| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yonghui Wang, Yana Sui, Yinggang Ta. Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway. Molecular medicine reports. vol 20. issue 5. 2020-02-28. PMID:31545492. |
the present results indicated that ga significantly inhibited the viability and enhanced the rate of apoptosis in paclitaxel‑resistant mda‑mb‑231 cells via activating the shh signaling pathway. |
2020-02-28 |
2023-08-13 |
human |
| Youping Chen, Weifang Zh. Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31406102. |
the effects of knockdown of expression levels of the shh gene were studied on cell survival, cell apoptosis, the cell cycle, gluconeogenesis, and the expression of pck1. |
2020-02-20 |
2023-08-13 |
human |
| Youping Chen, Weifang Zh. Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31406102. |
results knockdown of expression levels of the shh gene reduced cell proliferation and growth of hcc cells and induced cell apoptosis and g1 cell cycle arrest in both hcc cell lines. |
2020-02-20 |
2023-08-13 |
human |
| Youping Chen, Weifang Zh. Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-20. PMID:31406102. |
conclusions knockdown of the shh gene reduced cell survival of hcc cells by increasing apoptosis, reducing cell proliferation, inducing g1 cell cycle arrest, and restoring gluconeogenesis, and was associated with the inhibition of the pi3k/akt axis and induced the expression of pck1. |
2020-02-20 |
2023-08-13 |
human |
| Sharad S Singhal, Ravi Salgia, Nisan Verma, David Horne, Sanjay Awasth. RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis. Biochimica et biophysica acta. Reviews on cancer. vol 1873. issue 1. 2020-02-20. PMID:31904398. |
cde is an essential mechanism for internalizing ligand-receptor complexes that signal proliferation (egf, insulin, igf1), apoptosis (tnfα, trail, fas-l), and differentiation and morphogenesis (tgfβ, wnt, notch, shh). |
2020-02-20 |
2023-08-13 |
Not clear |
| Qing Xiao, Xiao-Ya Zhao, Ru-Chao Jiang, Xiu-Hui Chen, Xiang Zhu, Kai-Feng Chen, Sheng-Ying Chen, Xiao-Ling Zhang, Yuan Qin, Ying-Hua Liu, Jian-Dong Lu. Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524224. |
our previous studies revealed that an impaired sonic hedgehog (shh) pathway contributes to insufficient function in diabetic epcs; however, the roles of the shh pathway in diabetic epc apoptosis under basal and hypoxic/ischemic conditions remain unknown. |
2020-02-04 |
2023-08-13 |
mouse |
| Qing Xiao, Xiao-Ya Zhao, Ru-Chao Jiang, Xiu-Hui Chen, Xiang Zhu, Kai-Feng Chen, Sheng-Ying Chen, Xiao-Ling Zhang, Yuan Qin, Ying-Hua Liu, Jian-Dong Lu. Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524224. |
first, the in vitro results demonstrated that the apoptosis of diabetic epcs was reduced following treatment with shh protein for 24 h, under normal or hypoxic conditions. |
2020-02-04 |
2023-08-13 |
mouse |
| Qing Xiao, Xiao-Ya Zhao, Ru-Chao Jiang, Xiu-Hui Chen, Xiang Zhu, Kai-Feng Chen, Sheng-Ying Chen, Xiao-Ling Zhang, Yuan Qin, Ying-Hua Liu, Jian-Dong Lu. Increased expression of Sonic hedgehog restores diabetic endothelial progenitor cells and improves cardiac repair after acute myocardial infarction in diabetic mice. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524224. |
in conclusion, the present results demonstrated that the shh pathway restored diabetic epcs through the shh/bmi1/p53 axis, suppressed myocardial apoptosis and improved myocardial angiogenesis, thus reducing cardiac fibrosis and finally restoring myocardial repair and cardiac function in dmi. |
2020-02-04 |
2023-08-13 |
mouse |
| Evelina Miele, Sergio Valente, Vincenzo Alfano, Marianna Silvano, Paolo Mellini, Diana Borovika, Biagina Marrocco, Agnese Po, Zein Mersini Besharat, Giuseppina Catanzaro, Giuseppe Battaglia, Luana Abballe, Clemens Zwergel, Giulia Stazi, Ciro Milite, Sabrina Castellano, Marco Tafani, Peteris Trapencieris, Antonello Mai, Elisabetta Ferrett. The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells. Oncotarget. vol 8. issue 40. 2019-11-20. PMID:28978137. |
pharmacological inhibition of ezh2 impairs shh mb cells proliferation and self-renewal, and induces apoptosis |
2019-11-20 |
2023-08-13 |
mouse |
| Bin Wang, Yingying Zhang, Hongli Dong, Siyi Gong, Bin Wei, Man Luo, Hongyan Wang, Xiaohui Wu, Wei Liu, Xingshun Xu, Yufang Zheng, Miao Su. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell death & disease. vol 9. issue 5. 2019-11-08. PMID:29725084. |
in conclusion, our results show that tctn3 ko disrupts the shh signaling pathway and neural tube patterning, resulting in abnormal embryonic development, cellular apoptosis, and prenatal death in mice. |
2019-11-08 |
2023-08-13 |
mouse |
| Marah Hehemann, Shawn Choe, Elizabeth Kalmanek, Daniel Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlase. Pelvic and hypogastric nerves are injured in a rat prostatectomy model, contributing to development of stress urinary incontinence. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:30401879. |
cn, pn, hyg and ancillary (anc) of uninjured, sham and cn crush/mpg tension injured (prostatectomy model) adult sprague dawley rats (n = 37) were examined for apoptosis, sonic hedgehog (shh) pathway, and intrinsic and extrinsic apoptotic mechanisms. |
2019-10-22 |
2023-08-13 |
rat |
| Junsheng Fu, Anju Shrivastava, Sushant K Shrivastava, Rakesh K Srivastava, Sharmila Shanka. Triacetyl resveratrol upregulates miRNA‑200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent. International journal of oncology. vol 54. issue 4. 2019-08-16. PMID:30720134. |
the inhibitory effects of tcrv on emt and the induction of apoptosis were exerted through the suppression of the sonic hedgehog (shh) pathway, and through the modulation of cyclin d1 and bcl‑2 expression. |
2019-08-16 |
2023-08-13 |
human |
| Lian Liu, Bo Zhao, Xiaoxing Xiong, Zhongyuan Xi. The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke. Neurochemical research. vol 43. issue 12. 2019-05-23. PMID:30267379. |
in our review, we elaborate the roles of shh signaling in ischemic stroke from different aspects, including oxidative stress, excitotoxicity, neuroinflammation, apoptosis, angiogenesis, neuroplasticity, neurogenesis, astrogliosis and oligodendrogenesis. |
2019-05-23 |
2023-08-13 |
Not clear |
| Jian-Chun Lin, Zhong-Guo Liu, Bin Yu, Xian-Rong Zhan. MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway. Biochemical and biophysical research communications. vol 506. issue 1. 2019-05-21. PMID:30342851. |
besides, elevated expression of mir-874, shh, ptch, smo, bmp2, runx2 and pcna, as well as increased cell viability, alp activity and calcium nodules but decreased expression of sufu and bax, and reduced cell apoptosis were confirmed when treated with mir-874 mimic. |
2019-05-21 |
2023-08-13 |
mouse |
| A-Ching Chao, Chien-Hui Chen, Shih-Hsin Chang, Chao-Tzu Huang, Wei-Chao Hwang, Ding-I Yan. Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29721855. |
in this work, we tested the hypothesis that aβ-induced id1 and shh contribute to cell cycle reentry leading to apoptosis in neurons. |
2019-04-01 |
2023-08-13 |
Not clear |
| A-Ching Chao, Chien-Hui Chen, Shih-Hsin Chang, Chao-Tzu Huang, Wei-Chao Hwang, Ding-I Yan. Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29721855. |
taken together, our results revealed the critical roles of id1 and shh mediating aβ-dependent cell cycle reentry and subsequently caspase-dependent apoptosis in the fully differentiated post-mitotic neurons, at least in vitro. |
2019-04-01 |
2023-08-13 |
Not clear |
| Jingmin Li, Heng Cai, Hongxing Li, Yanguo Liu, Yirong Wang, Yan Shi, Yan Sun, Haoran Song, Dong Wan. Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer. Oncology reports. vol 41. issue 3. 2019-03-06. PMID:30747231. |
the results revealed that the dual use of the shh inhibitor and the hdac inhibitor effectively synergized to inhibit proliferation, and promote apoptosis in liver cancer cells. |
2019-03-06 |
2023-08-13 |
human |
| Pingyi Liu, Lingling Che. Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma. Leukemia research. vol 64. 2018-11-05. PMID:29132010. |
the present study explored the effects of forkhead box q1 (foxq1) on cell proliferation, cell cycle and apoptosis via the sonic hedgehog (shh) pathway in natural killer/t-cell lymphoma (nktcl). |
2018-11-05 |
2023-08-13 |
Not clear |
| Pingyi Liu, Lingling Che. Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma. Leukemia research. vol 64. 2018-11-05. PMID:29132010. |
the inhibition of foxq1 restricted nktcl cell proliferation and growth but induced apoptosis via blocking the shh signaling pathway. |
2018-11-05 |
2023-08-13 |
Not clear |
| Kuang-Yao Chen, Cheng-Hsun Chiu, Lian-Chen Wan. Anti-apoptotic effects of Sonic hedgehog signalling through oxidative stress reduction in astrocytes co-cultured with excretory-secretory products of larval Angiostrongylus cantonensis. Scientific reports. vol 7. 2018-10-18. PMID:28169282. |
co-culturing astrocytes with soluble antigens of a. cantonensis activated the sonic hedgehog (shh) signalling pathway and inhibited the apoptosis of astrocytes via the activation of bcl-2. |
2018-10-18 |
2023-08-13 |
mouse |