| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan-Hua Shen, Hai-Xing Jiang, Shan-Yu Qin, Liu-Ping Wei, Yun-Chao Meng, Wei Lu. [Activation of hepatocyte growth factor promotes apoptosis of hepatic stellate cells via the Rho pathway]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 22. issue 2. 2019-11-20. PMID:24735597. |
to investigate the role of activated hepatocyte growth factor (hgf) in apoptosis of hepatic stellate cells (hscs) and in modulating the rho signaling pathway. |
2019-11-20 |
2023-08-13 |
Not clear |
| Ambrish Kumar, Nadia Al-Sammarraie, Donald J DiPette, Ugra S Sing. Correction: Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. Oncotarget. vol 7. issue 27. 2019-11-20. PMID:27924056. |
correction: metformin impairs rho gtpase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma. |
2019-11-20 |
2023-08-13 |
mouse |
| Laetitia Mouly, Kenza Mamouni, Remi Gence, Agnese Cristini, Julia Cherier, Adrien Castinel, Morgane Legrand, Gilles Favre, Olivier Sordet, Sylvie Monferra. PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin. Cell death & disease. vol 9. issue 9. 2019-11-11. PMID:30209297. |
together, these findings highlight rnd1 as an atypical rho gtpase early induced by top1cc, and show that the top1cc-parp-1-rnd1 pathway protects cells against apoptosis induced by camptothecin. |
2019-11-11 |
2023-08-13 |
Not clear |
| Seniz Demiryürek, Elif Baysalman, Azad Mammadov, Abdullah T Demiryüre. Contribution of the Rho-kinase to Systemic Sclerosis and Behçet's Disease. Current pharmaceutical design. vol 24. issue 29. 2019-10-24. PMID:29962333. |
the small gtpase rho family and its effectors, rho-kinases (rock) play essential roles in the actin cytoskeleton organization and coordinate a broad range of cellular functions, such as inflammatory responses, cell contractility, migration, adhesion, proliferation, and apoptosis. |
2019-10-24 |
2023-08-13 |
Not clear |
| Justyna S Grothaus, Guillermo Ares, Carrie Yuan, Douglas R Wood, Catherine J Hunte. Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 4. 2019-08-16. PMID:29927318. |
rho kinase (rock) is a serine/threonine kinase that affects multiple cellular processes, including tight junction (tj) function, cellular permeability, and apoptosis. |
2019-08-16 |
2023-08-13 |
human |
| Chaker Slaymi, Emmanuel Vignal, Gaëlle Crès, Pierre Roux, Anne Blangy, Peggy Raynaud, Philippe For. The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium. Biology of the cell. vol 111. issue 5. 2019-07-29. PMID:30834544. |
the atypical rhou/wrch1 rho gtpase controls cell proliferation and apoptosis in the gut epithelium. |
2019-07-29 |
2023-08-13 |
Not clear |
| Michael D Bright, Paul A Clarke, Paul Workman, Faith E Davie. Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling. Cellular signalling. vol 44. 2019-06-26. PMID:29329780. |
small rho family gtpases are linked to many cell responses including cell growth and apoptosis. |
2019-06-26 |
2023-08-13 |
Not clear |
| Wenwen Si, Shanyu Ye, Zhenxing Ren, Xin Liu, Zimei Wu, Yi Li, Jianhong Zhou, Saixia Zhang, Yiwei Li, Rudong Deng, Dongfeng Che. miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke. International journal of molecular medicine. vol 43. issue 3. 2019-05-31. PMID:30747210. |
the results revealed that mir‑335 was downregulated during acute ischemic stroke, which was concomitant with reduced sg formation, enhanced apoptosis levels and increased rho associated protein kinase 2 (rock2) expression. |
2019-05-31 |
2023-08-13 |
rat |
| Satoshi Yasuda, Shinji Kusakawa, Takuya Kuroda, Takumi Miura, Keiko Tano, Nozomi Takada, Satoko Matsuyama, Akifumi Matsuyama, Michiyo Nasu, Akihiro Umezawa, Takao Hayakawa, Hideki Tsutsumi, Yoji Sat. Tumorigenicity-associated characteristics of human iPS cell lines. PloS one. vol 13. issue 10. 2019-03-18. PMID:30286143. |
we first established quantitative and sensitive tumorigenicity testing of hipscs dissociated into single cells using nod/shi-scid il2rγnull (nog) mice by inhibiting apoptosis of hipscs with a rho kinase inhibitor. |
2019-03-18 |
2023-08-13 |
mouse |
| Sarah P Short, Jumpei Kondo, Whitney G Smalley-Freed, Haruna Takeda, Michael R Dohn, Anne E Powell, Robert H Carnahan, Mary K Washington, Manish Tripathi, D Michael Payne, Nancy A Jenkins, Neal G Copeland, Robert J Coffey, Albert B Reynold. p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia. The Journal of clinical investigation. vol 127. issue 12. 2019-02-26. PMID:29130932. |
in tumor-derived organoid cultures, elimination of both p120 alleles resulted in caspase-3-dependent apoptosis that was blocked by inhibition of rho kinase (rock). |
2019-02-26 |
2023-08-13 |
mouse |
| Javad Alizadeh, Amir A Zeki, Nima Mirzaei, Sandipan Tewary, Adel Rezaei Moghadam, Aleksandra Glogowska, Pandian Nagakannan, Eftekhar Eftekharpour, Emilia Wiechec, Joseph W Gordon, Fred Y Xu, Jared T Field, Ken Y Yoneda, Nicholas J Kenyon, Mohammad Hashemi, Grant M Hatch, Sabine Hombach-Klonisch, Thomas Klonisch, Saeid Ghavam. Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells. Scientific reports. vol 7. 2018-11-12. PMID:28344327. |
these results indicate that mev cascade inhibition by simvastatin induced the intrinsic apoptosis pathway via inhibition of rho family prenylation and depletion of ggpp, in a variety of different human cancer cell lines. |
2018-11-12 |
2023-08-13 |
human |
| Zhe Zhao, Jinxin Liu, Yiqin Deng, Wen Huang, Chunhua Ren, Douglas R Call, Chaoqun H. The Vibrio alginolyticus T3SS effectors, Val1686 and Val1680, induce cell rounding, apoptosis and lysis of fish epithelial cells. Virulence. vol 9. issue 1. 2018-09-17. PMID:29252102. |
val1686 is a fic-domain containing protein that not only contributed to cell rounding by inhibiting rho guanosine triphosphatases (gtpases), but was requisite for the induction of apoptosis because the deletion mutant (Δval1686) was severely weakened in its ability to induce cell rounding and apoptosis in fish cells. |
2018-09-17 |
2023-08-13 |
Not clear |
| Hui-Zhen Zheng, Xue-Kun Fu, Jiu-Long Shang, Rong-Xi Lu, Yong-Fang Ou, Chun-Ling Che. Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1. European journal of pharmacology. vol 822. 2018-08-20. PMID:29307726. |
rbmscs treated with hypoxia and serum deprivation for 24h (h/sd-rbmscs) showed the up-regulated expression of ras homolog family member a (rhoa), rho associated coiled-coil containing protein kinase 1 (rock-1), myosin light chain 2 (mlc-2), bcl2 associated agonist of cell death (bad) and bcl2 associated x, apoptosis regulator (bax); while the expression of mir-148b-3p, mir-148b-5p and mir-494-3p was down-regulated. |
2018-08-20 |
2023-08-13 |
rat |
| Ting Wang, Wenyan Kang, Lingqian Du, Shaohua G. Rho-kinase inhibitor Y-27632 facilitates the proliferation, migration and pluripotency of human periodontal ligament stem cells. Journal of cellular and molecular medicine. vol 21. issue 11. 2018-06-12. PMID:28661039. |
the rho gtpases and downstream rho kinases are central regulators of cytoskeletal dynamics during cell cycle and determine the balance between stem cells self-renewal, lineage commitment and apoptosis. |
2018-06-12 |
2023-08-13 |
human |
| Sonja Mertsch, Oliver H Kräme. The interplay between histone deacetylases and rho kinases is important for cancer and neurodegeneration. Cytokine & growth factor reviews. vol 37. 2018-05-29. PMID:28606734. |
rho associated coiled-coil containing kinases (rocks) respond to defined extra- and intracellular stimuli to control cell migration, cell proliferation, and apoptosis. |
2018-05-29 |
2023-08-13 |
Not clear |
| Klaus Aktories, Carsten Schwan, Thomas Jan. Clostridium difficile Toxin Biology. Annual review of microbiology. vol 71. 2018-05-08. PMID:28657883. |
inactivation of rho proteins disturbs the organization of the cytoskeleton and affects multiple rho-dependent cellular processes, including loss of epithelial barrier functions, induction of apoptosis, and inflammation. |
2018-05-08 |
2023-08-13 |
Not clear |
| Verena Ziegler, Christian Henninger, Ioannis Simiantonakis, Marcel Buchholzer, Mohammad Reza Ahmadian, Wilfried Budach, Gerhard Frit. Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation. Cell death & disease. vol 8. issue 8. 2018-04-30. PMID:28796249. |
rho inhibition by lovastatin affects apoptosis and dsb repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation. |
2018-04-30 |
2023-08-13 |
mouse |
| Santhosh Kumar Nagarajan, Sathya Babu, Honglae Sohn, Panneer Devaraju, Thirumurthy Madhava. 3D-QSAR studies on indole and 7-azoindole derivatives as ROCK-2 inhibitors: An integrative computational approach. Computational biology and chemistry. vol 71. 2018-04-23. PMID:29153889. |
rho kinases (rock) has been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. |
2018-04-23 |
2023-08-13 |
Not clear |
| Hongwei Ye, Guanjun Zhang, Ruiping Cao, Pinfang Kang, Zhenghong Li, Qin Ga. [Fasudil attenuates mitochondrial injury and apoptosis in rat model of myocardial ischemia/reperfusion injury]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 7. 2018-02-06. PMID:28712398. |
conclusion fasudil can protect against myocardial i/r damage through inhibiting rho kinase, which has no clear correlation with mfn2 protein expression, but may be related with decreasing drp1 protein expression and reducing mitochondrial injury, thereby inhibiting apoptosis. |
2018-02-06 |
2023-08-13 |
rat |
| Matias Julian Stagno, Nefeli Zacharopoulou, Jonas Bochem, Anna Tsapara, Lisann Pelzl, Tamer Al-Maghout, Galatea Kallergi, Saad Alkahtani, Konstantinos Alevizopoulos, Konstantinos Dimas, Theodora Calogeropoulou, Steven W Warmann, Florian Lang, Evi Schmid, Christos Stournara. Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 42. issue 4. 2017-10-26. PMID:28704809. |
recent findings established that this steroidal drug exhibits potent apoptotic responses in prostate tumors in vitro and in vivo, by affecting key signaling orchestrating proliferation and apoptosis, such as c-myc and caspase 3, rho gtpases and actin cytoskeleton dynamics. |
2017-10-26 |
2023-08-13 |
Not clear |