| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuezheng Liu, Zhongfu Zuo, Wanpeng Liu, Zhiyun Wang, Yang Hou, Yunjie Fu, Yuzhi Ha. Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats. Neural regeneration research. vol 9. issue 8. 2014-09-10. PMID:25206894. |
when rna interference was used to suppress nogo receptor expression in rat retina, rho kinase expression was obviously inhibited, and retinal ganglion cell apoptosis was evidently reduced in rats with diabetes mellitus. |
2014-09-10 |
2023-08-13 |
rat |
| Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Tadahiro Iimura, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tetsuhiko Tachikawa, Kazuki Nakao, Matsuo Yamamoto, Akira Yamaguchi, Atsu Aiba, Ryutaro Kamij. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mechanisms of development. vol 129. issue 1-4. 2014-09-08. PMID:22387309. |
cdc42, a member of the rho subfamily of small gtpases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. |
2014-09-08 |
2023-08-12 |
mouse |
| Ju Gao, Tao Huang, Luo-Jing Zhou, Ya-Li Ge, Shun-Yan Lin, Yan Da. Preconditioning effects of physiological cyclic stretch on pathologically mechanical stretch-induced alveolar epithelial cell apoptosis and barrier dysfunction. Biochemical and biophysical research communications. vol 448. issue 3. 2014-08-20. PMID:24699412. |
we aim to investigate the effects of preconditioning of physiological cyclic stretch on the alveolar epithelial cell apoptosis induced by pathologically mechanical stretch and barrier dysfunction and how these effects are linked to differential expression of small gtpases rac and rho mrna. |
2014-08-20 |
2023-08-13 |
Not clear |
| Anke Augspach, Joachim H List, Philipp Wolf, Heike Bielek, Carsten Schwan, Ursula Elsässer-Beile, Klaus Aktories, Gudula Schmid. Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells. Toxins. vol 5. issue 11. 2014-06-19. PMID:24284827. |
we asked whether these rho activators could induce apoptosis in lncap cells. |
2014-06-19 |
2023-08-12 |
human |
| Anke Augspach, Joachim H List, Philipp Wolf, Heike Bielek, Carsten Schwan, Ursula Elsässer-Beile, Klaus Aktories, Gudula Schmid. Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells. Toxins. vol 5. issue 11. 2014-06-19. PMID:24284827. |
analysis of the underlying signaling pathway reveals that apoptosis induction requires the activity of rho kinase (rock) and myosin activation, an apoptotic pathway previously identified in cancer stem cells. |
2014-06-19 |
2023-08-12 |
human |
| Bibo Tan, Yong Li, Qun Zhao, Liqiao Fan, Dong Wang, Yü Li. Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 2. 2014-04-28. PMID:24072493. |
vav3, a rho gtpase guanine nucleotide exchange factor, is associated with tumor growth, apoptosis, invasion and metastasis, and angiogenesis. |
2014-04-28 |
2023-08-12 |
Not clear |
| Harshil D Dhruv, Timothy G Whitsett, Nathan M Jameson, Falak Patel, Jeffrey A Winkles, Michael E Berens, Nhan L Tra. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation. Carcinogenesis. vol 35. issue 1. 2014-04-03. PMID:23975833. |
tumor necrosis factor-like weak inducer of apoptosis (tweak), a member of the tumor necrosis factor superfamily, can stimulate glioma cell invasion via binding to fibroblast growth factor-inducible 14 (fn14) and subsequent activation of the rho guanosine triphosphatase family member rac1. |
2014-04-03 |
2023-08-12 |
Not clear |
| Alessia Fabbri, Sara Travaglione, Giulia Ballan, Stefano Loizzo, Carla Fiorentin. The cytotoxic necrotizing factor 1 from E. coli: a janus toxin playing with cancer regulators. Toxins. vol 5. issue 8. 2014-02-28. PMID:23949007. |
this rho gtpases-activating toxin induces dysfunctions in transformed epithelial cells, such as apoptosis counteraction, pro-inflammatory cytokines' release, cox2 expression, nf-kb activation and boosted cellular motility. |
2014-02-28 |
2023-08-12 |
human |
| Aditi U Gurkar, Kiki Chu, Lakshmi Raj, Richard Bouley, Seung-Hwan Lee, Young-Bum Kim, Sandra E Dunn, Anna Mandinova, Sam W Le. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nature communications. vol 4. 2014-01-30. PMID:23877263. |
the ser/thr rho kinase 1 (rock1) is known to have major roles in a wide range of cellular activities, including those involved in tumour metastasis and apoptosis. |
2014-01-30 |
2023-08-12 |
mouse |
| Denis Selimovic, Helene E Badura, Abdelouahid El-Khattouti, Martine Soell, Benjamin B O W Porzig, Achim Spernger, Foued Ghanjati, Simeon Santourlidis, Youssef Haikel, Mohamed Hassa. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23564313. |
vinblastine-induced apoptosis of melanoma cells is mediated by ras homologous a protein (rho a) via mitochondrial and non-mitochondrial-dependent mechanisms. |
2014-01-10 |
2023-08-12 |
Not clear |
| Denis Selimovic, Helene E Badura, Abdelouahid El-Khattouti, Martine Soell, Benjamin B O W Porzig, Achim Spernger, Foued Ghanjati, Simeon Santourlidis, Youssef Haikel, Mohamed Hassa. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23564313. |
moreover, inhibitory experiments addressed a central role for rho a in the regulation of vinblastine-induced apoptosis of melanoma cells via mitochondrial and non-mitochondrial-dependent mechanisms. |
2014-01-10 |
2023-08-12 |
Not clear |
| Denis Selimovic, Helene E Badura, Abdelouahid El-Khattouti, Martine Soell, Benjamin B O W Porzig, Achim Spernger, Foued Ghanjati, Simeon Santourlidis, Youssef Haikel, Mohamed Hassa. Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms. Apoptosis : an international journal on programmed cell death. vol 18. issue 8. 2014-01-10. PMID:23564313. |
in conclusion, the present study addresses for the first time a central role for rho a in the modulation of vinblastine-induced apoptosis of melanoma cells and thereby provides an insight into the molecular action of vinblastine in melanoma treatment. |
2014-01-10 |
2023-08-12 |
Not clear |
| Francesca Cencetti, Caterina Bernacchioni, Francesca Tonelli, Edward Roberts, Chiara Donati, Paola Brun. TGFβ1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 11. 2014-01-07. PMID:23913862. |
herein we report the identification of a new signaling pathway, relying on rho kinase-2 stimulation, subsequent to smad-dependent s1p4 up-regulation and transactivation via sphingosine kinase (sk)-2, that accounts for tgfβ1-induced apoptosis in cultured myoblasts. |
2014-01-07 |
2023-08-12 |
Not clear |
| Shan Li, Lianfa Shi, Zhiyong Yang, Hanping Fen. Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol. Pathogens and disease. vol 67. issue 1. 2013-11-12. PMID:23620115. |
they did eventually cause cell rounding, glucosylation of rho gtpases, and apoptosis that was indistinguishable from that caused by tcdb. |
2013-11-12 |
2023-08-12 |
Not clear |
| Shannon P Fortin Ensign, Ian T Mathews, Jennifer M Eschbacher, Joseph C Loftus, Marc H Symons, Nhan L Tra. The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2. The Journal of biological chemistry. vol 288. issue 30. 2013-11-04. PMID:23775076. |
tnf-like weak inducer of apoptosis (tweak)-fn14 ligand-receptor signaling is one mechanism in gb that promotes cell invasiveness and survival and is dependent upon the activity of multiple rho gtpases, including rac1. |
2013-11-04 |
2023-08-12 |
Not clear |
| Sanae Kanno, Seishiro Hirano, Morihisa Sagi, Shoetsu Chiba, Hiroshi Takeshita, Toru Ikawa, Kazue Ichiba, Tomonori Nagai, Meri Takada, Kana Sakamoto, Toshiji Muka. Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells. Archives of toxicology. vol 87. issue 7. 2013-10-17. PMID:23479079. |
sulfide induces apoptosis and rho kinase-dependent cell blebbing in jurkat cells. |
2013-10-17 |
2023-08-12 |
human |
| Nicholl K Pakes, Douwe M Veltman, Robin S B William. Zizimin and Dock guanine nucleotide exchange factors in cell function and disease. Small GTPases. vol 4. issue 1. 2013-09-13. PMID:23247359. |
together the rho family of small gtpases and the dock/zizimin proteins play a vital role in a number of cell processes including cell migration, apoptosis, cell division and cell adhesion. |
2013-09-13 |
2023-08-12 |
Not clear |
| Giulia Benedetti, Michiel Fokkelman, Kuan Yan, Lisa Fredriksson, Bram Herpers, John Meerman, Bob van de Water, Marjo de Graau. The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch. Molecular pharmacology. vol 84. issue 1. 2013-09-11. PMID:23625948. |
pharmacological inhibition of rho kinase signaling re-established the synergistic apoptosis induced by combined cisplatin/tnf-α treatment of shrelb cells. |
2013-09-11 |
2023-08-12 |
Not clear |
| Giulia Benedetti, Michiel Fokkelman, Kuan Yan, Lisa Fredriksson, Bram Herpers, John Meerman, Bob van de Water, Marjo de Graau. The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch. Molecular pharmacology. vol 84. issue 1. 2013-09-11. PMID:23625948. |
in conclusion, our study shows for the first time that relb is required for the cisplatin/tnf-α-induced cytoskeletal reorganization and apoptosis in renal cells by controlling a rho kinase-dependent signaling network. |
2013-09-11 |
2023-08-12 |
Not clear |
| Z Hasan, K Palani, S Zhang, M Lepsenyi, R Hwaiz, M Rahman, I Syk, B Jeppsson, Henrik Thorlaciu. Rho kinase regulates induction of T-cell immune dysfunction in abdominal sepsis. Infection and immunity. vol 81. issue 7. 2013-08-15. PMID:23630965. |
inhibition of rho kinase activity decreased apoptosis and enhanced proliferation of cd4 t cells in septic animals. |
2013-08-15 |
2023-08-12 |
mouse |