| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumei Li, Jingxiang Wang, Yurong Lu, Yuqing Zhao, Richard A Prinz, Xiulong X. Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells. Cell death & disease. vol 12. issue 5. 2021-10-14. PMID:33966040. |
we have uncovered a previously unrecognized role of tak1 in shh pathway inhibition-induced autophagy and apoptosis. |
2021-10-14 |
2023-08-13 |
Not clear |
| Sarah Martin, Daniel A Harrington, Samuel Ohlander, Samuel I Stupp, Kevin T McVary, Carol A Podlase. Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction. Nanomedicine : nanotechnology, biology, and medicine. vol 37. 2021-10-07. PMID:34314869. |
we examine two important aspects required for clinical application of the biomaterials: if shh pa suppresses intrinsic (caspase 9) and extrinsic (caspase 8) apoptotic mechanisms, and if suppressing one apoptotic mechanism forces apoptosis to occur via a different mechanism. |
2021-10-07 |
2023-08-13 |
Not clear |
| Xin Mao, Rong-Mei Yao, Yan-Yan Bao, Jing Sun, Xiao-Lan Cui, Hai-Jiang Zhang, Yu-Jing Sh. [Effect of polysaccharides from seeds of Vaccaria segetalis in alleviating urinary tract infection induced bladder injury by inhibiting NLRP3 inflammasome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 13. 2021-08-17. PMID:34396759. |
western blot and immunofluorescence staining were used to detect the expressions of sonic hedgehog( shh) and nlrp3 inflammasome [nod-like receptor thermoprotein domain 3( nlrp3),apoptosis associated speck like protein( asc) and pro-caspase-1]. |
2021-08-17 |
2023-08-13 |
rat |
| Jingchuan Wu, Junchi He, Xiaocui Tian, Jianjun Zhong, Hui Li, Xiaochuan Su. Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit. Translational stroke research. vol 11. issue 4. 2021-07-21. PMID:31898187. |
the effect of shh on the nvu in vivo was evaluated by detecting the degrees of cerebral edema and neuronal apoptosis. |
2021-07-21 |
2023-08-13 |
rat |
| Jingchuan Wu, Junchi He, Xiaocui Tian, Jianjun Zhong, Hui Li, Xiaochuan Su. Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit. Translational stroke research. vol 11. issue 4. 2021-07-21. PMID:31898187. |
the results showed that exogenous shh reduced cerebral edema and neuronal apoptosis and promoted neurological recovery after tbi in rats. |
2021-07-21 |
2023-08-13 |
rat |
| Yangyang Guo, Yu Tong, Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Lumeng Shang, Wenjing Zheng, Shumei Ma, Xiaodong Liu, Yongheng Ba. Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways. Cell biology and toxicology. vol 37. issue 3. 2021-07-15. PMID:33070227. |
we conclude that quercetin inhibited the growth, migration, and invasion and induced apoptosis of pccs by antagonizing shh and tgf-β/smad signaling pathways. |
2021-07-15 |
2023-08-13 |
mouse |
| Ruiqi Li, Yong Liu, Xiaofeng Huan. Effect of Sonic hedgehog on the proliferation in mouse tongue epithelial cells. Oral diseases. 2021-06-24. PMID:33751723. |
to investigate sonic hedgehog (shh) effects on proliferation and apoptosis of tongue epithelial cells in embryonic and ageing mice. |
2021-06-24 |
2023-08-13 |
mouse |
| Ambreen Shoaib, Mohammad Tabish, Shafat Ali, Azher Arafah, Muneeb U Rehman, Shadma Wahab, Feras M Al-Marshadh, Summya Rashi. Dietary Phytochemicals in Cancer Signalling Pathways: Role of miRNA targeting. Current medicinal chemistry. 2021-04-21. PMID:33881968. |
curcumin down-regulates shh pathways, epigallocatechin-3-gallate regulates the notch pathway, inhibits tgfβ1/smad signalling, resveratrol regulates the wnt/β-catenin pathway, and carnosic acid-induced apoptosis in colon cancer cell via jak2/stat3 signalling pathway. |
2021-04-21 |
2023-08-13 |
Not clear |
| Mu-Yao Wu, Fan Gao, Xiao-Mei Yang, Xia Qin, Guo-Zhao Chen, Di Li, Bao-Qi Dang, Gang Che. Matrix metalloproteinase-9 regulates the blood brain barrier via the hedgehog pathway in a rat model of traumatic brain injury. Brain research. vol 1727. 2021-04-05. PMID:31734396. |
application of sb-3ct at 24 h after tbi significantly reduced neuronal apoptosis and bbb permeability, while increasing expressions of scube2 and shh. |
2021-04-05 |
2023-08-13 |
rat |
| Zipeng Xie, Fang Wang, Lingqiang Lin, Shaoxian Duan, Xiangyang Liu, Xiaoyu Li, Ting Li, Mei Xue, Ying Cheng, He Ren, Yi Zh. An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells. Cancer letters. vol 495. 2021-03-25. PMID:32931885. |
an sglt2 inhibitor modulates shh expression by activating ampk to inhibit the migration and induce the apoptosis of cervical carcinoma cells. |
2021-03-25 |
2023-08-13 |
mouse |
| Zipeng Xie, Fang Wang, Lingqiang Lin, Shaoxian Duan, Xiangyang Liu, Xiaoyu Li, Ting Li, Mei Xue, Ying Cheng, He Ren, Yi Zh. An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells. Cancer letters. vol 495. 2021-03-25. PMID:32931885. |
empagliflozin intervention and downregulation of sonic hedgehog signaling molecule (shh) inhibited the migration and promoted the apoptosis of cervical cancer cells in nude mice. |
2021-03-25 |
2023-08-13 |
mouse |
| Zipeng Xie, Fang Wang, Lingqiang Lin, Shaoxian Duan, Xiangyang Liu, Xiaoyu Li, Ting Li, Mei Xue, Ying Cheng, He Ren, Yi Zh. An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells. Cancer letters. vol 495. 2021-03-25. PMID:32931885. |
in vitro experiments also showed that empagliflozin (50 μm) inhibited the migration of cervical cancer cells and induced their apoptosis by activating the ampk/foxa1 pathway and inhibiting the expression of shh. |
2021-03-25 |
2023-08-13 |
mouse |
| Zipeng Xie, Fang Wang, Lingqiang Lin, Shaoxian Duan, Xiangyang Liu, Xiaoyu Li, Ting Li, Mei Xue, Ying Cheng, He Ren, Yi Zh. An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells. Cancer letters. vol 495. 2021-03-25. PMID:32931885. |
the downregulation of shh with small interfering rna (sirna) inhibited the migration and invasion and promoted the apoptosis of hela cells. |
2021-03-25 |
2023-08-13 |
mouse |
| Hui Tian, Zhenkun H. Anti-hepatoma effect of taccalonolide A through suppression of sonic hedgehog pathway. Artificial cells, nanomedicine, and biotechnology. vol 48. issue 1. 2021-03-23. PMID:32496832. |
more importantly, activation of the shh pathway attenuated taccalonolide a-induced inhibition on cell viability and promotion on apoptosis and cell cycle arrest in hcc. |
2021-03-23 |
2023-08-13 |
Not clear |
| Hui Tian, Zhenkun H. Anti-hepatoma effect of taccalonolide A through suppression of sonic hedgehog pathway. Artificial cells, nanomedicine, and biotechnology. vol 48. issue 1. 2021-03-23. PMID:32496832. |
we clarified that taccalonolide a suppressed cell viability facilitated apoptosis, and improved the cytotoxicity of sorafenib in hcc by inhibition of the activation of the shh pathway, providing alternative treatments for hcc. |
2021-03-23 |
2023-08-13 |
Not clear |
| Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Tsevelmaa Nanjidsuren, Bong-Seok Song, Yeung Bae Jin, Sang-Rae Lee, Sun-Uk Kim, Bo-Woong Si. Effect of Oocyte Quality Assessed by Brilliant Cresyl Blue (BCB) Staining on Cumulus Cell Expansion and Sonic Hedgehog Signaling in Porcine during In Vitro Maturation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580308. |
therefore, this study investigated the effect of oocyte quality assessed by bcb staining on cumulus cell expansion, oocyte nuclear maturation, subsequent embryo development, apoptosis levels, and shh signaling protein expression, in porcine cocs. |
2021-03-19 |
2023-08-13 |
Not clear |
| Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Tsevelmaa Nanjidsuren, Bong-Seok Song, Yeung Bae Jin, Sang-Rae Lee, Sun-Uk Kim, Bo-Woong Si. Effect of Oocyte Quality Assessed by Brilliant Cresyl Blue (BCB) Staining on Cumulus Cell Expansion and Sonic Hedgehog Signaling in Porcine during In Vitro Maturation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580308. |
in conclusion, high-quality oocytes had a greater potential to expand their surrounding cumulus cells with active shh signaling and a lower apoptosis. |
2021-03-19 |
2023-08-13 |
Not clear |
| Wei Lei, Zhenyun Hu. Jervine inhibits non-small cell lung cancer (NSCLC) progression by suppressing Hedgehog and AKT signaling via triggering autophagy-regulated apoptosis. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-15. PMID:32972750. |
of note, enhancing shh signaling dramatically diminished the stimulative effects of jer on autophagy-mediated apoptosis in vitro, demonstrating the importance of hedgehog signaling in jer-regulated cell death. |
2021-03-15 |
2023-08-13 |
mouse |
| Huijuan Kuang, Wanyi Zhang, Lin Yang, Zoraida P Aguilar, Hengyi X. Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine. Environmental toxicology. vol 36. issue 4. 2021-03-12. PMID:33236829. |
in the ovary, zno nps induce cell apoptosis in shh pathway activated ovary cells, and affect the synthesis of steroidogenesis. |
2021-03-12 |
2023-08-13 |
mouse |
| Huashan Huang, Huizhen Yu, Liang Lin, Junming Chen, Pengli Zh. Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling. International journal of molecular medicine. vol 45. issue 6. 2021-01-21. PMID:32186749. |
however, whether shh is involved in atherosclerosis and plays a role in endothelial apoptosis induced by oxidized low‑density lipoprotein (ox‑ldl) has not been reported. |
2021-01-21 |
2023-08-13 |
human |