
2021-08-11 |
2023-08-13 |
Not clear |
| Sadaf Dorandish, Sarah Atali, Ravel Ray, Hind Al Khashali, Kai-Ling Coleman, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Differences in the Relative Abundance of ProBDNF and Mature BDNF in A549 and H1299 Human Lung Cancer Cell Media. International journal of molecular sciences. vol 22. issue 13. 2021-07-29. PMID:34209215. |
downregulation of either mmp2 or mmp9 by sirna showed that mmp9 sirna treatment of either a549 or h1299 cells resulted in decreased cell viability and increased apoptosis, an effect diminished upon the same treatment with probdnf immunodepleted media, suggesting that mmp9 regulates the cytotoxic effects induced by probdnf in lung cancer cells. |
2021-07-29 |
2023-08-13 |
human |
| Abdolamir Ghadaksaz, Abbas Ali Imani Fooladi, Hamideh Mahmoodzadeh Hosseini, Taher Nejad Satari, Mohsen Ami. ARA-linker-TGFαL3: a novel chimera protein to target breast cancer cells. Medical oncology (Northwood, London, England). vol 38. issue 8. 2021-07-27. PMID:34273028. |
moreover, rt-pcr was conducted to study the expression of apoptosis (bax, bcl2, and casp3), angiogenesis (vegfr2), and metastasis (mmp2 and mmp9) genes. |
2021-07-27 |
2023-08-13 |
Not clear |
| Jia Li, Gang Zhang, Guoqiang W. Effect of paeonol on proliferation, apoptosis, migration, invasion and glutamine of gastric cancer cells via circSFMBT2/miR-665 axis. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 8. 2021-06-27. PMID:34174974. |
for this purpose, the mtt method was used to detect cell viability; flow cytometry experiment was used to detect cell apoptosis; transwell chamber experiment was used to detect cell migration and invasion; western blotting was used to detect the expression levels of mmp2 and mmp9 protein; the decomposition of glutamine was evaluated by detecting the expression levels of glutamine, glutamic acid and α-ketoglutarate (α-kg). |
2021-06-27 |
2023-08-13 |
Not clear |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
downregulation of lncrna tug1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging mir-449b-5p via targeting hmgb1 and mmp2. |
2021-06-10 |
2023-08-13 |
Not clear |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
the levels of inflammation, apoptosis, and the expression of hmgb1 and mmp2 were detected. |
2021-06-10 |
2023-08-13 |
Not clear |
| Yuan Xu, Yulin Niu, Haiyang Li, Guanghui Pa. Downregulation of lncRNA TUG1 attenuates inflammation and apoptosis of renal tubular epithelial cell induced by ischemia-reperfusion by sponging miR-449b-5p via targeting HMGB1 and MMP2. Inflammation. vol 43. issue 4. 2021-06-10. PMID:32206944. |
these findings demonstrated that tug1 silencing attenuates i/r-induced inflammation and apoptosis via targeting mir-449b-5p and regulating hmgb1 and mmp2 expression. |
2021-06-10 |
2023-08-13 |
Not clear |
| Huan Hu, Yang Fu, Meng Li, Huasong Xia, Yue Liu, Xiaopei Sun, Yang Hu, Fulin Song, Xiaoshu Cheng, Ping Li, Yanqing W. Interleukin-35 pretreatment attenuates lipopolysaccharide-induced heart injury by inhibition of inflammation, apoptosis and fibrotic reactions. International immunopharmacology. vol 86. 2021-05-17. PMID:32679538. |
furthermore, decreased number of apoptotic myocardial cells, increased bcl-2 levels and decreased bax levels inhibited apoptosis, and lps-induced upregulation of the expression of cardiac pro-fibrotic genes (mmp2 and mmp9) and fibrotic factor (collagen type i) was inhibited. |
2021-05-17 |
2023-08-13 |
mouse |
| Peng Shen, Yanfeng Chen. Long noncoding RNA lncARSR confers resistance to Adriamycin and promotes osteosarcoma progression. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32404870. |
further investigation revealed that the upregulation of lncarsr enhanced multidrug resistance-associated protein-1 (mrp1), apoptosis inhibitor survivin, and matrix metalloproteinase-2 (mmp2) through activating akt. |
2021-04-07 |
2023-08-13 |
mouse |