| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Zhao, Hongdan Li, Yijie Shi, Guan Wang, Liwei Liu, Chang Su, Rongjian S. Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78. International journal of nanomedicine. vol 10. 2016-08-19. PMID:25565817. |
our new findings suggest that mab grp78-nps could enhance drug accumulation by effectively transporting nps into cell surface grp78-overexpressed human hepatocellular carcinoma cells and then inhibit cell proliferation and viability and induce cell apoptosis by regulating caspase-3. |
2016-08-19 |
2023-08-13 |
human |
| Jung-Hwa Oh, Mi-Young Son, Mi-Sun Choi, Soojin Kim, A-Young Choi, Hyang-Ae Lee, Ki-Suk Kim, Janghwan Kim, Chang Woo Song, Seokjoo Yoo. Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles. Toxicology and applied pharmacology. vol 299. 2016-08-18. PMID:26551752. |
in addition, ag nps induced cell cycle arrest and apoptosis following a significant increase in oxidative stress in these cells. |
2016-08-18 |
2023-08-13 |
human |
| Cuiping Yang, Fei Xiong, Jun Dou, Jun Xue, Xi Zhan, Fangfang Shi, Miao Li, Songyan Wu, Shouhua Luo, Tianzhu Zhang, Yu Zhang, Ji Ming, Ning G. Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26314844. |
all the treated mice showed decrease in bone lesions, renal damages and anemia but increase in apoptosis compared with the mice treated with nps only. |
2016-08-16 |
2023-08-13 |
mouse |
| Lei Sheng, Ling Wang, Mingyu Su, Xiaoyang Zhao, Renping Hu, Xiaohong Yu, Jie Hong, Dong Liu, Bingqing Xu, Yunting Zhu, Han Wang, Fashui Hon. Mechanism of TiO2 nanoparticle-induced neurotoxicity in zebrafish (Danio rerio). Environmental toxicology. vol 31. issue 2. 2016-08-15. PMID:25059219. |
our data indicated that spatial recognition memory and levels of norepinephrine, dopamine, and 5-hydroxytryptamine were significantly decreased and no levels were markedly elevated, and over proliferation of glial cells, neuron apoptosis, and tio2 np aggregation were observed after low dose exposures of tio2 nps. |
2016-08-15 |
2023-08-13 |
zebrafish |
| Fashui Hong, Yajing Wang, Yingjun Zhou, Qi Zhang, Yushuang Ge, Ming Chen, Jie Hong, Ling Wan. Exposure to TiO2 Nanoparticles Induces Immunological Dysfunction in Mouse Testitis. Journal of agricultural and food chemistry. vol 64. issue 1. 2016-08-11. PMID:26720763. |
the results showed that male mice exhibited significant reduction of fertility, infiltration of inflammatory cells, rarefaction, apoptosis, and/or necrosis of spermatogenic cells and sertoli cells due to tio2 nps. |
2016-08-11 |
2023-08-13 |
mouse |
| Fengqian Chen, Jinming Zhang, Lu Wang, Yitao Wang, Meiwan Che. Tumor pH(e)-triggered charge-reversal and redox-responsive nanoparticles for docetaxel delivery in hepatocellular carcinoma treatment. Nanoscale. vol 7. issue 38. 2016-07-25. PMID:26355843. |
the positively charged nps exhibited a stronger inhibitory effect on cell proliferation, promoted cell cycle arrest in the g2/m phase, and increased the rate of apoptosis. |
2016-07-25 |
2023-08-13 |
mouse |
| De-Sheng Liang, Hai-Tao Su, Yu-Jie Liu, Ai-Ting Wang, Xian-Rong Q. Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-α-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers. Biomaterials. vol 71. 2016-07-12. PMID:26310359. |
in vitro studies demonstrated that the tlpts/hats nps exhibited enhanced intracellular delivery and much better anti-invasion ability, cytotoxicity, and apoptosis against both invasive pc-3 and mda-mb-231 cells as compared to the non-tlyp-1-functionalized hats nps. |
2016-07-12 |
2023-08-13 |
mouse |
| Hongmei Wang, Xin Zhao, Caihong Guo, Dunqiang Ren, Yandong Zhao, Wei Xiao, Wenjie Jia. Aptamer-Dendrimer Bioconjugates for Targeted Delivery of miR-34a Expressing Plasmid and Antitumor Effects in Non-Small Cell Lung Cancer Cells. PloS one. vol 10. issue 9. 2016-06-17. PMID:26406332. |
in addition, we revealed pam-ap/pmir-34a nps significantly inhibited cell growth, migration, invasion and induced apoptosis of lung cancer cells compared with non-targeted nps. |
2016-06-17 |
2023-08-13 |
Not clear |
| Bin Song, YanLi Zhang, Jia Liu, XiaoLi Feng, Ting Zhou, LongQuan Sha. Is Neurotoxicity of Metallic Nanoparticles the Cascades of Oxidative Stress? Nanoscale research letters. vol 11. issue 1. 2016-06-14. PMID:27295259. |
oxidative stress (os), apoptosis, and the inflammatory response are believed to be the main mechanisms underlying the neurotoxicity of metallic nps. |
2016-06-14 |
2023-08-13 |
human |
| Elisabetta Cenni, Sofia Avnet, Donatella Granchi, Caterina Fotia, Manuela Salerno, Dorotea Micieli, Maria Grazia Sarpietro, Rosario Pignatello, Francesco Castelli, Nicola Baldin. The effect of poly(d,l-lactide-co-glycolide)-alendronate conjugate nanoparticles on human osteoclast precursors. Journal of biomaterials science. Polymer edition. vol 23. issue 10. 2016-05-26. PMID:21781381. |
to show if ale retained the antiosteoclastic properties after the conjugation with plga and the production of nps, we treated human osteoclasts, derived from circulating precursors, with plga-ale nps and compared the effects on actin ring generation, apoptosis and type-i collagen degradation with those of free ale and with nps made of pure plga. |
2016-05-26 |
2023-08-12 |
human |
| Elisabetta Cenni, Sofia Avnet, Donatella Granchi, Caterina Fotia, Manuela Salerno, Dorotea Micieli, Maria Grazia Sarpietro, Rosario Pignatello, Francesco Castelli, Nicola Baldin. The effect of poly(d,l-lactide-co-glycolide)-alendronate conjugate nanoparticles on human osteoclast precursors. Journal of biomaterials science. Polymer edition. vol 23. issue 10. 2016-05-26. PMID:21781381. |
plga-ale nps disrupted actin ring, induced apoptosis and inhibited collagen degradation. |
2016-05-26 |
2023-08-12 |
human |
| Ester Boix-Garriga, Pilar Acedo, Ana Casadó, Angeles Villanueva, Juan Carlos Stockert, Magdalena Cañete, Margarita Mora, Maria Lluïsa Sagristá, Santi Nonel. Poly(D, L-lactide-co-glycolide) nanoparticles as delivery agents for photodynamic therapy: enhancing singlet oxygen release and photototoxicity by surface PEG coating. Nanotechnology. vol 26. issue 36. 2016-05-23. PMID:26293792. |
plga nps are internalized by endocytosis, deliver their cargo to lysosomes and induce cell death by apoptosis upon exposure to light. |
2016-05-23 |
2023-08-13 |
Not clear |
| Li-fu Miao, Yong-liang Cui, Yan-ping Yin, Lian-feng Chen, Hua Zhang, Pei-mao Liu, Wen-ling Zhu, Cun-Xian Song, Jing Yan. [Effects of Rapamycin and Rapamycin-loaded Poly(lactic-co-glycolic)Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27(kip1) Proteins of Human Umbilical Arterial Vascular Smooth Muscle Cell]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 37. issue 6. 2016-05-20. PMID:26725384. |
to investgate the effects of rapamycin(rpm)and rpm-loaded poly(lactic-co-glycolic)acid(plga)nanoparticles(nps)on the apoptosis of human umbilical arterial vascular smooth muscle cells(huasmcs)in vitro and expression of bcl-2 and p27(kip1) protein. |
2016-05-20 |
2023-08-13 |
human |
| Caixia Wang, Xiaoke Hu, Yan Gao, Yinglu J. ZnO Nanoparticles Treatment Induces Apoptosis by Increasing Intracellular ROS Levels in LTEP-a-2 Cells. BioMed research international. vol 2015. 2016-05-18. PMID:26339612. |
results showed that zno nps (≥ 0.01 μg/ml) significantly inhibited proliferation (p < 0.05) and induced substantial apoptosis in ltep-a-2 cells after 4 h of exposure. |
2016-05-18 |
2023-08-13 |
human |
| Caixia Wang, Xiaoke Hu, Yan Gao, Yinglu J. ZnO Nanoparticles Treatment Induces Apoptosis by Increasing Intracellular ROS Levels in LTEP-a-2 Cells. BioMed research international. vol 2015. 2016-05-18. PMID:26339612. |
the intracellular ros level rose up to 30-40% corresponding to significant depletion (approximately 70-80%) in gsh content in ltep-a-2 cells (p < 0.05), suggesting that zno nps induced apoptosis mainly through increased ros production. |
2016-05-18 |
2023-08-13 |
human |
| Violet Aileen Senapati, Abhishek Kumar Jain, Govind Sharan Gupta, Alok Kumar Pandey, Alok Dhawa. Chromium oxide nanoparticle-induced genotoxicity and p53-dependent apoptosis in human lung alveolar cells. Journal of applied toxicology : JAT. vol 35. issue 10. 2016-05-17. PMID:26086747. |
further, the oxygen species led to a decrease in mitochondrial membrane potential and an increase in the ratio of bax/bcl-2 leading to mitochondria-mediated apoptosis induced by cr2 o3 nps, which ultimately leads to cell death. |
2016-05-17 |
2023-08-13 |
human |
| Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun, Xianzheng Wu, Liming Cheng, Jing Zhang, Shilong Wan. Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cells through the PI3K signaling pathway. Nanoscale. vol 7. issue 25. 2016-05-13. PMID:26060037. |
evaluation of cell viability, lactate dehydrogenase release, ros generation and apoptosis demonstrated the low cytotoxicity of ldh nps. |
2016-05-13 |
2023-08-13 |
mouse |
| S Sruthi, P V Mohana. Investigation on cellular interactions of astrocytes with zinc oxide nanoparticles using rat C6 cell lines. Colloids and surfaces. B, Biointerfaces. vol 133. 2016-05-02. PMID:26057374. |
the mode of cell death induced by zno nps was apoptosis as revealed by the nuclear condensation studies, live dead assay using acridine orange/ethidium bromide and apoptosis detection kit. |
2016-05-02 |
2023-08-13 |
rat |
| Wen Bao, Ran Liu, Yonglu Wang, Fei Wang, Guohua Xia, Haijun Zhang, Xueming Li, Haixiang Yin, Baoan Che. PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway. International journal of nanomedicine. vol 10. 2016-04-21. PMID:25609961. |
in summary, the results obtained from this study showed that the novel nps dds could improve the efficacy of dnr in the treatment of leukemia and induce apoptosis via intrinsic pathway. |
2016-04-21 |
2023-08-13 |
Not clear |
| Abhishek Aggarwal, Julia Höbaus, Samawansha Tennakoon, Maximilian Prinz-Wohlgenannt, João Graça, Sally A Price, Petra Heffeter, Walter Berger, Sabina Baumgartner-Parzer, Enikö Kálla. Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt B. 2016-04-19. PMID:25758239. |
1,25-d3 enhanced the anti-proliferative effects of ca(2+) and induced differentiation and apoptosis only in cells with a functional casr, which were further enhanced in the presence of nps r-568, a positive allosteric modulator of casr. |
2016-04-19 |
2023-08-13 |
mouse |