| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haixia Yang, Jiupeng Zhou, Jianqiang Mi, Ke Ma, Yangwei Fan, Jing Ning, Chuying Wang, Xin Wei, Huadong Zhao, Enxiao L. HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma. Oncology reports. vol 34. issue 4. 2016-05-20. PMID:26260613. |
the stable overexpression of hoxd10 by lentivirus vector significantly inhibited cell invasion partly by downregulating the expression of mmp2 and mmp9, and significantly increased early apoptosis in ccc cell lines and induced g1 phase cell cycle arrest, contributing to the inhibition of cell proliferation in vitro. |
2016-05-20 |
2023-08-13 |
human |
| Yi Zhang, Xilin Song, Weipeng Gong, Zhenyu Zhu, Xin Liu, Qingsheng Hou, Yanlai Sun, Jie Chai, Lei Zou, Jie Gua. RLIP76 blockade by siRNA inhibits proliferation, enhances apoptosis, and suppresses invasion in HT29 colon cancer cells. Cell biochemistry and biophysics. vol 71. issue 2. 2016-04-21. PMID:25213293. |
our results indicated that rlip76 downregulation in ht29 crc cells suppressed cell growth, enhanced cell apoptosis, induced cell cycle arrest, and inhibited cell invasion by decreasing mmp2 expression. |
2016-04-21 |
2023-08-13 |
human |
| Shuo Chen, Xi Chen, Yin-Ling Xiu, Kai-Xuan Sun, Yang Zha. Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933027. |
mir-106b transfection reduced cell proliferation; promoted g1 or s arrest and apoptosis (p < 0.05); suppressed cell migration and invasion (p < 0.05); reduced ras homolog gene family member c (rhoc), p70 ribosomal s6 kinase (p70s6k), bcl-xl, matrix metallopeptidase 2 (mmp2), mmp9 mrna and protein expression; and induced p53 expression (p < 0.05). |
2016-02-04 |
2023-08-13 |
mouse |
| Qiang Liu, Ran Zou, Rouxi Zhou, Chaofan Gong, Zhifei Wang, Tao Cai, Chaochao Tan, Jiasheng Fan. miR-155 Regulates Glioma Cells Invasion and Chemosensitivity by p38 Isforms In Vitro. Journal of cellular biochemistry. vol 116. issue 7. 2016-01-29. PMID:25535908. |
knockdown of mir-155 enhanced the anticancer effect of tmz on glioma by targeting the mapk13 and mapk14-mediated oxidative stress and apoptosis, but did not affect the secretion of mmp2 and mmp9. |
2016-01-29 |
2023-08-13 |
Not clear |
| Yu Leng Phua, Jessica Y S Chu, April K Marrone, Andrew J Bodnar, Sunder Sims-Lucas, Jacqueline H. Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiological reports. vol 3. issue 10. 2015-10-06. PMID:26438731. |
although the initial lineage specification of foxd1(+) stroma was not perturbed, both the glomerular mesangium and renal interstitium exhibited ectopic apoptosis, which was associated with increased expression of bcl2l11 (bim) and p53 effector genes (bax, trp53inp1, jun, cdkn1a, mmp2, and arid3a). |
2015-10-06 |
2023-08-13 |
mouse |
| Liuying Zheng, Xiaogang Jia, Cheng Zhang, Dong Wang, Zhongnan Cao, Jin Wang, Xinping D. Angiotensin II in atrial structural remodeling: the role of Ang II/JAK/STAT3 signaling pathway. American journal of translational research. vol 7. issue 6. 2015-08-17. PMID:26279747. |
using rat models, we demonstrated that ang ii infusion induced profound changes in the level of apoptosis, expression of collagen subtypes i and iii, caspase-3, caspase-8, mmp1, mmp2 and redistribution of cytochrome c. the data further support the key role of ang ii in the development of af and highlight the specific mechanisms and changes associated with this process. |
2015-08-17 |
2023-08-13 |
human |
| Chenxi Wang, Ting Wu, Xiaojuan Hu, Ritai Huang, Feng Lian, Weijun Wang, Yuan Feng, Bo Xie, Zhenlei Hu, Xinming Zhai, Jidong Liu, Jianmin Gu, Yao Chen, Jun Li, Song Xu. Identification and characterization of CD4(+)AT2(+) T lymphocyte population in human thoracic aortic aneurysm. American journal of translational research. vol 7. issue 2. 2015-04-22. PMID:25901193. |
in conclusion, we have identified a novel population of cd4(+)at2(+) t lymphocytes that show protective effect in taa through inhibition of growth, apoptosis, and mmp2 expression in ecs. |
2015-04-22 |
2023-08-13 |
human |
| Wen-Juan Wang, Yu Yao, Li-Li Jiang, Ting-Hua Hu, Jie-Qun Ma, Zi-Jun Liao, Jun-Tao Yao, Dong-Fan Li, Shu-Hong Wang, Ke-Jun Na. Knockdown of lymphoid enhancer factor 1 inhibits colon cancer progression in vitro and in vivo. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098538. |
furthermore, lef1 knockdown reduced tumor cell viability, invasion capacity, mmp2 and mmp-9 expression, but induced apoptosis. |
2014-04-29 |
2023-08-12 |
mouse |
| Seung Eun Song, Yong-Woon Kim, Jong-Yeon Kim, Dong Hyup Lee, Jae-Ryong Kim, So-Young Par. IGFBP5 mediates high glucose-induced cardiac fibroblast activation. Journal of molecular endocrinology. vol 50. issue 3. 2013-11-01. PMID:23417767. |
while recombinant igfbp5 increased erk phosphorylation, cell proliferation, and the mrna levels of collagen iii, mmp2, and mmp9 in fibroblasts, igfbp5 increased c-jun n-terminal kinase phosphorylation and induced apoptosis in cardiomyocytes. |
2013-11-01 |
2023-08-12 |
rat |
| Bernal-Lopez M Rosa, Llorente-Cortes Vicenta, Gomez-Carrillo Victor, Lopez-Carmona Dolores, Calleja Fernando, Gomez-Huelgas Ricardo, Badimon Lina, Francisco J Tinahone. Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes. Cardiovascular diabetology. vol 11. 2012-12-21. PMID:22828168. |
after analyzing 46 genes, opa showed higher expression levels than ima or fv for genes involved in thrombosis (f3), apoptosis (mmp2, mmp9, timp1 and tim3), lipid metabolism (lrp1 and ndufa), immune response (tlr2) and monocytes adhesion (cd83). |
2012-12-21 |
2023-08-12 |
Not clear |
| M Buchtová, J Stembírek, K Glocová, E Matalová, A S Tucke. Early regression of the dental lamina underlies the development of diphyodont dentitions. Journal of dental research. vol 91. issue 5. 2012-05-30. PMID:22442052. |
cells deactivate epithelial markers (e-cadherin, cytokeratin), up-regulate slug and mmp2, and activate mesenchymal markers (vimentin), while residual lamina cells are removed by apoptosis. |
2012-05-30 |
2023-08-12 |
Not clear |
| Marie-Claude Déry, Parvesh Chaudhry, Valérie Leblanc, Sophie Parent, Anne-Marie Fortier, Eric Asseli. Oxytocin increases invasive properties of endometrial cancer cells through phosphatidylinositol 3-kinase/AKT-dependent up-regulation of cyclooxygenase-1, -2, and X-linked inhibitor of apoptosis protein. Biology of reproduction. vol 85. issue 6. 2012-04-12. PMID:21816851. |
using pharmacological inhibitors, invasion assay, rna interference, and immunofluorescence, we found that ot enhances the invasive properties of hec cells through up-regulation of x-linked inhibitor of apoptosis protein (xiap), matrix-metalloproteinase 2 (mmp2), and matrix-metalloproteinase 14 (mmp14). |
2012-04-12 |
2023-08-12 |
human |
| Pei-Li Yao, Yi-Chen Lin, John H Richbur. Transcriptional suppression of Sertoli cell Timp2 in rodents following mono-(2-ethylhexyl) phthalate exposure is regulated by CEBPA and MYC. Biology of reproduction. vol 85. issue 6. 2012-04-12. PMID:21832167. |
activation of mmp2 is important for triggering germ cell apoptosis and instigating germ cell detachment from sertoli cells. |
2012-04-12 |
2023-08-12 |
rat |
| Wen Ru Yu, Michael G Fehling. Fas/FasL-mediated apoptosis and inflammation are key features of acute human spinal cord injury: implications for translational, clinical application. Acta neuropathologica. vol 122. issue 6. 2012-04-10. PMID:22038545. |
we also found significantly reduced apoptosis, expression of gfap, nf-κb, p-ikappab and iba1, increased number of cd4 positive t cells and mmp2 expression and reduced neurological dysfunction in lpr mice when compared with wt mice after sci. |
2012-04-10 |
2023-08-12 |
mouse |
| Hong Zhu, Yadong Feng, Jie Zhang, Xiqiao Zhou, Bo Hao, Guoxin Zhang, Ruihua Sh. Inhibition of hypoxia inducible factor 1α expression suppresses the progression of esophageal squamous cell carcinoma. Cancer biology & therapy. vol 11. issue 11. 2011-10-03. PMID:21519196. |
our in vitro studies demonstrated that shrna or chemical mediated inhibition of hif-1α led to reduced proliferation and increased apoptosis of esophageal carcinoma cells, as well as the downregulatuion of hif-1α targets vegf, mmp2 and bcl2. |
2011-10-03 |
2023-08-12 |
mouse |
| Valerio M Portela, Angela Veiga, Christopher A Pric. Regulation of MMP2 and MMP9 metalloproteinases by FSH and growth factors in bovine granulosa cells. Genetics and molecular biology. vol 32. issue 3. 2011-07-14. PMID:21637514. |
although we cannot link mmp expression with apoptosis, the specific down regulation by the gonadotropic hormones fsh and igf1 in vitro suggests that excess mmp2 and mmp9 expression is neither required nor desired for follicle development. |
2011-07-14 |
2023-08-12 |
cattle |
| Paola Secchiero, Arianna Gonelli, Federica Corallini, Claudio Ceconi, Roberto Ferrari, Giorgio Zaul. Metalloproteinase 2 cleaves in vitro recombinant TRAIL: potential implications for the decreased serum levels of TRAIL after acute myocardial infarction. Atherosclerosis. vol 211. issue 1. 2010-10-26. PMID:20233617. |
this study was designed to evaluate the potential role of metalloproteinase 2 (mmp2) in promoting the cleavage of tnf-related apoptosis inducing ligand (trail), whose circulating levels are decreased after acute myocardial infarction (ami). |
2010-10-26 |
2023-08-12 |
Not clear |
| Ghulam Mohammad, Renu A Kowlur. Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 9. 2010-09-29. PMID:20479714. |
inhibition of mmp2 ameliorated glucose-induced increase in mitochondrial superoxide and membrane permeability, prevented cytochrome c leakage from the mitochondria, and inhibited capillary cell apoptosis. |
2010-09-29 |
2023-08-12 |
mouse |
| Ghulam Mohammad, Renu A Kowlur. Matrix metalloproteinase-2 in the development of diabetic retinopathy and mitochondrial dysfunction. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 9. 2010-09-29. PMID:20479714. |
these results implicate that, in diabetes, mmp2 activates apoptosis of retinal capillary cells by mitochondrial dysfunction increasing their membrane permeability. |
2010-09-29 |
2023-08-12 |
mouse |
| Pei-Li Yao, Yi-Chen Lin, John H Richbur. Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biology of reproduction. vol 82. issue 3. 2010-06-07. PMID:19828778. |
previously, we reported that sertoli cell injury in rodents after mono-(2-ethylhexyl) phthalate (mehp) exposure results in the activation of matrix metalloproteinase 2 (mmp2) and increases the sensitivity of germ cells to undergo apoptosis. |
2010-06-07 |
2023-08-12 |
mouse |