| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yating Xiao, Jing Liu, Mengyu Guo, Huige Zhou, Jun Jin, Jiaming Liu, Ying Liu, Zhanjun Zhang, Chunying Che. Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance. Nanoscale. vol 10. issue 26. 2019-01-30. PMID:29943786. |
these spherical cst/dox nps can improve the water-solubility of cst, reduce the dosage of dox, and therefore significantly enhance cellular drug accumulation by activating heat shock factor 1 (hsf-1) and inhibiting nf-κb to depress p-gp expression, which results in apoptosis and autophagy of dox resistant cells through the ros/jnk signaling pathway. |
2019-01-30 |
2023-08-13 |
Not clear |
| Xing Chen, Xiang Ling, Lili Zhao, Fei Xiong, Geoffrey Hollett, Yang Kang, Austin Barrett, Jun W. Biomimetic Shells Endow Sub-50 nm Nanoparticles with Ultrahigh Paclitaxel Payloads for Specific and Robust Chemotherapy. ACS applied materials & interfaces. vol 10. issue 40. 2019-01-23. PMID:30203956. |
in vitro results showed that after being trafficked through caveolae-mediated endocytosis, app1i@e nps successfully escaped from endo-/lysosomes and then rapidly released cargos in the acidic cytosol, which continued to enhance cytotoxicity by mitochondrial control of apoptosis and suppression of microtubule dynamics. |
2019-01-23 |
2023-08-13 |
Not clear |
| Xiaoli Cai, Yanan Luo, Yang Song, Dong Liu, Hongye Yan, He Li, Dan Du, Chengzhou Zhu, Yuehe Li. Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy. Nanoscale. vol 10. issue 48. 2018-12-26. PMID:30500027. |
in a combination of the peroxidase-like pt nps with mitochondria-targeting ability of tpp, a reactive oxygen species (ros) burst in the mitochondria was achieved and resulted in the cell apoptosis. |
2018-12-26 |
2023-08-13 |
Not clear |
| Mahaveer P Purohit, Neeraj K Verma, Aditya K Kar, Amrita Singh, Debabrata Ghosh, Satyakam Patnai. Inhibition of Thioredoxin Reductase by Targeted Selenopolymeric Nanocarriers Synergizes the Therapeutic Efficacy of Doxorubicin in MCF7 Human Breast Cancer Cells. ACS applied materials & interfaces. vol 9. issue 42. 2018-12-19. PMID:28945070. |
detailed molecular studies on mcf7 cells also established that upon exposure to se@cmha-dox nps, mcf7 cells endure g2/m cell cycle arrest and p53-mediated caspase-independent apoptosis. |
2018-12-19 |
2023-08-13 |
human |
| Xiang Ling, Xing Chen, Imogen A Riddell, Wei Tao, Junqing Wang, Geoffrey Hollett, Stephen J Lippard, Omid C Farokhzad, Jinjun Shi, Jun W. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano letters. vol 18. issue 7. 2018-12-14. PMID:29902013. |
following systematic screening, the optimized nps (referred to as cp5 nps) showed a small particle size (76.2 nm), high loading of pt(iv) prodrugs (15.50% pt), a sharp response to gsh, the rapid release of platinum (pt) ions, and notable apoptosis of cisplatin-resistant a2780cis cells. |
2018-12-14 |
2023-08-13 |
Not clear |
| Elham Ahmadian, Solmaz Maleki Dizaj, Elaheh Rahimpour, Amir Hasanzadeh, Aziz Eftekhari, Hasan Hosain Zadegan, Jamal Halajzadeh, Hale Ahmadia. Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line. Materials science & engineering. C, Materials for biological applications. vol 93. 2018-12-12. PMID:30274079. |
ag nps cytotoxicity was associated with induction of ros and cell apoptosis in hepg2 cell line. |
2018-12-12 |
2023-08-13 |
human |
| N Sanoj Rejinold, Yunho Han, Jisang Yoo, Hae Yong Seok, Ji Ho Park, Yeu-Chun Ki. Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29382898. |
the developed ptx loaded mn:zns nps with different cpps (pen, pvec and r9) showed enhanced anti-cancer effect compared to bare ptx, which has been validated by mtt assay followed by apoptosis assay and dna fragmentation analysis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qian Lv, Meng-Yue Gao, Zi-He Cheng, Qiao Chen, Ai-Guo Shen, Ji-Ming H. Rational synthesis of hollow cubic CuS@Spiky Au core-shell nanoparticles for enhanced photothermal and SERS effects. Chemical communications (Cambridge, England). vol 54. issue 95. 2018-11-27. PMID:30426112. |
hollow cubic cus@spiky au core-shell nanoparticles (nps) were rationally synthesized both for guided highly efficient damage to cancer cells by the photothermal effect and for the real-time monitoring of biochemical responses during cellular apoptosis, totally based on label-free sers intracellular imaging. |
2018-11-27 |
2023-08-13 |
Not clear |
| Giovanna Gomes Lara, Gracielle Ferreira Andrade, Marcelo Fernandes Cipreste, Wellington Marcos da Silva, Pedro Lana Gastelois, Dawidson Assis Gomes, Marcelo Coutinho de Miranda, Waldemar Augusto de Almeida Macedo, Maria Jose Neves, Edésia Martins Barros de Sous. Protection of normal cells from irradiation bystander effects by silica-flufenamic acid nanoparticles. Journal of materials science. Materials in medicine. vol 29. issue 8. 2018-11-26. PMID:30074096. |
our results show that mcm-41 and functionalized samples have high biocompatibility with mcr-5 and hela cells, and most importantly, the ffa delivered by these nps was able to halt apoptosis, one of main bystander effects. |
2018-11-26 |
2023-08-13 |
Not clear |
| By Jihye Choi, Kyung Oh Jung, Edward E Graves, Guillem Prat. A gold nanoparticle system for the enhancement of radiotherapy and simultaneous monitoring of reactive-oxygen-species formation. Nanotechnology. vol 29. issue 50. 2018-11-26. PMID:30229748. |
these nps were able to effectively radiosensitize cells, as measured by increased cell apoptosis following rt. |
2018-11-26 |
2023-08-13 |
Not clear |
| Zhenyu Duan, Hao Cai, Hu Zhang, Kai Chen, Ning Li, Zhuping Xu, Qiyong Gong, Kui Lu. PEGylated Multistimuli-Responsive Dendritic Prodrug-Based Nanoscale System for Enhanced Anticancer Activity. ACS applied materials & interfaces. vol 10. issue 42. 2018-11-26. PMID:30246536. |
in vitro studies on dox released from the nps induced mitochondrial dysfunction during apoptosis. |
2018-11-26 |
2023-08-13 |
mouse |
| Zhenyu Duan, Hao Cai, Hu Zhang, Kai Chen, Ning Li, Zhuping Xu, Qiyong Gong, Kui Lu. PEGylated Multistimuli-Responsive Dendritic Prodrug-Based Nanoscale System for Enhanced Anticancer Activity. ACS applied materials & interfaces. vol 10. issue 42. 2018-11-26. PMID:30246536. |
in the 4t1 breast cancer model, these nps exhibited a superior antitumor efficacy confirmed by inhibiting angiogenesis, proliferation of tumor tissues, and inducing procedural apoptosis of tumor cells. |
2018-11-26 |
2023-08-13 |
mouse |
| Nisha Bara, Gautam Kau. Enhanced steroidogenic and altered antioxidant response by ZnO nanoparticles in mouse testis Leydig cells. Toxicology and industrial health. vol 34. issue 8. 2018-11-20. PMID:29768980. |
our findings confirm the adverse effects of zno nps by being cytotoxic, enhancing apoptosis, causing steroidogenic effect in leydig cells and increasing autophagic vacuole formation possibly via alteration of antioxidant enzyme activity in tm3 cells. |
2018-11-20 |
2023-08-13 |
mouse |
| Hongying Liang, Tong He, Jimin Long, Liangliang Liu, Guochao Liao, Yanhuai Ding, Yi Ca. Influence of bovine serum albumin pre-incubation on toxicity and ER stress-apoptosis gene expression in THP-1 macrophages exposed to ZnO nanoparticles. Toxicology mechanisms and methods. vol 28. issue 8. 2018-11-08. PMID:29783874. |
exposure to zno nps promoted the expression of endoplasmic reticulum (er) stress markers (ddit3 and xbp-1s) and apoptosis genes (casp9 and casp12). |
2018-11-08 |
2023-08-13 |
cattle |
| Manisha Kumari, Mahaveer Prasad Purohit, Satyakam Patnaik, Yogeshwer Shukla, Pradeep Kumar, Kailash Chand Gupt. Curcumin loaded selenium nanoparticles synergize the anticancer potential of doxorubicin contained in self-assembled, cell receptor targeted nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. vol 130. 2018-11-05. PMID:29969665. |
combination of these nanoparticles (nps) increased ros level, decreased mitochondrial membrane potential, induced cell cycle arrest and apoptosis in hct116 cells. |
2018-11-05 |
2023-08-13 |
mouse |
| Rammohan Devulapally, Kira Foygel, Thillai V Sekar, Juergen K Willmann, Ramasamy Paulmuruga. Gemcitabine and Antisense-microRNA Co-encapsulated PLGA-PEG Polymer Nanoparticles for Hepatocellular Carcinoma Therapy. ACS applied materials & interfaces. vol 8. issue 49. 2018-11-01. PMID:27960411. |
flow cytometry analysis showed that control nps and antisense-mirna-21-loaded nps are not cytotoxic to both hcc cell lines, whereas treatment with free gem and gem-loaded nps resulted in ∼9% and ∼15% apoptosis, respectively. |
2018-11-01 |
2023-08-13 |
human |
| Yanqiu Liu, Xiujuan Zhang, Mengjiao Zhou, Xueyan Nan, Xianfeng Chen, Xiaohong Zhan. Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance. ACS applied materials & interfaces. vol 9. issue 50. 2018-11-01. PMID:29171954. |
detailed mechanism studies reveal that tpp-lnd-dox nps could induce significant reactive oxygen species production, mitochondrial membrane potential decrease, and mitochondrial apoptosis pathway, thereby leading to great cytotoxicity in cancer cells. |
2018-11-01 |
2023-08-13 |
Not clear |
| Yanqiu Liu, Xiujuan Zhang, Mengjiao Zhou, Xueyan Nan, Xianfeng Chen, Xiaohong Zhan. Mitochondrial-Targeting Lonidamine-Doxorubicin Nanoparticles for Synergistic Chemotherapy to Conquer Drug Resistance. ACS applied materials & interfaces. vol 9. issue 50. 2018-11-01. PMID:29171954. |
this work demonstrates the potential use of our tpp-lnd-dox nps to jointly promote the mitochondria apoptosis pathway and contribute to conquer drug resistance in cancer therapy. |
2018-11-01 |
2023-08-13 |
Not clear |
| Vanna Sanna, Chandra K Singh, Rahime Jashari, Vaqar M Adhami, Jean Christopher Chamcheu, Islam Rady, Mario Sechi, Hasan Mukhtar, Imtiaz A Siddiqu. Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapy. Scientific reports. vol 7. 2018-10-18. PMID:28145499. |
the behavior of egcg encapsulated in nps in modulating apoptosis and cell-cycle, was also determined. |
2018-10-18 |
2023-08-13 |
mouse |
| Hongliang Yu, Jian He, Qian Lu, Da Huo, Shanmei Yuan, Zhengyang Zhou, Peipei Xu, Yong H. Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS applied materials & interfaces. vol 8. issue 44. 2018-10-16. PMID:27754664. |
due to the high level of mmp expressed by tumor cells inside the tumor tissue, these nps would shed their peg layers, resulting in the exposure of anti-fas antibody to bind the fas receptor and triggering the apoptosis of tumor cells. |
2018-10-16 |
2023-08-13 |
Not clear |