| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Fustaino, Giuliana Papoff, Francesca Ruberti, Giovina Rubert. Co-Expression Network Analysis Unveiled lncRNA-mRNA Links Correlated to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance and/or Intermediate Epithelial-to-Mesenchymal Transition Phenotypes in a Human Non-Small Cell Lung Cancer Cellular Model System. International journal of molecular sciences. vol 25. issue 7. 2024-04-13. PMID:38612674. |
processes enriched in the selected modules included rho (a, b, c) gtpase and regulatory signaling pathways, apoptosis, inflammatory and interleukin signaling pathways, cell adhesion, cell migration, cell and extracellular matrix organization, metabolism, and lipid metabolism. |
2024-04-13 |
2024-04-15 |
human |
| Iván Palomo, Sergio Wehinger, Vicente Andrés, Francisco J García-García, Eduardo Fuente. RhoA/rho kinase pathway activation in age-associated endothelial cell dysfunction and thrombosis. Journal of cellular and molecular medicine. vol 28. issue 8. 2024-04-03. PMID:38568071. |
the small gtpase rhoa and the downstream rho kinase (rock) regulate several cell functions and pathological processes in the vascular system that contribute to the age-dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production and apoptosis. |
2024-04-03 |
2024-04-05 |
Not clear |
| Ling Liu, Jun Liu, Junshuai Wang, Yu Chen, Gang Li. Ulinastatin protects against myocardial ischemia/reperfusion injury in rats via Rho/ROCK signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279430. |
we aimed to study the influences of ulinastatin on diseased myocardial tissues, cardiomyocyte apoptosis and inflammatory reaction in rats with myocardial ischemia/reperfusion injury (iri) via the ras homolog (rho)/rho-associated kinase (rock) signaling pathway and its mechanism. |
2024-01-27 |
2024-01-29 |
rat |
| Haowen Li, Guihu Lin, Meiyue Cui, Lingling Wang, Danyang Ding, Xiangyi Li, Xingyue Fan, Qian Yang, Ye Wang, Chunbo Kang, Lei Zhang, Bin Liu, Jianzhi S. Hub biomarkers in ultrasound-guided bladder cancer and osteosarcoma: Myosin light chain kinase and caldesmon. Medicine. vol 102. issue 48. 2023-12-05. PMID:38050320. |
functional enrichment analysis revealed significant enrichment in terms of cellular differentiation, cartilage development, skeletal development, muscle actin cytoskeleton, actin filament, rho gtpase binding, dna binding, fibroblast binding, mapk signaling pathway, apoptosis, and cancer pathways. |
2023-12-05 |
2023-12-10 |
Not clear |
| Hailin Xu, Hao Yang, Zhiyong Wang, Qizhi Tang, Xiaoling Cao, Chufen Chen, Yunxian Dong, Zhongye Xu, Dongming Lv, Yanchao Rong, Miao Chen, Bing Tang, Wuguo Deng, Jiayuan Zhu, Zhicheng H. Epidermal stem cell derived exosomes alleviate excessive autophagy induced endothelial cell apoptosis by delivering miR200b-3p to diabetic wounds. The Journal of investigative dermatology. 2023-10-14. PMID:37838331. |
synapse defective rho gtpase homolog 1 (syde1) was identified the target of mir200b-3p and affected the phosphorylation of erk to regulate intracellular autophagy and apoptosis. |
2023-10-14 |
2023-11-08 |
mouse |
| Di Zhou, Qiaohui Yang, Jialin Li, Sicong Zeng, Zhuo Li, Xiao Liu, Jin Li, Wang Zhou, Yujiao Cha. Retinal organoid models show heterozygous rhodopsin mutation favors endoplasmic reticulum stress-induced apoptosis in rods. Stem cells and development. 2023-07-20. PMID:37470211. |
furthermore, the development of chhes-406 organoids may be delayed, and apoptosis detection and co-localization revealed that chhes-406 organoids had more apoptotic cells than chhes-90 in the outer nuclear layer (onl), mutant rho protein was mislocalized in the endoplasmic reticulum and stress-related and apoptotic gene expression increased. |
2023-07-20 |
2023-08-14 |
Not clear |
| Di Zhou, Qiaohui Yang, Jialin Li, Sicong Zeng, Zhuo Li, Xiao Liu, Jin Li, Wang Zhou, Yujiao Cha. Retinal organoid models show heterozygous rhodopsin mutation favors endoplasmic reticulum stress-induced apoptosis in rods. Stem cells and development. 2023-07-20. PMID:37470211. |
overall, our study elucidated a possible mechanism by which er stress caused by rho p171l protein mislocalization may lead to onl cell apoptosis. |
2023-07-20 |
2023-08-14 |
Not clear |
| Noelle C Punessen, Claudia Pena, Alexandra Sandberg, Lilia A Koza, Daniel A Linsema. A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons. Molecular and cellular neurosciences. 2023-06-01. PMID:37263460. |
rho family gtpases are molecular switches with recognized importance in proper neuronal development and migration that have more recently emerged as central regulators of apoptosis and neuronal survival. |
2023-06-01 |
2023-08-14 |
rat |
| Noelle C Punessen, Claudia Pena, Alexandra Sandberg, Lilia A Koza, Daniel A Linsema. A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons. Molecular and cellular neurosciences. 2023-06-01. PMID:37263460. |
here, we investigated a role for the rho gtpase family member, cdc42, and its downstream effectors, in neuronal survival and apoptosis. |
2023-06-01 |
2023-08-14 |
rat |
| Fatma H Rizk, Mervat H El-Saka, Rowida Raafat Ibrahim, Omnia Safwat El-Deeb, Hoda A Ibrahim, Amira A El Saadany, Shaimaa S Mashal, Leila Ammar, Amal M Abdelsattar, Ramez A Barhom. Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho-associated kinase pathway. BioFactors (Oxford, England). 2023-04-27. PMID:37103121. |
also, it mitigated diabetic lung injury via suppressing effect on rho a/rock pathway, apoptosis, inflammatory reactions, oxidative stress, and fibrosis of lung tissue. |
2023-04-27 |
2023-08-14 |
rat |
| Kai Chen, Wen-Ya Xu, Si-Si Sun, Hong-Wei Zho. Corneal endothelial cells and acoustic cavitation in phacoemulsification. World journal of clinical cases. vol 11. issue 8. 2023-03-27. PMID:36969995. |
the rho related helical coil kinase inhibitor y-27632 can inhibit cec apoptosis after phacoemulsification. |
2023-03-27 |
2023-08-14 |
human |
| Xueying Ma, Yizhe Dai, Tiantong Qiu, Xin Chen, Peng Xiao, Wenhua L. Effects of acute exposure to amisulbrom on retinal development in zebrafish (Danio rerio) embryos. Environmental science and pollution research international. 2023-01-30. PMID:36715803. |
compared with the control group, amisulbrom-treated zebrafish embryos displayed phenotypic microphthalmia, dysregulation of gene transcription levels (alcama, prox1a, sox2, vsx1, rho, bluops, rdops, uvops, and grops) related to the retinal cell layer differentiation, and increased retinal apoptosis. |
2023-01-30 |
2023-08-14 |
zebrafish |
| Guiqing Zhou, Ji Wang, Lihua Ren, Jianhui Liu, Xiangyang Li, Yue Zhang, Yujian Sang, Leqiang Gao, Yanbo Li, Zhiwei Sun, Xianqing Zho. Silica nanoparticles suppressed the spermatogenesis via downregulation of miR-450b-3p by targeting Layilin in spermatocyte of mouse. Environmental pollution (Barking, Essex : 1987). 2022-12-16. PMID:36526052. |
in vivo study, we found that sinps caused apoptosis of spermatocytes, decreased quantity and quality of sperms, up-regulated the cytoskeleton proteins (layilin, talin, and vinculin), activated the hippo pathway (rho a, yap, and p73), downregulated the expression of mir-450b-3p, damaged the compactness and density of desmosomes between spermatocytes and the basal of the testis. |
2022-12-16 |
2023-08-14 |
mouse |
| Weizhuo Lu, Jiyue We. H Metabolic brain disease. 2022-12-05. PMID:36469178. |
in the pathological process of ischemic stroke, the up-regulation of ras homolog gene family, member a (rhoa) and its downstream effector, ras homolog gene family (rho)-associated coiled coil-containing kinase (rock), contribute to the neuroinflammation, blood-brain barrier (bbb) dysfunction, neuronal apoptosis, axon growth inhibition and astrogliosis. |
2022-12-05 |
2023-08-14 |
Not clear |
| Ling Qin, Lan Yang, Jiaru Zhao, Wanlin Zeng, Minxuan Su, Shihua Wang, Jun Yua. GTPase Rac Regulates Conidiation, AFB1 Production and Stress Response in Pathogenic Fungus Toxins. vol 14. issue 9. 2022-09-22. PMID:36136519. |
gtpase rac regulates conidiation, afb1 production and stress response in pathogenic fungus as a member of the rho family, rac plays important roles in many species, including proliferation, differentiation, apoptosis, dna damage responses, metabolism, angiogenesis, and immunosuppression. |
2022-09-22 |
2023-08-14 |
Not clear |
| Zhiyun Zhu, Bo Qiu, Qiang Wang, Wei Wei, Jinlong Huang, Wenfen Dua. Fasudil on Myocardial Injury in Rats with Myocardial Ischemia and Reperfusion through Rho-ROCK Signal Pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 67. issue 5. 2022-07-12. PMID:35818270. |
it has been reported that the rho kinase inhibitor fasudil can interfere with cardiomyocyte apoptosis through the rho-rock signaling pathway, so it is often used to treat cardiovascular diseases. |
2022-07-12 |
2023-08-14 |
mouse |
| Durga Ganesh, Anne L Coleman, Vivian P Shibayama, Victoria L Tsen. Netarsudil-Induced Corneal Flattening in a Child with Secondary Open-Angle Glaucoma. Case reports in ophthalmology. vol 13. issue 2. 2022-06-15. PMID:35702654. |
rho kinase inhibitors may increase cell proliferation and adhesion within the corneal endothelium, hence decreasing apoptosis and promoting cell preservation. |
2022-06-15 |
2023-08-14 |
Not clear |
| Guowei Yin, Guohua Lv, Jerry Zhang, Hongmei Jiang, Tianqi Lai, Yushan Yang, Yong Ren, Jing Wang, Chenju Yi, Hao Chen, Yun Huang, Chaoni Xia. Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy. Pharmacology & therapeutics. 2022-01-10. PMID:35007659. |
small gtpase or ras superfamily, including ras, rho, rab, ran and arf, are fundamental in regulating a wide range of cellular processes such as growth, differentiation, migration and apoptosis. |
2022-01-10 |
2023-08-13 |
human |
| Eva Crosas-Molist, Remi Samain, Leonie Kohlhammer, Jose L Orgaz, Samantha L George, Oscar Maiques, Jaume Barcelo, Victoria Sanz-Moren. Rho GTPase signaling in cancer progression and dissemination. Physiological reviews. vol 102. issue 1. 2021-12-09. PMID:34541899. |
rho gtpases contribute to tumor initiation and progression, by regulating proliferation and apoptosis, but also metabolism, senescence, and cancer cell stemness. |
2021-12-09 |
2023-08-13 |
Not clear |
| Bertrand C Lian. Increased expression but not sensitivity to Fas/CD95 in glioblastoma cells depleted of mitochondrial DNA. Experimental and therapeutic medicine. vol 1. issue 6. 2021-10-21. PMID:22993639. |
however, when cells were evaluated for sensitivity to apoptosis using fas-engagement, there was no difference between the rho(+) and rho(-) cells in either cell line. |
2021-10-21 |
2023-08-12 |
Not clear |