| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ikram Ullah, Hae Young Lee, Min Jung Kim, Shahid Ali Shah, Haroon Badshah, Tae Hyun Kim, Hak-Jae Chung, Byoung Chul Yang, Myeong Ok Ki. Rho GTPase activating protein 15 (arhGAP15) siRNA effect apoptosis-induced by ethanol in bovine fibroblast cells. Pakistan journal of pharmaceutical sciences. vol 26. issue 3. 2013-08-01. PMID:23625437. |
members of rho gtpases including rhoa, rhoc and rac1 play a major role in regulation of apoptosis in different kind of stress conditions. |
2013-08-01 |
2023-08-12 |
cattle |
| Ikram Ullah, Hae Young Lee, Min Jung Kim, Shahid Ali Shah, Haroon Badshah, Tae Hyun Kim, Hak-Jae Chung, Byoung Chul Yang, Myeong Ok Ki. Rho GTPase activating protein 15 (arhGAP15) siRNA effect apoptosis-induced by ethanol in bovine fibroblast cells. Pakistan journal of pharmaceutical sciences. vol 26. issue 3. 2013-08-01. PMID:23625437. |
here we investigated the rho gtpase activating protein 15 (arhgap15) gene knock-down effect on apoptosis induced by ethanol in bovine fibroblast cells. |
2013-08-01 |
2023-08-12 |
cattle |
| Ikram Ullah, Hae Young Lee, Min Jung Kim, Shahid Ali Shah, Haroon Badshah, Tae Hyun Kim, Hak-Jae Chung, Byoung Chul Yang, Myeong Ok Ki. Rho GTPase activating protein 15 (arhGAP15) siRNA effect apoptosis-induced by ethanol in bovine fibroblast cells. Pakistan journal of pharmaceutical sciences. vol 26. issue 3. 2013-08-01. PMID:23625437. |
our results suggest that apoptosis induced by ethanol involves the activation of rho gtpase activating protein 15 and silencing of the said gene protects apoptosis. |
2013-08-01 |
2023-08-12 |
cattle |
| S Choudhury, Y Bhootada, O Gorbatyuk, M Gorbatyu. Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration. Cell death & disease. vol 4. 2013-06-17. PMID:23470535. |
the rna and protein analyses of t17m rho+csp7-sirna, tn+csp7-sirna 661w cells and t17m rho casp-7 retinas revealed that caspase-7 ablation reprograms the upr and reduces jnk-induced apoptosis. |
2013-06-17 |
2023-08-12 |
mouse |
| Amy L Firth, Il-Whan Choi, Won Sun Par. Animal models of pulmonary hypertension: Rho kinase inhibition. Progress in biophysics and molecular biology. vol 109. issue 3. 2013-06-03. PMID:22713173. |
indeed rho proteins are known to play essential roles in actin cytoskeleton organization in all eukaryotic cells and thus rho and rho-gtpases are implicated in fundamental cellular processes such as cellular proliferation, migration, adhesion, apoptosis and gene expression. |
2013-06-03 |
2023-08-12 |
Not clear |
| Bart-Jan de Kreuk, Peter L Hordij. Control of Rho GTPase function by BAR-domains. Small GTPases. vol 3. issue 1. 2013-04-03. PMID:22714417. |
rho gtpase signaling is tightly regulated and mislocalization or constitutive activation may lead to, for example, morphogenetic abnormalities, tumor cell metastasis or apoptosis. |
2013-04-03 |
2023-08-12 |
Not clear |
| Alanna Stanley, Ailish Hynes, Cord Brakebusch, Fabio Quondamatte. Rho GTPases and Nox dependent ROS production in skin. Is there a connection? Histology and histopathology. vol 27. issue 11. 2013-03-14. PMID:23018239. |
rho gtpases are a family of small gtp binding proteins most commonly known for the regulation of many cellular processes, including actin cytoskeleton re-organisation, cell proliferation, signal transduction and regulation of apoptosis. |
2013-03-14 |
2023-08-12 |
Not clear |
| Birgit Kreiseder, Lukas Orel, Constantin Bujnow, Stefan Buschek, Maren Pflueger, Wolfgang Schuett, Harald Hundsberger, Rainer de Martin, Christoph Wiesne. α-Catulin downregulates E-cadherin and promotes melanoma progression and invasion. International journal of cancer. vol 132. issue 3. 2013-01-29. PMID:22733455. |
α-catulin (ctnnal1) is a cytoplasmic molecule that integrates the crosstalk between nuclear factor-kappa b and rho signaling pathways, binds to β-catenin and increases the level of both α-catenin and β-catenin and therefore has potential effects on inflammation, apoptosis and cytoskeletal reorganization. |
2013-01-29 |
2023-08-12 |
Not clear |
| Zheng Wu, Zhiyong Wu, Jun Li, Xiaomei Yang, Yahui Wang, Yi Yu, Jun Ye, Congjian Xu, Wenxin Qin, Zhigang Zhan. MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22610942. |
mcam is likely to participate in the regulation of the rho signalling pathway to protect ovarian cancer cells from apoptosis and promote their malignant invasion and metastasis. |
2012-12-26 |
2023-08-12 |
Not clear |
| Filipe Modolo, Michelle Tillmann Biz, Suzana Machado de Sousa, Rodolfo de Lima Fachinelli, Virgínia Oliveira Crem. Immunohistochemical expression of Rho GTPases in ameloblastomas. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 41. issue 5. 2012-11-16. PMID:22092654. |
rho gtpases are proteins that regulate cell cycle, shape, polarization, invasion, migration, and apoptosis, which are important characteristics of normal and neoplastic cells. |
2012-11-16 |
2023-08-12 |
Not clear |
| Ling-Huei Yih, Yi-Chen Wu, Nai-Chi Hsu, Hsiao-Hui Ku. Arsenic trioxide induces abnormal mitotic spindles through a PIP4KIIγ/Rho pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 1. 2012-11-13. PMID:22496355. |
furthermore, depletion of pip4kiiγ, but not other isoforms of the pipk family, not only reduced rho gtpase activation in ato-treated cells but also alleviated ato-induced spindle defects, mitotic arrest, and mitotic cell apoptosis. |
2012-11-13 |
2023-08-12 |
human |
| Daniel M Lewallen, Caitlin J Steckler, Bryan Knuckley, Michael J Chalmers, Paul R Thompso. Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates. Molecular bioSystems. vol 8. issue 6. 2012-11-05. PMID:22456874. |
the bacterial effector vops from vibrio parahaemolyticus modifies host rho gtpases to prevent downstream signalling, which leads to cell rounding and eventually apoptosis. |
2012-11-05 |
2023-08-12 |
Not clear |
| Catherine Qiurong Pan, Boon Chuan Lo. Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics. FEBS letters. vol 586. issue 17. 2012-10-29. PMID:22710163. |
the bnip-2 and cdc42gap homology (bch) domains constitute a new and expanding family of highly conserved scaffold protein domains that regulate rho, ras and mapk signaling, leading to cell growth, apoptosis, morphogenesis, migration and differentiation. |
2012-10-29 |
2023-08-12 |
Not clear |
| Fernanda Leve, José A Morgado-Día. Rho GTPase signaling in the development of colorectal cancer. Journal of cellular biochemistry. vol 113. issue 8. 2012-10-19. PMID:22467564. |
the involvement of rho gtpases in major aspects of cancer development, such as cell proliferation, apoptosis, cell polarity, adhesion, migration, and invasion, have recently been attracting increasing attention. |
2012-10-19 |
2023-08-12 |
Not clear |
| Kyung Hee Chang, Abel Sanchez-Aguilera, Shuhong Shen, Amitava Sengupta, Malav N Madhu, Ashley M Ficker, Susan K Dunn, Ashley M Kuenzi, Jorden L Arnett, Rebecca A Santho, Xabier Agirre, John P Perentesis, Michael W Deininger, Yi Zheng, Xose R Bustelo, David A Williams, Jose A Cancela. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. vol 120. issue 4. 2012-10-09. PMID:22692505. |
vav3 deficiency induces apoptosis of murine and human leukemic lymphoid progenitors, decreases the activation of rho gtpase family members and p21-activated kinase, and is associated with increased bad phosphorylation and up-regulation of bax, bak, and bik. |
2012-10-09 |
2023-08-12 |
human |
| Peng Zhang, Xinglong Wu, Chunchao Hu, Pengbo Wang, Xiangyun L. Rho kinase inhibitor Y-27632 and Accutase dramatically increase mouse embryonic stem cell derivation. In vitro cellular & developmental biology. Animal. vol 48. issue 1. 2012-10-01. PMID:22179675. |
recently, the rho kinase inhibitor y-27632 and the cell dissociation reagent accutase were reported to significantly inhibit apoptosis of human es cells during passaging. |
2012-10-01 |
2023-08-12 |
mouse |
| Tsuyoshi Ohta, Toshifumi Takahashi, Tae Shibuya, Mitsuyoshi Amita, Noriko Henmi, Kazuhiro Takahashi, Hirohisa Kurach. Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells. Cancer biology & therapy. vol 13. issue 1. 2012-09-19. PMID:22336585. |
in the present study, we have shown that rho/rock pathway inhibition by fasudil, an orally administered inhibitor of rho kinases, enhanced cisplatin-induced growth inhibition and apoptosis in human ovarian cancer cell lines. |
2012-09-19 |
2023-08-12 |
human |
| F R Ferreira, A M Oliveira, A R Dinarte, D G Pinheiro, L J Greene, W A Silva, S R Joca, F S Guimarãe. Changes in hippocampal gene expression by 7-nitroindazole in rats submitted to forced swimming stress. Genes, brain, and behavior. vol 11. issue 3. 2012-09-10. PMID:22142142. |
genego analyses revealed that genes related to oxidative phosphorylation, apoptosis and survival controlled by htr1a signaling and cytoskeleton remodeling controlled by rho gtpases were significantly changed by fst. |
2012-09-10 |
2023-08-12 |
rat |
| Liming Wang, Mathew J Ellis, Jose A Gomez, William Eisner, Walter Fennell, David N Howell, Phillip Ruiz, Timothy A Fields, Robert F Spurne. Mechanisms of the proteinuria induced by Rho GTPases. Kidney international. vol 81. issue 11. 2012-09-10. PMID:22278020. |
active v14 rho enhanced actin polymerization, caused a reduction in nephrin mrna and protein levels, promoted podocyte apoptosis, and decreased endogenous rho a levels. |
2012-09-10 |
2023-08-12 |
mouse |
| Liming Wang, Mathew J Ellis, Jose A Gomez, William Eisner, Walter Fennell, David N Howell, Phillip Ruiz, Timothy A Fields, Robert F Spurne. Mechanisms of the proteinuria induced by Rho GTPases. Kidney international. vol 81. issue 11. 2012-09-10. PMID:22278020. |
in contrast, the dominant-negative n19 rho caused a loss of podocyte stress fibers, did not alter the expression of either nephrin or rho a, and did not cause podocyte apoptosis. |
2012-09-10 |
2023-08-12 |
mouse |