| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deepti Soodgupta, Dipanjan Pan, Grace Cui, Angana Senpan, Xiaoxia Yang, Lan Lu, Katherine N Weilbaecher, Edward V Prochownik, Gregory M Lanza, Michael H Tomasso. Small Molecule MYC Inhibitor Conjugated to Integrin-Targeted Nanoparticles Extends Survival in a Mouse Model of Disseminated Multiple Myeloma. Molecular cancer therapeutics. vol 14. issue 6. 2016-04-12. PMID:25824336. |
an sn 2 lipase-labile prodrug inhibitor of myc-max dimerization (mi1-pd) was developed which decreased cell proliferation and induced apoptosis in cultured multiple myeloma cell lines alone (p < 0.05) and when incorporated into integrin-targeted lipid-encapsulated nps (p < 0.05). |
2016-04-12 |
2023-08-13 |
mouse |
| Kasivelu Govindaraju, Karthikeyan Krishnamoorthy, Suliman A Alsagaby, Ganesan Singaravelu, Mariappan Premanatha. Green synthesis of silver nanoparticles for selective toxicity towards cancer cells. IET nanobiotechnology. vol 9. issue 6. 2016-04-08. PMID:26647807. |
this study suggested that a mechanism underlying the toxicity of ag nps towards cancer cells is due to dna damage and apoptosis. |
2016-04-08 |
2023-08-13 |
human |
| Nilanjana Chatterjee, Baibaswata Bhattacharje. Revelation of ZnS Nanoparticles Induces Follicular Atresia and Apoptosis in the Ovarian Preovulatory Follicles in the Catfish Mystus tengara (Hamilton, 1822). Scientifica. vol 2016. 2016-04-07. PMID:27051555. |
due to exposure at relatively lower concentration of zns nps (250 μg/l), most of the maturing follicles of m. tengara failed to complete the process of vitellogenesis properly and underwent preovulatory atresia followed by oocytic apoptosis. |
2016-04-07 |
2023-08-13 |
Not clear |
| Liting Guo, Haijun Zhang, Fei Wang, Ping Liu, Yonglu Wang, Guohua Xia, Ran Liu, Xueming Li, Haixiang Yin, Hulin Jiang, Baoan Che. Targeted multidrug-resistance reversal in tumor based on PEG-PLL-PLGA polymer nano drug delivery system. International journal of nanomedicine. vol 10. 2016-04-01. PMID:26213467. |
injection of dnr-tet-tf-peg-pll-plga nps into nude mice bearing mdr leukemia cell k562/a02 xenografts was shown to inhibit tumor growth, and contemporaneous immunohistochemical analysis of tumor tissue showed the targeted nps induced apoptosis in tumor cells. |
2016-04-01 |
2023-08-13 |
mouse |
| Dede K W Man, Luca Casettari, Marco Cespi, Giulia Bonacucina, Giovanni Filippo Palmieri, Stephen C W Sze, George P H Leung, Jenny K W Lam, Philip C L Kwo. Oleanolic Acid Loaded PEGylated PLA and PLGA Nanoparticles with Enhanced Cytotoxic Activity against Cancer Cells. Molecular pharmaceutics. vol 12. issue 6. 2016-03-22. PMID:25881668. |
the oa-loaded nps produced significant cytotoxic effects through apoptosis in cancer cell lines. |
2016-03-22 |
2023-08-13 |
Not clear |
| Bing-Feng Zhang, Lei Xing, Peng-Fei Cui, Feng-Zhen Wang, Rong-Lin Xie, Jia-Liang Zhang, Mei Zhang, Yu-Jing He, Jin-Yuan Lyu, Jian-Bin Qiao, Bao-An Chen, Hu-Lin Jian. Mitochondria apoptosis pathway synergistically activated by hierarchical targeted nanoparticles co-delivering siRNA and lonidamine. Biomaterials. vol 61. 2016-03-02. PMID:26004233. |
remarkably, the tcpl/sirna/ppf nps simultaneously released sibcl-2 into the cytoplasm and delivered lnd to mitochondria in the same cancer cell after fa-directed internalization, and even synergistically activated mitochondria apoptosis pathway. |
2016-03-02 |
2023-08-13 |
Not clear |
| A A Shumakova, E N Trushina, O K Mustafina, S Kh Soto, I V Gmoshinsky, S Aa Khotimchenk. [Lead toxicity at its joint administration with nanostructured silica]. Voprosy pitaniia. vol 84. issue 2. 2016-03-01. PMID:26841551. |
no additional adverse effect was noticed in pb co-administration with nps on haematological parameters and hepatocyte apoptosis. |
2016-03-01 |
2023-08-13 |
rat |
| Chao Yu, Zhiguo Zhou, Jun Wang, Jin Sun, Wei Liu, Yanan Sun, Bin Kong, Hong Yang, Shiping Yan. In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro. Journal of hazardous materials. vol 283. 2016-02-23. PMID:25464291. |
firstly, reactive oxygen species (ros) is generated induced by mno@sio2 nps, then p53 is activated followed by an increase in the bax and a decrease in the bcl-2, ultimately leading to g2/m phase arrest, increasing the activity of caspase-3 and inducing apoptosis. |
2016-02-23 |
2023-08-13 |
mouse |
| Qi Wang, Ying Sun, Zhirong Zhang, Yourong Dua. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. vol 56. 2016-02-16. PMID:25934295. |
comparison between peg-modified and non-peg-modified nps showed that peg-modified nps increased k(+) efflux, easily escaped from lysosomes, affected the mitochondria, induced mitochondrial apoptosis, had longer circulation time, and easily targeted tumors. |
2016-02-16 |
2023-08-13 |
Not clear |
| Qi Wang, Ying Sun, Zhirong Zhang, Yourong Dua. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. vol 56. 2016-02-16. PMID:25934295. |
non-peg-modified nps induce the endoplasmic reticulum apoptosis pathway. |
2016-02-16 |
2023-08-13 |
Not clear |
| Qi Wang, Ying Sun, Zhirong Zhang, Yourong Dua. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. vol 56. 2016-02-16. PMID:25934295. |
comparison between positively and negatively charged nps showed that negatively charged nps have less effect on the k(+) efflux of normal cells and more effect on the mitochondrial apoptosis of tumor cells. |
2016-02-16 |
2023-08-13 |
Not clear |
| Priyanka Khare, Madhavi Sonane, Yogendra Nagar, Nida Moin, Shakir Ali, Kailash Chand Gupta, Aruna Satis. Size dependent toxicity of zinc oxide nano-particles in soil nematode Caenorhabditis elegans. Nanotoxicology. vol 9. issue 4. 2016-02-12. PMID:25051332. |
taken together, our study provides evidence that exposure to zno nps disrupts various physiological processes and causes apoptosis in the germ-line even at very low concentration in a size dependent manner. |
2016-02-12 |
2023-08-13 |
caenorhabditis_elegans |
| Guiyin Li, Liangli Cao, Zhide Zhou, Zhencheng Chen, Yong Huang, Yongxiang Zha. Rapamycin loaded magnetic Fe3O4/carboxymethylchitosan nanoparticles as tumor-targeted drug delivery system: Synthesis and in vitro characterization. Colloids and surfaces. B, Biointerfaces. vol 128. 2015-12-28. PMID:25779605. |
the morphology, composition, and properties of the fe3o4/cmcs-rapa nps were characterized by fourier transform infrared spectroscopy (ft-ir), transmission electron microscope (tem), x-ray diffraction (xrd), thermal analysis (tg/dsc), vibration sample magnetometer (vsm), and drug release kinetics, cytotoxicity, cellular uptake, apoptosis studies in vitro. |
2015-12-28 |
2023-08-13 |
human |
| Jian Wu, Xiangyuan Bu, Limei Dou, Liang Fang, Qi She. Co-Delivery of Docetaxel and Berbamine by Chitosan/Sulfobutylether-β-Cyclodextrin Nanoparticles for Enhancing Bioavailability and Anticancer Activities. Journal of biomedical nanotechnology. vol 11. issue 10. 2015-11-20. PMID:26502647. |
the dual-drug cd/cs nps exhibited higher cytotoxicity, cellular uptake, apoptosis and inhibition with the survivin mrna expression. |
2015-11-20 |
2023-08-13 |
Not clear |
| Raju Vivek, Ramar Thangam, Varukattu NipunBabu, Chandrababu Rejeeth, Srinivasan Sivasubramanian, Palani Gunasekaran, Krishnasamy Muthuchelian, Soundarapandian Kanna. Multifunctional HER2-antibody conjugated polymeric nanocarrier-based drug delivery system for multi-drug-resistant breast cancer therapy. ACS applied materials & interfaces. vol 6. issue 9. 2015-11-17. PMID:24780315. |
furthermore, the possible signaling pathway of apoptotic induction in mcf-7 cells was explored by western blotting, and it was demonstrated that drug-loaded plga nps were capable of inducing apoptosis in a caspase-dependent manner. |
2015-11-17 |
2023-08-13 |
Not clear |
| Sergio Anguissola, David Garry, Anna Salvati, Peter J O'Brien, Kenneth A Dawso. High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles. PloS one. vol 9. issue 9. 2015-11-16. PMID:25238162. |
cell lines representative of different organ cell types, including lung, endothelium, liver, kidney, macrophages, glia, and neuronal cells were exposed to 50 nm amine-modified polystyrene (ps-nh2) nps previously reported to induce apoptosis and to 50 nm sulphonated and carboxyl-modified polystyrene nps that were reported to be silent. |
2015-11-16 |
2023-08-13 |
Not clear |
| Sergio Anguissola, David Garry, Anna Salvati, Peter J O'Brien, Kenneth A Dawso. High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles. PloS one. vol 9. issue 9. 2015-11-16. PMID:25238162. |
all cell lines apart from raw 264.7 executed apoptosis in response to ps-nh2 nps, showing specific sequences of ec50 thresholds; lysosomal acidification was the most sensitive parameter. |
2015-11-16 |
2023-08-13 |
Not clear |
| E M Grzincic, J A Yang, J Drnevich, P Falagan-Lotsch, C J Murph. Global transcriptomic analysis of model human cell lines exposed to surface-modified gold nanoparticles: the effect of surface chemistry. Nanoscale. vol 7. issue 4. 2015-11-12. PMID:25491924. |
coated au nps affect genes implicated in proliferation, angiogenesis, and metabolism in hdf cells, and inflammation, angiogenesis, proliferation apoptosis regulation, survival and invasion in pc3 cells. |
2015-11-12 |
2023-08-13 |
human |
| Manasi Das, Wei Duan, Sanjeeb K Saho. Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy. Nanomedicine : nanotechnology, biology, and medicine. vol 11. issue 2. 2015-11-06. PMID:25240596. |
a wide spectrum of in vitro analysis (cellular uptake study, cytotoxicity assay, cell cycle and apoptosis analysis, apoptosis associated proteins study) revealed superior therapeutic potentiality of targeted nps over other formulations in epcam expressing cells. |
2015-11-06 |
2023-08-13 |
Not clear |
| Jiashing Yu, Che-Hao Hsu, Chih-Chia Huang, Po-Yang Chan. Development of therapeutic Au-methylene blue nanoparticles for targeted photodynamic therapy of cervical cancer cells. ACS applied materials & interfaces. vol 7. issue 1. 2015-11-04. PMID:25494339. |
cellular staining examinations showed that the hela cells reacted with au@polymer/mb-tf nps and the 660 nm light excitation triggered pdt, which caused the cells to undergo apoptosis ("programmed" cell death). |
2015-11-04 |
2023-08-13 |
Not clear |