| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shutao Guo, C Michael Lin, Zhenghong Xu, Lei Miao, Yuhua Wang, Leaf Huan. Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation. ACS nano. vol 8. issue 5. 2015-11-02. PMID:24720540. |
furthermore, plga nps containing both cisplatin cores and rapa induced significant apoptosis on a375-luc human melanoma cells in vitro. |
2015-11-02 |
2023-08-13 |
human |
| Yi Xie, Binbin Wang, Fanchi Li, Lie Ma, Min Ni, Weide Shen, Fashui Hong, Bing L. Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971466. |
furthermore, digital gene expression profile (dge) analysis and real time quantitative pcr (qrt-pcr) assay revealed that tio2 nps pretreatment inhibited the up-regulated expression of ace1, cytochrome c, caspase-9, caspase-3, bm109 and down-regulated expression of bmiap caused by phoxim; these genes are involved in nerve conduction, oxidative stress and apoptosis. |
2015-10-28 |
2023-08-13 |
Not clear |
| Lei Sheng, Yuguan Ze, Ling Wang, Xiaohong Yu, Jie Hong, Xiaoyang Zhao, Xiao Ze, Dong Liu, Bingqing Xu, Yunting Zhu, Yi Long, Anan Lin, Chi Zhang, Yue Zhao, Fashui Hon. Mechanisms of TiO2 nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons. Journal of biomedical materials research. Part A. vol 103. issue 3. 2015-10-26. PMID:25045142. |
in this study, primary cultured hippocampal neurons from one-day-old fetal sprague-dawley rats were exposed to 5, 15, or 30 µg/ml tio2 nps for 24 h, we investigated cell viability, ultrastructure, and mitochondrial membrane potential (mmp), calcium homeostasis, oxidative stress, antioxidant capacity, apoptotic signaling pathway associated with the primary cultured hippocamal neuron apoptosis. |
2015-10-26 |
2023-08-13 |
rat |
| Lei Sheng, Yuguan Ze, Ling Wang, Xiaohong Yu, Jie Hong, Xiaoyang Zhao, Xiao Ze, Dong Liu, Bingqing Xu, Yunting Zhu, Yi Long, Anan Lin, Chi Zhang, Yue Zhao, Fashui Hon. Mechanisms of TiO2 nanoparticle-induced neuronal apoptosis in rat primary cultured hippocampal neurons. Journal of biomedical materials research. Part A. vol 103. issue 3. 2015-10-26. PMID:25045142. |
these findings suggested that hippocampal neuron apoptosis caused by tio2 nps may be associated with mitochondria-mediated signal pathway and endoplasmic reticulum-mediated signal pathway. |
2015-10-26 |
2023-08-13 |
rat |
| J Xiao, X M Tian, C Yang, P Liu, N Q Luo, Y Liang, H B Li, D H Chen, C X Wang, L Li, G W Yan. Ultrahigh relaxivity and safe probes of manganese oxide nanoparticles for in vivo imaging. Scientific reports. vol 3. 2015-10-16. PMID:24305731. |
we for the first time demonstrate these mn3o4 nps biocompatibilities both in vitro and in vivo are satisfactory based on systematical studies of the intrinsic toxicity including cell viability of human nasopharyngeal carcinoma cells, normal nasopharyngeal epithelium, apoptosis in cells and in vivo immunotoxicity. |
2015-10-16 |
2023-08-12 |
human |
| Caterina Fede, Caterina Millino, Beniamina Pacchioni, Barbara Celegato, Chiara Compagnin, Paolo Martini, Francesco Selvestrel, Fabrizio Mancin, Lucia Celotti, Gerolamo Lanfranchi, Maddalena Mognato, Stefano Cagni. Altered gene transcription in human cells treated with Ludox® silica nanoparticles. International journal of environmental research and public health. vol 11. issue 9. 2015-09-15. PMID:25170680. |
by gene-by-gene and gene set analyses, we evidenced a specific cell response in relation to nps size and elapsed time after treatment, with the smaller nps (sm30) having higher impact on inflammatory and apoptosis processes than the bigger ones. |
2015-09-15 |
2023-08-13 |
human |
| Adeline Tarantini, Rachelle Lanceleur, Annick Mourot, Marie-Thérèse Lavault, Gérald Casterou, Gérard Jarry, Kevin Hogeveen, Valérie Fessar. Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 2. 2015-09-14. PMID:25448807. |
the ability of these nps to induce cytotoxicity (xtt viability test), genotoxicity (γh2ax and micronucleus assay), apoptosis (caspase 3), oxidative stress (oxidation of 2,7-dichlorodihydrofluorescein diacetate probe) and proinflammatory effects (interleukin il-8 secretion) was evaluated. |
2015-09-14 |
2023-08-13 |
human |
| Sourav Chattopadhyay, Sandeep Kumar Dash, Satyajit Tripathy, Panchanan Pramanik, Somenath Ro. Phosphonomethyl iminodiacetic acid-conjugated cobalt oxide nanoparticles liberate Co(++) ion-induced stress associated activation of TNF-α/p38 MAPK/caspase 8-caspase 3 signaling in human leukemia cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 20. issue 1. 2015-09-14. PMID:25534662. |
pmida-coo nps caused dna damage in leukemic cell lines, which was reflected by an increase in apoptosis of jurkat, kg-1a and k562 cells. |
2015-09-14 |
2023-08-13 |
human |
| Sourav Chattopadhyay, Sandeep Kumar Dash, Satyajit Tripathy, Panchanan Pramanik, Somenath Ro. Phosphonomethyl iminodiacetic acid-conjugated cobalt oxide nanoparticles liberate Co(++) ion-induced stress associated activation of TNF-α/p38 MAPK/caspase 8-caspase 3 signaling in human leukemia cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 20. issue 1. 2015-09-14. PMID:25534662. |
pmida-coo nps induced apoptosis by increasing pro-inflammatory cytokines, primarily tnf-α. |
2015-09-14 |
2023-08-13 |
human |
| Xueqin Wang, Liang Wang, Xiaorong Tan, Huiru Zhang, Guibin Su. Construction of doxorubicin-loading magnetic nanocarriers for assaying apoptosis of glioblastoma cells. Journal of colloid and interface science. vol 436. 2015-09-08. PMID:25280371. |
in this study, the biodegradable chitosan-modified magnetite (fe3o4) nps (cs-mnps) are firstly synthesized using as nanocarriers, and then encapsulated with anti-tumor drug doxorubicin (dox) to construct dox-loaded cs-mnps (dox-cs-mnps), which are further applied to assay apoptosis of glioblastoma multiforme u251 cells. |
2015-09-08 |
2023-08-13 |
human |
| Hui Yao, Kaiyuan Wang, Yi Wang, Shanshan Wang, Jianfeng Li, Jinning Lou, Liya Ye, Xueying Yan, Weiyue Lu, Rongqin Huan. Enhanced blood-brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system. Biomaterials. vol 37. 2015-08-17. PMID:25453963. |
furthermore, lnp-modified nps mediated strongest and most intensive apoptosis on the tumor site, and the longest median survival time of glioma-bearing mice. |
2015-08-17 |
2023-08-13 |
mouse |
| Chang Su, Hongdan Li, Yijie Shi, Guan Wang, Liwei Liu, Liang Zhao, Rongjian S. Carboxymethyl-β-cyclodextrin conjugated nanoparticles facilitate therapy for folate receptor-positive tumor with the mediation of folic acid. International journal of pharmaceutics. vol 474. issue 1-2. 2015-08-07. PMID:25149123. |
from in vitro cytotoxicity assay, cell apoptosis study, intracellular atp level assay and western blot, we can see that fa-cm-β-cd-bsa nps as good monodispersity, negative charge, and homogenous particle size have a high encapsulation efficiency. |
2015-08-07 |
2023-08-13 |
Not clear |
| Chang Su, Hongdan Li, Yijie Shi, Guan Wang, Liwei Liu, Liang Zhao, Rongjian S. Carboxymethyl-β-cyclodextrin conjugated nanoparticles facilitate therapy for folate receptor-positive tumor with the mediation of folic acid. International journal of pharmaceutics. vol 474. issue 1-2. 2015-08-07. PMID:25149123. |
the results showed that mtt and cell apoptosis demonstrated that fa-decorated nps exhibit stronger inhibition rate and induce obvious apoptosis in fr positive hela cells as compared to free drug and fa undecorated nps. |
2015-08-07 |
2023-08-13 |
Not clear |
| Chang Su, Hongdan Li, Yijie Shi, Guan Wang, Liwei Liu, Liang Zhao, Rongjian S. Carboxymethyl-β-cyclodextrin conjugated nanoparticles facilitate therapy for folate receptor-positive tumor with the mediation of folic acid. International journal of pharmaceutics. vol 474. issue 1-2. 2015-08-07. PMID:25149123. |
taken together, fa-cm-β-cd-bsa nps enhance fr receptor-mediated endocytosis and lead to more intracellular uptake of drug, inducing the higher apoptosis ratio of cells than free 5-fu. |
2015-08-07 |
2023-08-13 |
Not clear |
| Javed Ahmad, Hisham A Alhadlaq, Maqsood A Siddiqui, Quaiser Saquib, Abdulaziz A Al-Khedhairy, Javed Musarrat, Maqusood Ahame. Concentration-dependent induction of reactive oxygen species, cell cycle arrest and apoptosis in human liver cells after nickel nanoparticles exposure. Environmental toxicology. vol 30. issue 2. 2015-07-27. PMID:23776134. |
upregulation of cell cycle checkpoint gene p53 and bax/bcl-2 ratio with a concomitant loss in mitochondrial membrane potential suggested that ni nps induced apoptosis in hepg2 cells was mediated through mitochondrial pathway. |
2015-07-27 |
2023-08-12 |
human |
| Feng-lei Wu, Ru-Tian Li, Mi Yang, Guo-Feng Yue, Hui-yu Wang, Qin Liu, Fang-bo Cui, Pu-yuan Wu, Hui Ding, Li-Xia Yu, Xiao-Ping Qian, Bao-Rui Li. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer letters. vol 363. issue 1. 2015-07-20. PMID:25592042. |
thus, the incorporation of dac into nps significantly enhanced the sensitivity of gc cells to 5-fu by inhibiting cell growth rate and inducing cell apoptosis. |
2015-07-20 |
2023-08-13 |
Not clear |
| Yurong Wang, Haiyan Cui, Jiaping Zhou, Fengjuan Li, Jinju Wang, Mianhua Chen, Qingdai Li. Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environmental science and pollution research international. vol 22. issue 7. 2015-07-08. PMID:25339530. |
in this study, cytotoxicity, dna damage, and apoptosis induced by tio2 nps (5 nm) in a549 cells were investigated. |
2015-07-08 |
2023-08-13 |
human |
| Yurong Wang, Haiyan Cui, Jiaping Zhou, Fengjuan Li, Jinju Wang, Mianhua Chen, Qingdai Li. Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environmental science and pollution research international. vol 22. issue 7. 2015-07-08. PMID:25339530. |
taken together, these findings suggest that tio2 nps can inhibit a549 cell proliferation, cause dna damage, and induce apoptosis via a mechanism primarily involving the activation of the intrinsic mitochondrial pathway. |
2015-07-08 |
2023-08-13 |
human |
| Yurong Wang, Haiyan Cui, Jiaping Zhou, Fengjuan Li, Jinju Wang, Mianhua Chen, Qingdai Li. Cytotoxicity, DNA damage, and apoptosis induced by titanium dioxide nanoparticles in human non-small cell lung cancer A549 cells. Environmental science and pollution research international. vol 22. issue 7. 2015-07-08. PMID:25339530. |
the assay data provide strong evidence that tio2 nps can induce cytotoxicity, significant dna damage, and apoptosis of a549 cells, suggesting that exposure to tio2 nps could cause cell injury and be hazardous to health. |
2015-07-08 |
2023-08-13 |
human |
| Xingxing Chuan, Qin Song, Jialiang Lin, Xianhui Chen, Hua Zhang, Wenbing Dai, Bing He, Xueqing Wang, Qiang Zhan. Novel free-paclitaxel-loaded redox-responsive nanoparticles based on a disulfide-linked poly(ethylene glycol)-drug conjugate for intracellular drug delivery: synthesis, characterization, and antitumor activity in vitro and in vivo. Molecular pharmaceutics. vol 11. issue 10. 2015-06-24. PMID:25208098. |
the influence of peg-ss-ptx/ptx nps on in vitro cytotoxicity, cell cycle progression, and cellular apoptosis was determined in the mcf-7 cell line, and the nps demonstrated a superior anti-proliferative activity associated with ptx-induced cell cycle arrest in g2/m phase and apoptosis compared to their nonresponsive counterparts. |
2015-06-24 |
2023-08-13 |
mouse |