| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingbo Yang, Yinfa M. Irradiation-Enhanced Cytotoxicity of Zinc Oxide Nanoparticles. International journal of toxicology. vol 33. issue 3. 2018-01-17. PMID:24700570. |
although recent studies have shown the cytotoxic effects of these nps, including oxidative stress, apoptosis and necrosis induction, genotoxicity, and others, irradiation-induced cytotoxicity has not been systematically studied. |
2018-01-17 |
2023-08-13 |
Not clear |
| Andrew M Hall, Ruth Hemmer, Robert Spaulding, Hanna N Wetzel, Joseph Curcio, Bernhard A Sabel, Petra Henrich-Noack, Sarah Pixley, Tracy Hopkins, Richard L Boyce, Patrick J Schultheis, Kristi L Hai. Cytotoxicity and apoptotic gene expression in an in vitro model of the blood-brain barrier following exposure to poly(butylcyanoacrylate) nanoparticles. Journal of drug targeting. vol 24. issue 7. 2018-01-17. PMID:26707984. |
methods the co-cultures were exposed to uncoated pbca nps, pbca-ps80 nps or pbca-ps80-dox nps at varying concentrations and evaluated using a resazurin-based cytotoxicity assay and an 84-gene apoptosis rt-pcr array. |
2018-01-17 |
2023-08-13 |
rat |
| Ankit Saneja, Robin Kumar, Amarinder Singh, Ravindra Dhar Dubey, Mubashir J Mintoo, Gurdarshan Singh, Dilip M Mondhe, Amulya K Panda, Prem N Gupt. Development and evaluation of long-circulating nanoparticles loaded with betulinic acid for improved anti-tumor efficacy. International journal of pharmaceutics. vol 531. issue 1. 2018-01-10. PMID:28823888. |
the enhanced cytotoxicity of ba nps was also supported by increased cellular apoptosis, mitochondrial membrane potential loss, generation of high reactive oxygen species (ros) and cell cycle arrest. |
2018-01-10 |
2023-08-13 |
mouse |
| Mahboubeh Ebrahimian, Sahar Taghavi, Ahad Mokhtarzadeh, Mohammad Ramezani, Maryam Hashem. Co-delivery of Doxorubicin Encapsulated PLGA Nanoparticles and Bcl-xL shRNA Using Alkyl-Modified PEI into Breast Cancer Cells. Applied biochemistry and biotechnology. vol 183. issue 1. 2018-01-02. PMID:28236188. |
in this study, alkyl-modified polyethylenimine (pei 10 kd) was used for co-delivery of doxorubicin (dox) encapsulated into poly lactic-co-glycolic acid (plga) nanoparticles (nps) and bcl-xl shrna (one class of molecules that block apoptosis of tumor cells) into breast cancer cells. |
2018-01-02 |
2023-08-13 |
Not clear |
| Lei Zhao, Guojun Chen, Jun Li, Yingmei Fu, Timur A Mavlyutov, Annie Yao, Robert W Nickells, Shaoqin Gong, Lian-Wang Gu. An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration. Journal of controlled release : official journal of the Controlled Release Society. vol 247. 2017-12-28. PMID:28063892. |
consistent with s1r functions, targeted nps relative to non-targeted nps showed markedly better inhibitory effects on apoptosis and oxidative/inflammatory stresses in the rgc layer. |
2017-12-28 |
2023-08-13 |
mouse |
| Shiqian Gao, Huayu Tian, Zhenkai Xing, Dawei Zhang, Ye Guo, Zhaopei Guo, Xiaojuan Zhu, Xuesi Che. A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment. Journal of controlled release : official journal of the Controlled Release Society. vol 243. 2017-12-27. PMID:27794494. |
moreover, the ppa/hsv-tk nps showed remarkably anti-glioma effect and survival benefit in an invasive orthotopic human gbm mouse model through inhibiting proliferation and inducing apoptosis (p<0.05 vs control). |
2017-12-27 |
2023-08-13 |
mouse |
| Cong Luo, Lei Miao, Yi Zhao, Sara Musetti, Yuhua Wang, Kai Shi, Leaf Huan. A novel cationic lipid with intrinsic antitumor activity to facilitate gene therapy of TRAIL DNA. Biomaterials. vol 102. 2017-12-19. PMID:27344367. |
dobp-lpd-trail nps demonstrated distinct superiority in delaying tumor progression over dotap-lpd-trail nps, due to the intrinsic antitumor activity combined with trail-induced apoptosis in the tumor. |
2017-12-19 |
2023-08-13 |
human |
| Jing Yang, Shifu Hu, Meng Rao, Lixia Hu, Hui Lei, Yanqing Wu, Yingying Wang, Dandan Ke, Wei Xia, Chang-Hong Zh. Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats. International journal of nanomedicine. vol 12. 2017-12-18. PMID:28860760. |
the results demonstrated that the cu nps exhibited obvious accumulation in the rat ovaries, leading to ovarian injury, an imbalance of sex hormones, and ovarian cell apoptosis. |
2017-12-18 |
2023-08-13 |
rat |
| Divya Arora, Amit Kumar, Prasoon Gupta, Gousia Chashoo, Sundeep Jagla. Preparation, characterization and cytotoxic evaluation of bovine serum albumin nanoparticles encapsulating 5-methylmellein: A secondary metabolite isolated from Xylaria psidii. Bioorganic & medicinal chemistry letters. vol 27. issue 23. 2017-12-18. PMID:29100800. |
the enhancement in cytotoxicity of 5-mm bsa nps was also supported by increase in cellular apoptosis, mitochondrial membrane potential loss and generation of high reactive oxygen species (ros). |
2017-12-18 |
2023-08-13 |
human |
| Nisar Ul Khaliq, Febrina Carolina Sandra, Dal Yong Park, Jae Young Lee, Keun Sang Oh, Dongkyu Kim, Youngro Byun, In-San Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yu. Doxorubicin/heparin composite nanoparticles for caspase-activated prodrug chemotherapy. Biomaterials. vol 101. 2017-12-12. PMID:27286189. |
with the accumulation of the composite nps in the tumor tissue by the enhanced permeation and retention (epr) effect, a small exposure of dox in the tumor cells initiated apoptosis in a localized area of the tumor tissue, which induced caspase-3 activation. |
2017-12-12 |
2023-08-13 |
Not clear |
| Sandesh Chibber, Rishi Shanke. Can CuO nanoparticles lead to epigenetic regulation of antioxidant enzyme system? Journal of applied toxicology : JAT. vol 37. issue 1. 2017-12-04. PMID:27687502. |
accordingly, the main cause for induction of toxicity by cuo nps is the generation of reactive oxygen species (ros) followed by the mitochondrial destruction that leads to apoptosis via the intrinsic pathway or under the condition such as hypoxia cell on exposure to cuo nps may commit to necrosis. |
2017-12-04 |
2023-08-13 |
human |
| Basmah A Othman, Christina Greenwood, Ayman F Abuelela, Anil A Bharath, Shu Chen, Ioannis Theodorou, Trevor Douglas, Maskai Uchida, Mary Ryan, Jasmeen S Merzaban, Alexandra E Porte. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Advanced healthcare materials. vol 5. issue 11. 2017-11-20. PMID:27275627. |
correlative light-electron microscopy shows that nps dissolve into ionic zn(2+) (blue) upon uptake and cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. |
2017-11-20 |
2023-08-13 |
Not clear |
| Mingyu He, Lillian Ro, Jing Liu, Chih-Chang Ch. Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells. Journal of biomedical materials research. Part A. vol 105. issue 2. 2017-11-02. PMID:27706899. |
the ga at 2 µg/ml concentration delivered by the fa-arg-peuu np carriers had higher cytotoxicity and induced a higher apoptosis percentage against folate receptor (fr)-overexpressed hela or hct116 than arg-peuu nps. |
2017-11-02 |
2023-08-13 |
Not clear |
| Paromita Kundu, Manasi Das, Kalpalata Tripathy, Sanjeeb K Saho. Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease. ACS chemical neuroscience. vol 7. issue 12. 2017-10-20. PMID:27642670. |
in vitro results demonstrated augmented inhibition of αs protein into oligomers and fibrils, reduced rotenone induced toxicity, oxidative stress, and apoptosis, and activation of autophagic pathway by dual drug loaded nps compared to native counterpart. |
2017-10-20 |
2023-08-13 |
mouse |
| Fei Gao, Jinming Zhang, Chaomei Fu, Xiaoming Xie, Fu Peng, Jieshu You, Hailin Tang, Zhiyu Wang, Peng Li, Jianping Che. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. International journal of nanomedicine. vol 12. 2017-10-16. PMID:28615942. |
compared to free isl and non-irgd-modified counterparts, isl-irgd nps showed higher cytotoxicity and cell apoptosis against the different type of breast cancer cells. |
2017-10-16 |
2023-08-13 |
mouse |
| Sudeshna Mukherjee, Sayan Ghosh, Dipesh Kr Das, Priyanka Chakraborty, Sreetama Choudhury, Payal Gupta, Arghya Adhikary, Sanjit Dey, Sreya Chattopadhya. Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection--synthesis, characterization and in vitro evaluation. The Journal of nutritional biochemistry. vol 26. issue 11. 2017-09-25. PMID:26310506. |
these nps significantly decreased nuclear translocation of nf-κb, coupled with decreased phosphorylation of iĸb and down-regulation of nf-κb-dependent anti-apoptotic proteins bcl2 and akt in a dose-dependent manner, triggering onset of apoptosis. |
2017-09-25 |
2023-08-13 |
mouse |
| Yi Cao, Jimin Long, Liangliang Liu, Tong He, Leying Jiang, Chunxue Zhao, Zhen L. A review of endoplasmic reticulum (ER) stress and nanoparticle (NP) exposure. Life sciences. vol 186. 2017-09-19. PMID:28782531. |
meanwhile, nanomedicinal studies also used er stress inducing nps or nps loaded with er stress inducer to selectively induce er stress mediated apoptosis in cancer cells for cancer therapy. |
2017-09-19 |
2023-08-13 |
human |
| Mansour I Almansour, Mosaid A Alferah, Ziad A Shraideh, Bashir M Jarra. Zinc oxide nanoparticles hepatotoxicity: Histological and histochemical study. Environmental toxicology and pharmacology. vol 51. 2017-08-08. PMID:28236584. |
in comparison with the control rats, the following histological and histochemical alterations were demonstrated in the hepatic tissues of rats exposed to zno nps: sinusoidal dilatation, kupffer cells hyperplasia, lobular and portal triads inflammatory cells infiltration, necrosis, hydropic degeneration, hepatocytes apoptosis, anisokaryosis, karyolysis, nuclear membrane irregularity, glycogen content depletion and hemosidrosis. |
2017-08-08 |
2023-08-13 |
human |
| Jing Tian, Shasha Xu, Hongbing Deng, Xinxing Song, Xiujuan Li, Jiajia Chen, Feng Cao, Bin L. Fabrication of self-assembled chitosan-dispersed LDL nanoparticles for drug delivery with a one-step green method. International journal of pharmaceutics. vol 517. issue 1-2. 2017-06-13. PMID:27845214. |
in addition, flow cytometry and terminal-deoxynucleotidyl-transferase-mediated dutp nick-end labeling assay demonstrated that cs-ldl-dox nps induced the apoptosis of cancer cells. |
2017-06-13 |
2023-08-13 |
Not clear |
| Sumeet Kapoor, Dikishi Gupta, Manoj Kumar, Sapna Sharma, Amit K Gupta, M M Misro, Harpal Sing. Intracellular delivery of peptide cargos using polyhydroxybutyrate based biodegradable nanoparticles: Studies on antitumor efficacy of BCL-2 converting peptide, NuBCP-9. International journal of pharmaceutics. vol 511. issue 2. 2017-05-18. PMID:27492021. |
confocal laser microscopy confirmed efficient cellular uptake and induction of apoptosis by peptide loaded nps in a time dependent manner. |
2017-05-18 |
2023-08-13 |
mouse |