| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Zugasti, W Rul, P Roux, C Peyssonnaux, A Eychene, T F Franke, P Fort, U Hibne. Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt. Molecular and cellular biology. vol 21. issue 19. 2001-09-27. PMID:11533257. |
dominant-negative mutants of two members of rho family gtpases, rac1 and cdc42, mimic the loss of anchorage in primary mouse fibroblasts and are potent inducers of apoptosis. |
2001-09-27 |
2023-08-12 |
mouse |
| O Zugasti, W Rul, P Roux, C Peyssonnaux, A Eychene, T F Franke, P Fort, U Hibne. Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt. Molecular and cellular biology. vol 21. issue 19. 2001-09-27. PMID:11533257. |
our data demonstrate that the gtpases of the rho family control three major components of cellular signal transduction, namely, p53, akt, and erks, which collaborate in the induction of apoptosis due to the loss of anchorage. |
2001-09-27 |
2023-08-12 |
mouse |
| Y W Eom, M H Yoo, C H Woo, K C Hwang, W K Song, Y J Yoo, J S Chun, J H Ki. Implication of the small GTPase Rac1 in the apoptosis induced by UV in Rat-2 fibroblasts. Biochemical and biophysical research communications. vol 285. issue 3. 2001-08-16. PMID:11453667. |
however, the role of rac, a member of rho family gtpases, in the uv-induced apoptosis has never been examined. |
2001-08-16 |
2023-08-12 |
Not clear |
| T Trapp, L Oláh, I Hölker, M Besselmann, C Tiesler, K Maeda, K A Hossman. GTPase RhoB: an early predictor of neuronal death after transient focal ischemia in mice. Molecular and cellular neurosciences. vol 17. issue 5. 2001-08-09. PMID:11358485. |
activation of caspase-3, a crucial step in apoptosis, could be inhibited by cytochalasin d, a substance that counteracts the actin-modulating activity of rho gtpases, indicating that rho proteins may have impact on injury-initiated neuronal signal transduction. |
2001-08-09 |
2023-08-12 |
mouse |
| I Petrache, A D Verin, M T Crow, A Birukova, F Liu, J G Garci. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. American journal of physiology. Lung cellular and molecular physiology. vol 280. issue 6. 2001-06-14. PMID:11350795. |
reductions in mlc phosphorylation by the inhibition of either mlc kinase (ml-7, cholera toxin) or rho kinase (y-27632) dramatically attenuated tnf-alpha-induced stress fiber formation, indexes of apoptosis, and caspase-8 activity but not tnf-alpha-induced barrier dysfunction. |
2001-06-14 |
2023-08-12 |
Not clear |
| M L Coleman, E A Sahai, M Yeo, M Bosch, A Dewar, M F Olso. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nature cell biology. vol 3. issue 4. 2001-05-21. PMID:11283606. |
here we show that the rho effector protein rock i, which contributes to phosphorylation of myosin light-chains, myosin atpase activity and coupling of actin-myosin filaments to the plasma membrane, is cleaved during apoptosis to generate a truncated active form. |
2001-05-21 |
2023-08-12 |
Not clear |
| J W Erickson, R A Cerion. Multiple roles for Cdc42 in cell regulation. Current opinion in cell biology. vol 13. issue 2. 2001-05-17. PMID:11248548. |
the rho family member cdc42 can signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. |
2001-05-17 |
2023-08-12 |
Not clear |
| J Wang, J P Silva, C M Gustafsson, P Rustin, N G Larsso. Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 7. 2001-05-03. PMID:11259653. |
furthermore, mtdna-less (rho(0)) cell lines were susceptible to apoptosis induced by different stimuli in vitro. |
2001-05-03 |
2023-08-12 |
human |
| S Aznar, J C Laca. Rho signals to cell growth and apoptosis. Cancer letters. vol 165. issue 1. 2001-04-26. PMID:11248412. |
rho signals to cell growth and apoptosis. |
2001-04-26 |
2023-08-12 |
human |
| S Aznar, J C Laca. Rho signals to cell growth and apoptosis. Cancer letters. vol 165. issue 1. 2001-04-26. PMID:11248412. |
in this review, an attempt to briefly integrate recent findings in transcriptional regulation by rho gtpases in the context of carcinogenesis and metastasis as well as apoptosis is made. |
2001-04-26 |
2023-08-12 |
human |
| N Embade, P F Valerón, S Aznar, E López-Collazo, J C Laca. Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production. Molecular biology of the cell. vol 11. issue 12. 2001-02-08. PMID:11102528. |
different members of the family of human rho gtpases, including rhoa, rhoc, and rac1, participate in the regulation of apoptosis in response to cytokines and serum deprivation in different cell systems. |
2001-02-08 |
2023-08-12 |
human |
| E Vignal, M De Toledo, F Comunale, A Ladopoulou, C Gauthier-Rouvière, A Blangy, P For. Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. The Journal of biological chemistry. vol 275. issue 46. 2000-12-29. PMID:10967094. |
gtpases of the rho family control a wide variety of cellular processes such as cell morphology, motility, proliferation, differentiation, and apoptosis. |
2000-12-29 |
2023-08-12 |
human |
| A H Hobson, M Donovan, M M Humphries, G Tuohy, N McNally, R Carmody, T Cotter, G J Farrar, P F Kenna, P Humphrie. Apoptotic photoreceptor death in the rhodopsin knockout mouse in the presence and absence of c-fos. Experimental eye research. vol 71. issue 3. 2000-10-18. PMID:10973734. |
precise knowledge of apoptotic photoreceptor cell death, together with factors which may influence apoptosis will be required for optimum utility of rho(-/-)mice as a model for therapeutic genetic intervention. |
2000-10-18 |
2023-08-12 |
mouse |
| A H Hobson, M Donovan, M M Humphries, G Tuohy, N McNally, R Carmody, T Cotter, G J Farrar, P F Kenna, P Humphrie. Apoptotic photoreceptor death in the rhodopsin knockout mouse in the presence and absence of c-fos. Experimental eye research. vol 71. issue 3. 2000-10-18. PMID:10973734. |
a peak phase of apoptosis of the photoreceptors of rho(-/-)mice was shown to occur at 24 days post-birth. |
2000-10-18 |
2023-08-12 |
mouse |
| R Kettritz, Y X Xu, B Faass, J B Klein, E C Müller, A Otto, A Busjahn, F C Luft, H Halle. TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator. Journal of leukocyte biology. vol 68. issue 2. 2000-08-29. PMID:10947073. |
tnf-alpha-mediated neutrophil apoptosis involves ly-gdi, a rho gtpase regulator. |
2000-08-29 |
2023-08-12 |
Not clear |
| P S Costello, S C Cleverley, R Galandrini, S W Henning, D A Cantrel. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. The Journal of experimental medicine. vol 192. issue 1. 2000-08-15. PMID:10880528. |
here we define the survival pathways controlled by rho in pre-t cells and show that this gtpase is a pivotal regulator of the p53-mediated checkpoint operating at the time of beta selection: loss of rho function results in apoptosis in pre-t cells, but this cell death is prevented by loss of p53. |
2000-08-15 |
2023-08-12 |
Not clear |
| G Scita, P Tenca, E Frittoli, A Tocchetti, M Innocenti, G Giardina, P P Di Fior. Signaling from Ras to Rac and beyond: not just a matter of GEFs. The EMBO journal. vol 19. issue 11. 2000-07-20. PMID:10835338. |
among small gtpases, ras and the rho family of proteins hierarchically and/or coordinately regulate signaling pathways leading to phenotypes as important as proliferation, differentiation and apoptosis. |
2000-07-20 |
2023-08-12 |
Not clear |
| P Lassus, P Roux, O Zugasti, A Philips, P Fort, U Hibne. Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathway. Oncogene. vol 19. issue 20. 2000-06-14. PMID:10828879. |
one of the pathways signalling apoptosis is controlled by the small gtpases of the rho family, also involved in cell proliferation, differentiation and motility. |
2000-06-14 |
2023-08-12 |
Not clear |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
rho family proteins modulate rapid apoptosis induced by cytotoxic t lymphocytes and fas. |
2000-05-04 |
2023-08-12 |
Not clear |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
little is known about the role of rho proteins in apoptosis produced by stimuli evolved specifically to produce apoptosis, such as granzymes from cytotoxic t lymphocytes (ctls) and fas. |
2000-05-04 |
2023-08-12 |
Not clear |