| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaojuan Chi, Song Wang, Yifan Huang, Mark Stamnes, Ji-Long Che. Roles of rho GTPases in intracellular transport and cellular transformation. International journal of molecular sciences. vol 14. issue 4. 2015-07-07. PMID:23538840. |
rho family gtpases belong to the ras gtpase superfamily and transduce intracellular signals known to regulate a variety of cellular processes, including cell polarity, morphogenesis, migration, apoptosis, vesicle trafficking, viral transport and cellular transformation. |
2015-07-07 |
2023-08-12 |
Not clear |
| Trisha R Stankiewicz, Sai Anandi Ramaswami, Ron J Bouchard, Klaus Aktories, Daniel A Linsema. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. The Journal of biological chemistry. vol 290. issue 15. 2015-06-26. PMID:25666619. |
neuronal apoptosis induced by selective inhibition of rac gtpase versus global suppression of rho family gtpases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. |
2015-06-26 |
2023-08-13 |
Not clear |
| Trisha R Stankiewicz, Sai Anandi Ramaswami, Ron J Bouchard, Klaus Aktories, Daniel A Linsema. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. The Journal of biological chemistry. vol 290. issue 15. 2015-06-26. PMID:25666619. |
adenoviral expression of a constitutively active mutant of mek5 is sufficient to attenuate neuronal cell death induced by selective inhibition of rac with nsc23766 but not apoptosis induced by global inhibition of rho gtpases with toxb. |
2015-06-26 |
2023-08-13 |
Not clear |
| Katharina Wohlan, Sebastian Goy, Alexandra Olling, Sangar Srivaratharajan, Helma Tatge, Harald Genth, Ralf Gerhar. Pyknotic cell death induced by Clostridium difficile TcdB: chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity. Cellular microbiology. vol 16. issue 11. 2015-06-16. PMID:24898616. |
both toxins inhibit rho gtpases, and consequently, apoptosis is induced in the affected cells. |
2015-06-16 |
2023-08-13 |
Not clear |
| A Ozdemir, B Ibisolu, Y D Simay, B Polat, M Ar. [Ouabain induces Rho-dependent rock activation and membrane blebbing incultured endothelial cells]. Molekuliarnaia biologiia. vol 49. issue 1. 2015-05-26. PMID:25916120. |
small g protein rho and its most studied effectors, rock i and rock ii, are involved in several cellular fuctions including smooth muscle and non-muscle cell contractions, cell migration and apoptosis. |
2015-05-26 |
2023-08-13 |
human |
| Angelo M Taveira-DaSilva, Joel Mos. Clinical features, epidemiology, and therapy of lymphangioleiomyomatosis. Clinical epidemiology. vol 7. 2015-04-21. PMID:25897262. |
because sirolimus and everolimus only affect the activity of mtor complex 1, therapies targeting rhoa gtpases with simvastatin, which inhibits rho gtpases and promotes apoptosis, are being investigated. |
2015-04-21 |
2023-08-13 |
Not clear |
| X Yue, X Yang, X Lin, T Yang, X Yi, Y Dai, J Guo, T Li, J Shi, L Wei, G-C Fan, C Chen, J Chan. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell death & disease. vol 5. 2015-02-12. PMID:24901055. |
rho family guanosine triphosphatase (gtpase) 3 (rnd3), a member of the small rho gtpase family, has been suggested to regulate cell actin cytoskeleton dynamics, cell migration, and apoptosis through the rho kinase-dependent signaling pathway. |
2015-02-12 |
2023-08-13 |
mouse |
| X Yue, X Yang, X Lin, T Yang, X Yi, Y Dai, J Guo, T Li, J Shi, L Wei, G-C Fan, C Chen, J Chan. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell death & disease. vol 5. 2015-02-12. PMID:24901055. |
remarkable apoptosis, increased caspase-3 activity, and elevated rho kinase activity were detected in the rnd3(+/-) haploinsufficient animal hearts. |
2015-02-12 |
2023-08-13 |
mouse |
| X Yue, X Yang, X Lin, T Yang, X Yi, Y Dai, J Guo, T Li, J Shi, L Wei, G-C Fan, C Chen, J Chan. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell death & disease. vol 5. 2015-02-12. PMID:24901055. |
pharmacological inhibition of rho kinase by fasudil treatment partially improved rnd3(+/-) mouse cardiac functions and attenuated myocardial apoptosis. |
2015-02-12 |
2023-08-13 |
mouse |
| Derya Isler, Mehmet Ozaslan, Isik Didem Karagoz, Ibrahim Halil Kilic, Metin Karakok, Seyithan Taysi, Izzettin Guler, Ahmet Cakmak, Abdullah Tuncay Demiryure. Antitumoral effect of a selective Rho-kinase inhibitor Y-27632 against Ehrlich ascites carcinoma in mice. Pharmacological reports : PR. vol 66. issue 1. 2015-02-05. PMID:24905316. |
the rho proteins and rho-kinase (rock) enzymes are responsible for signal transduction, and cause cell permeability, contractility, differentiation, migration, proliferation or apoptosis depending on cell types. |
2015-02-05 |
2023-08-13 |
mouse |
| Huanlong Liu, Xueyan Chen, Yu Han, Chaoyi Li, Pingping Chen, Suwen Su, Yongjian Zhang, Zhenhua Pa. Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 3. 2014-12-12. PMID:24406296. |
rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via jnk and p38 mapk pathway. |
2014-12-12 |
2023-08-12 |
rat |
| Liuping Wei, Shanyu Qin, Haixing Jiang, Yanhua Shen, Yunchao Men. [Mechanism of bone marrow-derived mesenchymal stem cell-promoted apoptosis of hepatic stellate cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 22. issue 3. 2014-12-11. PMID:24824127. |
to explore the role of the rho pathway in the hepatocyte growth factor (hgf) paracrine signal-mediated bone marrow-derived mesenchymal stem cell (bmsc) promotion of apoptosis of hepatic stellate cells (hscs). |
2014-12-11 |
2023-08-13 |
Not clear |
| Z Yin, J Su. Curcumin induces human SKOV3 cell apoptosis via the activation of Rho-kinase. European journal of gynaecological oncology. vol 35. issue 4. 2014-10-23. PMID:25118487. |
in this study, the authors demonstrated that curcumin induced human skov3 cell apoptosis and explored the underlying mechanism concerning rho a/rho-kinase pathway. |
2014-10-23 |
2023-08-13 |
human |
| Tripat Kaur Oberoi-Khanuja, Krishnaraj Rajalinga. Ubiquitination of Rac1 by inhibitors of apoptosis (IAPs). Methods in molecular biology (Clifton, N.J.). vol 1120. 2014-09-28. PMID:24470018. |
recently, we have uncovered that inhibitors of apoptosis (iaps) function as direct e3 ubiquitin ligases for rho gtpase rac1 and target it for proteasomal degradation. |
2014-09-28 |
2023-08-12 |
Not clear |
| Olga S Sizova, Vishal M Shinde, Austin R Lenox, Marina S Gorbatyu. Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors. Cellular signalling. vol 26. issue 4. 2014-09-24. PMID:24378535. |
we also looked for changes in the expression of bcl2 family proteins, autophagy proteins and the mtor/akt pathways, as well as for the induction of mitochondria-associated apoptosis in the p23h rho retina. |
2014-09-24 |
2023-08-12 |
Not clear |
| Olga S Sizova, Vishal M Shinde, Austin R Lenox, Marina S Gorbatyu. Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors. Cellular signalling. vol 26. issue 4. 2014-09-24. PMID:24378535. |
our data demonstrated that the elevation of calpain and caspase-12 activity was concomitantly observed with a decrease in the bcl2-xl/bax ratio and an increase in mtor levels in the p23h-3 rho retina suggesting a vulnerability of p23h rho photoreceptors to apoptosis. |
2014-09-24 |
2023-08-12 |
Not clear |
| Nadia D'Ambrosi, Simona Rossi, Valeria Gerbino, Mauro Cozzolin. Rac1 at the crossroad of actin dynamics and neuroinflammation in Amyotrophic Lateral Sclerosis. Frontiers in cellular neuroscience. vol 8. 2014-09-24. PMID:25249940. |
rac1 is a major player of the rho family of small gtpases that controls multiple cell signaling pathways, such as the organization of cytoskeleton (including adhesion and motility), cell proliferation, apoptosis and activation of immune cells. |
2014-09-24 |
2023-08-13 |
Not clear |
| Kazuho Sakamoto, Junko Kimur. Mechanism of statin-induced rhabdomyolysis. Journal of pharmacological sciences. vol 123. issue 4. 2014-09-22. PMID:24257439. |
these isoprenoids are especially important for anchoring small gtpases to the membrane before they function; e.g., ras gtpases modulate proliferation and apoptosis, rho gtpases control cytoskeleton formation, and rab gtpases are essential for intracellular vesicle trafficking. |
2014-09-22 |
2023-08-12 |
Not clear |
| Qinghong Cui, Yongbo Zhang, Hui Chen, Jimei L. Rho kinase: A new target for treatment of cerebral ischemia/reperfusion injury. Neural regeneration research. vol 8. issue 13. 2014-09-10. PMID:25206412. |
rho kinase inhibitor fasudil hydrochloride has been shown to reduce cerebral vasospasm, to inhibit inflammation and apoptosis and to promote the recovery of neurological function. |
2014-09-10 |
2023-08-13 |
Not clear |
| Xuezheng Liu, Zhongfu Zuo, Wanpeng Liu, Zhiyun Wang, Yang Hou, Yunjie Fu, Yuzhi Ha. Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats. Neural regeneration research. vol 9. issue 8. 2014-09-10. PMID:25206894. |
at 12 weeks after onset of diabetes mellitus, nogo receptor and rho kinase expression significantly increased in the retina, and retinal ganglion cell apoptosis was apparent. |
2014-09-10 |
2023-08-13 |
rat |