| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
dominant-negative mutants of each rho family member and clostridium difficile toxin b, an inhibitor of all family members, strongly inhibited the susceptibility of cells to ctl- and fas-induced apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| M C Subauste, M Von Herrath, V Benard, C E Chamberlain, T H Chuang, K Chu, G M Bokoch, K M Hah. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734125. |
rho family proteins may regulate apoptosis through their effects on the actin cytoskeleton. |
2000-05-04 |
2023-08-12 |
Not clear |
| Y Kagawa, S H Cha, K Hasegawa, T Hamamoto, H End. Regulation of energy metabolism in human cells in aging and diabetes: FoF(1), mtDNA, UCP, and ROS. Biochemical and biophysical research communications. vol 266. issue 3. 2000-02-03. PMID:10603304. |
we cultured human rho(o) cells (cells without mtdna) in synthetic media and elucidated relationships among mtdna, ndna, delta muh(+), ucps, ros, and apoptosis. |
2000-02-03 |
2023-08-12 |
human |
| B R Lanoue, J R Jacob. Rhomboid function in the midline of the Drosophila CNS. Developmental genetics. vol 25. issue 4. 2000-01-11. PMID:10570464. |
rho expression is required continuously from embryonic stage 9-17 to suppress apoptosis in the mg. |
2000-01-11 |
2023-08-12 |
drosophila_melanogaster |
| S Jiang, J Cai, D C Wallace, D P Jone. Cytochrome c-mediated apoptosis in cells lacking mitochondrial DNA. Signaling pathway involving release and caspase 3 activation is conserved. The Journal of biological chemistry. vol 274. issue 42. 1999-11-19. PMID:10514472. |
in the present study, we examined mitochondrial mechanisms of apoptosis in rho(0) osteosarcoma cells treated with staurosporine. |
1999-11-19 |
2023-08-12 |
Not clear |
| R H Weiss, A Ramirez, A Jo. Short-term pravastatin mediates growth inhibition and apoptosis, independently of Ras, via the signaling proteins p27Kip1 and P13 kinase. Journal of the American Society of Nephrology : JASN. vol 10. issue 9. 1999-11-04. PMID:10477139. |
levels of the cyclin-dependent kinase inhibitor p27kip1 are increased when cells were preincubated with pravastatin for 1 h and then exposed to pdgf, and apoptosis is induced by pravastatin incubation times as short as 1 to 4 h. thus, short-term, high-dose pravastatin inhibits vascular smooth muscle cell growth and induces apoptosis independently of ras, likely by means of the drug's effect on p27kip1, mediated by rho and/or phosphatidylinositol-3 kinase. |
1999-11-04 |
2023-08-12 |
rat |
| R J Krieser, A Eastma. Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis. Cell death and differentiation. vol 6. issue 5. 1999-09-09. PMID:10381642. |
cleavage and nuclear translocation of the caspase 3 substrate rho gdp-dissociation inhibitor, d4-gdi, during apoptosis. |
1999-09-09 |
2023-08-12 |
human |
| C Fiorentini, M Gauthier, G Donelli, P Boque. Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation. Cell death and differentiation. vol 5. issue 9. 1999-05-28. PMID:10200530. |
c3 and cnf1 have opposite effects on rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis. |
1999-05-28 |
2023-08-12 |
Not clear |
| C P Fall, J P Bennet. Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cells. Journal of neuroscience research. vol 55. issue 5. 1999-05-24. PMID:10082084. |
rho(o) cells, lacking a functional etc, showed no ros production, compensatory lactate production or apoptosis after exposure to mpp+. |
1999-05-24 |
2023-08-12 |
human |
| P Aspenströ. Effectors for the Rho GTPases. Current opinion in cell biology. vol 11. issue 1. 1999-03-16. PMID:10047515. |
the rho gtpases are simple enzymes with complex roles in regulating cell morphology, gene transcription, cell cycle progression, apoptosis and tumour progression. |
1999-03-16 |
2023-08-12 |
human |
| J P Moorman, D Luu, J Wickham, D A Bobak, C S Hah. A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene. vol 18. issue 1. 1999-02-26. PMID:9926919. |
previously, we reported that inactivation of rho led to induction of apoptosis, implying that rho may play an important role in cell survival signaling. |
1999-02-26 |
2023-08-12 |
Not clear |
| J P Moorman, D Luu, J Wickham, D A Bobak, C S Hah. A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene. vol 18. issue 1. 1999-02-26. PMID:9926919. |
this signaling, however, is not affected by expression of any forms of rac1 or cdc42, and only inactivation of rho led to induction of apoptosis. |
1999-02-26 |
2023-08-12 |
Not clear |
| K Nishida, Y Kaziro, T Sato. Anti-apoptotic function of Rac in hematopoietic cells. Oncogene. vol 18. issue 2. 1999-02-16. PMID:9927197. |
activated rac(g12v), when ectopically expressed in baf3 cells, rendered the cells resistant to apoptosis upon interleukin-3 deprivation, while activated mutants of rho and cdc42 displayed no significant anti-apoptotic effect. |
1999-02-16 |
2023-08-12 |
cattle |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
we report that several human rho proteins including rho a, rho c and rac 1, are capable of inducing apoptosis in different cell systems like murine nih3t3 fibroblasts and the human erythroleukemia k562 cell line. |
1998-11-25 |
2023-08-12 |
human |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
since k562 cells are devoid of p53, apoptosis induced by rho in this system is independent of p53. |
1998-11-25 |
2023-08-12 |
human |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
furthermore, the human oncogenes vav and ost that have been shown to function as guanine exchange factors for rho proteins, were also able to induce apoptosis under similar conditions. |
1998-11-25 |
2023-08-12 |
human |
| P Esteve, N Embade, R Perona, B Jiménez, L del Peso, J León, M Arends, T Miki, J C Laca. Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene. vol 17. issue 14. 1998-11-25. PMID:9778052. |
furthermore, tnf alpha-induced apoptosis in these cells is inhibited by expression of a dominant negative mutant of rac 1 but it is not affected by a similar mutant of rho a. |
1998-11-25 |
2023-08-12 |
human |
| I M Zohn, S L Campbell, R Khosravi-Far, K L Rossman, C J De. Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene. vol 17. issue 11 Reviews. 1998-11-23. PMID:9779988. |
rho family proteins are key components in cellular processes that control the organization of the actin cytoskeleton, activate kinase cascades, regulate gene expression, regulate membrane trafficking, promote growth transformation and induce apoptosis. |
1998-11-23 |
2023-08-12 |
Not clear |
| G Li, V B Segu, M E Rabaglia, R H Luo, A Kowluru, S A Met. Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis. Endocrinology. vol 139. issue 9. 1998-09-23. PMID:9724027. |
indeed, impeding the function of g proteins of the rho family (via glucosylation using clostridium difficile toxin b), although not itself inducing apoptosis, potentiated cell death induced by mpa or lovastatin. |
1998-09-23 |
2023-08-12 |
rat |
| J Gómez, A González, C Martínez-A, A Reboll. IL-2-induced cellular events. Critical reviews in immunology. vol 18. issue 3. 1998-08-31. PMID:9637410. |
ras and rho have been defined as dual molecules because ras- and rho-initiated signals can either promote or inhibit apoptosis. |
1998-08-31 |
2023-08-12 |
Not clear |