| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail V Shepelev, Jonathan Chernoff, Igor V Korobk. Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small GTPases. vol 2. issue 1. 2021-10-20. PMID:21686277. |
rho gtpases regulate numerous cellular processes including apoptosis. |
2021-10-20 |
2023-08-12 |
Not clear |
| Nathaniel B Goldstein, Andrea Steel, Chauncey C Barbulescu, Maranke I Koster, Michael J Wright, Kenneth L Jones, Bifeng Gao, Brian Ward, Brian Woessner, Zachary Trottier, Jen Pakieser, Junxiao Hu, Karoline A Lambert, Yiqun G Shellman, Mayumi Fujita, William A Robinson, Dennis R Roop, David A Norris, Stanca A Birle. Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling. The Journal of investigative dermatology. vol 141. issue 3. 2021-10-08. PMID:32800877. |
knockdown studies in cultured human mcs of rhoj, the upmost differentially expressed rho family component, corroborated with our findings in patients with vitiligo, identified rhoj involvement in uv response and melanization, and confirmed previously identified roles in melanocytic cell migration and apoptosis. |
2021-10-08 |
2023-08-13 |
human |
| Yingjie Lv, Pengsheng Ma, Jialing Wang, Qingbin Xu, Jun Fan, Lin Yan, Ping Ma, Ru Zho. Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension. European journal of pharmacology. vol 910. 2021-10-04. PMID:34245749. |
pulmonary vascular remodeling was shown to lead to pulmonary arterial hypertension (pah), further trigger excessive apoptosis of cardiomyocytes, and ultimately cause right ventricular failure (rvf), which involves the activation of rho a/rock signaling pathway. |
2021-10-04 |
2023-08-13 |
rat |
| Jun Gao, Chao Dai, Xin Yu, Xiang-Bao Yin, Fan Zho. Upregulated microRNA-194 impairs stemness of cholangiocarcinoma cells through the Rho pathway via inhibition of ECT2. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31960990. |
more important, the elevated expression of mir-194 or ect2 silencing inhibited the rho pathway, and further promoted the apoptosis and suppressed the stem cell proliferation, migration, and invasion of cca in vitro. |
2021-07-12 |
2023-08-13 |
mouse |
| Jun Gao, Chao Dai, Xin Yu, Xiang-Bao Yin, Fan Zho. Upregulated microRNA-194 impairs stemness of cholangiocarcinoma cells through the Rho pathway via inhibition of ECT2. Journal of cellular biochemistry. vol 121. issue 10. 2021-07-12. PMID:31960990. |
in a word, mir-194 inhibits ect2 and blocks the activation of rho signaling pathway, thus promoting apoptosis, inhibiting proliferation and migration of cca stem cells, and suppressing tumor growth. |
2021-07-12 |
2023-08-13 |
mouse |
| Yan Su, Langtao Hu, Yanni Wang, Gangqiang Ying, Chunyang Ma, Jiali We. The Rho kinase signaling pathway participates in tubular mitochondrial oxidative injury and apoptosis in uric acid nephropathy. The Journal of international medical research. vol 49. issue 6. 2021-06-28. PMID:34167354. |
the rho kinase signaling pathway participates in tubular mitochondrial oxidative injury and apoptosis in uric acid nephropathy. |
2021-06-28 |
2023-08-13 |
Not clear |
| Chuan Jiang, Ning Dong, Jianli Feng, Maolin Ha. MiRNA-190 exerts neuroprotective effects against ischemic stroke through Rho/Rho-kinase pathway. Pflugers Archiv : European journal of physiology. vol 473. issue 1. 2021-06-03. PMID:33196911. |
furthermore, knockdown of rho significantly downregulated the increased mrna and protein expression of rho/rho kinase and cell apoptosis, while these effects were inhibited by mir-190 inhibitors in rats suffering with i/r. |
2021-06-03 |
2023-08-13 |
rat |
| Kossay Zaoui, Stephanie Duhame. Colorimetric RhoB GTPase Activity Assay. Bio-protocol. vol 10. issue 9. 2021-05-07. PMID:33659574. |
the rho gtpases are crucial regulators of actin cytoskeleton rearrangements and fa dynamics and are required for effective cell migration and invasion, as well as cell cycle progression and apoptosis. |
2021-05-07 |
2023-08-13 |
Not clear |
| Anna Cecília Dias Maciel Carneiro, Fernanda Bernadelli De Vito, Helio Moraes-Souza, Virgínia Oliveira Crem. RhoA/ROCKs signaling is increased by treatment with TKI-258 and leads to increased apoptosis in SCC-4 oral squamous cell carcinoma cell line. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 50. issue 4. 2021-04-19. PMID:33222274. |
this study evaluated the effect of treatment with tki-258 on apoptosis, involving rho gtpases and their effectors in scc-4 cells of oral squamous cell carcinoma. |
2021-04-19 |
2023-08-13 |
Not clear |
| W-M Zhang, P Cao, L Xin, Y Zhang, Z Liu, N Yao, Y-Y M. Effect of miR-133 on apoptosis of trophoblasts in human placenta tissues via Rho/ROCK signaling pathway. European review for medical and pharmacological sciences. vol 23. issue 24. 2021-02-08. PMID:31858525. |
the aim of this study was to explore the role of micro ribonucleic acid (mir)-133 in the apoptosis of human placental trophoblasts through the ras homolog gene family (rho)/rho-associated coiled-coil forming protein kinase (rock) signaling pathway. |
2021-02-08 |
2023-08-13 |
human |
| Pengfei Li, Huina Lv, Min Xu, Bin Zang, Yegang M. ARHGAP6 Promotes Apoptosis and Inhibits Glycolysis in Lung Adenocarcinoma Through STAT3 Signaling Pathway. Cancer management and research. vol 12. 2020-10-30. PMID:33116826. |
recent work has indicated that rho gtpase-activating protein 6 (arhgap6) promotes cell cycle arrest and apoptosis in cervical and breast cancers. |
2020-10-30 |
2023-08-13 |
Not clear |
| Zhenci Yi, Jiaying Ke, Yaoguo Wang, Kaijin Ca. Fluvastatin protects myocardial cells in mice with acute myocardial infarction through inhibiting RhoA/ROCK pathway. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104271. |
after the rho member a (rhoa)/rock pathway agonist ang ii was added, the mitigation effect of flu on myocardial apoptosis in the infarction region in ami mice was evidently weakened. |
2020-09-28 |
2023-08-13 |
mouse |
| Pavol Zubor, Zuzana Dankova, Zuzana Kolkova, Veronika Holubekova, Dusan Brany, Sandra Mersakova, Marek Samec, Alena Liskova, Lenka Koklesova, Peter Kubatka, Jan Bujnak, Karol Kajo, Milos Mlyncek, Frank A Giordano, Olga Golubnitschaj. Rho GTPases in Gynecologic Cancers: In-Depth Analysis toward the Paradigm Change from Reactive to Predictive, Preventive, and Personalized Medical Approach Benefiting the Patient and Healthcare. Cancers. vol 12. issue 5. 2020-09-28. PMID:32443784. |
rho gtpases play a key regulatory role in gene expression, cell cycle control and proliferation, epithelial cell polarity, cell migration, survival, and apoptosis, among others. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xuezhi Zhang, Jun Guan, Minglei Guo, Hongyan Dai, Shanglang Cai, Changyong Zhou, Yongbin Wang, Qiaoji Qi. Rho GTPase‑activating protein 1 promotes apoptosis of myocardial cells in an ischemic cardiomyopathy model. Kardiologia polska. vol 77. issue 12. 2020-06-18. PMID:31664016. |
rho gtpase‑activating protein 1 promotes apoptosis of myocardial cells in an ischemic cardiomyopathy model. |
2020-06-18 |
2023-08-13 |
Not clear |
| Matthew Koslow, Kevin J O'Keefe, Zeinab F Hosseini, Deirdre A Nelson, Melinda Larse. ROCK inhibitor increases proacinar cells in adult salivary gland organoids. Stem cell research. vol 41. 2020-06-02. PMID:31731180. |
the rho kinase (rock) inhibitor, y27632, has been used to increase the proliferation and reduce apoptosis of progenitor cells grown in vitro. |
2020-06-02 |
2023-08-13 |
mouse |
| Marco Zarbin, Ilene Sugino, Ellen Townes-Anderso. Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration. Stem cells translational medicine. vol 8. issue 5. 2020-04-30. PMID:30748126. |
synaptic disjunction and photoreceptor apoptosis associated with retinal detachment can be reduced with rho kinase inhibitors. |
2020-04-30 |
2023-08-13 |
Not clear |
| Xianqi Feng, Ling Zhang, Shumin Nie, Likun Zhuang, Wei Wang, Junxia Huang, Xueshen Yan, Fanjun Men. The Effect of Ras Homolog C/Rho-Associated Coiled-Protein Kinase (Rho/ROCK) Signaling Pathways on Proliferation and Apoptosis of Human Myeloma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31599230. |
furthermore, rho and rock inhibitors significantly inhibit cell growth and induce cell apoptosis in the human multiple myeloma cell lines rpmi-8226 and u266. |
2020-02-20 |
2023-08-13 |
human |
| Kai Zhang, Yuxiang Liu, Xiumei Liu, Meiting Peng, Jinxiang Liu, Quanqi Zhan. A functional polymorphism in the promoter of RhoB is associated with susceptibility to Vibrio anguillarum in turbot (Scophthalmus maximus). Fish & shellfish immunology. vol 93. 2020-01-06. PMID:31306762. |
as an isoform of rho family gtpases, rhob plays a pivotal role in cytoskeletal organization, cell proliferation, apoptosis and immune response. |
2020-01-06 |
2023-08-13 |
Not clear |
| Derek Strassheim, Evgenia Gerasimovskaya, David Irwin, Edward C Dempsey, Kurt Stenmark, Vijaya Karoo. RhoGTPase in Vascular Disease. Cells. vol 8. issue 6. 2019-12-23. PMID:31174369. |
ras-homologous (rho)a/rho-kinase pathway plays an essential role in many cellular functions, including contraction, motility, proliferation, and apoptosis, inflammation, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. |
2019-12-23 |
2023-08-13 |
Not clear |
| Yan-Hua Shen, Hai-Xing Jiang, Shan-Yu Qin, Liu-Ping Wei, Yun-Chao Meng, Wei Lu. [Activation of hepatocyte growth factor promotes apoptosis of hepatic stellate cells via the Rho pathway]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 22. issue 2. 2019-11-20. PMID:24735597. |
[activation of hepatocyte growth factor promotes apoptosis of hepatic stellate cells via the rho pathway]. |
2019-11-20 |
2023-08-13 |
Not clear |