| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Fiorentini, P Matarrese, E Straface, L Falzano, A Fabbri, G Donelli, A Cossarizza, P Boquet, W Malorn. Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. Experimental cell research. vol 242. issue 1. 1998-08-10. PMID:9665831. |
in this work, we report that an escherichia coli protein toxin (cytotoxic necrotizing factor 1, cnf1) which activates the rho gtp-binding protein and prevent apoptosis in epithelial cells was able to: (i) influence the mitochondrial homeostasis and (ii) modulate the expression of proteins belonging to the bcl-2 family. |
1998-08-10 |
2023-08-12 |
human |
| C Fiorentini, P Matarrese, E Straface, L Falzano, A Fabbri, G Donelli, A Cossarizza, P Boquet, W Malorn. Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. Experimental cell research. vol 242. issue 1. 1998-08-10. PMID:9665831. |
cytochalasin b, which provokes most of the morphological changes typical of cnf1, including cell spreading, but without the involvement of rho, was unable to counteract apoptosis. |
1998-08-10 |
2023-08-12 |
human |
| J Gómez, C Martínez-A, A González, A Reboll. Dual role of Ras and Rho proteins: at the cutting edge of life and death. Immunology and cell biology. vol 76. issue 2. 1998-07-30. PMID:9619482. |
to date, isoforms of the ras and rho groups have been related to both promotion and suppression of apoptosis. |
1998-07-30 |
2023-08-12 |
Not clear |
| C Fiorentini, A Fabbri, L Falzano, A Fattorossi, P Matarrese, R Rivabene, G Donell. Clostridium difficile toxin B induces apoptosis in intestinal cultured cells. Infection and immunity. vol 66. issue 6. 1998-06-25. PMID:9596731. |
rather, the inhibition of proteins belonging to the rho family due to cdb seems to play a role in the induction of apoptosis in intestinal cells. |
1998-06-25 |
2023-08-12 |
Not clear |
| C O Reiser, T Lanz, F Hofmann, G Hofer, H D Rupprecht, M Goppelt-Strueb. Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins. The Biochemical journal. vol 330 ( Pt 3). 1998-05-21. PMID:9494074. |
specific inhibition of proteins of the small g-protein subfamily rho with toxin b from clostridium difficile led to changes in mesangial cell morphology without induction of apoptosis. |
1998-05-21 |
2023-08-12 |
rat |
| J C Mills, N L Stone, J Erhardt, R N Pittma. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. The Journal of cell biology. vol 140. issue 3. 1998-03-09. PMID:9456322. |
the model system described here should facilitate future studies of mlck, rho, and other signal transduction pathways activated during the execution phase of apoptosis. |
1998-03-09 |
2023-08-12 |
Not clear |
| J Gómez, C Martínez, M Giry, A García, A Reboll. Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction. European journal of immunology. vol 27. issue 11. 1998-01-02. PMID:9394801. |
rho prevents apoptosis through bcl-2 expression: implications for interleukin-2 receptor signal transduction. |
1998-01-02 |
2023-08-12 |
Not clear |
| L R Cavalli, M Varella-Garcia, B C Lian. Diminished tumorigenic phenotype after depletion of mitochondrial DNA. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 8. issue 11. 1997-12-30. PMID:9372242. |
no changes in expression of the apoptosis genes bcl-2 and bax, nor the drug resistance genes mdr1, mrp, or o6-alkyltransferase was found in any of the cell types (de novo, rho(-), or cybrid). |
1997-12-30 |
2023-08-12 |
Not clear |
| D Bobak, J Moorman, A Guanzon, L Gilmer, C Hah. Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis. Oncogene. vol 15. issue 18. 1997-12-23. PMID:9393976. |
inactivation of the small gtpase rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis. |
1997-12-23 |
2023-08-12 |
rat |
| D Bobak, J Moorman, A Guanzon, L Gilmer, C Hah. Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis. Oncogene. vol 15. issue 18. 1997-12-23. PMID:9393976. |
in this study, we examined potential roles for rho in adhesion-dependent and -independent pathways regulating apoptosis. |
1997-12-23 |
2023-08-12 |
rat |
| D Bobak, J Moorman, A Guanzon, L Gilmer, C Hah. Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis. Oncogene. vol 15. issue 18. 1997-12-23. PMID:9393976. |
most intriguingly, we found that dssin-based expression of c3 or loss of function mutants of rho could each induce apoptosis and, in rsm, this effect was observed to be adhesion-independent. |
1997-12-23 |
2023-08-12 |
rat |
| H Althoefer, P Eversole-Cire, M I Simo. Constitutively active Galphaq and Galpha13 trigger apoptosis through different pathways. The Journal of biological chemistry. vol 272. issue 39. 1997-10-23. PMID:9305896. |
whereas galphaq induced apoptosis via a protein kinasec-dependent pathway, galpha13 caused programmed cell death through a pathway involving the activation of the small g-protein rho. |
1997-10-23 |
2023-08-12 |
Not clear |
| R Galandrini, S W Henning, D A Cantrel. Different functions of the GTPase Rho in prothymocytes and late pre-T cells. Immunity. vol 7. issue 1. 1997-09-04. PMID:9252129. |
the selective apoptosis defect in rho prothymocytes can be rescued by expression of a bcl-2 transgene. |
1997-09-04 |
2023-08-12 |
mouse |
| J C Laca. Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling. FEBS letters. vol 410. issue 1. 1997-08-28. PMID:9247126. |
regulation of proliferation and apoptosis by ras and rho gtpases through specific phospholipid-dependent signaling. |
1997-08-28 |
2023-08-12 |
Not clear |
| R Perona, S Montaner, L Saniger, I Sánchez-Pérez, R Bravo, J C Laca. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes & development. vol 11. issue 4. 1997-03-24. PMID:9042860. |
here we report a novel signaling pathway activated by the rho proteins that may be responsible for their biological activities, including cytoskeleton organization, transformation, apoptosis, and metastasis. |
1997-03-24 |
2023-08-12 |
human |
| P F Lebowitz, D Sakamuro, G C Prendergas. Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment. Cancer research. vol 57. issue 4. 1997-03-05. PMID:9044849. |
furthermore, apoptosis was significantly attenuated by ectopic expression of a farnesyl-independent form of rhob, a rho protein previously implicated as a critical target for inhibition by ftis. |
1997-03-05 |
2023-08-12 |
Not clear |
| J P Moorman, D A Bobak, C S Hah. Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 11. 1996-08-08. PMID:8666781. |
inactivation of the small gtp binding protein rho induces multinucleate cell formation and apoptosis in murine t lymphoma el4. |
1996-08-08 |
2023-08-12 |
Not clear |
| J P Moorman, D A Bobak, C S Hah. Inactivation of the small GTP binding protein Rho induces multinucleate cell formation and apoptosis in murine T lymphoma EL4. Journal of immunology (Baltimore, Md. : 1950). vol 156. issue 11. 1996-08-08. PMID:8666781. |
in addition, dssin:c3-mediated inactivation of rho was a potent activator of apoptosis in el4 cells. |
1996-08-08 |
2023-08-12 |
Not clear |
| S Na, T H Chuang, A Cunningham, T G Turi, J H Hanke, G M Bokoch, D E Danle. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. The Journal of biological chemistry. vol 271. issue 19. 1996-06-27. PMID:8626669. |
here we report that d4-gdi, an abundant hematopoietic cell gdp dissociation inhibitor for the ras-related rho family gtpases, is a substrate of the apoptosis protease cpp32/yama/apopain. |
1996-06-27 |
2023-08-12 |
Not clear |
| S Na, T H Chuang, A Cunningham, T G Turi, J H Hanke, G M Bokoch, D E Danle. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. The Journal of biological chemistry. vol 271. issue 19. 1996-06-27. PMID:8626669. |
these data suggest that regulation by d4-gdi of rho family gtpases may be disrupted during apoptosis by cpp32-mediated cleavage of the gdi protein. |
1996-06-27 |
2023-08-12 |
Not clear |