| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huashan Huang, Huizhen Yu, Liang Lin, Junming Chen, Pengli Zh. Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling. International journal of molecular medicine. vol 45. issue 6. 2021-01-21. PMID:32186749. |
the present study used recombinant shh‑n protein (rshh‑n) and a plasmid encoding the human shh gene (phshh) to investigate the role of shh in ox‑ldl‑mediated human umbilical vein endothelial cell (huvec) apoptosis. |
2021-01-21 |
2023-08-13 |
human |
| Huashan Huang, Huizhen Yu, Liang Lin, Junming Chen, Pengli Zh. Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling. International journal of molecular medicine. vol 45. issue 6. 2021-01-21. PMID:32186749. |
the present study found that ox‑ldl was able to induce apoptosis in huvecs and that shh protein expression was downregulated. |
2021-01-21 |
2023-08-13 |
human |
| Huashan Huang, Huizhen Yu, Liang Lin, Junming Chen, Pengli Zh. Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling. International journal of molecular medicine. vol 45. issue 6. 2021-01-21. PMID:32186749. |
together, the present findings suggested that shh serves an important protective role in alleviating ox‑ldl‑mediated endothelial apoptosis by inhibiting the nf‑κb signaling pathway phosphorylation and bcl‑2 mediated mitochondrial signaling. |
2021-01-21 |
2023-08-13 |
human |
| Xiao-Qin Zhu, Hong Yang, Ming-He Lin, Hai-Xia Shang, Jun Peng, Wu-Jin Chen, Xu-Zheng Chen, Jiu-Mao Li. Qingjie Fuzheng Granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via Sonic Hedgehog pathway. Journal of gastrointestinal oncology. vol 11. issue 6. 2021-01-19. PMID:33456987. |
sonic hedgehog (shh) signaling pathway plays a critical role in cell proliferation, apoptosis, and tumor angiogenesis in various types of malignancies including colorectal cancer (crc). |
2021-01-19 |
2023-08-13 |
mouse |
| Emílio Pereira de Brito Neto, Evelyze Pinheiro Dos Reis, Jurandy Mauro Penitente-Filho, José Carlos Montes, Karine Assis Costa, Susana Amaral Teixeira, Walmir Silva, Rogério Pinho, José Domingos Guimarães, Eduardo Paulino da Costa, Marcos Soares Lopes, Simone Eliza Facioni Guimarãe. Expression of apoptosis and myogenesis related genes during prenatal life in two divergent breeds of pigs. Theriogenology. vol 145. 2021-01-07. PMID:32004820. |
expression of apoptosis and myogenesis related genes (bax, bcl2, fgf4, ihh, hhip, shh, sox2, wnt1 and wnt4) were evaluated by quantitative real time pcr. |
2021-01-07 |
2023-08-13 |
Not clear |
| Pierre-Antoine Bissey, Pauline Mathot, Catherine Guix, Mélissa Jasmin, Isabelle Goddard, Clélia Costechareyre, Nicolas Gadot, Jean-Guy Delcros, Sachitanand M Mali, Rudi Fasan, André-Patrick Arrigo, Robert Dante, Gabriel Ichim, Patrick Mehlen, Joanna Fombonn. Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis. Cancer research. vol 80. issue 10. 2020-10-26. PMID:32060146. |
we reported earlier that the shh receptor patched (ptch) is a dependence receptor that triggers apoptosis in the absence of shh through a pathway that differs from the canonical one, thus generating a state of dependence on shh for survival. |
2020-10-26 |
2023-08-13 |
human |
| Pierre-Antoine Bissey, Pauline Mathot, Catherine Guix, Mélissa Jasmin, Isabelle Goddard, Clélia Costechareyre, Nicolas Gadot, Jean-Guy Delcros, Sachitanand M Mali, Rudi Fasan, André-Patrick Arrigo, Robert Dante, Gabriel Ichim, Patrick Mehlen, Joanna Fombonn. Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis. Cancer research. vol 80. issue 10. 2020-10-26. PMID:32060146. |
here, we propose a dual function for shh: its binding to ptch not only activates the shh canonical pathway but also blocks ptch-induced apoptosis. |
2020-10-26 |
2023-08-13 |
human |
| Zhongxiao Lin, Hansong Sheng, Chaoguo You, Ming Cai, Yiping Zhang, Li Sheng Yu, Xiaoming Yu, Jian Lin, Nu Zhan. Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1. Experimental and therapeutic medicine. vol 13. issue 1. 2020-10-01. PMID:28123507. |
therefore, the present study investigated whether the shh signaling pathway promotes the apoptosis of mb cells via downregulation of gli1. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jinhua Li, Dandan Zong, Yan Chen, Ping Che. Anti-apoptotic effect of the Shh signaling pathway in cigarette smoke extract induced MLE 12 apoptosis. Tobacco induced diseases. vol 17. 2020-10-01. PMID:31516492. |
anti-apoptotic effect of the shh signaling pathway in cigarette smoke extract induced mle 12 apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jinhua Li, Dandan Zong, Yan Chen, Ping Che. Anti-apoptotic effect of the Shh signaling pathway in cigarette smoke extract induced MLE 12 apoptosis. Tobacco induced diseases. vol 17. 2020-10-01. PMID:31516492. |
we aimed to verify the anti-apoptotic effect of shh in the aecii apoptosis induced by cse. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chuanqing Wu, Shaobo Hu, Ji Cheng, Guobin Wang, Kaixiong Ta. Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines. Experimental and therapeutic medicine. vol 13. issue 5. 2020-09-29. PMID:28565875. |
cell proliferation was inhibited, while apoptosis was increased by gdc-0449, whereas the expression of b-cell lymphoma 2 (bcl-2), a downstream target of shh signaling, was decreased. |
2020-09-29 |
2023-08-13 |
Not clear |
| Gianmarco Pallavicini, Giorgia Iegiani, Gaia Elena Berto, Elisa Calamia, Edoardo Trevisiol, Andrea Veltri, Simona Allis, Ferdinando Di Cunt. CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents. Cancers. vol 12. issue 3. 2020-09-28. PMID:32111106. |
citron kinase protein (citk) has been proposed as a promising target for shh mb, whose inactivation leads to dna damage and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| S J Li, Q H Mei, S Y Zeng, L L Lai, J Quan, X Zhan. Protective effect of sonic hedgehog signaling pathway activation on acute myocardial infarction. Journal of biological regulators and homeostatic agents. vol 34. issue 2. 2020-09-16. PMID:32515175. |
in conclusion, activation of the shh signaling pathway improved cardiac functions and myocardial remodeling and reduced the apoptosis of myocardial cells. |
2020-09-16 |
2023-08-13 |
mouse |
| Tiantian Su, Hui Liu, Di Zhang, Guojin Xu, Jiali Liu, Sylvia M Evans, Jirong Pan, Sheng Cu. LIM homeodomain transcription factor Isl1 affects urethral epithelium differentiation and apoptosis via Shh. Cell death & disease. vol 10. issue 10. 2020-08-27. PMID:31558700. |
lim homeodomain transcription factor isl1 affects urethral epithelium differentiation and apoptosis via shh. |
2020-08-27 |
2023-08-13 |
mouse |
| Qing Guo, Mei-Fu Xuan, Zhao-Bo Luo, Jun-Xia Wang, Sheng-Zhong Han, Myong-Hak Ri, Yong-Gyu Choe, Kyung-Min Hwang, Xi-Jun Yin, Jin-Dan Kan. Baicalin improves the in vitro developmental capacity of pig embryos by inhibiting apoptosis, regulating mitochondrial activity and activating sonic hedgehog signaling. Molecular human reproduction. vol 25. issue 9. 2020-07-14. PMID:31553448. |
in conclusion, baicalin improves the in vitro developmental capacity of pa and ivf pig embryos by inhibiting ros production and apoptosis, regulating mitochondrial activity and activating shh signaling. |
2020-07-14 |
2023-08-13 |
Not clear |
| Vikas Bhuria, Jun Xing, Tim Scholta, Khac Cuong Bui, Mai Ly Thi Nguyen, Nisar P Malek, Przemyslaw Bozko, Ruben R Plent. Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinoma. Experimental cell research. vol 385. issue 2. 2020-06-18. PMID:31634481. |
cyclopamine induced apoptosis in cc cells under hypoxia, suggesting that hypoxia induced activation of shh pathway has modulatory effects on cc progression. |
2020-06-18 |
2023-08-13 |
Not clear |
| Malte Hellwig, Marlen C Lauffer, Michael Bockmayr, Michael Spohn, Daniel J Merk, Luke Harrison, Julia Ahlfeld, Annabel Kitowski, Julia E Neumann, Jasmin Ohli, Dörthe Holdhof, Judith Niesen, Melanie Schoof, Marcel Kool, Cornelia Kraus, Christiane Zweier, Dan Holmberg, Ulrich Schülle. TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma. Acta neuropathologica. vol 137. issue 4. 2020-04-21. PMID:30830316. |
in vivo, a prenatal knockout of tcf4 in mice caused a significant increase in apoptosis accompanied by a decreased proliferation and failed migration of cerebellar granule neuron precursor cells (cgnp), which are thought to be the cells of origin for shh mb. |
2020-04-21 |
2023-08-13 |
mouse |
| Shawn Choe, Elizabeth Kalmanek, Christopher Bond, Daniel A Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlase. Optimization of Sonic Hedgehog Delivery to the Penis from Self-Assembling Nanofiber Hydrogels to Preserve Penile Morphology after Cavernous Nerve Injury. Nanomedicine : nanotechnology, biology, and medicine. vol 20. 2020-03-04. PMID:31173931. |
we developed a self-assembling peptide amphiphile (pa) nanofiber hydrogel for extended release of shh protein to the penis after cn injury, to suppress sm apoptosis. |
2020-03-04 |
2023-08-13 |
Not clear |
| Shawn Choe, Elizabeth Kalmanek, Christopher Bond, Daniel A Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlase. Optimization of Sonic Hedgehog Delivery to the Penis from Self-Assembling Nanofiber Hydrogels to Preserve Penile Morphology after Cavernous Nerve Injury. Nanomedicine : nanotechnology, biology, and medicine. vol 20. 2020-03-04. PMID:31173931. |
shh treatment suppressed apoptosis and preserved sm 48%. |
2020-03-04 |
2023-08-13 |
Not clear |
| Yonghui Wang, Yana Sui, Yinggang Ta. Gambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway. Molecular medicine reports. vol 20. issue 5. 2020-02-28. PMID:31545492. |
in the present study, the cell counting kit‑8 assay was used to examine the effect of ga and/or paclitaxel on the viability of tnbc cells; flow cytometry was used to examine the effects of ga on cell apoptosis; and western blotting and reverse transcription‑quantitative pcr were used to determine the effects of ga on the expression of sonic hedgehog (shh) signaling pathway target genes. |
2020-02-28 |
2023-08-13 |
human |