| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliane Macedo Sobrinho Santos, Rogério Gonçalves da Rocha, Hércules Otacílio Santos, Talita Antunes Guimarães, Carlos Alberto de Carvalho Fraga, Luiz Henrique da Silveira, Paulo Ricardo Batista, Paulo Sérgio Lopes de Oliveira, Geraldo Aclécio Melo, Sérgio Henrique Santos, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães, Lucyana Conceição Faria. Gallic acid modulates phenotypic behavior and gene expression in oral squamous cell carcinoma cells by interfering with leptin pathway. Pathology, research and practice. vol 214. issue 1. 2018-08-30. PMID:29254802. |
the expression levels of cell migration-related genes (mmp2, mmp9, col1a1, and e-cadherin), angiogenesis (hif-1α, mir210), leptin signaling (lepr, p44/42 mapk), apoptosis (casp-3), and secreted leptin levels by oral squamous cell carcinoma cells were also measured. |
2018-08-30 |
2023-08-13 |
Not clear |
| P M Abdul-Muneer, Adriano Andrea Conte, Debanjan Haldar, Mathew Long, Rachel K Patel, Vijayalakshmi Santhakumar, Christopher M Overall, Bryan J Pfiste. Traumatic brain injury induced matrix metalloproteinase2 cleaves CXCL12α (stromal cell derived factor 1α) and causes neurodegeneration. Brain, behavior, and immunity. vol 59. 2018-08-23. PMID:27614125. |
mmp2 has a significant role in neuroinflammation and neurodegeneration by modulating the chemokine cxcl12α (stromal cell derived factor sdf-1α) signaling pathway and the induction of apoptosis. |
2018-08-23 |
2023-08-13 |
rat |
| Xiaoxu Li, Zhicheng Yang, Zewen Han, Yanhui Wen, Zeyun Ma, Yixiang Wan. Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251334. |
in this study, we found that niclosamide could not only inhibit proliferation and promote apoptosis of oral cancer cells, but also inhibited vm formation in vitro and in vivo through downregulation of the expression of vm-related genes vegfa, mmp2, rock1 and cdc42. |
2018-08-23 |
2023-08-13 |
human |
| Jingjing Zhang, Lu Liu, Sai Han, Yi Li, Qiuhong Qian, Qianqian Zhang, Hui Zhang, Ziyan Yang, Youzhong Zhan. B7-H3 is related to tumor progression in ovarian cancer. Oncology reports. vol 38. issue 4. 2018-07-05. PMID:28765941. |
the ability of cell invasion, migration, proliferation decreased after silencing b7-h3 whereas the apoptosis increased, which was related to the upregulation of bax, caspase-8, cleaved caspase-8 and the downregulation of bcl-2, bcl-xl, matrix metalloproteinase-2 (mmp2) by western blotting. |
2018-07-05 |
2023-08-13 |
Not clear |
| Jian-Zhong Hu, Xiao-Kai Wang, Yong Cao, Dong-Zhe Li, Tian-Ding Wu, Tao Zhang, Da-Qi Xu, Hong-Bin L. Tetramethylpyrazine Facilitates Functional Recovery after Spinal Cord Injury by Inhibiting MMP2, MMP9, and Vascular Endothelial Cell Apoptosis. Current neurovascular research. vol 14. issue 2. 2018-03-22. PMID:28294065. |
tetramethylpyrazine facilitates functional recovery after spinal cord injury by inhibiting mmp2, mmp9, and vascular endothelial cell apoptosis. |
2018-03-22 |
2023-08-13 |
Not clear |
| Jason M Knight, Eunji Kim, Ivan Ivanov, Laurie A Davidson, Jennifer S Goldsby, Meredith A J Hullar, Timothy W Randolph, Andrew M Kaz, Lisa Levy, Johanna W Lampe, Robert S Chapki. Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. Physiological genomics. vol 48. issue 9. 2018-01-25. PMID:27401218. |
for example, consistent with a key role of stroma in the crypt niche, mrnas associated with immunoregulatory and inflammatory processes (i.e., cxcl14, antxr1), smooth muscle contraction (cald1), proliferation and apoptosis (glp2r, igfbp3), and modulation of extracellular matrix (mmp2, col3a1, mfap4) were all highly expressed in the stroma. |
2018-01-25 |
2023-08-13 |
human |
| Raffaela Silvestre Ignarro, Gustavo Facchini, Daniela Rodrigues de Melo, Karin Juliane Pelizzaro-Rocha, Carmen Veríssima Ferreira, Roger Frigério Castilho, Fabio Rogeri. Characteristics of sulfasalazine-induced cytotoxicity in C6 rat glioma cells. Neuroscience letters. vol 638. 2017-11-17. PMID:28007652. |
we treated c6 cells with 25μm tmz and/or 0.25mm or 0.5mm sas for 1, 3 or 5days and evaluated viability, apoptosis, total glutathione levels and metalloproteinase mmp2 and mmp9 activities. |
2017-11-17 |
2023-08-13 |
human |
| Tingting Fang, Jiayun Hou, Mingyan He, Lingyan Wang, Minghuan Zheng, Xiangdong Wang, Jinglin Xi. Actinidia chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression. Cell biology and toxicology. vol 32. issue 6. 2017-09-29. PMID:27475644. |
treatment with acroots and ep3 antagonist l-798106 led to decreases in vegf, egfr, mmp2, and mmp9 expression in hcc cells, along with significant effects on growth, migration, invasion, and apoptosis; the effects were reversed/blocked by the ep3 agonist sulprostone. |
2017-09-29 |
2023-08-13 |
Not clear |
| Abhishek Kumar, Priyashree Sunita, Shivesh Jha, Shakti Prasad Pattanaya. Daphnetin inhibits TNF-α and VEGF-induced angiogenesis through inhibition of the IKKs/IκBα/NF-κB, Src/FAK/ERK1/2 and Akt signalling pathways. Clinical and experimental pharmacology & physiology. vol 43. issue 10. 2017-09-12. PMID:27297262. |
dap reduced the elevated mrna expression of inos, mmp2 and also, induced apoptosis in vegf-stimulated huvecs by the caspase-3 dependent pathway. |
2017-09-12 |
2023-08-13 |
human |
| Jian-Hua Xu, Wei-Hua Chang, Hang-Wei Fu, Wei-Qun Shu, Tao Yuan, Ping Che. Upregulated long non-coding RNA LOC90784 promotes cell proliferation and invasion and is associated with poor clinical features in HCC. Biochemical and biophysical research communications. vol 490. issue 3. 2017-08-18. PMID:28651931. |
knockdown of lncrna loc90784 expression inhibited proliferation and induced apoptosis and cell cycle arrest by promoting bax and repressing cdk4 and cyclin d1 protein expression; it also inhibited invasion and migration by repressing mmp2 and mmp9 expression in hcc cells. |
2017-08-18 |
2023-08-13 |
Not clear |
| Yong Wang, Baocun Sun, Huizhi Sun, Xiulan Zhao, Xudong Wang, Nan Zhao, Yanhui Zhang, Yanlei Li, Qiang Gu, Fang Liu, Bing Shao, Jindan A. Regulation of proliferation, angiogenesis and apoptosis in hepatocellular carcinoma by miR-26b-5p. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 8. 2017-02-09. PMID:26891666. |
both in vitro and in vivo studies showed that mir-26b-5p could suppress vascular mimicry (vm) and angiogenesis by down-regulating the expression of ve-cadherin, snail and mmp2 and could inhibit the apoptosis of hcc cells. |
2017-02-09 |
2023-08-13 |
mouse |
| Xiao-Chun Zhao, Ping An, Xiu-Ying Wu, Li-Min Zhang, Bo Long, Yue Tian, Xiao-Ying Chi, Dong-Yi Ton. Overexpression of hSNF2H in glioma promotes cell proliferation, invasion, and chemoresistance through its interaction with Rsf-1. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 6. 2017-02-07. PMID:26666816. |
furthermore, hsnf2h depletion decreased cyclin d1, cyclin e, p-rb, mmp2, ciap1, bcl-2 expression, and phosphorylation of iκbα and p65, suggesting hsnf2h regulates apoptosis through nf-κb pathway. |
2017-02-07 |
2023-08-13 |
human |
| Su-Xiu Chen, Jun-Feng Yin, Bao-Chai Lin, Hua-Fang Su, Zhen Zheng, Cong-Ying Xie, Zheng-Hua Fe. Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 5. 2017-02-06. PMID:26662309. |
furthermore, knockdown of snhg15 expression by sirna could inhibit cell proliferation and invasion and induce apoptosis, while ectopic expression of snhg15 promoted cell proliferation and invasion in gc cells partly via regulating mmp2 and mmp9 protein expression. |
2017-02-06 |
2023-08-13 |
Not clear |
| Shruti Sanjay Taparia, Aparna Khann. Procyanidin-rich extract of natural cocoa powder causes ROS-mediated caspase-3 dependent apoptosis and reduction of pro-MMP-2 in epithelial ovarian carcinoma cell lines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-01-30. PMID:27470560. |
apoptosis and mmp2 downregulation appear to be linked to the increase in intracellular ros levels, caused due to the prooxidant effect of cocoa procyanidin extract. |
2017-01-30 |
2023-08-13 |
human |
| Kai-Xuan Sun, Ying Chen, Shuo Chen, Bo-Liang Liu, Miao-Xiao Feng, Zhi-Hong Zong, Yang Zha. The correlation between microRNA490-3p and TGFα in endometrial carcinoma tumorigenesis and progression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26843615. |
mir-490-3p overexpression reduced proliferation; promoted g1 arrest and apoptosis; suppressed migration and invasion; and reduced tgfα, nf-kb, cyclin d1, survivin, matrix metalloproteinase 2 (mmp2) mrna and protein expression, and improved bax mrna and protein expression. |
2016-12-30 |
2023-08-13 |
mouse |
| Zhong Wu, Pengfei Zan, Shaohua Li, Jie Liu, Jianguang Wang, Dong Chen, Hua Wang, Yongqiang Qian, Linjie Luo, Xiang Huan. Knockdown of WWP1 inhibits growth and invasion, but induces apoptosis of osteosarcoma cells. International journal of clinical and experimental pathology. vol 8. issue 7. 2016-12-14. PMID:26339351. |
furthermore, knocking down wwp1 affected the protein levels of apoptosis (bcl2 and bax) and invasion related factor (mmp2, mmp9, β-catenin and e-cadherin). |
2016-12-14 |
2023-08-13 |
Not clear |
| Andreas Koch, Sven Arke Lang, Peter Johannes Wild, Susanne Gantner, Abdo Mahli, Gerrit Spanier, Mark Berneburg, Martina Müller, Anja Katrin Bosserhoff, Claus Hellerbran. Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget. vol 6. issue 32. 2016-08-09. PMID:26293674. |
glut1 suppressed melanoma cells revealed significantly reduced proliferation, apoptosis resistance, migratory activity and matrix metalloproteinase 2 (mmp2) expression. |
2016-08-09 |
2023-08-13 |
human |
| Andreas Koch, Sven Arke Lang, Peter Johannes Wild, Susanne Gantner, Abdo Mahli, Gerrit Spanier, Mark Berneburg, Martina Müller, Anja Katrin Bosserhoff, Claus Hellerbran. Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget. vol 6. issue 32. 2016-08-09. PMID:26293674. |
treatment of four different human melanoma cell lines with a pharmacological glut1 inhibitor caused a dose-dependent reduction of proliferation, apoptosis resistance, migratory activity and mmp2 expression. |
2016-08-09 |
2023-08-13 |
human |
| Yunita Sari, Hiromi Sanada, Takeo Minematsu, Gojiro Nakagami, Takashi Nagase, Lijuan Huang, Hiroshi Noguchi, Taketoshi Mori, Kotaro Yoshimura, Junko Sugam. Vibration inhibits deterioration in rat deep-tissue injury through HIF1-MMP axis. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 23. issue 3. 2016-06-06. PMID:25801385. |
macroscopic and histological features, hypoxia, oxidative stress, apoptosis, and mmp2 and mmp9 activities in compressed skin were analyzed. |
2016-06-06 |
2023-08-13 |
rat |
| Umut Fahrioğlu, Yavuz Dodurga, Levent Elmas, Mücahit Seçm. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. vol 576. issue 1 Pt 3. 2016-06-03. PMID:26516023. |
expression profiles of certain cell cycle and apoptosis genes such as ccnd1 (cyclin d1),cdk4, cdk6, rb, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, bcl-2, bcl-xl,bid, dr4,dr5,fadd,tradd,parp, apaf, bax, akt, pten, puma, noxa, mmp2, mmp9, timp1 and timp2 were determined by real-time pcr. |
2016-06-03 |
2023-08-13 |
human |